Clinical and experimental hypertension. Part B, Hypertension in pregnancy最新文献

Pre-eclampsia in a second pregnancy. 第二次怀孕的先兆子痫。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1985-11-01 DOI: 10.1097/00006254-198511000-00005

D. Campbell, R. Carr-Hill, A. E. Orisaseyi

引用次数: 1

A clinical follow-up study of 260 women with hypertension in pregnancy. 260例妊娠期高血压妇女临床随访研究

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1984-04-01 DOI: 10.1097/00006254-198404000-00007

A. Svensson, B. Andersch, L. Hansson

引用次数: 3

Prostacyclin production in whole blood throughout normal pregnancy. 正常妊娠全血中前列环素的产生。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309006079

B Spitz, H Deckmyn, F A Van Assche, J Vermylen

引用次数: 18

Diurnal rhythms of blood pressure, plasma renin activity, angiotensin II and catecholamines in normotensive and hypertensive pregnancies. 血压、血浆肾素活性、血管紧张素II和儿茶酚胺在正常和高血压妊娠期的昼夜节律。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309006086

L J Beilin, J Deacon, C A Michael, R Vandongen, C M Lalor, A E Barden, L Davidson, I Rouse

{"title":"Diurnal rhythms of blood pressure, plasma renin activity, angiotensin II and catecholamines in normotensive and hypertensive pregnancies.","authors":"L J Beilin, J Deacon, C A Michael, R Vandongen, C M Lalor, A E Barden, L Davidson, I Rouse","doi":"10.3109/10641958309006086","DOIUrl":"https://doi.org/10.3109/10641958309006086","url":null,"abstract":"Diurnal patterns of blood pressure and pressor hormones after 26 weeks gestation were compared in 10 normotensive women, 13 subjects with uncomplicated hypertension, and 8 with biochemical evidence of pre-eclampsia. 4 of the pre-eclamptics showed nocturnal hypertension. Levels of plasma renin activity fell progressively from 9 a.m. to midnight in all three groups, and were significantly lower in pre-eclampsia. Plasma angiotensin II levels fell during the day in normotensives and uncomplicated hypertensives, whereas pre-eclamptics showed loss of this pattern and significantly lower levels than the other groups. Free plasma norepinephrine levels fell during the day and to a similar extent in all three groups. A diurnal pattern for free plasma norepinephrine levels, with lower levels at midnight than during the day, was seen in normotensives and uncomplicated hypertensives but not in pre-eclamptics. Plasma norepinephrine sulphate levels rose from 9.00 a.m. to midnight in normotensives and uncomplicated hypertensives. This pattern was reversed in pre-eclamptics, including 3 of the 4 subjects with nocturnal hypertension. Plasma epinephrine sulphate levels rose progressively through the day, with no significant differences between groups. Failure of plasma angiotensin II or epinephrine levels to fall at night in pre-eclampsia may contribute to nocturnal hypertension in subjects with increased vascular reactivity. Suppression of plasma renin activity and angiotensin II levels suggests that perhaps as yet unidentified pressor mechanisms are involved in pre-eclampsia.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 2","pages":"271-93"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309006086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17408245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47

Therapeutic use of PGA1 infusions in severe pre-eclampsia - a major clinical potential. PGA1输注治疗重度先兆子痫-一个重要的临床潜力。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309006082

M K Toppozada, S A Shaala, H A Moussa

{"title":"Therapeutic use of PGA1 infusions in severe pre-eclampsia - a major clinical potential.","authors":"M K Toppozada, S A Shaala, H A Moussa","doi":"10.3109/10641958309006082","DOIUrl":"https://doi.org/10.3109/10641958309006082","url":null,"abstract":"Pilot studies showed that, i.v. infusions of the renal prostaglandin A1 (PGA1) induced a triad of beneficial clinical responses in severe pre-eclampsia; the blood pressure became normotensive, renal function was markedly improved and labour was successfully induced. The present study was an attempt to develop a therapeutic schedule of PGA1 administration in severe toxemia. Twenty one cases of severe pre-eclampsia (in 3 equal groups) received i.v. infusions of PGA1 in a dose range of 0.1-0.5 microgram/kgm/min for 12 - 24 hours and the B.P., uterine activity and FHR were continuously monitored during and for 12 hours following the infusion period. The 0.1 microgram/Kgm/min dose for 12 hours was inadequate while 0.5 microgram/Kgm/min for 12 hours induced a good hypotensive response and the cases delivered within 48 hours but a post-infusion rebound in hypertension was observed. The dose of 0.5 microgram/Kgm/min for 24 hours appeared to be optimal in clinical terms since a satisfactory effect on B.P. was recorded and all the subjects delivered normal babies during the infusion period with minimal or no post-infusion rebound rise in B.P. This approach holds a major potential in the treatment of severe pre-eclampsia.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 2","pages":"217-32"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309006082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17922080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

High risk hypertensive pregnancies: maternal and foetal outcome. 高危高血压妊娠:孕产妇和胎儿结局。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023456

J S Horvath, A Phippard, D H Smart, A Korda, G G Duggin, B M Hall, D J Tiller

引用次数: 2

Maternal hypertension during pregnancy and high blood pressure in children. Preliminary communication. 孕妇妊娠期高血压和儿童高血压。初步沟通。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309006080

A Svensson, L Sigström, B Andersch, L Hansson

引用次数: 10

Disposition of the adrenergic blocker metoprolol in the late pregnant women, the amniotic fluid, the cord blood and the neonate. 肾上腺素能阻滞剂美托洛尔在孕晚期妇女、羊水、脐带血及新生儿中的分布。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023460

B Sandström, S Lindeberg, P Lundborg, C G Regårdh

{"title":"Disposition of the adrenergic blocker metoprolol in the late pregnant women, the amniotic fluid, the cord blood and the neonate.","authors":"B Sandström, S Lindeberg, P Lundborg, C G Regårdh","doi":"10.3109/10641958309023460","DOIUrl":"https://doi.org/10.3109/10641958309023460","url":null,"abstract":"Pharmacokinetic studies of the concentration of the beta 1-blocker metoprolol have been performed in maternal plasma, amniotic fluid, breast milk and the plasma of the newborn. The concentration of metoprolol in maternal plasma exceeds that in the amniotic fluid initially but not later on. The quotient between the metoprolol concentration in the venous maternal blood and the mixed cord blood at the time of delivery is at about 1. In the maternal plasma the metoprolol concentration will decline in a rapid way after the latest dose probably because of an increased clearance. Blood levels of metoprolol during the first postnatal hours will increase almost fourfold and are generally followed by a decrease over the next 15 hours. Active metabolites of metoprolol (alfa-OH-metoprolol and O-demethyl-metoprolol) are found in the urine of the newborn. The breast milk concentration of metoprolol is 3 times higher than in the maternal milk but the sucking newborn will only show very low or unmeasurable plasma levels between consecutive breast feeding periods in the majority of cases.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 1","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309023460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17201347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Urinary protein patterns and preeclampsia. 尿蛋白模式和先兆子痫。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023466

F J Kaltenbach, W H Boesken, C Wilhelm, J Ziupa, M N Toussaint, L Quaas

{"title":"Urinary protein patterns and preeclampsia.","authors":"F J Kaltenbach, W H Boesken, C Wilhelm, J Ziupa, M N Toussaint, L Quaas","doi":"10.3109/10641958309023466","DOIUrl":"https://doi.org/10.3109/10641958309023466","url":null,"abstract":"A retrospective study of urinary protein patterns, as determined by SDS-PAA-disc-electrophoresis was performed in 107 patients in third trimester of pregnancy because of preeclampsia. The aim was to determine whether the protein patterns allow a differentiation between nephropathies associated with genuine toxaemia of pregnancy and those in which toxaemia was superimposed on preexisting renal glomerular or tubular disease. The magnitude and type of proteinuria was related to the mean arterial pressure (MAP). 47% of all patients showed a mixed protein pattern independent of the MAP-severity. This form of proteinuria is probably associated with a genuine toxaemia of pregnancy. It was not possible to determine if pure glomerulopathies whose frequency rose with MAP, had already been present before pregnancy. In a third of the 22 patients followed-up post-partum pathological protein patterns or increased protein excretion was detected. This implies that 35% of the nephropathies were present before pregnancy. However, differentiation between preexisting and toxaemia associated nephropathy was not always possible. SDS-PAA-analysis of urinary protein should be carried out in earlier stages of pregnancy in cases of increasing MAP and proteinuria.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 1","pages":"133-44"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309023466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17923170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The effect of pregnancy on heart size and blood pressure in renal hypertensive rats. 妊娠对肾性高血压大鼠心脏大小及血压的影响。

Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1983-01-01 DOI: 10.3109/10641958309023459

U Ljungblad, K Karlsson, Y Lundgren

{"title":"The effect of pregnancy on heart size and blood pressure in renal hypertensive rats.","authors":"U Ljungblad, K Karlsson, Y Lundgren","doi":"10.3109/10641958309023459","DOIUrl":"https://doi.org/10.3109/10641958309023459","url":null,"abstract":"The main purpose of this study on rats was to examine the effect of pregnancy on experimental renal hypertension and cardiac size. Renal hypertension in the rats (RHR) was induced by standardized clamping of the left renal artery early in pregnancy (SRHR) or 4 weeks before mating (ERHR). As controls served non-pregnant RHR with the duration of hypertension matched to each above mentioned group, as well as non-pregnant and pregnant normotensive rats. Only 16% of the rats with renal artery clamping early in pregnancy (SRHR) developed hypertension in contrast to 41% of similarly operated non-pregnant rats and 56% of ERHR decreased their blood pressure to normal levels during pregnancy. Concerning left ventricular heart weight there was a slight increase in left ventricular weight during normal pregnancy in spite of a significantly reduced blood pressure. In both SRHR and ERHR an increased left ventricular heart weight was noticed during pregnancy even when arterial pressure was not increased. The present results suggest an antihypertensive effect of pregnancy and the existence of \"trophic\" influences and/or a volume induced adaptation of the heart causing an increased myocardial mass which is associated with pregnancy and partly independent of blood pressure influences.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"2 1","pages":"61-74"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958309023459","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17922983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7