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Clinical and experimental hypertension. Part B, Hypertension in pregnancy最新文献

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A prospective study of circulating prolactin during primigravid pregnancy. 初孕期间循环催乳素的前瞻性研究。
Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1982-01-01 DOI: 10.3109/10641958209037181
R H Hayashi, T M Siler-Khodr, R A Becker
{"title":"A prospective study of circulating prolactin during primigravid pregnancy.","authors":"R H Hayashi,&nbsp;T M Siler-Khodr,&nbsp;R A Becker","doi":"10.3109/10641958209037181","DOIUrl":"https://doi.org/10.3109/10641958209037181","url":null,"abstract":"<p><p>A prospective, cross-sectional study of 164 primigravid patients was conducted to determine the role of prolactin in the pathogenesis of pregnancy induced hypertension. Clinically normal patients had peripheral venous blood sampled from the lateral and recumbent positions monthly in the morning during their last two trimesters in labor and six weeks postpartum. One-third of the patients had 24 hour urine collections. Homologous double antibody radioimmunoassays were performed to determine prolactin levels. The data were analyzed according to pregnancy outcome: pregnancy-induced hypertension or normotensive throughout pregnancy. Acute positional change did not influence prolactin level. Prolactin levels were significantly elevated in the hypertensive outcome group only at 37-39 weeks and were not correlated with sodium excretion. We conclude that circulating prolactin does not play a significant role in pathogenesis of pregnancy-induced hypertension, but perhaps the elevated levels may be reflecting pathophysiologic changes.</p>","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"1 1","pages":"57-71"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958209037181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18200415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effects of hypertensive disorders on the outcome of pregnancy: early findings of maternity care monitoring (MCM) in Debrecen, Hungary. 高血压疾病对妊娠结局的影响:匈牙利德布勒森产妇护理监测(MCM)的早期发现。
Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1982-01-01 DOI: 10.3109/10641958209037178
L Lampé, I Batár, R P Bernard
{"title":"Effects of hypertensive disorders on the outcome of pregnancy: early findings of maternity care monitoring (MCM) in Debrecen, Hungary.","authors":"L Lampé,&nbsp;I Batár,&nbsp;R P Bernard","doi":"10.3109/10641958209037178","DOIUrl":"https://doi.org/10.3109/10641958209037178","url":null,"abstract":"<p><p>Debrecen is one of the original testing sites of MCM. This report focuses on all single births having occurred from January, 1978 to June, 1980 (N = 8818). Pregnancy outcome associated with maternal Hypertensive Disorders in Pregnancy (HDP) shall be set against pregnancy outcome among women with No Primary Antenatal Conditions (Control), the respective sample sizes being N = 540 (HDP) and N = 5, 472 women. The findings are given in four sections: (1) Occurrence of HDP; (2) Characteristics other than presence/absence of HDP; (3) Reproductive experience prior to current delivery; and (4) Maternal and infant outcome for the current delivery. A specific look is also given at smoking during current pregnancy. Special attention is called for the primordial importance of prenatal visits, preventive care and proper obstetrical management. The role of the MCM early warning system is emphasized and broader use of the system and rationale is suggested for objective international and intranational comparisons to improve pregnancy outcome for both the mother and infant.</p>","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"1 1","pages":"1-37"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958209037178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18032133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune complexes and vasoactivity generated from platelets in pre-eclampsia. 子痫前期血小板产生的免疫复合物和血管活性。
Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1982-01-01 DOI: 10.3109/10641958209009623
R L Medcalf, R J Kuhn, J D Mathews, R F Moulds
{"title":"Immune complexes and vasoactivity generated from platelets in pre-eclampsia.","authors":"R L Medcalf,&nbsp;R J Kuhn,&nbsp;J D Mathews,&nbsp;R F Moulds","doi":"10.3109/10641958209009623","DOIUrl":"https://doi.org/10.3109/10641958209009623","url":null,"abstract":"<p><p>In vivo platelet activation by circulating immune complexes has been suggested as one of the underlying mechanisms in preeclampsia. Using a modification of the polyethylene glycol protein-A immune complex assay, immune complexes were found in excess of the equivalent of 20 micrograms/ml heat aggregated IgG in fourteen out of twenty patients diagnosed as having pre-eclampsia. Only six out of nineteen normal controls were found to have similar levels of immune complexes. Furthermore, using a small volume bio-assay method, concentrations of heat aggregated IgG in excess of 20 micrograms/ml were found to activate platelets to release sufficient concentrations of vasoactive agents to constrict a human blood vessel in vitro. These results support the hypothesis that in vivo platelet activation by immune complexes can release sufficient concentrations of vasoactive agents to contribute to the hypertension characteristic of pre-eclampsia.</p>","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"1 4","pages":"511-29"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958209009623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17284163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy. 妊娠期重度高血压患者静脉注射拉贝他洛尔和静脉注射二羟嗪。
Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1982-01-01 DOI: 10.3109/10641958209139860
A Garden, D A Davey, J Dommisse
{"title":"Intravenous labetalol and intravenous dihydralazine in severe hypertension in pregnancy.","authors":"A Garden,&nbsp;D A Davey,&nbsp;J Dommisse","doi":"10.3109/10641958209139860","DOIUrl":"https://doi.org/10.3109/10641958209139860","url":null,"abstract":"<p><p>The effect of intravenous infusion of labetalol and of dihydralazine in increasing doses was compared in 12 women with severe hypertension in pregnancy. In 5 our of 6 women labetalol produced a smooth, progressive fall in blood pressure to normal levels with minimal side effects. In 2 our of 6 women on dihydralazine the blood pressure control was satisfactory but in the remaining 4 patients treatment had to by discontinued because of unpredictable, sudden falls in blood pressure. One of the 6 infants of mothers treated with labetalol manifested signs of adrenergic blockade. Continuous infusion of labetalol appears to offer significant advantages in the management of severe hypertension in pregnancy and merits further trial.</p>","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"1 2-3","pages":"371-83"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958209139860","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18155864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 60
Changes in central hemodynamics during pregnancy in renal hypertensive rats. 肾性高血压大鼠妊娠期中央血流动力学的变化。
Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1982-01-01 DOI: 10.3109/10641958209009618
Y Lundgren, K Karlsson, U Ljungblad
{"title":"Changes in central hemodynamics during pregnancy in renal hypertensive rats.","authors":"Y Lundgren,&nbsp;K Karlsson,&nbsp;U Ljungblad","doi":"10.3109/10641958209009618","DOIUrl":"https://doi.org/10.3109/10641958209009618","url":null,"abstract":"<p><p>Central hemodynamics during late pregnancy were studied in normotensive rats and in rats with short-standing and \"established\" renal hypertension. In normal pregnancy cardiac output was increased 33%, due to increased stroke volume while mean arterial pressure and systemic resistance were reduced 17 and 40% respectively. The same changes, though less pronounced were noted during pregnancy in rats with short-standing renal hypertension, where cardiac output was increased 31%, due to equal increases in heart rate and stroke volume while systemic resistance was reduced only 27%. By contrast, no significant cardiac output increase, nor any resistance reduction was noted during pregnancy in rats with established hypertension. Thus, renal hypertension in rats seems to interfere with circulation during pregnancy mainly by restricting both the cardiac output increase and the systemic resistance reduction seen during normal pregnancy. This restriction seems to be more pronounced the longer the duration of hypertension.</p>","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"1 4","pages":"441-53"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958209009618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18179579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Fetal activity patterns in hypertensive pregnancies. 高血压妊娠的胎儿活动模式。
Clinical and experimental hypertension. Part B, Hypertension in pregnancy Pub Date : 1982-01-01 DOI: 10.3109/10641958209037185
W F Rayburn
{"title":"Fetal activity patterns in hypertensive pregnancies.","authors":"W F Rayburn","doi":"10.3109/10641958209037185","DOIUrl":"https://doi.org/10.3109/10641958209037185","url":null,"abstract":"This prospective investigation attempts to determine whether the maternal recording of perceived fetal motion is useful for fetal assessment in pregnancies complicated by hypertension. During a 21 month period, 124 patients whose pregnancies were complicated by either chronic or pregnancy-induced hypertension participated. The number of perceived movements per hour (24 +/- 11, mean +/- S.D.) and evidence for fetal inactivity (7 cases, 6%) did not vary significantly from a control group of normotensive pregnancies (p greater than 0.05). Fetal inactivity was predictive of an unfavorable perinatal outcome in 6 of 7 cases, including the three stillborn infants. No perinatal deaths occurred among the 117 hypertensive pregnancies with active fetuses, and the 6 cases with an unfavorable outcome were associated with mild intrauterine growth delay, prematurity, or acute changes such as placental abruption or umbilical cord accidents. Realizing these limitations, a record of fetal inactivity is worthwhile in managing the pregnancy complicated by hypertension.","PeriodicalId":79209,"journal":{"name":"Clinical and experimental hypertension. Part B, Hypertension in pregnancy","volume":"1 1","pages":"119-26"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10641958209037185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18199351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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