Green Chemistry最新文献_第2页

Activating dynamic Zn–ZnO interface with controllable oxygen vacancy in CO2 electroreduction for boosting CO production† 可控氧空位激活CO2电还原过程中动态Zn-ZnO界面，提高CO产率

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-29 DOI: 10.1039/D5GC00955C

Xueqi Liu, Jingmin Ge, Shiying Li, Huanhuan Yang, Huiwen Tian, Hongpo Liu, Yaxi Li, Xiaoli Zheng, Yapeng Tian, Xinwei Cui and Qun Xu

{"title":"Activating dynamic Zn–ZnO interface with controllable oxygen vacancy in CO2 electroreduction for boosting CO production†","authors":"Xueqi Liu, Jingmin Ge, Shiying Li, Huanhuan Yang, Huiwen Tian, Hongpo Liu, Yaxi Li, Xiaoli Zheng, Yapeng Tian, Xinwei Cui and Qun Xu","doi":"10.1039/D5GC00955C","DOIUrl":"https://doi.org/10.1039/D5GC00955C","url":null,"abstract":"Identification of the active sites of zinc oxide-derived catalysts and further elucidation of their catalytic mechanism for electrochemical CO2 reduction reaction (CO2RR) are limited by the dynamic structural evolution at real reaction conditions. Herein, we focused on the structural evolution of ZnO-T at the initial stage of CO2RR. ZnO-T underwent in situ reduction to Zn within dozen of minutes, which was followed by reoxidation of the outer layer. As a result, core–shell-like Zn@ZnO-T with controllable Zn–ZnO interfaces and oxygen vacancies was obtained via temperature-controlled annealing and electrochemical pre-treatment. Zn–ZnO interfaces altered the energy band structure of ZnO layer, while the oxygen vacancies modified the electron density of Zn sites. Thus, the obtained Zn@ZnO-T improved the charge transfer, facilitated CO2 activation, and lowered the energy barrier for *COOH and *CO intermediate formation. Expectedly, Zn@ZnO-T demonstrated excellent CO2RR performance for CO production with FE up to 92.1% at −1.2 V (vs. RHE) and a current density of −12.7 mA cm−2. In particular, Zn@ZnO-650 delivered a high FECO above 85% over a wide potential range from −1.0 to −1.3 V (vs. RHE). This study provides a new direction for mechanistic investigations on the relationship between intrinsic structure and catalytic performance, guiding the rational design of high-performance heterogeneous catalysts.","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" 21","pages":" 6133-6144"},"PeriodicalIF":9.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A photo-Fenton-like (trideutero)methylation reaction of N/O heterocycles with DMSO(-d6) induced by EDA complex photocatalysis† EDA复合光催化诱导N/O杂环与DMSO（-d6）的光fenton样（三氘）甲基化反应

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-29 DOI: 10.1039/D4GC05939E

Changsheng Qin, Chenxu Li, Fang Gao, Jingfang Wang, Zhihua Zhang, Shuai Zhang, Xinyue Li, Yi Sun, Meiqian Hu, Shoucai Wang, Fanghua Ji and Guangbin Jiang

{"title":"A photo-Fenton-like (trideutero)methylation reaction of N/O heterocycles with DMSO(-d6) induced by EDA complex photocatalysis†","authors":"Changsheng Qin, Chenxu Li, Fang Gao, Jingfang Wang, Zhihua Zhang, Shuai Zhang, Xinyue Li, Yi Sun, Meiqian Hu, Shoucai Wang, Fanghua Ji and Guangbin Jiang","doi":"10.1039/D4GC05939E","DOIUrl":"https://doi.org/10.1039/D4GC05939E","url":null,"abstract":"DMSO is a prominent and indispensable methylating agent within the realm of organic synthesis. We report an innovative strategy employing an in situ generated EDA (electron-donor–acceptor) complex as an active photocatalyst to achieve N/O heterocycle (deutero)methylation based on DMSO(-d6). Mechanistic investigations reveal that the reaction proceeds through the synergistic action of the EDA active catalyst, water, and oxygen, inducing the formation of hydroxyl radicals in a Fenton-like process. Compared to traditional Fenton-based methylation reactions utilizing DMSO, this approach circumvents the necessity for metal catalysts and strong oxidants, thereby exhibiting significant enhancements in environmental friendliness, safety, and economy. Furthermore, a variety of N/O heterocycles, including azauracils, quinoxalinones, and coumarins, are compatible with the reaction system, which was previously unattainable in conventional Fenton methylation reactions.","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" 21","pages":" 6206-6212"},"PeriodicalIF":9.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dipole moment regulation of a small-molecule quinone mediator boosts long-term cycling stability for decoupled water electrolysis† 偶极矩调节的小分子醌介质提高长期循环稳定性解耦水电解†

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-29 DOI: 10.1039/D5GC01266J

AJing Song, Xin Jin, Yuan Wei, Chunmao Xiong, Tongna Shi, Yuanyuan Ma and Jianping Yang

{"title":"Dipole moment regulation of a small-molecule quinone mediator boosts long-term cycling stability for decoupled water electrolysis†","authors":"AJing Song, Xin Jin, Yuan Wei, Chunmao Xiong, Tongna Shi, Yuanyuan Ma and Jianping Yang","doi":"10.1039/D5GC01266J","DOIUrl":"https://doi.org/10.1039/D5GC01266J","url":null,"abstract":"Decoupled water electrolysis with the aid of small-molecule quinone as a redox mediator, which separates the hydrogen evolution reaction and oxygen evolution reaction in both time and space, offers an efficient strategy for green hydrogen production with high purity and flexibility. However, the impact of molecular structure, particularly structural symmetry, on the properties of quinone-based materials is still unclear. Herein, we discuss the design of a series of small-molecule quinone compounds with different dipole moments and investigate their electrochemical performance in acidic aqueous electrolytes. Among them, the nonpolar tetramethylquinone (TMBQ) shows exceptional cycling stability (30 000 cycles), outperforming the majority of reported solid-state redox mediators. The remarkable stability of TMBQ is attributed to its low dipole moment, which significantly reduces its solubility in polar solvents. In addition, the TMBQ electrode also delivers excellent rate performance, enabled by rapid H+ diffusion (10−6 cm2 s−1) and favorable electronic conductivity. Using the environmentally friendly TMBQ as a solid-state redox mediator, a membrane-free decoupled water electrolysis system is constructed, achieving flexible and green hydrogen production.","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" 21","pages":" 6196-6205"},"PeriodicalIF":9.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-pot lignocellulose fractionation towards efficient whole sugar conversion and aromatic monomer production using a mild alkaline oxidation system† 采用温和碱性氧化系统的一锅木质纤维素分馏，实现高效全糖转化和芳香单体生产†

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-29 DOI: 10.1039/D5GC00999E

Ziyi Yang, Feiyue Shen, Weihong Dai, Zhiwen Zeng, Jiayi Xu, Li Zhao, Wei Qi, Jinguang Hu, Dong Tian and Fei Shen

{"title":"One-pot lignocellulose fractionation towards efficient whole sugar conversion and aromatic monomer production using a mild alkaline oxidation system†","authors":"Ziyi Yang, Feiyue Shen, Weihong Dai, Zhiwen Zeng, Jiayi Xu, Li Zhao, Wei Qi, Jinguang Hu, Dong Tian and Fei Shen","doi":"10.1039/D5GC00999E","DOIUrl":"https://doi.org/10.1039/D5GC00999E","url":null,"abstract":"The targeted extraction of native-like lignin while retaining highly accessible carbohydrate substrates in a one-pot biorefinery is a promising strategy but suffers from technical challenges. In this study, a mild alkaline-oxidation system (tetramethylammonium hydroxide/urea hydrogen peroxide, TMAH/UHP) was tailored to fractionate lignocellulose into protolignin and a carbohydrate-rich substrate for further renewable energy upgrading. During the TMAH/UHP biorefinery, the diverse reaction intensities and solvent concentrations were investigated to achieve a balance between lignin structure integrity and valuable carbohydrate recovery. A detailed study into lignin structure evolution was conducted to understand how the TMAH/UHP system extracted protolignin efficiently and maintained the high-accessibility of carbohydrate solids. The protolignin with a high content of β-O-4 linkages (45.1%–62.8%) was extracted via the dominant cleavage of lignin-carbohydrate ester bonds. Additionally, the high recovery of carbohydrates achieved an excellent whole-sugar conversion capacity (100.0% glucose yield and >50.0% xylose yield), and the protolignin exhibited feasible downstream valorization for the production of aromatic monomers via a catalytic oxidation process. Meanwhile, the spent solvent was enriched with abundant urea components, which could be used as water-soluble fertilizer for crop growth. This one-pot biorefinery method mitigates the challenge in extracting protolignin without compromising carbohydrate value under mild conditions, which is essential for a sustainable and scale-up future of biorefinery.","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" 21","pages":" 6244-6259"},"PeriodicalIF":9.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable potassium sorbate production from triacetic acid lactone in food-grade solvents† 在食品级溶剂中由三乙酸内酯可持续生产山梨酸钾†

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-29 DOI: 10.1039/D4GC04832F

Min Soo Kim, Sarang S. Bhagwat, Leoncio Santiago-Martínez, Xiaolei Shi, Kyuhyeok Choi, Jeremy S. Guest and George W. Huber

{"title":"Sustainable potassium sorbate production from triacetic acid lactone in food-grade solvents†","authors":"Min Soo Kim, Sarang S. Bhagwat, Leoncio Santiago-Martínez, Xiaolei Shi, Kyuhyeok Choi, Jeremy S. Guest and George W. Huber","doi":"10.1039/D4GC04832F","DOIUrl":"https://doi.org/10.1039/D4GC04832F","url":null,"abstract":"This study advances the production of potassium sorbate (KS) from triacetic acid lactone (TAL) utilizing food-grade solvents, ethanol (EtOH) and isopropyl alcohol (IPA). We have previously demonstrated the route to produce KS from TAL in tetrahydrofuran (THF) as the main solvent, but the use of THF is associated with environmental and health risks especially for food applications. The process employs a catalytic approach in food-grade solvents and includes three main steps: hydrogenation, etherification and hydrolysis, and ring-opening hydrolysis to produce KS from TAL. In the synthesis of KS from TAL, the use of IPA leads to higher yields and reduced reaction times compared to EtOH. As a result, the overall reaction time in IPA was reduced to 35.7 h, compared to 42.1 h in our previous study using THF and EtOH, while achieving a comparable KS yield of 84% from TAL. The synthesized KS exhibits a trans-2, trans-4 geometrical configuration, identical to that of commercially available KS. Through techno-economic analysis (TEA) and life cycle assessment (LCA), we estimated full-scale production of KS from sugarcane with the developed process in IPA could achieve a minimum product selling price (MPSP) of $8.27 per kg with a range of $7.06–10.16 per kg [5th–95th percentiles from 6000 Monte Carlo simulations] and a carbon intensity (CI) of 13.7 [9.6–18.6] kg CO2-eq per kg. This study highlights the synthesis of KS from TAL using food-grade solvents, demonstrating improved economic viability and environmental sustainability compared to our previous research (MPSP of $9.68 per kg [$8.47–11.45 per kg] and CI of 16.2 [12.0–21.2] kg CO2-eq per kg), as the total required reaction decreases while achieving the comparable overall yield of KS from TAL.","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" 21","pages":" 6087-6104"},"PeriodicalIF":9.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond. 天然深共晶溶剂（NaDES）：用于制药及其他领域的绿色溶剂。

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-28 DOI: 10.1039/d4gc06386d

Emma Chevé-Kools, Young Hae Choi, Catherine Roullier, Gwenaël Ruprich-Robert, Raphaël Grougnet, Florence Chapeland-Leclerc, Frank Hollmann

{"title":"Natural deep eutectic solvents (NaDES): green solvents for pharmaceutical applications and beyond.","authors":"Emma Chevé-Kools, Young Hae Choi, Catherine Roullier, Gwenaël Ruprich-Robert, Raphaël Grougnet, Florence Chapeland-Leclerc, Frank Hollmann","doi":"10.1039/d4gc06386d","DOIUrl":"https://doi.org/10.1039/d4gc06386d","url":null,"abstract":"Composed of various biosourced metabolites, NaDES offer significant economic, health, and environmental benefits. Their remarkable ability to interact with target compounds through non-covalent bonds enhances their versatility. As solvents, excipients, cofactors, catalysts, solubilisation promoters, stabilisers, and absorption agents, NaDES provide distinct advantages over conventional substances and can even act as active compounds themselves. Furthermore, their role in advancing innovative synthesis and formulation strategies, particularly in nanotechnology and biotechnology, is driving research in these areas. This review is the first to explore all the potential applications of NaDES in the pharmaceutical industry, while taking a comprehensive look at the theory behind them. It gives a precise definition of NaDES and describes their composition, characteristics, molecular interactions, preparation, stability and recovery. It presents detailed applications in pharmaceutical synthesis, extraction and formulation, and discusses roles as active compounds or tools for innovation. Using green metrics, the efficiency of routes including NaDES is compared to that of conventional processes. Lastly, this review addresses often overlooked points such as toxicity and process limitations.","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular-level design and green process engineering: optimizing pseudo-graphitic domains in pitch-derived hard carbon for fast sodium storage† 分子水平设计和绿色工艺工程：优化沥青衍生硬碳的伪石墨畴用于快速钠储存†

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-28 DOI: 10.1039/D5GC00902B

Dan Zhao, Hanqing Zhao, Lingwei Kong, Shulian Lei, Boyan Cui, Tingjun Fu and Zhong Li

{"title":"Molecular-level design and green process engineering: optimizing pseudo-graphitic domains in pitch-derived hard carbon for fast sodium storage†","authors":"Dan Zhao, Hanqing Zhao, Lingwei Kong, Shulian Lei, Boyan Cui, Tingjun Fu and Zhong Li","doi":"10.1039/D5GC00902B","DOIUrl":"https://doi.org/10.1039/D5GC00902B","url":null,"abstract":"This study leverages low-cost coal tar pitch (CTP) to enhance its application in hard carbon (HC) anodes for sodium-ion batteries (SIBs), offering significant environmental and economic benefits. Traditional CTP activation strategies often employ corrosive acids (e.g., H2SO4/HNO3) or toxic oxidants to enhance solubility. Moreover, the inability to precisely regulate pseudo-graphitic domains during carbonization results in disordered structures with limited Na+ storage kinetics and low initial coulombic efficiency (ICE). Herein, a green oxidation (HCOOH/H2O2)–hydrothermal cascade strategy is employed to yield soluble oxidized CTP and controllably grow graphite nanodomains in situ within the amorphous phase. By controlling the size of these nanodomains, short-range ordered pseudo-graphitic domains with large interlayer spacing and an optimized pore structure were formed during carbonization. The resulting HC demonstrated exceptional rate performance, delivering capacities from 318 to 181 mA h g−1 at current densities ranging from 0.03 to 2 A g−1, and achieved a high ICE of 96.7% when using a carboxymethyl cellulose binder. By integrating molecular-level design with green process engineering, this strategy establishes a universal paradigm for sustainable carbon materials, bridging the gap between sustainable chemistry and high-energy-density batteries.","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" 21","pages":" 6156-6169"},"PeriodicalIF":9.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional thermoregulating and water repellent cellulosic textile. 多功能调温拒水纤维纺织品。

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-28 DOI: 10.1039/d5gc00943j

Zahra Madani, Hossein Baniasadi, Pedro E S Silva, Maija Vaara, Marike Langhans, Inge Schlapp-Hackl, Lars Evenäs, Michael Hummel, Jaana Vapaavuori

{"title":"Multifunctional thermoregulating and water repellent cellulosic textile.","authors":"Zahra Madani, Hossein Baniasadi, Pedro E S Silva, Maija Vaara, Marike Langhans, Inge Schlapp-Hackl, Lars Evenäs, Michael Hummel, Jaana Vapaavuori","doi":"10.1039/d5gc00943j","DOIUrl":"10.1039/d5gc00943j","url":null,"abstract":"Enhancing thermal comfort in textiles can contribute to improved user well-being, both in wearable technology and everyday clothing. This study introduces thermoregulation properties by embedding a phase change material (PCM) into regenerated man-made cellulose fibers via the Ioncell® technology. Calorimetric analysis revealed that the incorporation of myristic acid as PCM enables the fibers to absorb and release thermal energy, providing dynamic thermal regulation in response to temperature changes. Specifically, the PCM-fiber containing 50% (w/w) myristic acid demonstrated a phase change melting enthalpy of 73 J g-1, with a melting temperature of 54 °C. The melting enthalpy remained largely stable even after 100 thermal cycling tests, highlighting the excellent durability of the PCM-incorporated textiles. Furthermore, the resulting thermoregulating textile was treated with a hydrophobic coating composed of octadecenyl succinic anhydride, resulting in an average water contact angle of 75°, after post-washing, demonstrating good water repellency. The developed fabric combines thermal regulation with water repellency through eco-friendly processes, offering a promising alternative to conventional functional textiles.","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":" ","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemically assisted deprotection of acetals, ketals, and dithioacetals under neutral conditions† 中性条件下缩醛，酮和二硫缩醛的电化学辅助脱保护

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-25 DOI: 10.1039/d4gc06348a

Yuka Abe , Tsuyoshi Yamada , Takuhei Yamamoto , Yukihiro Esaka , Takashi Ikawa , Hironao Sajiki

{"title":"Electrochemically assisted deprotection of acetals, ketals, and dithioacetals under neutral conditions†","authors":"Yuka Abe , Tsuyoshi Yamada , Takuhei Yamamoto , Yukihiro Esaka , Takashi Ikawa , Hironao Sajiki","doi":"10.1039/d4gc06348a","DOIUrl":"10.1039/d4gc06348a","url":null,"abstract":"<div><div>Electroorganic synthesis (EOS) enables unattainable molecular transformations that cannot be achieved through conventional acid/base or thermal reactions to be realized by exploiting molecular redox capabilities. The use of acetals as protecting groups for the carbonyl functionality is a pivotal component of natural product synthesis and drug discovery. Acetal deprotection typically requires aqueous acid hydrolysis. Herein, we present the development of an electrochemical deprotection reaction for cyclic acetal, ketal, and dithioacetal derivatives, with a diverse range of such aromatic and aliphatic substrates deprotected in yields of between 55% and quantitative. Mechanistic investigations provided insight into the electro-deprotection process involving acetals. Lithium perchlorate (LiClO4) plays a dual role, functioning as both the electrolyte and the oxygen source for the carbonyl moiety, with the electro-deprotection reaction proceeding to afford carbonyl products. Moreover, reaction efficiency was markedly enhanced by the addition of 1,3,5-trioxane, which acts as a Li activator.</div></div>","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":"27 19","pages":"Pages 5464-5470"},"PeriodicalIF":9.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper-catalysed radical amino-oxygenation of alkenes for the exclusive synthesis of 5-substituted 2-oxazolidinones† 铜催化烯烃自由基氨基氧化合成5-取代2-恶唑烷酮†

IF 9.3 1区化学

Green Chemistry Pub Date : 2025-04-25 DOI: 10.1039/d5gc00917k

Xuan Zhou , Xi Hu , Yi Chen , Hongxing Zhu , Muyang Yang , Guo-Jun Deng , Wen Shao

{"title":"Copper-catalysed radical amino-oxygenation of alkenes for the exclusive synthesis of 5-substituted 2-oxazolidinones†","authors":"Xuan Zhou , Xi Hu , Yi Chen , Hongxing Zhu , Muyang Yang , Guo-Jun Deng , Wen Shao","doi":"10.1039/d5gc00917k","DOIUrl":"10.1039/d5gc00917k","url":null,"abstract":"<div><div>Owing to the significance and difficulty in the precise construction of privileged drug-containing 5-substituted 2-oxazolidinones, we herein developed a copper-catalysed radical amino-oxygenation of alkenes with amine-derived tert-butyl chloro-carbamates. This newly developed method enables the one-step formation of C–N and C–O bonds and achieves a catalytic turnover under exogenous ligand- and base-free conditions. It offers a powerful alternative to existing methods for the exclusive synthesis of 5-substituted 2-oxazolidinones in 21–78% yields directly from abundant alkene feedstocks via an atom-economic procedure, featuring a broad substrate scope and functional group compatibility. The synthetic utility was further highlighted through the successful conversion of products to valuable β-amino alcohols, especially via the one-pot synthesis of a regioisomer of the cytokine modulator (±)-cytoxazone and a methylene derivative of epinephrine used in the pharmaceutical (±)-EpiPen®. Notably, the sustainability assessment by green metrics, such as the E-factor (2.9) and safety hazard scores (ES: 0.23/23.08 and SHS: 2.23/7.62), quantifies the obvious achievements of this protocol compared to precedents.</div></div>","PeriodicalId":78,"journal":{"name":"Green Chemistry","volume":"27 19","pages":"Pages 5616-5623"},"PeriodicalIF":9.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0