Annales de biologie clinique最新文献_第2页

[A case of lipidogram abnormality on post-surgical abdominal drain fluid]. [术后腹腔引流液脂质图异常1例]。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-07-21 DOI: 10.1684/abc.2023.1819

Lya Hamet, Lia Moreau, Claude Bendavid, Caroline Moreau

引用次数: 0

Association between the Estrogen receptor β rs1256049 polymorphism and prostate cancer risk:a meta-analysis. 雌激素受体β rs1256049多态性与前列腺癌风险的相关性:一项荟萃分析

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-07-21 DOI: 10.1684/abc.2023.1815

Hassane Gazzaz, Mohammed El Feniche, Ahmed Ameur, Abdellah Dami

{"title":"Association between the Estrogen receptor β rs1256049 polymorphism and prostate cancer risk:a meta-analysis.","authors":"Hassane Gazzaz, Mohammed El Feniche, Ahmed Ameur, Abdellah Dami","doi":"10.1684/abc.2023.1815","DOIUrl":"https://doi.org/10.1684/abc.2023.1815","url":null,"abstract":"The Estrogen receptor β (ESR-β) gene is suggested to have a growth inhibitory role in prostate tissue and was proposed as a new therapeutic target for prostate cancer (PCa). Precedent studies have investigated the association between the ESR-β rs1256049 polymorphism and PCa but findings were inconsistent. Thus, this meta-analysis was performed to assess whether the ESR-β rs1256049 polymorphism is associated with an increased susceptibility to PCa. Eligible studies published before February 5, 2022 were systematically searched in PubMed, Web of Science, ScienceDirect and Google Scholar databases. The sample set was extracted from 11 case-control studies involving 9390 cases and 10057 controls for the association between ESR-β rs1256049 polymorphism and PCa susceptibility. In our overall meta-analysis, no significant association between rs1256049 and PCa risk was found under all genetic models. In subgroup analysis according to ethnicity, Asians, had a significantly decreased cancer risk based on both the heterozygote genetic model (OR = 0.75, 95% CI = [0.63, 0.89] P = 0.01) and the dominant model (OR = 0.80, 95% CI [0.69, 0.94] P = 0.01). For the Caucasian group, there was a significantly increased risk observed in the allelic model (OR = 1.17, 95% CI = [1.04, 1.32] P = 0.01), heterozygote model (OR = 1.15, 95% CI = [1.01, 1.31] P = 0.03) and the dominant model (OR = 1.17, 95% CI = [1.03, 1.32] P = 0.01). Our results demonstrate that ESR-β r1256049 polymorphism may play a possible promising effect in PCa in Caucasians and a protective factor in Asians.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"81 3","pages":"280-288"},"PeriodicalIF":0.5,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9869278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-07-21 DOI: 10.1684/abc.2023.1820

Laurence Piéroni

引用次数: 0

[Flow cytometry in chronic lymphproliferative disorders: report of a survey on practices on behalf of CytHem]. [慢性淋巴增生性疾病的流式细胞术:代表CytHem的一项实践调查报告]。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-07-21 DOI: 10.1684/abc.2023.1818

Caroline Mayeur-Rousse, Sabrina Bouyer, Jean-François Lesesve, Magali Le Garff-Tavernier, Lucile Baseggio

引用次数: 0

[Long-term automated Bayesian management of IQC results: The experience of the Lyon Hospitals Board hemostasis laboratory]. [IQC结果的长期自动化贝叶斯管理:里昂医院委员会止血实验室的经验]。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-05-16 DOI: 10.1684/abc.2023.1800

Frédéric Sobas, Émilie Jousselme, Marie-Odile Geay Baillat, Estelle Cheli, Amy Dericquebourg, Christophe Nougier

引用次数: 0

Monoclonal B-cell lymphocytosis with a non-CLL immunophenotype - Review of 34 cases. 单克隆b细胞淋巴细胞增多症伴非cll免疫表型——附34例报告。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-05-16 DOI: 10.1684/abc.2023.1803

Isadoral Heraud, Claire Mauduit, Camille Golfier, Béatrice Grange, Lucile Baseggio

引用次数: 1

[Placenta percreta management in a patient with a severe congenital hypofibrinogenemia]. [1例严重先天性低纤维蛋白原血症患者的percreta处理]。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-05-16 DOI: 10.1684/abc.2023.1802

Jordan Wimmer, Laurent Sattler, Agathe Herb, Mary Pontvianne, Éric Boudier, Maryse Hengen, Vincent Thuet, Olivier Feugeas, Dominique Desprez

引用次数: 0

[Role and interest of hepcidin in iron homeostasis]. hepcidin在铁稳态中的作用和兴趣。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-05-16 DOI: 10.1684/abc.2023.1805

Julien Miozzo, Cécile Meunier, Sophie Park, Patrice Faure, Laetitia Van Noolen

{"title":"[Role and interest of hepcidin in iron homeostasis].","authors":"Julien Miozzo, Cécile Meunier, Sophie Park, Patrice Faure, Laetitia Van Noolen","doi":"10.1684/abc.2023.1805","DOIUrl":"https://doi.org/10.1684/abc.2023.1805","url":null,"abstract":"Iron is an essential element to the well functionning of the organism and requires careful maintenance of its homeostasis. This is mainly due to hepcidin, a hormone secreted by the liver that controls the flow of iron within the body. It has a hyposideremic action by reducing the expression of ferroportin, the only protein known to this day, which can export iron into the extracellular environment. This has the effect of decreasing intestinal absorption and increasing intracellular retention, especially in macrophages. Hepcidin is stimulated by elevation of iron and inflammation while activation of erythropoiesis inhibits it. Understanding its regulation allows a better understanding of the pathophysiological mechanisms of overload diseases and iron deficiency. Therefore, hepcidin analysis is interesting for the exploration of iron homeostasis. In combination with other biological parameters of iron status, it is possible to find better instructions for therapeutic managements of iron metabolism diseases. Thus, an assaying method by coupling liquid chromatography and tandem mass spectrometry has been implemented at Grenoble University Hospital and the analytical performances of this assay met the laboratory requirements in terms of reliability of the analysis.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"81 2","pages":"111-124"},"PeriodicalIF":0.5,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9483959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Prognostic value of residual disease detection in acute myeloid leukemia with normal karyotype and negative FLT3-ITD]. [残病检测对核型正常、FLT3-ITD阴性的急性髓系白血病的预后价值]。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-05-16 DOI: 10.1684/abc.2023.1798

Samiha Jaddaoui, Hanaa Bencharef, Sara Addakiri, Hind Dehbi, Amal Tazzite, Mouna Lamchahab, Bouchra Oukkache

{"title":"[Prognostic value of residual disease detection in acute myeloid leukemia with normal karyotype and negative FLT3-ITD].","authors":"Samiha Jaddaoui, Hanaa Bencharef, Sara Addakiri, Hind Dehbi, Amal Tazzite, Mouna Lamchahab, Bouchra Oukkache","doi":"10.1684/abc.2023.1798","DOIUrl":"https://doi.org/10.1684/abc.2023.1798","url":null,"abstract":"Introduction: Complete remission (CR) in patients with acute myeloid leukemia (AML) is still morphologicaly defined, thus corresponding to a wide range of tumor burden.Objectives: we aimed to evaluate the residual disease (MRD) status in patients with AML, as well as perform a molecular analysis of the FLT3/ITD gene in patients with normal karyotype.Material and methods: adult patients with AML, diagnosed according to the WHO 2016 criteria, were included. MRD was detected using flow cytometric techniques after induction treatment resulting in CR.Results: thirty patients met our inclusion criteria. 83 % of them had an intermediate risk status, 67 % of which (20/30) having a normal karyotype. MRD and leukemic stem cell (LSC) positivity in this group was predominant with considerable decrease in benign progenitor count. The relapse-free survival (RFS) in the group of MRD negative patients with normal cytogenetics and non-mutated FLT3 gene was better than the RFS in all of our patients studied.Conclusion: MRD and LSC are powerful prognostic factors for relapse. They should be routinely integrated to guide better management of AML.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"81 2","pages":"136-144"},"PeriodicalIF":0.5,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9483419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Sysmex UF-4000i urine analyzer as a screening test to rule out urinary tract infection and reduce urine cultures. 评价Sysmex UF-4000i尿液分析仪作为排除尿路感染和减少尿培养的筛选试验。

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2023-05-16 DOI: 10.1684/abc.2023.1797

Assiya El Kettani, Samy Housbane, Fatima Wakit, Karima Arioua Mikou, Houria Belabbes, Khalid Zerouali

{"title":"Evaluation of the Sysmex UF-4000i urine analyzer as a screening test to rule out urinary tract infection and reduce urine cultures.","authors":"Assiya El Kettani, Samy Housbane, Fatima Wakit, Karima Arioua Mikou, Houria Belabbes, Khalid Zerouali","doi":"10.1684/abc.2023.1797","DOIUrl":"https://doi.org/10.1684/abc.2023.1797","url":null,"abstract":"Introduction: Urinary tract infection (UTI) diagnosis by urine culture is time- and labor- consuming. In the Ibn Rochd microbiology laboratory, up to 70% of urine culture samples yield no growth or insignificant growth.Objective: To evaluate the new generation of Sysmex UF-4000i fluorescence flow cytometry analyzer with a blue semiconducting laser as a method to rule out negative urine samples for UTI, in comparison of urine culture.Material and methods: Flow cytometry and microbiological analysis were performed on 502 urine samples included in the study. We used ROC analysis to determine cutoff points at which optimal sensitivity and specificity are achieved for clinical use.Results: Our results showed that bacteria count at a cut-off of 100/μL, and/or the leucocytes count ≥ 45/μL are the optimal indicator for positive culture results. At these cut off, bacteria sensitivity (SE), specificity (SP), Positive predictive value (PPV) and negative predictive value (NPV) were 97,3%, 95%, 87,8% and 98,8% respectively. For leucocytes, SE, SP, PPV and NPV were 99,1%, 95,8%, 88,6% and 99,7% respectively.Discussion and conclusion: The bacterial and leucocytes counts generated by UF-4000i analysis may be useful in our context as a rapid screening to exclude UTI by reducing about 70% of urines cultures and then workload. Nevertheless, further validation is needed for different patient groups especially with urological disease or immunocompromised patients.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"81 2","pages":"156-161"},"PeriodicalIF":0.5,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9477562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0