Association between the Estrogen receptor β rs1256049 polymorphism and prostate cancer risk:a meta-analysis.

IF 0.4 4区 医学 Q4 MEDICAL LABORATORY TECHNOLOGY
Hassane Gazzaz, Mohammed El Feniche, Ahmed Ameur, Abdellah Dami
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Abstract

The Estrogen receptor β (ESR-β) gene is suggested to have a growth inhibitory role in prostate tissue and was proposed as a new therapeutic target for prostate cancer (PCa). Precedent studies have investigated the association between the ESR-β rs1256049 polymorphism and PCa but findings were inconsistent. Thus, this meta-analysis was performed to assess whether the ESR-β rs1256049 polymorphism is associated with an increased susceptibility to PCa. Eligible studies published before February 5, 2022 were systematically searched in PubMed, Web of Science, ScienceDirect and Google Scholar databases. The sample set was extracted from 11 case-control studies involving 9390 cases and 10057 controls for the association between ESR-β rs1256049 polymorphism and PCa susceptibility. In our overall meta-analysis, no significant association between rs1256049 and PCa risk was found under all genetic models. In subgroup analysis according to ethnicity, Asians, had a significantly decreased cancer risk based on both the heterozygote genetic model (OR = 0.75, 95% CI = [0.63, 0.89] P = 0.01) and the dominant model (OR = 0.80, 95% CI [0.69, 0.94] P = 0.01). For the Caucasian group, there was a significantly increased risk observed in the allelic model (OR = 1.17, 95% CI = [1.04, 1.32] P = 0.01), heterozygote model (OR = 1.15, 95% CI = [1.01, 1.31] P = 0.03) and the dominant model (OR = 1.17, 95% CI = [1.03, 1.32] P = 0.01). Our results demonstrate that ESR-β r1256049 polymorphism may play a possible promising effect in PCa in Caucasians and a protective factor in Asians.

雌激素受体β rs1256049多态性与前列腺癌风险的相关性:一项荟萃分析
雌激素受体β (ESR-β)基因被认为在前列腺组织中具有抑制生长的作用,并被认为是前列腺癌(PCa)的新治疗靶点。已有研究调查了ESR-β rs1256049多态性与PCa之间的关系,但结果不一致。因此,本荟萃分析旨在评估ESR-β rs1256049多态性是否与PCa易感性增加相关。在PubMed、Web of Science、ScienceDirect和Google Scholar数据库中系统检索了2022年2月5日前发表的符合条件的研究。样本来自11项病例对照研究,涉及9390例病例和10057例对照,研究ESR-β rs1256049多态性与PCa易感性的关系。在我们的整体荟萃分析中,在所有遗传模型中均未发现rs1256049与PCa风险之间的显著关联。在根据种族进行的亚组分析中,基于杂合子遗传模型(OR = 0.75, 95% CI = [0.63, 0.89] P = 0.01)和显性模型(OR = 0.80, 95% CI [0.69, 0.94] P = 0.01),亚洲人的癌症风险均显著降低。对于高加索人组,等位基因模型(OR = 1.17, 95% CI = [1.04, 1.32] P = 0.01)、杂合子模型(OR = 1.15, 95% CI = [1.01, 1.31] P = 0.03)和显性模型(OR = 1.17, 95% CI = [1.03, 1.32] P = 0.01)的风险均显著增加。我们的研究结果表明,ESR-β r1256049多态性可能在高加索人的前列腺癌中发挥重要作用,并可能是亚洲人的保护因子。
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来源期刊
Annales de biologie clinique
Annales de biologie clinique 医学-医学:研究与实验
CiteScore
0.80
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.
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