Algal Research-Biomass Biofuels and Bioproducts最新文献

{"title":"Biochar-alginate jointly immobilized Chlorella vulgaris in cathode enhanced power generation in photo microbial fuel cells","authors":"Yicheng Wu ,&nbsp;Yeling Zhou ,&nbsp;Fuda Chen ,&nbsp;Haiyan Fu ,&nbsp;Yong Xiao ,&nbsp;Zejie Wang","doi":"10.1016/j.algal.2024.103714","DOIUrl":"10.1016/j.algal.2024.103714","url":null,"abstract":"<div><p>The present research investigated for the first time the performance of photo microbial fuel cells (photo-MFCs) with biochar-alginate joint immobilized <em>Chlorella vulgaris</em> (BAJIC) as a cathodic microorganism. The results showed the stabilized voltage output reach 0.182 V in photo-MFCs with BAJIC, which is 61.1 % higher than that of the alginate immobilized <em>C. vulgaris</em> and 2.43 times that of suspended <em>C. vulgaris</em>. Light intensity affected both the cathodic potential and internal resistance of the photo-MFCs with BAJIC. The cathodic potential increased from −0.258 to −0.173 V (vs. Ag/AgCl) when the light intensity was increased from 1500 to 2500 lx. Meanwhile, the internal resistance decreased from 583.88 to 392.51 Ω. The results also showed that BAJIC with the smaller bead diameter generated larger voltage. BAJIC dosage affected the voltage of the increasing stage, while did not influence the stable voltage. This work demonstrated that biochar, as an efficient additive to the alginate immobilized microalgae beads, can boost the performance of microalgae matrix, and thus provide an economical and effective approach to enhance the efficiency of photo-MFCs.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103714"},"PeriodicalIF":4.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of intracellular extraction from Oscillatoria okine and the potential use of the extract as a supplement to fetal bovine serum in animal cell culture","authors":"Nuchanan Kankaew ,&nbsp;Worawat Surarit ,&nbsp;Veasarach Jonjaroen ,&nbsp;Katsaya Khumrangsee ,&nbsp;Arachaporn Thong-olran ,&nbsp;Ketnarin Panpeang ,&nbsp;Chatchol Kongsinkaew ,&nbsp;Theppanya Charoenrat ,&nbsp;Supenya Chittapun","doi":"10.1016/j.algal.2024.103713","DOIUrl":"10.1016/j.algal.2024.103713","url":null,"abstract":"<div><p>A robust cell wall and well-organized thylakoid cyanobacteria can be candidates as a promising resource for C-phycocyanin (C-PC) and intracellular applications in various biotechnological areas. However, the development of extraction techniques with minimal chemical contamination to obtain the components remains an ongoing challenge. This study aimed to assess the efficacy of C-PC and intracellular extraction from <em>Ocillatoria okeni</em> TISTR8549 utilizing freezing-thaw (FT), pulsed electric field (PEF), and high-pressure homogenization (HPH) techniques. Additionally, the potential of <em>O. okeni</em> extract as a supplement and substitute for fetal bovine serum (FBS) in HaCaT cell culture was investigated. FT appeared to be the most proper method for C-PC extraction, yielding the highest purity and yield, although requiring 18 cycles for product accomplishment. PEF seemed unsuitable for intracellular component extraction from cyanobacteria with thick cell walls. The need for increased pulses resulted in thermal elevation and prolonged incubation times led to protein degradation. HPH proves to be an effective method for intracellular extraction, yielding high protein content suitable for the potential substitution of FBS in mammalian cell culture. Particularly, increasing pressure during HPH extraction leads to a decrease in protein yield. Resazurin and SRB assays revealed that adding algal extract in culture medium at concentrations of 1 % (<em>w</em>/<em>v</em>) improved HaCaT cell viability without disrupting cell morphology and metabolic processes. However, substituting algal extract in FBS resulted in cell proliferation decrease. Therefore, supplementing <em>O. okeni</em> extract during cell culture improved HaCaT cell proliferation, but it was unsuitable substitute for FBS in the culture medium. However, the feasibility of employing algal extracts as FBS replacements in cell culture is interesting and warrants further detailed investigation into the specific intracellular components that could serve as substitutes for FBS. Such an approach could offer an alternative source, mitigating ethical concerns and reducing costs associated with FBS usage.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103713"},"PeriodicalIF":4.6,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of natural compounds derived from diatom C. gracilis as potential therapeutic agents: An in-silico networking and docking study","authors":"Raya Bhattacharjya ,&nbsp;Hina Bansal ,&nbsp;Seneha Santoshi ,&nbsp;Subha Rastogi ,&nbsp;Archana Tiwari","doi":"10.1016/j.algal.2024.103712","DOIUrl":"10.1016/j.algal.2024.103712","url":null,"abstract":"<div><p>Marine diatom <em>Chaetoceros gracilis</em> have been known as the key player regulating the nutritional content of aquaculture species. Being able to synthesize an array of high value bioactive compounds like amino acids, lipids, terpenoids and polysaccharides, it also serves as potential therapeutic and nutraceutical agent. This in silico-based study elucidates the interactive association of different compounds, proteins and pathways of the diatom <em>C. gracilis</em> through an integrated network pharmacology and molecular docking approach. According to the Network analysis of the 41 compounds detected, saturated hydrocarbons, diterpenoids and phenolic compounds scored the highest degree (score &gt; 140). These compounds were further coded for approximately 349 protein targets and almost 490 different pathways. HSP90AA1, STAT3, HIF1A, MTOR, ESR1, PIK3CA, MAPK1 and PTGS2 secured highest degree of protein-protein interaction according to STRING database. The gene enrichment analysis further revealed that these proteins were closely associated with metabolic pathways like Pathways in cancer, neuroactive ligand-receptor interaction, calcium and cAMP signaling pathway, PI3K-Akt signaling pathway, Alzheimer's disease and pathways of neurodegeneration which played an instrumental role in the metabolism of diseases and disorders like cancers of breast, prostrate, and liver, schizophrenia and other mental and hypertensive disorders. Furthermore, the molecular docking and toxicity assessment of a few novel compounds was done with mTOR and HSP90AA1 which revealed promising and stable interactions. Thus, this study provides the first in silico insight outlining the anti-cancerous and neuroprotective potential of novel bioactive compounds derived from marine diatom <em>C.gracilis</em>.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103712"},"PeriodicalIF":4.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening nitrogen-fixing cyanobacteria that can alleviate cadmium toxicity to rice and reduce cadmium accumulation in brown rice","authors":"Chen Zhuo,&nbsp;Xu Zhang,&nbsp;Xiaotian Liao,&nbsp;Qi Chen,&nbsp;Minhong Zhang,&nbsp;Hongzhi He","doi":"10.1016/j.algal.2024.103707","DOIUrl":"10.1016/j.algal.2024.103707","url":null,"abstract":"<div><p>Among food crops, rice is the most serious food crop contaminated with cadmium (Cd). It is critical to reduce Cd bioavailability in the soil and prevent its accumulation in brown rice. The use of microorganisms to lessen Cd toxicity in rice has been the subject of numerous studies carried out in recent years. The nitrogen-fixing cyanobacterium (NFC) is a potent biofertilizer and heavy metal biosorbent. However, there is a dearth of research on the impact of NFC supplementation on rice's susceptibility to Cd poisoning. This study screened for Cd-tolerant NFCs and assessed how well they might promote growth and lower the amount of Cd in rice. Four NFCs with tolerance to 1 mg L⁻¹ Cd were selected from ten NFCs. The results of seedling experiment showed that SCAU-10 treatment increased plant height and biomass while reducing Cd levels in seedlings by 62.0 %. The pot experiment also demonstrated that SCAU-10 was effective in lowering Cd content in brown rice by 85.3 %. Reducing the bioavailability of soil Cd, shielding rice roots, preventing Cd transfer from below to above ground, generating phytohormones, and enhancing the photochemical electron quantum yield of rice leaves are a few possible action mechanisms of the NFC. It indicates that <em>Trichormus</em> sp. SCAU-10 has a great deal of promise for use as a biofertilizer in the safe management of Cd-contaminated rice fields. This is the first report on using <em>Trichormus</em> sp. biofertilizer for relieving the toxicity of Cd to rice and reducing Cd accumulation in brown rice.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103707"},"PeriodicalIF":4.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142271716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentiating Chlorella vulgaris bioinput as a growth biostimulant in the production of basil seedlings with the addition of vitamin B3","authors":"Elen Saturnino Ferreira ,&nbsp;Flávio Ferreira da Silva Binotti ,&nbsp;Eliana Duarte Cardoso Binotti ,&nbsp;Edilson Costa ,&nbsp;Eduardo Pradi Vendruscolo ,&nbsp;Sebastião Ferreira de Lima ,&nbsp;Fausto Antônio Coli Neto","doi":"10.1016/j.algal.2024.103706","DOIUrl":"10.1016/j.algal.2024.103706","url":null,"abstract":"<div><p>Microalgae have been studied due to their biotechnological potential in agriculture and could be an important source of biostimulants. Similarly, other compounds, such as B₃ vitamins (niacin and nicotinamide), have been found to enhance the biostimulant effect on plant growth. This study aimed to evaluate the potentiating effect of <em>Chlorella vulgaris</em> bioinput as a growth biostimulant in the production of basil seedlings (<em>Ocimum basilicum</em> L.) with the addition of vitamin B₃. The experiment was conducted in a protected environment on the Mato Grosso do Sul State University - Cassilândia University Unit and the Sustainable Development Center of the Bolsão Sul Mato Grossense. The experiment was conducted in a completely randomized design, with four treatments: control, microalgae bioinput (Bio), vitamin B₃ (niacin + nicotinamide), and joint application of Bio + vitamin B₃, with four replications. The agronomic traits of growth and photosynthetic pigments of the seedlings were evaluated. For the growth of basil seedlings, applying bio input combined with vitamin B₃ had a significant impact (<em>p</em> &lt; 0.05) on several variables. This combination increased seedling height, stem diameter, root dry matter, shoot dry matter, total dry matter, and Dickson quality index (DQI) by 19 %, 11 %, 11 %, 41 %, 37 %, and 17 %, respectively, as well as regulating the production of photosynthetic pigments in basil. The results indicate that bioinput combined with niacin and nicotinamide stimulates various plant growth traits, favoring the production of seedlings.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103706"},"PeriodicalIF":4.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Instant Controlled Pressure Drop (DIC) as an innovative pre-treatment for extraction of natural compounds from the brown seaweed Sargassum muticum (Yendo) Fensholt 1955 (Ochrophytina, Fucales)","authors":"Hugo Pliego-Cortés ,&nbsp;Virginie Boy ,&nbsp;Nathalie Bourgougnon","doi":"10.1016/j.algal.2024.103705","DOIUrl":"10.1016/j.algal.2024.103705","url":null,"abstract":"<div><p>The effects of the Instant Controlled Pressure Drop (DIC) technology on the recovery of natural compounds from the brown seaweed <em>Sargassum muticum</em> (Yendo) Fensholt 1955 (Ochrophytina, Fucales) were investigated. Fresh biomass of <em>S. muticum</em> was collected on the Brittany Coast, France. Both fresh and Air Impingement-Dried (AID) thalli of 3 and 10 cm length were submitted to DIC during 20 s or 90 s of processing time under 100 or 800 kPa of saturated steam pressure. DIC treatment significantly improved the extraction of sulphate groups at 90 s, and carotene at 20 s under 100 kPa in thalli of 10 cm. While, coupling AID to DIC, the content of neutral sugars, proteins and antioxidants were higher in AID + DIC treatments. Further, a significant increase of 20 % in fucose-containing sulfated polysaccharides and 30 % in sodium alginate under 100 kPa during 90 s, compared to oven-dried, was observed. The biomass of the invasive <em>S. muticum</em> treated by DIC and AID + DIC represented a valuable contribution for extraction of natural compounds. Advantages for industrial integration of DIC were discussed.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103705"},"PeriodicalIF":4.6,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211926424003175/pdfft?md5=33713598ff1d0ae0c95ca96d5e62b868&pid=1-s2.0-S2211926424003175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring protein N-glycosylation in the green microalga Dunaliella salina","authors":"Jaber Dehghani,&nbsp;Juliette Balieu,&nbsp;Olivier Perruchon,&nbsp;Elodie Mathieu-Rivet,&nbsp;Narimane Mati-Baouche,&nbsp;Patrice Lerouge ,&nbsp;Muriel Bardor","doi":"10.1016/j.algal.2024.103711","DOIUrl":"10.1016/j.algal.2024.103711","url":null,"abstract":"<div><p><em>N</em>-glycosylation is a major post-translational modification of proteins that has a crucial influence on cell targeting, activity, and half-life. This process starts in the endoplasmic reticulum where an oligosaccharide precursor is added to the newly synthesized protein and continues in the Golgi apparatus where the <em>N</em>-linked carbohydrate sequences are processed. Importantly, the most approved recombinant pharmaceutical proteins (so-called biologics) are glycoproteins mainly currently produced in mammalian cells which is a lengthy, costly, and complex process. Today, several microalgae such as the diatom <em>Phaeodactylum tricornutum</em>, and the green microalgae <em>Chlamydomonas reinhardtii</em>, <em>Chlorella vulgaris</em>, and <em>Dunaliella salina</em> are considered as efficient and eco-friendly alternative platforms for the production of biologics. However, unlike for <em>C. reinhardtii</em>, <em>C. vulgaris</em>, and <em>P. tricornutum</em>, there is to date no data reported regarding the protein <em>N</em>-glycosylation pathway in <em>D. salina</em>. Here, we first investigated the protein <em>N</em>-glycosylation in this green microalga by MALDI-TOF mass spectrometry. These analyses showed that proteins from <em>D. salina</em> are <em>N</em>-glycosylated with Man₅GlcNAc₂ oligomannoside. Using genome mining approaches, we then identified genes encoding proteins involved in the <em>N</em>-glycosylation pathways in <em>D. salina</em>. Genetic similarities and phylogenetic relationships of the putative sequences with homologues from <em>C. reinhardtii</em>, <em>P. tricornutum</em>, and humans were investigated. These data revealed that in <em>D. salina</em> the biosynthesis of nucleotide sugars and <em>N</em>-glycan biosynthesis share mainly similarities with the GnT I-independent pathway of <em>C. reinhardtii</em> that gives rise to the synthesis of a non-canonical oligomannoside Man₅GlcNAc₂. Although an α(1,3)-fucosyltransferase is identified in the <em>D. salina</em> genome, impairment of the cytosolic GDP-Fuc biosynthesis prevents the Golgi fucosylation of <em>N</em>-glycans. Taken together, these data demonstrated that proteins from <em>D. salina</em> are homogeneously <em>N</em>-glycosylated with a non-canonical Man₅GlcNAc₂.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103711"},"PeriodicalIF":4.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211926424003230/pdfft?md5=bac82a2207e8769737316fcaf130ed9b&pid=1-s2.0-S2211926424003230-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcellular distribution of the β-N-methylamino-L-alanine-containing proteins in marine diatoms","authors":"Xianyao Zheng ,&nbsp;Aifeng Li ,&nbsp;Jiangbing Qiu ,&nbsp;Guowang Yan","doi":"10.1016/j.algal.2024.103708","DOIUrl":"10.1016/j.algal.2024.103708","url":null,"abstract":"<div><p>Neurotoxin <em>β</em>-<em>N</em>-methylamino-<em>L</em>-alanine (BMAA) has been implicated as a major inducer of human neurodegenerative diseases. In recent years, marine diatoms were verified to produce BMAA-containing proteins. It will be an important cue to elucidate the subcellular distribution of BMAA in marine diatoms for disclosing its biosynthesis pathway. In this study, three species of <em>Thalassiosira</em> (<em>T. andamanica</em>, <em>T. allenii</em> and <em>T. minima</em>) were used to investigate the subcellular distribution of BMAA in organelles. Results showed that the crushing efficiency of diatoms was species-specific and increased with the rise of ultrasonic intensity of 22, 50 and 100 W (pulse = 0.2 s/s, 4 min), of which <em>T. andamanica</em> and <em>T. allenii</em> obtained the lowest and highest crushing efficiency, respectively. Interestingly, although <em>T. allenii</em> and <em>T. minima</em> were more efficiently crushed at 50 W and 100 W power (pulse = 0.2 s/s), their organelles were largely fragmented, which was verified by cytochrome <em>c</em> oxidase (CCO) enzyme analysis and transmission electron microscopy (TEM) observation. Their organelles were not fragmented only at 22 W. However, the crushing efficiency of <em>T. andamanica</em> was more reliable, and its organelles were essentially intact and only damaged at 100 W. Analysis of the BMAA-containing proteins showed that these proteins exclusively distribute in the Golgi and endoplasmic reticulum (ER) organelles. The nearly intact membranes of nucleus, mitochondria, Golgi and ER organelles testified that the absence of BMAA in other organelles was not caused by damage of nucleus or mitochondria. Results demonstrated that the BMAA-containing proteins were produced and accumulated in the ER and Golgi of diatoms.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103708"},"PeriodicalIF":4.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dynamic model for predicting biomass and phycocyanin yields in Arthrospira (Spirulina) platensis: A guidance for effective batch cultivation","authors":"Noppathonthan Aowtrakool ,&nbsp;Aukkrimapann Sopitthummakhun ,&nbsp;Teeraphan Laomettachit ,&nbsp;Marasri Ruengjitchatchawalya","doi":"10.1016/j.algal.2024.103709","DOIUrl":"10.1016/j.algal.2024.103709","url":null,"abstract":"<div><p>C-phycocyanin (C-PC) is a highly valuable bioproduct from the cyanobacterium <em>Arthrospira platensis</em>. A crucial factor affecting growth and C-PC production yield is nitrogen nutrients. In this work, an ODE-based dynamic model was constructed to simulate the effect of ammonium concentrations in a batch system on cyanobacterial growth and C-PC production. The model included dynamic regulation of the ammonium transporter and key enzymes involved in the nitrogen assimilation pathway. The prediction of C-PC production, cyanobacterial growth, and remaining ammonium concentration over 24 h strongly correlated with experimental data. Furthermore, the model was able to capture the response of genes involved in ammonium assimilation and C-PC production, as well as the primary metabolites. The dynamic interplay among ammonium, glutamine, and glutamate levels reflects the complexity of nitrogen metabolism in regulating the transcription of genes involved in ammonium uptake, assimilation, and C-PC synthesis and degradation, thus highlighting the cellular response to nitrogen stress. These findings provide a foundation for understanding these biological processes and offer a potential tool for further exploring the complex relationship between nitrogen availability and C-PC accumulation in <em>A. platensis</em> C1 using ammonium as a nitrogen source.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103709"},"PeriodicalIF":4.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Leptolyngbya for antiproliferative and antimicrobial metabolites through lens of modern techniques: A review","authors":"Rahul Negi ,&nbsp;Manisha Nigam ,&nbsp;Rahul Kunwar Singh","doi":"10.1016/j.algal.2024.103702","DOIUrl":"10.1016/j.algal.2024.103702","url":null,"abstract":"<div><p>Cancer and antimicrobial resistance are pressing global health concerns, with cancer ranking as a foremost reason of death across the world, estimated to be about 10 million in 2020, while antimicrobial resistance (AMR) poses a significant threat, with projected deaths attributed to AMR set to exceed 10 million by 2050. Recent research has highlighted Actinomyces, Bacteroidetes, Proteobacteria, and Cyanobacteria as promising sources of therapeutic compounds. Among cyanobacteria, the genus <em>Leptolyngbya</em> has garnered relatively less attention. <em>Leptolyngbya</em> is a polyphyletic in nature and widely distributed across various ecosystems. Although over 140 species have been identified within this genus, its systematic position has only recently been clarified. <em>Leptolyngbya</em>'s diverse metabolite spectrum, including compounds with antioxidant, antimicrobial, and antiproliferative properties, as discussed in this review, makes it a valuable candidate for drug discovery. However, challenges in laboratory cultivation have hindered the identification of novel metabolites from <em>Leptolyngbya</em>, which would have been otherwise discovered. Hence, this article focuses on the antiproliferative and antimicrobial activities of the diverse genus <em>Leptolyngbya</em>, as well as the cutting-edge technologies that have the potential to expand the untapped metabolite spectrum of the genus.</p></div>","PeriodicalId":7855,"journal":{"name":"Algal Research-Biomass Biofuels and Bioproducts","volume":"83 ","pages":"Article 103702"},"PeriodicalIF":4.6,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}