African Health Sciences最新文献

{"title":"Comparative genomics of spike, envelope, and nucleocapsid protein of severe acute respiratory syndrome coronavirus 2","authors":"Sufyan Sohail Khan, Anwar Ullah","doi":"10.4314/ahs.v23i3.45","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.45","url":null,"abstract":"Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) upsurge sprang up in Wuhan, China, in late December 2019.
 Objectives: Due to the exceptionally high mutation frequency, comparative genomics of viruses isolated throughout time and in various geographical locations are crucial. To better understand how SARS-CoV-2 heterogeneity has changed around the globe, this research was conducted.
 Methods: Nucleotide and protein sequences of SARS-CoV-2, SARS-CoV, and bat SARS-like CoV were extracted from the NCBI Virus database. The Wuhan SARS-CoV-2 variant was used as a reference. Molecular Evolutionary Genetics Study performed the phylogenetic analysis, while the Genome Detective Coronavirus Typing Tool performed the mutational analysis.
 Results: The evolutionary research has revealed that bats are the primary host for coronavirus evolution and the origin of the formation of SARS-CoV and SARS-CoV-2. Numerous mutations have been discovered in the spike, envelope, and nucleocapsid protein.
 Conclusions: The current research findings may have an implication that facilitates the development of prospective immunization candidates/small pharmacological compounds targeting COVID-19.
 Keywords: SARS-CoV-2; COVID-19; pandemic; comparative genomics; spike protein; envelope protein; nucleocapsid protein.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the relationship between miR-499C/T (rs3746444) polymorphism and lung carcinoma in Iranian population; a case-control study","authors":"Mehdi Torabi, Mostafa Khafaei, Behnaz Jahanbin, Morteza Sadeghi","doi":"10.4314/ahs.v23i3.36","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.36","url":null,"abstract":"Introduction: Lung carcinoma is characterized by uncontrollable division of respiratory system cells with detrimental and lethalconsequences on human health. Critical roles of microRNAs (miR) are scientifically approved in biological and pathologicalpathways, such as the role of miR-499 (rs3746444) in lung carcinomas. Thus, in this case-control investigation, we aimed toassess the probable relationship between miR-499C/T variant and the occurrence of lung carcinoma in Iranian population forthe first time.&#x0D; Methods: Genotype of miR-499 polymorphism was described by the Polymerase Chain Reaction-Restriction Fragment LengthPolymorphism (PCR-RFLP) assay in patients and healthy individuals. Following definite diagnosis of lung carcinoma, the bloodsamples were collected, and the DNA extraction was performed by Salting-Out method. Finally, data were analysed by SPSS (v.20) and the significant level was considered p-value<0.05.&#x0D; Results: Statistically, the frequency of combined genotypes of CC+CT were 83.33% and 35% and TT+CT were 100% and 92%in case and control individuals, respectively. Also, individuals with genotypes of TC (OR: 3.08, CI95%: 3.03-3.17, p<0.0001),TC+CC (OR: 0.10, CI95%: 0.05-0.23, p<0.0001), CC (OR: 0, CI95%: 0.00-0.60, p=0.0214), and TC (OR: 0.07, CI95%: 0.03-0.15, p<0.0001) represented statistically significant (p<0.05) differences lung carcinoma than those with TT, TT, TT+TC, andTT+CC genotypes, respectively. The frequency of miR-499C (78.5%) and miR-499T (21.5%) alleles were also statistically significantly(p<0.05) difference associated with lung carcinoma in patients than controls.&#x0D; Conclusion: In this study, a possible relationship among miR-499C/T polymorphism and lung carcinoma was detected in Iranianpopulation. Since this study was conducted for the first time, thus other supplementary assessments are needed for definiteconclusion.&#x0D; Keywords: Lung, neoplasm; carcinoma; rs3746444; miR-499C/T; miR-499A/G; RFLP-PCR; Polymorphism; Iran.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"254 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic esophageal foreign body removal among children at Lubaga Hospital, Kampala, Uganda","authors":"Michael Okello, Sabrina Bakeera-Kitaka, Ponsiano Ocama, Esther Patience Nabwire, Dave Darshit, Christine Namata, Annah Ainembabazi Tinka","doi":"10.4314/ahs.v23i3.27","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.27","url":null,"abstract":"Background: Diagnostic upper gastrointestinal endoscopy involves examination of the lining of the esophagus, stomach and part of the duodenum. Interventional endoscopy in addition to evaluating the upper gastrointestinal tract to make a diagnosis, also offers a treatment benefit. Traditionally, esophageal foreign bodies (FBs) in Uganda were removed using rigid endoscopy. We therefore report an emerging trend of using flexible endoscopy to remove these FBs.&#x0D; Objective: To describe participant characteristics and endoscopic findings among children who underwent esophageal FB removal in Lubaga Hospital in Kampala.&#x0D; Methods: This was a retrospective review of endoscopy reports for children who underwent endoscopic esophageal FB removal at Lubaga Hospital from December 2014 to March 2022.&#x0D; Results: Overall, 61 symptomatic children underwent this procedure. The majority of the FBs were removed by flexible endoscopy (n=55, 90.16%). The mean age of the participants was 7.88 (SD=2.12) years old. The majority of the children were females (72.13%) and coins were the most ingested FBs (84%), others included steel crucifix, nails etc. The upper esophageal sphincter was the commonest site for FB impaction (74%).&#x0D; Conclusion: We report high success rates of 90.16% for endoscopic removal of impacted esophageal foreign bodies among Ugandan children using the now widely available flexible endoscopy.&#x0D; Keywords: Endoscopy; esophagus; foreign body.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cancer awareness and risk factors among women residing in an urban slum in Lagos, Southwest Nigeria","authors":"Tope Olubodun, Oluwatoyin O Ogundele, Zainab A Salisu, Yetunde O Odusolu, Ugonnaya U Caleb-Ugwuowo","doi":"10.4314/ahs.v23i3.33","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.33","url":null,"abstract":"Background: Poor awareness of cervical cancer and high prevalence of its risk factors may be responsible for the large burdenof cervical cancer in low-income countries. This study assessed awareness of cervical cancer and prevalence of risk factorsamong women residing in a slum in Lagos, Nigeria.&#x0D; Methods: This was a descriptive cross-sectional study carried out amongst 305 women of reproductive age (15-49 years) inIdi-Araba, a slum in Urban Lagos. Data were collected using interviewer administered questionnaires. Analysis was done withSPSS 20 software.&#x0D; Results: Mean age of respondents was 33.5(9.0) years. Only 12.8% of the respondents had heard of cervical cancer. Ninety-fivepercent of respondents were sexually active and 56.2% had more than one lifetime sexual partner. Close to half (47.3%) ofrespondents had their first sexual intercourse before the age of 20. One in five (22.2%) had 5 or more children. Half of therespondents (54.8%) had had abnormal vaginal discharge.&#x0D; Conclusion: Awareness of cervical cancer among the women was poor and prevalence of risk factors of cervical cancer washigh. Campaigns aimed at increasing awareness of cervical cancer, and screening should be carried out by governmental andcharitable organizations for women residing in slums.&#x0D; Keywords: Cervical cancer; awareness; risk factors; slum; Nigeria.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136211814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digestive manifestations of Covid-19 in children: a retrospective study","authors":"Abderrahmane Jallouli, Karima El Fakiri, Houda Nassih, Rabiy EL Qadiry, Aicha Bourrahouat, Imane Ait Sab, Noureddine Rada, Ghizlane Draiss, Mohammed Bouskraoui","doi":"10.4314/ahs.v23i3.22","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.22","url":null,"abstract":"Background: The world is currently facing a pandemic due to a new species of the Coronaviridae family called SARS-CoV-2,discovered in the city of Wuhan in China in December 2019. The WHO has named the resulting disease COVID-19 (CoronavirusDisease 2019). It has been a global health problem due to its major socio-economic damage. The aim of this study was toshow the prevalence of gastrointestinal and hepatic manifestations in symptomatic children with COVID-19.&#x0D; Methods: We performed a retrospective study, including 36 symptomatic children infected by SARS-CoV-2 hospitalized at themother and child hospital of university hospital of Mohammed VI, Marrakech in Morocco, over a period of 7 months. Clinicaland biological manifestations of the digestive system were evaluated for all patients.&#x0D; Results: The digestive symptomatology came in second place after the respiratory manifestations. 14 patients (38.89 % ofsymptomatic patients) in our study had digestive symptoms on admission: 12 (33.33%) presented with diarrhea, 4 (11.11%) hadabdominal pain and only one child (2.78%) had vomiting. Aspartate aminotransferase (AST) was elevated in one patient, whilealanine transaminase (ALT) was elevated in 6 patients. The prothrombin level was normal in all patients. All patients were dischargedwith good general condition without morbidity and mortality.&#x0D; Conclusion: This study concludes with the high prevalence of digestive manifestations of COVID-19 in symptomatic children.There were no severe clinical or biological abnormalities in our study. Digestive manifestations during COVID-19 in childrenare frequent, which requires the awareness of health professionals&#x0D; Keywords: COVID-19; digestive manifestations; children.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Values of serum neutrophil gelatinase-associated lipocalin and cystatin C after percutaneous coronary intervention for early diagnosis of contrast-induced nephropathy","authors":"Ping Luo, Wei Ao, Dikai Xiang, Jian Wang, Jia Liu","doi":"10.4314/ahs.v23i3.69","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.69","url":null,"abstract":"Objective: Serum creatinine (SCr) is not a sensitive and reliable index for the early diagnosis of acute kidney injury caused bycontrast-induced nephropathy (CIN). The aim of this study was to explore the values of serum neutrophil gelatinase-associatedlipocalin (NGAL) and cystatin C (Cys-C) after percutaneous coronary intervention (PCI) for the early diagnosis of CIN.&#x0D; Methods: Three hundred patients receiving PCI from January 2018 to December 2020 were assigned to a CIN group (n=25)and a non-CIN group (n=275), respectively. SCr, Cys-C and NGAL levels were measured, and their sensitivities for early CINdiagnosis were evaluated by the area under the receiver operating characteristic curve (AUC) values.&#x0D; Results: The NGAL and Cys-C levels of the CIN group began to rise 6 and 12 h after operation, respectively (P<0.05). TheCIN group had higher NGAL and Cys-C levels than those of the non-CIN group 12, 24 and 48 h after operation (P<0.05). TheAUC values of NGAL, Cys-C and SCr 24 h after operation were 0.885, 0.874 and 0.856, respectively.&#x0D; Conclusion: The serum NGAL and Cys-C levels of patients after PCI reflect the early changes of renal function, which arevaluable for early CIN diagnosis.&#x0D; Keywords: Contrast; cystatin C; nephropathy; neutrophil gelatinase-associated lipocalin; percutaneous coronary intervention.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136214053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of iron isomaltoside ferumoxytol with iron sucrose for iron deficiency anemia: a meta-analysis of randomized controlled trials","authors":"Lunbo Shi, Yan Zhao, Aihua Rao","doi":"10.4314/ahs.v23i3.25","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.25","url":null,"abstract":"Introduction: The efficacy of iron isomaltoside ferumoxytol versus iron sucrose to treat iron deficiency anemia remains controversial. We conduct this meta-analysis to explore the influence of iron isomaltoside ferumoxytol versus iron sucrose on iron deficiency anemia.&#x0D; Methods: We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through March 2021 for randomized controlled trials (RCTs) assessing the effect of iron isomaltoside ferumoxytol versus iron sucrose on iron deficiency anemia. Meta-analysis was performed using the random-effect model.&#x0D; Results: Four RCTs involving 3892 patients were included in the meta-analysis. Overall, compared with iron sucrose for iron deficiency anemia, iron isomaltoside showed similar change of Hb (SMD=0.14; 95% CI=-0.07 to 0.35; P=0.18), Hb responder (SMD=1.41; 95% CI=0.71 to 2.81; P=0.33), serum ferritin (SMD=15.13; 95% CI=-23.45 to 53.71; P=0.44), and transferrin saturation (SMD=1.20; 95% CI=-1.08 to 3.47; P=0.30). However, iron isomaltoside further improved serum-ferritin at week 2 than iron sucrose (SMD=204.79; 95% CI=38.23 to 371.35; P=0.02).&#x0D; Conclusions: Iron isomaltoside ferumoxytol showed comparable efficacy to iron sucrose for the treatment of iron deficiency anemia.&#x0D; Keywords: Iron isomaltoside ferumoxytol; iron sucrose; iron deficiency anemia; randomized controlled trials.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136211963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between antimicrobial resistance and virulence factors in uropathogenic Escherichia coli isolates from Ramadi, Iraq: phenotype and genotype identification","authors":"Ahmed Dhahir Abed, Thamer Y Mutter","doi":"10.4314/ahs.v23i3.56","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.56","url":null,"abstract":"Background: Uropathogenic Escherichia coli (UPEC) is the most predominant pathogen that causes severe urinary tract infections (UTIs). Their therapeutic options are limited due to the rising of antibiotic resistance.&#x0D; Objective: The aim of the study was to evaluate the level of antibiotic resistance profile, redundancy of virulence genes, and their correlation.&#x0D; Methods: 41 UPEC isolates were collected from patients diagnosed with UTI, identified by the standard microbiological analysis, and tested for susceptibility to 12 antibiotic agents using the Kirby-Bauer method. The ability of UPEC isolates to produce biofilm, hemolyze and cause clumping of blood was determined. Virulence genes were detected by PCR analysis.&#x0D; Results: The percentage of UPEC isolates was higher in females (78.1%) than in males (21.9%). UPEC isolates showed a high degree of resistance towards Ceftriaxone (90.2%), Cefepime (90.2%), Ciprofloxacin (82.9%), Levofloxacin (82.9%), and Trimethoprim-Sulfamethoxazole (80.4%). Biofilm formation (87.8%) and hemagglutinin activity (80.4%) were the most predominant virulence markers expressed in UPEC and showed a high degree of correlation with the antibiotic resistance profile. PCR analysis showed that fimH (85.3%) was the most prevalent gene detected in UPEC isolates, followed by aac3-II (80.4%) among the five genes tested, blaTEM, aac3-II, sul2, hlyA, and fimH. The correlation between antibiotic resistant patterns and the presence aac3-II gene was significantly high. The resistance to the sulfonamides’ combined antibiotic was highly correlated with the presence of sulf2 gene.&#x0D; Conclusion: Antimicrobial resistance was significantly linked to phenotypic and genotypic virulence factors. These results will aid in elucidating the pathogenicity of UTIs and guiding treatment decisions.&#x0D; Keywords: UPEC resistance profile; virulence factor; Biofilm formation; hemagglutinin; hemolysin.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatio-temporal modelling of under-five mortality in Lesotho using demographic and health survey data","authors":"Mthobisi Mxolisi Zondi, Henry G Mwambi, Sileshi Fanta Melesse","doi":"10.4314/ahs.v23i3.21","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.21","url":null,"abstract":"Background: Lesotho is in the Sustainable Development Goal (SDG) region which aims to reduce the under-five mortality (U5M) to the average of 25 deaths per 1000 live births by the end of 2030 under the sustainable development goals (SDGs) initiative by the United Nations&#x0D; Methodology: This paper makes use of the Lesotho Demographic and Health Survey (LDHS dataset, which focuses on female reproductive ages 15-49 and male reproductive ages 15-54 The spatio-temporal models were used in this study to investigate how the proposed covariates change over time.&#x0D; Results: The results showed that children who were breastfed had a lower odd of death compared to children who were not breastfed, children from more educated mothers had significantly lower odds of U5M compared to those from less educated mothers. Having a larger number of children under the age of five also contributed significantly to an increased risk of U5M. The likelihood of U5M increased with age.&#x0D; Conclusion: The study recommends that mothers of under-five children be educated about breastfeeding and encouraged to use contraception in order to postpone birth and reduce parity. Rural development should be prioritized through improved primary health care; and public health services should be made more accessible to rural residents.&#x0D; Keywords: Spatio-temporal modelling; under-five mortality; Integrated Laplace nested approximation; Lesotho demographic and health survey data.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of CVP+VIVC in predicting fluid resuscitation in patients with septic shock","authors":"Haitao Zhang, Chang Liu, Aiping Cao, Qiong Hang","doi":"10.4314/ahs.v23i3.52","DOIUrl":"https://doi.org/10.4314/ahs.v23i3.52","url":null,"abstract":"Objective: To explore the clinical value of central venous pressure (CVP) + inferior vena cava respiratory variability (VIVC) in fluid resuscitation in spontaneously breathing patients with septic shock.&#x0D; Methods: In retrospective observational study, during October 2019 to December 2021, 145 patients with septic shock treated in our hospital were enrolled by the method of observational study. According to the change rate of cardiac output (△ CO) ≥15% or △ CO<15% after 30 minutes, they were assigned into volume-responsive and volume-unresponsive group depending early fluid resuscitation in sepsis. The clinical value of combination of CVP and VIVC in predicting fluid resuscitation in patients with septic shock was compared.&#x0D; Results: The CVP of the study group was higher at 12h and 24h after fluid resuscitation, and the VIVC level of the study group at 6h, 12h and 24h after fluid resuscitation was higher (P<0.05). Pearson correlation analysis indicated that CVP, and VIVC levels were noticeably correlated with fluid resuscitation in patients with septic shock (P<0.05). The area under curve (AUC) of receiver operating characteristic curve (ROC) of CVP for predicting fluid resuscitation in septic shock patients was 0.694 and the cut-off value was 0.932, the sensitivity was 46.9%, and the specificity was 87.5%. VIVC predicted fluid resuscitation in septic shock patients with an AUC of 0.776, which was a cut-off value of 0.688, a sensitivity of 50.0%, and a specificity of 90.0%. Combination of CVP and VIVC predicted fluid resuscitation in septic shock patients with an AUC of 0.948, which was a cut-off value of 1.420, a sensitivity of 90.6%, and a specificity of 87.5%.&#x0D; Conclusion: Combination of CVP and VIVC may have a good effect on the evaluation of volume responsiveness in patients with septic shock, which is better than single CVP and VIVC. Combination of CVP and VIVC can be adopted to predict fluid responsiveness volume responsiveness in septic shock patients, which is of great significance for guiding clinical fluid responsiveness therapy.&#x0D; Keywords: Septic shock; fluid resuscitation; CVP; VIVC.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136213632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}