African Health Sciences最新文献_第10页

Appropriateness and diagnostic yield of open access gastroscopy in two tertiary centers in South-western Nigeria 尼日利亚西南部两家三级医院开放胃镜检查的适宜性和诊断率

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.44

Emuobor A Odeghe, Opeyemi O Owoseni, Evaristus S Chukwudike, Oluwafunmilayo F Adeniyi, Babatunde E Adigun, Ganiyat K Oyeleke, Aderemi O Oluyemi, Olufunmilayo A Lesi

{"title":"Appropriateness and diagnostic yield of open access gastroscopy in two tertiary centers in South-western Nigeria","authors":"Emuobor A Odeghe, Opeyemi O Owoseni, Evaristus S Chukwudike, Oluwafunmilayo F Adeniyi, Babatunde E Adigun, Ganiyat K Oyeleke, Aderemi O Oluyemi, Olufunmilayo A Lesi","doi":"10.4314/ahs.v23i2.44","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.44","url":null,"abstract":"Background: There is need for the appropriate use of gastroscopy. Objective: To determine the appropriateness of upper gastrointestinal endoscopy, and its association with significant endoscopyfindings in our environment. Methods: This was a prospective study of subjects who underwent gastroscopy at two centers in south-western Nigeria betweenAugust 2020 and August 2021. Indications were classified as either appropriate or inappropriate according to the ASGE guidelines, gastroscopic findings as either significant or not significant, patients as either elderly (≥ 60 years) or not, inpatients or outpatients, and referrals as either gastroenterologist referral, or not. Results: There were 227 subjects, 131 (57.7%) females, mean age 45 ± 13.7 years. Fifteen percent were elderly, 65.6% were gastroenterologist referrals, 14.1% were inpatients, while 45.8% had co-morbidities. Endoscopy was appropriately indicated in 81.9%, and significant endoscopy findings were detected in 95.6%. Appropriateness was not associated with significant endoscopy findings. The sensitivity, specificity and AUROC of the ASGE guidelines were 10%, 82%, and 0.46 respectively. Conclusion: According to our study, most procedures are appropriately indicated. However, appropriateness did not determineendoscopy yield. Larger studies are needed to determine the utility of the ASGE guidelines in our environment. Keywords: Appropriateness; endoscopy; Nigeria.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, severity, and correlates of erectile dysfunction among male adult patients of a primary care clinic in North-West Nigeria 尼日利亚西北部一家初级保健诊所成年男性患者勃起功能障碍的患病率、严重程度和相关因素

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.77

Abdullahi Z Muhammad, Bukar A Grema, A. Shuaibu, Godpower C Michael

{"title":"Prevalence, severity, and correlates of erectile dysfunction among male adult patients of a primary care clinic in North-West Nigeria","authors":"Abdullahi Z Muhammad, Bukar A Grema, A. Shuaibu, Godpower C Michael","doi":"10.4314/ahs.v23i2.77","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.77","url":null,"abstract":"Background: Erectile dysfunction (ED) is a common sexual problem that profoundly affects intimate relationships. It is poorly studied in North-western Nigeria. Objectives: To assess the prevalence, severity and predictors of ED among adult males attending a primary care clinic in Northwest Nigeria. Methods: A cross-section of 392 males (aged ≥25 years) were randomly selected from attendees of a family medicine clinic in Kano, Nigeria. Information regarding their biodata, lifestyle factors, and clinical characteristics was obtained using a structured questionnaire. The International Index of Erectile Function Questionnaire (version 5) and Patient Health Questionnaire-2 assessed ED and depression, respectively. Results: The participants' mean age was 45±14.1 years (range: 26-86 years). Most participants were married (88.8%), had one sexual partner (71.7%), had tertiary education (44.4%) and were traders (49.7%). The prevalence of ED was 52.3% (205/392) [comprising mild (36.0%), mild-to-moderate (14.3%), moderate (1.5%) and severe (0.5%)]. Age, body mass index (BMI), marital status, number of sexual partners, monthly income, type of exercise, hypertension history, blood pressure reading, antihypertensive and peptic ulcer drug use were associated with ED (P<0.05). However, age (≥50years) (OR= 1.91, 95%CI [1.28-2.85], P=0.001) and overweight/obesity (OR =1.81, 95%CI [1.18-2.77], P=0.007) were the predictors of ED in this population. Conclusion: ED prevalence was high, although mainly of the mild form. Age (≥50years) and overweight/obesity predicted ED. Hence, the need for early screening, objective grading of ED, identification of modifiable risk factors (e.g., overweight/obesity) and commencing proper treatment and prevention in this setting. Keywords: Correlates; erectile dysfunction; obesity; primary care; severity; Northwest Nigeria.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colorectal cancer in a region of western of Algeria: results of 581 cases in 5 years 阿尔及利亚西部一个地区的结直肠癌：5 年内 581 例病例的结果

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.39

Bouchra Dahmani, L. Boublenza, Naffissa Chabni, D. Behar, H. Hassaine, N. Masdoua, A. Nahet, K. Meguenni, Ilyes Zetla

{"title":"Colorectal cancer in a region of western of Algeria: results of 581 cases in 5 years","authors":"Bouchra Dahmani, L. Boublenza, Naffissa Chabni, D. Behar, H. Hassaine, N. Masdoua, A. Nahet, K. Meguenni, Ilyes Zetla","doi":"10.4314/ahs.v23i2.39","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.39","url":null,"abstract":"Aims: The objective of this work is to evaluate the epidemiological profile of colorectal cancers, histologically proven over a 5-year period (2012-2016) in the Tlemcen region. Methods: A retrospective study of 581 cases of colorectal cancer collected at the epidemiology department of the UniversityHospital Center (UHC) of Tlemcen between January 2012 and December 2016 was performed. Epidemiological data were processedusing SPSS version 25 and Microsoft Excel 2010. Results: The epidemiological profile has shown that colorectal cancer in our region ranks 3rd in both sexes. There were 322 men(55.4%) affected compared to 259 women (44.6%) with a sex ratio of 1.2. A predominance of males is noted in 50-60 age group, while for the female sex, the dominance is between 60-70 years old. The mean age of CRC occurrence was 60±13 years, with an extremity ranging from16 to 90. A significantly higher rate was recorded for rectal cancer (43.7%) followed by sigmoid colon (5.7%). Variable rates were recorded during the 5 years with a peak in 2014 (27.9%). Conclusion: Regular analysis of these data, if supplemented with additional data on diagnostic modalities like circular RNA diagnostic, will contribute to the assessment of the impact over time of public policies on nationally organized CRC screening. Keywords: Colorectal cancer; epidemiology; Algeria; Tlemcen province.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular complications and associated factors among traditional eye medicines users attending the eye clinic at Mulago national referral hospital, Uganda 乌干达穆拉戈国家转诊医院眼科诊所传统眼药使用者的眼部并发症及相关因素

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.53

Fransisco Msonge, Lusobya Rebecca Clare, Anne A Musika, I. Atukunda, Caroline Otike, Juma Paul, Elizabeth Nagawa, Eunice Headcraph, Lydia Nakiyingi, Charles M Yancey, Agaba John, Juliet Otiti-Sengeri

{"title":"Ocular complications and associated factors among traditional eye medicines users attending the eye clinic at Mulago national referral hospital, Uganda","authors":"Fransisco Msonge, Lusobya Rebecca Clare, Anne A Musika, I. Atukunda, Caroline Otike, Juma Paul, Elizabeth Nagawa, Eunice Headcraph, Lydia Nakiyingi, Charles M Yancey, Agaba John, Juliet Otiti-Sengeri","doi":"10.4314/ahs.v23i2.53","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.53","url":null,"abstract":"Background: Over the past decades there has been a phenomenal increase in the use of Traditional Eye medicines (TEM) worldwide and there are several factors that compel patients to use TEM. Objectives: We conducted a study to determine the types of traditional eye medicine, ocular complications, and associated factors among traditional eye medicine users at the Mulago National Referral Hospital (MNRH) eye clinic. Methods and Materials: A hospital-based cross-sectional study among TEM users at MNRH eye clinic from June to August 2021. Epi Data version 4.2 and STATA version 15 used for analysis. A modified Poisson regression with robust standard errors was used to determine the associated factors. Results: Overall, 182 TEM users (males:53.3%) were enrolled, with a mean age of 36±21SD years. The most frequently used type of TEM were plant products (47.8%). 70% of TEM users had ocular complications, the most frequent manifestation was conjunctivitis (53.9%). Ocular complications were significantly associated with living in the urban areas (p< 0.006) and participants who reported ease and availability of TEM (p < 0.001). Conclusion: Plant-based products were the most frequently used types of TEM, a large proportion of the TEM users were found with sight-threatening ocular complications. Keywords: Traditional eye medicine; Uganda; Complications.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advice for smokers in smoking cessation clinic: a review 戒烟门诊为吸烟者提供的建议：综述

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.42

Xuechan Yu, Meihua Wang, Jie Cen, Mianzhi Ye, Sha Li, Younuo Wang, Qingwen Su, Hui Chen, Ruyi Xu, Shuya Zhang, Shanshan Wang, Yiming Yu, Zaichun Deng, Zhongbo Chen

引用次数: 0

Experiences of female clients in the assisted reproductive technology process in Nigeria 尼日利亚女性客户在辅助生殖技术过程中的经历

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.76

Ijeoma V Ezeome, Simisola O Akintola, Ayodele S Jegede

{"title":"Experiences of female clients in the assisted reproductive technology process in Nigeria","authors":"Ijeoma V Ezeome, Simisola O Akintola, Ayodele S Jegede","doi":"10.4314/ahs.v23i2.76","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.76","url":null,"abstract":"Background: Though assisted reproductive technology (ART) has been a source of hope for many infertile couples, it is knownto be associated with physical, social, psychological, and ethical challenges in different settings. Objective: The study objective was to explore the experiences of female clients who accessed services in ART clinics in Nigeria. Methods: An exploratory qualitative design, using snowballing technique was employed. It involved in-depth interviews of eightwomen who had gone through the assisted conception process, using an interview guide. Data collection was from November 2019 to January 2020. Results: The age range of the participants was 30 – 52 years with a mean of 41.88 years. Majority of the clients presented at advanced age to their ART providers because of lack of funds and ignorance. Other challenges were suboptimal risk disclosure, high cost of services, feelings of shame and stigmatization during and after the process. Conclusion: Cost of ART remain unaffordable to most Nigerians hence the need for government subsidization and in-corporation of ART services into the National Health Insurance Scheme. Additionally, lack of adequate information disclosure, shared decision-making and gendered suffering are areas of great concern among the study participants. A national regulatory guideline will ensure uniform international standard of care. Keywords: Experience; clients; assisted reproductive technology.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, influencing factors, and outcomes of emergency caesarean section in public hospitals situated in the urban state of Lagos, Nigeria 尼日利亚拉各斯城市公立医院紧急剖腹产的发生率、影响因素和结果

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.74

A. Banke-Thomas, Cephas Ke-on Avoka, Olakunmi Ogunyemi

{"title":"Prevalence, influencing factors, and outcomes of emergency caesarean section in public hospitals situated in the urban state of Lagos, Nigeria","authors":"A. Banke-Thomas, Cephas Ke-on Avoka, Olakunmi Ogunyemi","doi":"10.4314/ahs.v23i2.74","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.74","url":null,"abstract":"Background: Caesarean section (CS) performed in an emergency can be life-saving for both the pregnant woman and her baby. In Nigeria, CS rates have been estimated to be 2.7% nationally, with the highest regional rate of 7.0% reported in the South-West of the country. Our objective in this facility-based retrospective cross-sectional study was to describe patterns and assess factors, obstetric indications, and outcomes of emergency CS in Lagos, Nigeria. Methods: Socio-demographic, travel, and obstetric data of pregnant women were extracted from case notes. Travel data was inputted in Google Maps to extract travel time from the pregnant women’ home to the hospital. Univariate, bivariate and multivariable logistic regression analyses were conducted. Results: Of the 3,134 included pregnant women, 1,923 (61%) delivered via emergency CS. The odds of an emergency CS were significantly higher among women who were booked (OR=1.97, 95%CI 1.64–2.35), presented with obstructed labour (OR=2.59, 95%CI 1.68–3.99), pre-eclampsia/eclampsia (OR=1.67, 95%CI 1.08–2.56), multiple gestations (OR=2.71, 95%CI 1.72–4.28) and travelled from suburban areas (OR=1.43, 95%CI 1.15–1.78). There was an increasing dose-effect response between travel time to the hospital and emergency CS. Conclusion: Optimisation of CS rates requires a multi-pronged approach during pregnancy and childbirth, with particular emphasis on supporting pregnant women living in the suburbs. Keywords: Caesarean section; emergency obstetric care; prevalence; factors; urban; Nigeria.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interferon in the treatment of ill adults with Covid-19 in the Republic of Guinea 干扰素在几内亚共和国治疗患有 Covid-19 的成人病人中的应用

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.6

Valentín Santiago Rodríguez Moya, Ladys Alfonso Águila, Nohuou Mangué Camara, Sékuo Ditinn Cisse, Doukure Mamady, Sakoba Keïta, Kava Mamady Bakary, Lianet Díaz Pérez, Elaine Díaz Casañas

{"title":"Interferon in the treatment of ill adults with Covid-19 in the Republic of Guinea","authors":"Valentín Santiago Rodríguez Moya, Ladys Alfonso Águila, Nohuou Mangué Camara, Sékuo Ditinn Cisse, Doukure Mamady, Sakoba Keïta, Kava Mamady Bakary, Lianet Díaz Pérez, Elaine Díaz Casañas","doi":"10.4314/ahs.v23i2.6","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.6","url":null,"abstract":"Background: Effective and safe antiviral treatments are required to refrain the COVID-19. Objectives: Investigate the efficacy and safety of interferon in the treatment of COVID-19. Methods: The inclusion criteria were patients who gave their signed consent, with detection confirmed by RT-PCR of SARSCoV- 2, 18 years and older. Patients received therapy as per the Guinea COVID-19 protocol in the group B; the group A received the same treatment including administration of interferon. The outcome measures the time to negative conversion of SARSCoV- 2, mortality, patients transferred to ICU and safety, according to the reports of adverse events. Results: 345 patients were included, 171 in the group A and 174 in the group B. After the treatments, the RT-PCR negative results were attained in the patients in the group A in 9.15±4.79 days and in those in the group B in 14.83±6.67 days. No patient in the group A had to be transferred to ICU, and they all survived; in the group B, 26 patients were transferred to ICU and six of them died. There were eight adverse events with causality relation with interferon administration. Conclusions: The interferon resulted effective and safe in contributing to the viral replication conversion to negative results in shorter time and to survival. Keywords: SARS-Cov-2; COVID 19; zoonosis; human recombinant interferon.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Value of dynamic contrast-enhanced magnetic resonance imaging in combination with mammography for screening early-stage breast cancer 动态对比增强磁共振成像与乳腺 X 射线摄影相结合对筛查早期乳腺癌的价值

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.33

Weiwei Su, Xiaoming Hou, Bo Yu

{"title":"Value of dynamic contrast-enhanced magnetic resonance imaging in combination with mammography for screening early-stage breast cancer","authors":"Weiwei Su, Xiaoming Hou, Bo Yu","doi":"10.4314/ahs.v23i2.33","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.33","url":null,"abstract":"Objective: To study the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in combination with mammography for screening early-stage breast cancer. Methods: Ninety-three female patients visiting Zhejiang Zhuji Hospital of Traditional Chinese Medicine from January 2020 to March 2022 were enrolled to receive DCE-MRI and mammography. The diagnostic efficiencies of different methods were assessed with pathological diagnosis as the golden standard. The factors affecting diagnostic sensitivity were investigated based on clinicopathological characteristics. Results: Forty-one patients were diagnosed as malignant pathological changes by DCE-MRI, and the signs were unclear boundary with surrounding tissues and irregular or unsmooth edges. The maximum linear slope and ratio of the maximum linear SlopeR of malignant pathological changes were significantly larger than those of benign pathological changes (P<0.05). Forty-five patients were diagnosed as malignant pathological changes by mammography combined with DCE-MRI. Compared to single diagnosis method, the combined diagnosis had significantly increased sensitivity, specificity, accuracy, positive predictive value and negative predictive value, and decreased rates of missed diagnosis and misdiagnosis (P<0.05). Lesion diameter was an independent risk factor affecting the diagnostic sensitivity (P<0.05). Conclusion: Mammography and DCE-MRI play key roles in the early diagnosis of breast cancer, and their combination can increase the diagnostic efficiency. Keywords: Breast cancer; diagnosis; magnetic resonance imaging; mammography.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between vaginal flora and cervical immune function of human papilloma virus-infected patients with cervical cancer 人乳头瘤病毒感染的宫颈癌患者阴道菌群与宫颈免疫功能之间的相关性

IF 1 4区医学

African Health Sciences Pub Date : 2023-07-13 DOI: 10.4314/ahs.v23i2.19

Qiang Wang, Wenmin Qin, Wei Gao, Kai Zhao, Xiaohong Pan, Xiaofei Jiang, Juan Zhao

{"title":"Correlation between vaginal flora and cervical immune function of human papilloma virus-infected patients with cervical cancer","authors":"Qiang Wang, Wenmin Qin, Wei Gao, Kai Zhao, Xiaohong Pan, Xiaofei Jiang, Juan Zhao","doi":"10.4314/ahs.v23i2.19","DOIUrl":"https://doi.org/10.4314/ahs.v23i2.19","url":null,"abstract":"Background: To analyse the correlation between vaginal flora and cervical immune function of HPV-infected patients with cervical cancer. Methods: Six hundred females with genital tract infections treated in Xuzhou Hospital of Traditional Chinese Medicine from January 2014 to December 2016 were selected and divided into a high-risk HPV group (n=246) and a control group (n=354). The vaginal flora and human T lymphocyte subsets (CD3+, CD4+, CD8+) were detected. Multivariate logistic regression analysis was performed to explore the risk factors for HPV infection. Results: The numbers of CD4+ and CD4+/CD8+ T cells of the high-risk HPV group were significantly lower than those of the control group (P<0.05). The two groups had similar numbers of CD3+ and CD8+ T cells. In the high-risk HPV group, the positive rates of Lactobacillus, Chlamydia trachomatis, Mycoplasma hominis, mycetes, Ureaplasma urealyticum and bacterial vaginosis were significantly higher than those of the control group (P<0.05). There was no significant difference in the positive rates of trichomonads between the two groups. Multivariate logistic regression analysis revealed that C. trachomatis and U. urealyticum were independent risk factors for high-risk HPV infection (P<0.05). Conclusion: High-risk HPV infection in patients with cervical cancer was associated with vaginal flora and immune function. C. trachomatis and U. urealyticum were independent risk factors for high-risk HPV infection. Keywords: Cervical cancer; human papilloma virus; immune function; vaginal flora.","PeriodicalId":7853,"journal":{"name":"African Health Sciences","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0