Comparative genomics of spike, envelope, and nucleocapsid protein of severe acute respiratory syndrome coronavirus 2

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

African Health Sciences Pub Date : 2023-10-11 DOI:10.4314/ahs.v23i3.45

Sufyan Sohail Khan, Anwar Ullah

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引用次数: 0

Abstract

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) upsurge sprang up in Wuhan, China, in late December 2019. Objectives: Due to the exceptionally high mutation frequency, comparative genomics of viruses isolated throughout time and in various geographical locations are crucial. To better understand how SARS-CoV-2 heterogeneity has changed around the globe, this research was conducted. Methods: Nucleotide and protein sequences of SARS-CoV-2, SARS-CoV, and bat SARS-like CoV were extracted from the NCBI Virus database. The Wuhan SARS-CoV-2 variant was used as a reference. Molecular Evolutionary Genetics Study performed the phylogenetic analysis, while the Genome Detective Coronavirus Typing Tool performed the mutational analysis. Results: The evolutionary research has revealed that bats are the primary host for coronavirus evolution and the origin of the formation of SARS-CoV and SARS-CoV-2. Numerous mutations have been discovered in the spike, envelope, and nucleocapsid protein. Conclusions: The current research findings may have an implication that facilitates the development of prospective immunization candidates/small pharmacological compounds targeting COVID-19. Keywords: SARS-CoV-2; COVID-19; pandemic; comparative genomics; spike protein; envelope protein; nucleocapsid protein.

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严重急性呼吸综合征冠状病毒刺突、包膜和核衣壳蛋白的比较基因组学研究

背景:2019年12月下旬，中国武汉爆发了严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)疫情。目的:由于异常高的突变频率，在不同时间和不同地理位置分离的病毒的比较基因组学至关重要。为了更好地了解SARS-CoV-2的异质性在全球范围内是如何变化的，我们进行了这项研究。方法:从NCBI病毒数据库中提取SARS-CoV-2、SARS-CoV和蝙蝠sars样冠状病毒的核苷酸和蛋白序列。武汉SARS-CoV-2变体被用作参考。分子进化遗传学研究进行系统发育分析，基因组检测冠状病毒分型工具进行突变分析。结果:进化研究表明，蝙蝠是冠状病毒进化的主要宿主，也是SARS-CoV和SARS-CoV-2形成的起源。在刺突、包膜和核衣壳蛋白中发现了许多突变。结论:目前的研究结果可能有助于开发针对COVID-19的前瞻性免疫候选物/小药理学化合物。关键词:SARS-CoV-2;COVID-19;大流行;比较基因组学;峰值蛋白质;包膜蛋白;核衣壳蛋白。

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来源期刊

African Health Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

179

审稿时长

>12 weeks

期刊介绍： The African Health Sciences is an internationally refereed journal publishing original articles on research, clinical practice, public health, policy, planning, implementation and evaluation, in the health and related sciences relevant to Africa and the tropics. Its objectives are to: Advocate for and promote the growth of reading culture in sub Saharan Africa; Provide a high quality journal in which health and policy and other researchers and practitioners in the region can and world wide, can publish their work; Promote relevant health system research and publication in the region including alternative means of health care financing, the burden of and solution of health problems in marginalized urban and rural communities amongst the displaced and others affected by conflict; Promote research and the systematic collection and collation and publication of data on diseases and conditions of equity and influence; Promote development of evidence-based policies and guidelines for clinical, public health and other practitioners. African Health Sciences acknowledges support provided by the African Health Journals Partnership Project that is funded by the US National Institutes of Health (through the National Library of Medicine and the Fogarty International Center) and facilitated by the Council of Science Editors.