Anatolian Journal of Cardiology最新文献

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Changes in Acute Coronary Syndrome Clinic after the Devastating Earthquake in Türkiye. 土耳其大地震后急性冠状动脉综合征门诊的变化。
IF 1.3 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-06-04 DOI: 10.14744/AnatolJCardiol.2024.4207
Oğuz Akkuş, Ramazan Yadsıbaş, Ramazan Furkan Demirkıran, Veysel Elitaş, Özkan Bekler, Fatih Şen, Hülya Binokay, Gamze Akkuş, Ertuğrul Okuyan
{"title":"Changes in Acute Coronary Syndrome Clinic after the Devastating Earthquake in Türkiye.","authors":"Oğuz Akkuş, Ramazan Yadsıbaş, Ramazan Furkan Demirkıran, Veysel Elitaş, Özkan Bekler, Fatih Şen, Hülya Binokay, Gamze Akkuş, Ertuğrul Okuyan","doi":"10.14744/AnatolJCardiol.2024.4207","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2024.4207","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the clinical and angiographic characteristics of patients with acute coronary syndrome (ACS) who survived this devastating earthquake and were admitted to our hospital in Antakya/Türkiye.</p><p><strong>Methods: </strong>We retrospectively examined the impact of the earthquake on the occurrences of acute coronary syndromes in Antakya/Türkiye. All 248 consecutive patients with ACS, also survivors of the earthquake in Antakya, were enrolled as the earthquake group. The earthquake group was created from patients hospitalized between February and June in 2023 after the earthquake. In total, 209 consecutive ACS patients who were hospitalized in our cardiology clinic in similar months of 2022 named as the control group.</p><p><strong>Results: </strong>Patients admitted before the earthquake were more hospitalized with multivessel disease compared to after the earthquake group (P <.001). Myocardial infarction with non-obstructive coronary artery disease (MINOCA) was the main reason for the significant increase rate of ACS after the earthquake. The earthquake patient group had lesser diabetes mellitus than the control group (P <.001). The risk of men suffering from ACS after an earthquake is approximately 2.1 times higher than women (P =.023). Those with a history of revascularization are approximately 1.8 times more likely to have ACS after an earthquake (P =.05). The risk of experiencing ACS after an earthquake is approximately 3.5 times higher for those with a family history than for those without (P <.001).</p><p><strong>Conclusion: </strong>Effects of the devastating earthquake on the heart are the increase in MINOCA patients triggered by great sudden environmental stress and the decrease in diabetes due to worsening nutritional conditions, respectively.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Outcomes of Cryoballoon-based Empirical Superior Vena Cava Isolation in Addition to Pulmonary Vein Isolation in Persistent Atrial Fibrillation. 基于冷冻球囊的经验性上腔静脉隔离术与肺静脉隔离术并用治疗顽固性心房颤动的长期效果。
IF 1.3 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-06-04 DOI: 10.14744/AnatolJCardiol.2024.4092
Uğur Canpolat, Hikmet Yorgun, Kudret Aytemir
{"title":"Long-term Outcomes of Cryoballoon-based Empirical Superior Vena Cava Isolation in Addition to Pulmonary Vein Isolation in Persistent Atrial Fibrillation.","authors":"Uğur Canpolat, Hikmet Yorgun, Kudret Aytemir","doi":"10.14744/AnatolJCardiol.2024.4092","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2024.4092","url":null,"abstract":"<p><strong>Background: </strong>Superior vena cava (SVC) is atrial fibrillation (AF)'s most common non-pulmonary vein (PV) foci. Studies reported conflictory results when SVC isolation (SVCi) was combined with PVi and long-term outcomes were lacking. Therefore, we aimed to evaluate the long-term efficacy and safety of empirical SVCi as an adjunct to cryoballoon-based PV isolation (PVi) in persistent AF ablation.</p><p><strong>Methods: </strong>A total of 40 consecutive persistent AF patients (60.6 ± 8.2 years, 52.5% females) who underwent SVCi in addition to PVi compared with a propensity score matched cohort of 40 persistent AF patients (58.6 ± 8.7 years, 50% female) in whom PVi-only was performed. Second-generation cryoballoon (CB2) was used in all procedures. Atrial tachyarrhythmia (ATa) recurrence was defined as the detection of AF, atrial flutter, or atrial tachycardia (≥30 s) after a 3-month blanking period.</p><p><strong>Results: </strong>Pulmonary veins and SVC were successfully isolated in all patients. At a mean of 46.7 ± 7.8 months follow-up, 22 (55%) patients in the PVi-only group, and 27 (67.5%) patients in the PVi + SVCi group were free of ATa after the index procedure (P =.359). Phrenic nerve injury (PNI) was detected in 2 (5%) patients in the PVi-only group (during right PVi) and 2 (5%) patients in the PVi + SVCi group (during SVCi) (P = 1.00). Cox regression analysis revealed that early recurrence was the only predictor of recurrence (hazard ratio 4.88, 95% confidence interval 1.59-14.96; P =.005).</p><p><strong>Conclusion: </strong>Long-term results of our small sample-sized study revealed that CB-based PVi + SVCi was associated with outcomes similar to the PVi-only strategy in patients with persistent AF. Although complication rates were similar between the groups, close follow-up of diaphragmatic movement is crucial to prevent PNI during SVCi.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141236211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging the Gap: Insights from the AIZANOI Study on Low-Density Lipoprotein-Cholesterol Management in Türkiye. 缩小差距:土耳其低密度脂蛋白胆固醇管理 AIZANOI 研究的启示。
IF 1.4 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-06-01 DOI: 10.14744/AnatolJCardiol.2024.4607
Meral Kayıkçıoğlu
{"title":"Bridging the Gap: Insights from the AIZANOI Study on Low-Density Lipoprotein-Cholesterol Management in Türkiye.","authors":"Meral Kayıkçıoğlu","doi":"10.14744/AnatolJCardiol.2024.4607","DOIUrl":"10.14744/AnatolJCardiol.2024.4607","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiojet Rheolytic Thrombectomy, AIZANOI study and COVID-19. 血管喷射溶栓术、AIZANOI 研究和 COVID-19。
IF 1.3 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-06-01 DOI: 10.14744/AnatolJCardiol.2024.6
Çetin Erol
{"title":"Angiojet Rheolytic Thrombectomy, AIZANOI study and COVID-19.","authors":"Çetin Erol","doi":"10.14744/AnatolJCardiol.2024.6","DOIUrl":"10.14744/AnatolJCardiol.2024.6","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adherence to Current Dyslipidemia Guideline in Patients Utilizing Statins According to Risk Groups and Gender Differences: The AIZANOI Study. 使用他汀类药物的患者根据风险组别和性别差异遵守现行血脂异常指南的情况:爱沙尼研究
IF 1.4 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-06-01 DOI: 10.14744/AnatolJCardiol.2024.4218
Taner Şen, Lale Dinç Asarcıklı, Saadet Güven, Umut Kocabaş, Mehmet Özgeyik, Mevlüt Demir, Tülay Oskay, Halil İbrahim Durmuş, Belma Kalaycı, Muhammet Cihat Çelik, Fatih Kahraman, Ökkeş Utku, Mehmet Ali Astarcıoğlu, Sabiye Yılmaz, Abdullah Tunçez
{"title":"Adherence to Current Dyslipidemia Guideline in Patients Utilizing Statins According to Risk Groups and Gender Differences: The AIZANOI Study.","authors":"Taner Şen, Lale Dinç Asarcıklı, Saadet Güven, Umut Kocabaş, Mehmet Özgeyik, Mevlüt Demir, Tülay Oskay, Halil İbrahim Durmuş, Belma Kalaycı, Muhammet Cihat Çelik, Fatih Kahraman, Ökkeş Utku, Mehmet Ali Astarcıoğlu, Sabiye Yılmaz, Abdullah Tunçez","doi":"10.14744/AnatolJCardiol.2024.4218","DOIUrl":"10.14744/AnatolJCardiol.2024.4218","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the adherence to the current European Society of Cardiology dyslipidemia guidelines, the ratio of reaching target values according to risk groups, and the reasons for not reaching LDL-cholesterol (LDL-C) goals in patients on already statin therapy in a cardiology outpatient population.</p><p><strong>Methods: </strong>The AIZANOI study is a multi-center, cross-sectional observational study including conducted in 9 cardiology centers between August 1, 2021, and November 1, 2021.</p><p><strong>Results: </strong>A total of 1225 patients (mean age 62 ± 11 years, 366 female) who were already on statin therapy for at least 3 months were included. More than half (58.2%) of the patients were using high-intensity statin regimens. Only 26.2% of patients had target LDL-C level according to their risk score. Despite 58.4% of very high-risk patients and 44.4% of high-risk patients have been using a high-intensity statin regimen, only 24.5% of very-high-risk patients and only 34.9% of high-risk patients have reached guideline-recommended LDL-C levels. Most prevalent reason for not using target dose statin was physician preference (physician inertia) (40.3%).</p><p><strong>Conclusion: </strong>The AIZANOI study showed that we achieved a target LDL-C level in only 26.2% of patients using statin therapy. Although 58.4% of patients with a very high SCORE risk and 44.4% of patients with a high SCORE risk were using a target dose statin regimen, we were only able to achieve guideline-recommended LDL-C levels in 24.5% and 34.9% of them, respectively, in cardiology outpatients clinics. Physician inertia is one of the major factors in non-adherence to guidelines. These findings highlight that combination therapy is needed in most of the patients.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Agreement Between Transthoracic Echocardiography and Computed Tomography Pulmonary Angiography for Detection of Right Ventricular Dysfunction in Pulmonary Embolism. 经胸超声心动图与计算机断层扫描肺血管造影在检测肺栓塞右心室功能障碍方面的一致性。
IF 1.4 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-05-27 DOI: 10.14744/AnatolJCardiol.2024.3562
Serhat Erol, Aslıhan Gürün Kaya, Fatma Arslan, Sümeyye Ayöz, Ayşegül Gürsoy Çoruh, Melahat Kul, Evren Özçınar, Aydın Çiledağ, Zeynep Pınar Önen, Akın Kaya, Özlem Özdemir Kumbasar, Stavros V Konstantinides
{"title":"Agreement Between Transthoracic Echocardiography and Computed Tomography Pulmonary Angiography for Detection of Right Ventricular Dysfunction in Pulmonary Embolism.","authors":"Serhat Erol, Aslıhan Gürün Kaya, Fatma Arslan, Sümeyye Ayöz, Ayşegül Gürsoy Çoruh, Melahat Kul, Evren Özçınar, Aydın Çiledağ, Zeynep Pınar Önen, Akın Kaya, Özlem Özdemir Kumbasar, Stavros V Konstantinides","doi":"10.14744/AnatolJCardiol.2024.3562","DOIUrl":"10.14744/AnatolJCardiol.2024.3562","url":null,"abstract":"<p><strong>Background: </strong>Right ventricular dysfunction (RVD) is the main determinant of mortality in patients with pulmonary embolism (PE). Thus, guidelines recommend the assessment of RVD with transthoracic echocardiography (TTE) or computed tomography pulmonary angiography (CTPA) among these patients. In this study, we investigated the agreement between TTE and CTPA for the detection of RVD.</p><p><strong>Methods: </strong>This single-center retrospective study included patients who were diagnosed with CTPA and underwent TTE within the first 24 hours following the diagnosis.</p><p><strong>Results: </strong>Two hundred fifty-eight patients met the inclusion criteria. In 71.3% (184) of them, CTPA and TTE agreed on both the presence and absence of RVD. There was a moderate agreement between the 2 tests (Cohen's kappa = 0.404, P <.001). The agreement between right ventricle dysfunction on TTE and the increased right ventricle/left ventricle (RV/LV) on CTPA was fair (Cohen's kappa = 0.388, P <.001). Three patients died due to PE, and another 5 patients required urgent reperfusion therapy. Overall, adverse outcomes occurred in 4% (8) of patients. The sensitivity of modalities in the detection of adverse outcomes was 100%. Transthoracic echocardiography was more specific compared to CTPA (43% vs. 28%). Statistically, flattening/bulging of the interventricular septum on TTE was significantly associated with adverse outcomes. No individual CTPA parameter was related to adverse outcomes.</p><p><strong>Conclusion: </strong>Both CTPA and TTE are reliable imaging modalities in the detection of RVD. However, TTE is more specific, and this may help in the identification and appropriate management of patients at higher risk of decompensation. A combination of CTPA parameters rather than individual RV/LV ratios increases the sensitivity of CTPA.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11317779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptomatic Right Atrial Appendage Aneurysm Associated with Tricuspid Regurgitation in a 7-year-old Boy. 一名 7 岁男孩伴有三尖瓣反流的无症状右房阑尾动脉瘤。
IF 1.3 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-05-24 DOI: 10.14744/AnatolJCardiol.2024.4320
Ruofan Zhou, Xi Li, Jun Gu, Shuhua Luo
{"title":"Asymptomatic Right Atrial Appendage Aneurysm Associated with Tricuspid Regurgitation in a 7-year-old Boy.","authors":"Ruofan Zhou, Xi Li, Jun Gu, Shuhua Luo","doi":"10.14744/AnatolJCardiol.2024.4320","DOIUrl":"10.14744/AnatolJCardiol.2024.4320","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Huge Pseudoaneursym Presenting with Silent Myocardial Infarction and Stroke. 巨大假性动脉瘤并发无声心肌梗死和中风
IF 1.3 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-05-21 DOI: 10.14744/AnatolJCardiol.2024.4431
Muhammed İkbal Şaşmaz, Bülent Demir, Mustafa Uçar, Akkan Avci
{"title":"Huge Pseudoaneursym Presenting with Silent Myocardial Infarction and Stroke.","authors":"Muhammed İkbal Şaşmaz, Bülent Demir, Mustafa Uçar, Akkan Avci","doi":"10.14744/AnatolJCardiol.2024.4431","DOIUrl":"10.14744/AnatolJCardiol.2024.4431","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the Effects of Recent Coronavirus 2019 Infection and Vaccination on the Prognosis of Acute Coronary Syndrome: A Retrospective Study Conducted in a Single Center in Türkiye. 近期感染 2019 年冠状病毒和接种疫苗对急性冠状动脉综合征预后影响的比较:土耳其单个中心开展的一项回顾性研究。
IF 1.3 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-05-21 DOI: 10.14744/AnatolJCardiol.2024.4372
Özlem Özbek, Mehmet Mustafa Can
{"title":"Comparison of the Effects of Recent Coronavirus 2019 Infection and Vaccination on the Prognosis of Acute Coronary Syndrome: A Retrospective Study Conducted in a Single Center in Türkiye.","authors":"Özlem Özbek, Mehmet Mustafa Can","doi":"10.14744/AnatolJCardiol.2024.4372","DOIUrl":"10.14744/AnatolJCardiol.2024.4372","url":null,"abstract":"<p><strong>Background: </strong>We aimed to examine the effects of COVID-19 infection versus vaccination within the month prior to acute coronary syndrome (ACS) diagnosis with respect to their impact on the development of mortality or major adverse cardiovascular events (MACE).</p><p><strong>Methods: </strong>This retrospective cohort study included patients hospitalized with a diagnosis of ACS between June 2020 and December 2022. Patients diagnosed with ACS were grouped according to the presence of COVID-19 infection (post-COVID), vaccination (post-vaccine), or non-exposure during the month prior to ACS diagnosis. Patients with and without MACE were also compared separately.</p><p><strong>Results: </strong>We analyzed 1890 ACS patients (mean age 57.43 ± 11.53 years, 79.15% males). Of these, 319 (16.88%) were in the post-vaccine group, and 334 (17.67%) were in the post-COVID group. Major adverse cardiovascular events occurred in 569 (30.11%) patients. Mortality was recorded in 271 (14.34%) patients. In the post-COVID group, the frequencies of MACE and mortality and length of stay in hospital were significantly higher (vs. post-vaccine and vs. non-exposure groups; both P <.001). High age, ST-elevation myocardial infarction, having suffered from Post-COVID ACS, and high glucose were independently associated with increased MACE risk; whereas, hyperlipidemia, 3 or more COVID vaccinations, receipt of the Biontech vaccine, and high estimated glomerular filtration rate were independently associated with decreased MACE risk.</p><p><strong>Conclusion: </strong>Acute coronary syndrome patients who have recently had COVID-19 infection may have a worse prognostic course compared to those with recent vaccination, necessitating continuing care for pandemic-related risk factors as well as previously known factors impacting MACE and prognosis.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation Between Serum microRNA-18a Level and Endothelial Function and Prognosis in Female Coronary Heart Disease Patients. 女性冠心病患者血清 microRNA-18a 水平与内皮功能和预后的相关性
IF 1.4 4区 医学
Anatolian Journal of Cardiology Pub Date : 2024-05-21 DOI: 10.14744/AnatolJCardiol.2024.4178
Huiyao Lu, Ling Xu, Hong Chen, Zhendong Cheng, Mingwei Huang, Naping Lin, Wenwen Lai
{"title":"Correlation Between Serum microRNA-18a Level and Endothelial Function and Prognosis in Female Coronary Heart Disease Patients.","authors":"Huiyao Lu, Ling Xu, Hong Chen, Zhendong Cheng, Mingwei Huang, Naping Lin, Wenwen Lai","doi":"10.14744/AnatolJCardiol.2024.4178","DOIUrl":"10.14744/AnatolJCardiol.2024.4178","url":null,"abstract":"<p><strong>Background: </strong>The aim was to analyze the correlation between serum microRNA (miR)-18a level, endothelial function, and prognosis in female coronary heart disease (CHD) patients.</p><p><strong>Methods: </strong>One hundred sixtyfemale patients admitted to our hospital for the first occurrences of chest pain and tightness were divided into CHD and non-CHD groups based on the coronary angiography results. Clinical data, laboratory indexes, serum miR-18a level, and endothelial function [flow-mediated dilation (FMD) function, endothelin 1 (ET-1), and nitric oxide (NO)] were compared.</p><p><strong>Results: </strong>There were no significant differences in clinical data (except CHD family history) between 2 groups. Coronary heart disease group had significantly lower levels of NO and FMD, while significantly higher levels of miR-18a and ET-1 than non-CHD group (P <.05). Pearson correlation showed that serum miR-18a level was positively correlated with ET-1 (r = 0.492, P <.001), and negatively correlated with NO and FMD (r = -0.504, -0.307, P <.001). The receiver operating characteristic) curve showed that the area under the curve of serum miR-18a level in predicting the occurrence of CHD in women was 0.878 (95% CI:  0.828-0.928). Compared with good prognosis group, poor prognosis group had signifi-cantly lower NO, and FMD levels, while higher proportions of acute coronary syndrome, multivessel disease, miR-18a, and ET-1 levels (P <.05).</p><p><strong>Conclusion: </strong>The expression of serum miR-18a in female CHD patients was high, which was related to endothelial function. The increase in serum miR-18a level was a risk factor for the occurrence of MACE in female CHD patients during follow-up, and the serum miR-18a level could effectively predict the occurrence of CHD in female patients.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11230584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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