Anatolian Journal of Cardiology最新文献

{"title":"Sequential Transcatheter Valve-in-Valve-in-Valve Implantation Within a Degenerated Bio-Bentall Conduit in a Patient with Marfan Syndrome.","authors":"Sercan Karaoğlan, Necdet Batuhan Tamcı, Bahri Akdeniz, Özer Badak","doi":"10.14744/AnatolJCardiol.2026.6684","DOIUrl":"10.14744/AnatolJCardiol.2026.6684","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forest Therapy and Cardiovascular Outcomes in Elderly Hypertensive Patients: Points for Consideration.","authors":"Büşra Güvendi Şengör, Tuba Unkun","doi":"10.14744/AnatolJCardiol.2026.6726","DOIUrl":"10.14744/AnatolJCardiol.2026.6726","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Echo Contrast or Thrombus? Intracardiac Echocardiography and Isoproterenol Infusion Provide the Answer.","authors":"Can Sezer, Cem Çöteli, Gül Sinem Kılıç, Uğur Canpolat, Hikmet Yorgun, Kudret Aytemir","doi":"10.14744/AnatolJCardiol.2026.6791","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6791","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter to the Editor: \"Ambiguity of Medina 0.0.1 Bifurcation Disease Without Intravascular Imaging\".","authors":"Halil Akın, Önder Bilge, Ferhat Işık, Abdurrahman Akyüz, Emre Kıvrak, Esra Yılmaz, İlke Çelikkale, Özcan Özdemir, İbrahim Halil Tanboğa","doi":"10.14744/AnatolJCardiol.2026.6760","DOIUrl":"10.14744/AnatolJCardiol.2026.6760","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seven-Year Clinical and Durability Outcomes of Balloon-Expandable Transcatheter Aortic Valve Implantation in a Turkish Single-Center Cohort.","authors":"Ali Hakan Konuş, Ali Rıza Akyüz, Ahmet Özderya, Murat Gökhan Yerlikaya, Levent Korkmaz","doi":"10.14744/AnatolJCardiol.2026.6352","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6352","url":null,"abstract":"<p><strong>Background: </strong>Long-term durability data for early-generation balloon-expandable transcatheter aortic valve implantation (TAVI) in Turkish populations remain limited. The authors evaluated 7-year clinical outcomes and valve durability according to the Valve Academic Research Consortium (VARC-3) criteria.</p><p><strong>Methods: </strong>In this single-center registry, 270 consecutive patients with symptomatic severe aortic stenosis treated with the early-generation balloon-expandable SAPIEN XT valve (January 2012-March 2017) were included. Clinical and echocardiographic outcomes were assessed up to 7 years. The primary endpoint was all-cause mortality. Structural valve deterioration (SVD) and bioprosthetic valve failure (BVF) were defined according to the VARC-3 criteria. Cumulative incidence was estimated using competing-risk analysis, with death from any cause treated as a competing event. Predictors of mortality were evaluated using Cox regression.</p><p><strong>Results: </strong>At 7 years, cumulative survival was 29.6%. Cardiovascular and non-cardiovascular mortality occurred at comparable rates. In multivariable analysis, higher Katz index, reflecting better functional status, and higher body mass index were inversely associated with all-cause mortality, whereas eGFR <30 mL/min/1.73 m² was associated with increased mortality risk. The 5- and 7-year cumulative incidences of combined Stage 2-3 SVD were 0.74% and 3.72%, respectively; BVF rates were 1.11% and 2.23%, respectively.</p><p><strong>Conclusion: </strong>In this Turkish single-center cohort treated during the early TAVI era, long-term outcomes reflected the advanced age and comorbidity burden of the study population. Using a competing-risk framework, the observed cumulative incidence of SVD and BVF was low at 5 and 7 years; however, these findings should be interpreted in the context of substantial competing mortality.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambiguity of Medina 0.0.1 Bifurcation Disease Without Intravascular Imaging.","authors":"Ezgi Gültekin Güner, Ahmet Güner","doi":"10.14744/AnatolJCardiol.2026.6745","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6745","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Damage Analysis with Oxidative Stress Index and 8-Hydroxy 2'-Deoxy Guanosine Level in Patients Developing Contrast Nephropathy After Coronary Angiography.","authors":"Özge Demirkıran, Neslihan Tezcan, Evin Kocatürk, Selda Murat, Bahar Demiryürek Duysak, Cengiz Bal, Rüya Mutluay","doi":"10.14744/AnatolJCardiol.2026.6059","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6059","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced nephropathy (CIN) is a common cause of hospital-acquired acute kidney injury, and oxidative stress is thought to play a crucial role in its pathogenesis. Evidence regarding DNA damage after contrast exposure remains limited. This study aimed to evaluate oxidative stress and DNA damage in patients develop-ng CIN by assessing total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels as well as clinical factors associated with CIN.</p><p><strong>Methods: </strong>A total of 191 patients undergoing coronary angiography were prospectively evaluated. Blood samples were obtained before the procedure and at 72 hours afterward. CIN was defined as ≥25% or ≥0.5 mg/dL increase in serum creatinine. Patients were classified into CIN (n = 85) and control groups (n = 106).</p><p><strong>Results: </strong>Advanced age and heart failure were the strongest predictors of CIN. Hypertension, anemia, chronic kidney disease, and hyperuricemia were also more frequent in the CIN group. After angiography, TAS increased and TOS decreased in both groups; however, the reduction in TOS reached significance only in controls. Post-procedure TAS levels were higher in the CIN group (P = .033). Baseline 8-OHdG levels were higher in patients who later developed CIN, whereas the post-procedure decline in 8-OHdG was significant only in controls (P = .02). No significant differences in TOS, OSI, or post-procedure 8-OHdG were observed between groups.</p><p><strong>Conclusion: </strong>This study is among the first to investigate DNA damage in CIN using 8-OHdG levels. The higher baseline DNA damage in CIN patients and the greater reduction in controls suggest a possible link between DNA injury and CIN. Oxidative stress markers did not differ significantly, which may reflect the use of modern low-toxicity contrast agents or the involvement of multifactorial mechanisms. Further studies are needed to clarify the role of oxidative stress and DNA damage in CIN.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Protein Biomarkers for Primary Cardiomyopathy: Evidence from Mendelian Randomization and Clinical Validation.","authors":"Jie He, Xiaoyan Liu, Jianhui Tang, Chunrong Tang, Xiaofen Liu, Zhuoyuan Yu","doi":"10.14744/AnatolJCardiol.2026.5927","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.5927","url":null,"abstract":"<p><strong>Background: </strong>Primary (non-ischemic) cardiomyopathy poses diagnostic challenges due to phenotypic heterogeneity and non-specific clinical presentation, and commonly used circulating biomarkers have limited disease specificity. The aim was to prioritize mechanism-informed plasma biomarkers and evaluate their diagnostic discrimination in a clinical cohort.</p><p><strong>Methods: </strong>pQTL data from 8 proteomic studies covering 5,034 proteins were integrated, and Mendelian randomization was performed across 3 cardiomyopathy GWAS datasets. Top MR candidates were clinically validated by enzyme-linked immunosorbent assays quantification in a prospective case-control cohort of 81 subjects (48 cardiomyopathy patients and 33 healthy controls). Echocardiography evaluated cardiac function and remodeling, correlating with plasma biomarker levels.</p><p><strong>Results: </strong>Proteome-wide MR prioritized 27 proteins linked to cardiomyopathy risk. Clinical validation confirmed significant differences in plasma levels of 5 selected biomarkers (CD163, LGALS3BP, FABP5, FSTL3, VCAM1). CD163 (odds ratio (OR) = 1.019, P < .0001) was positively associated with CM, while LGALS3BP (OR = 0.390, P < .0001), FABP5, FSTL3, and VCAM1 showed inverse associations. Multivariate analysis revealed CD163 and LGALS3BP as independent CM predictors, strongly correlating with echocardiographic indices of cardiac dysfunction. Receiver operating characteristic analyses showed individual area under the curve (AUC) ranging from 0.632 (VCAM1) to 0.917 (CD163). Given the modest discrimination of VCAM1, 5- versus 4-protein combined models were compared, and a parsimonious 4-protein panel was selected (CD163, LGALS3BP, FABP5, FSTL3). The 4-protein panel achieved an apparent AUC of 0.993, with optimism-corrected and repeated cross-validated AUCs of 0.988 and 0.980.</p><p><strong>Conclusion: </strong>This integrative genetic-to-clinical approach supports a 4-protein plasma panel with promising diagnostic discrimination for primary cardiomyopathy, warranting external validation. CD163 and LGALS3BP emerged as particularly informative markers for further evaluation.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unexpectedly Discovered Large Muscular Diverticulum of the Left Ventricular Outflow Tract.","authors":"Qian Lu, Zhengchun Yu, Renhui Cai","doi":"10.14744/AnatolJCardiol.2026.6813","DOIUrl":"https://doi.org/10.14744/AnatolJCardiol.2026.6813","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Assisted Catheter-Directed Thrombolysis vs. Low-Dose Intravenous Tissue-Type Plasminogen Activator Treatments in Acute Intermediate-High Risk Pulmonary Embolism: Insights from a Retrospective Study.","authors":"Cihangir Kaymaz, Barkın Kültürsay, Hacer Ceren Tokgöz, Seda Tanyeri, Berhan Keskin, Çağdaş Buluş, Çağlar Emre Çağlıyan, Deniz Mutlu, Simay Erdal, Faruk Akalın, Rıdvan Bolataslan, Aykun Hakgör, Şeyhmus Külahcıoğlu, İbrahim Halil Tanboğa, Nihal Özdemir","doi":"10.14744/AnatolJCardiol.2026.6510","DOIUrl":"10.14744/AnatolJCardiol.2026.6510","url":null,"abstract":"<p><strong>Background: </strong>Comparative data on ultrasound-assisted catheter-directed thromboly-sis (USAT) and systemic low-dose tissue-type plasminogen activator (tPA) for intermediate-high-risk (IHR) pulmonary embolism (PE) remain limited. The efficacy and safety outcomes of USAT vs. intravenous (IV) low-dose tPA were evaluated in this population.</p><p><strong>Methods: </strong>This study enrolled 329 IHR PE patients treated with USAT (n = 205) or IV low-dose tPA (n = 124). Post-treatment changes in clot burden (Qanadli score), right ventricular (RV) strain, and long-term mortality (median follow-up 95.8 months) were assessed. Propensity score analysis with inverse probability weighting (IPW) was employed to adjust for confounders.</p><p><strong>Results: </strong>Ultrasound-assisted catheter-directed thrombolysis was predominantly bilateral (82.9%), with a mean tPA dose of 38.5 ± 13.6 mg. In the IV tPA cohort, 58.9% required a second infusion to achieve stabilization. While IV tPA was associated with more pronounced early reductions in heart rate and RV/LV (left ventricle) ratio, USAT provided significantly greater thrombus resolution (all P < .005). After IPW adjustment, USAT demonstrated clear superiority over IV tPA in reducing residual clot burden (P < .001). However, improvements in oxygen saturation, tricuspid annular plane systolic excursion , and pulmonary artery systolic pressure (PASP) were comparable. No significant differences were observed in in-hospital mortality, PE recurrence, or long-term survival between cohorts. Higher PE severity indexes scores independently predicted in-hospital adverse events, whereas older age, male sex, and higher discharge PASP were predictors of shortened long-term survival.</p><p><strong>Conclusions: </strong>In IHR PE, IV low-dose tPA relates to more pronounced early hemodynamic and RV diameter improvements, whereas USAT achieves superior thrombus resolution. Despite these divergent surrogate responses, both strategies yield comparable early and long-term clinical outcomes, supporting their roles as viable reperfusion options.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}