Muhammed İkbal Şaşmaz, Bülent Demir, Mustafa Uçar, Akkan Avci
{"title":"Reply to Letter to the Editor: \"Management of Ventricular Pseudoaneurysms\".","authors":"Muhammed İkbal Şaşmaz, Bülent Demir, Mustafa Uçar, Akkan Avci","doi":"10.14744/AnatolJCardiol.2024.4703","DOIUrl":"10.14744/AnatolJCardiol.2024.4703","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to Letter to the Editor: \"Critical Review: Methodological and Interpretative Issues in COVID-19 and Acute Coronary Syndrome Study\".","authors":"Özlem Özbek, Mehmet Mustafa Can","doi":"10.14744/AnatolJCardiol.2024.4660","DOIUrl":"10.14744/AnatolJCardiol.2024.4660","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142456271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lithium Toxicity with Sinus Bradycardia and Takotsubo Syndrome in a Patient with Bipolar Disorder.","authors":"Spyridon-Filippos Papadopoulos, Evdoxia Stavropoulou, Konstantinos C Theodoropoulos, Antonios Kouparanis, Antonios Ziakas, Theodoros Karamitsos, Matthaios Didagelos","doi":"10.14744/AnatolJCardiol.2024.4749","DOIUrl":"10.14744/AnatolJCardiol.2024.4749","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fu Li Liang, You Fu Tong, Xiao Chun Zhang, Xiao Feng Ma
{"title":"Hsa-circ-ACSL1 Enhances Apoptosis and Autophagy in Myocarditis Cardiomyocytes Through the miR-7-5p/XBP1 Axis.","authors":"Fu Li Liang, You Fu Tong, Xiao Chun Zhang, Xiao Feng Ma","doi":"10.14744/AnatolJCardiol.2024.4472","DOIUrl":"10.14744/AnatolJCardiol.2024.4472","url":null,"abstract":"<p><strong>Background: </strong>Viral myocarditis (VMC) is a common cardiovascular disease, and circular RNAs (circRNAs) have been identified to play an important role in the pathophysiology of cardiovascular disease. However, the clinical significance, biological functions, and regulatory mechanisms of circRNAs in VMC remain poorly understood. Therefore, this study explored the biological functions and regulatory mechanisms of circ-ACSL1 in VMC.</p><p><strong>Methods: </strong>The animal and cell models of VMC were established by infecting BABL/C mice and interleukin-2 cells with coxsackievirus B3 (CVB3). Pro-inflammatory factors, markers of myocardial injury, apoptosis, and autophagy were detected to evaluate the degree of myocardial inflammation and myocardial injury after altering circ-ACSL1, microRNA-7-5p (miR-7-5p), and X-box binding protein 1 (XBP1) expression alone or in combination.</p><p><strong>Results: </strong>Knocking down circ-ACSL1 could inhibit inflammation, autophagy, and apoptosis in VMC animals and cells. Mechanistically, circ-ACSL1 targeted miR-7-5p to regulate the downstream target XBP1. In addition, depleting miR-7-5p rescued the therapeutic effect of depleting circ-ACSL1. Overexpression of circ-ACSL1 aggravated VMC; however, this effect was saved by knocking down XBP1.</p><p><strong>Conclusion: </strong>By competitively absorbing miR-7-5p, circ-ACSL1 increases XBP1 expression and aggravates myocardial inflammation. Meaningfully, VMC treatment may benefit from circ-ACSL1 as a potential biomarker for precise diagnosis and as a potential therapeutic target.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoshiyuki Yamashita, Massimo Baudo, Serge Sicouri, Mujtaba Zafar, Roberto Rodriguez, Eric M Gnall, Paul M Coady, Scott M Goldman, William A Gray, Basel Ramlawi
{"title":"Effect of Elevated Body Mass Index on Outcomes of Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis.","authors":"Yoshiyuki Yamashita, Massimo Baudo, Serge Sicouri, Mujtaba Zafar, Roberto Rodriguez, Eric M Gnall, Paul M Coady, Scott M Goldman, William A Gray, Basel Ramlawi","doi":"10.14744/AnatolJCardiol.2024.4637","DOIUrl":"10.14744/AnatolJCardiol.2024.4637","url":null,"abstract":"<p><strong>Background: </strong>The association of body mass index (BMI) and an \"obesity paradox\" with cardiovascular risk prediction is controversial. This study aimed to evaluate the impact of elevated BMI on the outcome of transcatheter aortic valve replacement (TAVR) for aortic stenosis.</p><p><strong>Methods: </strong>This retrospective study included 1019 patients with a BMI of ≥18.5 kg/m2 divided into 3 groups: 1) normal BMI (18.5-24.9 kg/m2), 2) overweight (25-29.9 kg/m2), and 3) obese (≥30 kg/m2). Propensity score matching was used to compare normal BMI with overweight and normal BMI with obese.</p><p><strong>Results: </strong>The median age of the cohort was 82 years, and 348 patients had a normal BMI, while 319 and 352 patients were overweight and obese, respectively. After 1 : 1 propensity score matching, 258 and 192 pairs between normal BMI and overweight, and normal BMI and obese patients, respectively, were analyzed. Both overweight and obese patients had higher post-transaortic mean gradients and lower indexed effective orifice areas compared to normal BMI patients. During a median follow-up of 25 (range: 0.1-72) months, all-cause mortality was similar between overweight or obese patients and patients with a normal BMI. However, in a subgroup analysis of patients with moderate/severe chronic lung disease, all-cause mortality was significantly higher in obese patients compared with normal BMI patients (hazard ratio = 3.49, 95% confidence interval, 1.21-10.0, P = .021).</p><p><strong>Conclusions: </strong>In this study, the \"obesity paradox\" was not observed in patients undergoing TAVR; rather, in patients with significant lung disease, obesity may be associated with worse midterm outcomes after TAVR.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac MR and Cardiomyopathy, New Ratio for Pulmonary Embolism.","authors":"Çetin Erol","doi":"10.14744/AnatolJCardiol.2024.10","DOIUrl":"10.14744/AnatolJCardiol.2024.10","url":null,"abstract":"","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":"28 10","pages":"466"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hülya Şirin, Ahmet Arslan, İbrahim Sefa Güneş, Arslan Öcal, Fatma Sena Konyalıoğlu, Gamze Ketrez, Asiye Çiğdem Şimşek, Salim Yaşar, Cem Barçın
{"title":"Comparison of Home Blood Pressure Monitoring with and without Training: Does Adherence to the Recommended Instructions Overlook Hypertension?","authors":"Hülya Şirin, Ahmet Arslan, İbrahim Sefa Güneş, Arslan Öcal, Fatma Sena Konyalıoğlu, Gamze Ketrez, Asiye Çiğdem Şimşek, Salim Yaşar, Cem Barçın","doi":"10.14744/AnatolJCardiol.2024.4530","DOIUrl":"10.14744/AnatolJCardiol.2024.4530","url":null,"abstract":"<p><strong>Background: </strong>Home blood pressure monitoring (HBPM) is commonly used to diagnose hypertension (HT), with a diagnostic threshold of ≥135/85 mm Hg, the same as daytime ambulatory BP monitoring (ABPM). This study hypothesizes that training and adherence to HBPM guidelines will yield more accurate BP readings compared to ABPM.</p><p><strong>Methods: </strong>The study involved 129 patients with elevated office BP but no prior HT diagnosis. After a two-week observation period with lifestyle advice, HBPM was conducted over a week before and after structured measurement training, with ABPM performed in each period. Adherence to instructions post-training was also assessed.</p><p><strong>Results: </strong>Post-training, mean systolic and diastolic home BP values significantly decreased (from 128 ± 13.1/84.9 ± 8.2 to 122.6 ± 12.7/81.8 ± 7.8; P < 0.001 for both), while daytime ABPM values remained unchanged (131.7 ± 11.1/86.7 ± 9.3 before vs. 130.7 ± 11.7/85.9 ± 8.6 after; P = 0.185). Although HBPM values were consistently lower than ABPM values, the discrepancy grew post-training. The number of patients reaching the HT threshold via HBPM decreased significantly post-training [71 (55%) to 54 (41.9%); P = 0.006], whereas the number via daytime ABPM remained similar [82 (64.3%) vs. 84 (65.1%); P = 1.000].</p><p><strong>Conclusion: </strong>Training and adherence to HBPM guidelines led to lower BP readings and fewer HT diagnoses. Contrary to the hypothesis, this method under \"ideal conditions\" underestimated HT prevalence when compared to daytime ABPM. Further studies with clinical endpoints are needed to refine HBPM methods and establish new BP thresholds for more accurate HT detection.</p>","PeriodicalId":7835,"journal":{"name":"Anatolian Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}