Anatomy & Cell Biology最新文献_第3页

Glycosylated fibronectin: a maternal serum biomarker for diagnosing gestational diabetes mellitus. 糖基化纤维连接蛋白：诊断妊娠期糖尿病的母体血清生物标志物。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2025-11-21 DOI: 10.5115/acb.25.211

Rohini Huliyar Nagendra Prasad, Prabhakara Somanna, Vishma H Shetty, Rekha Kadabgere Ningappa, Megha Krishnappa

{"title":"Glycosylated fibronectin: a maternal serum biomarker for diagnosing gestational diabetes mellitus.","authors":"Rohini Huliyar Nagendra Prasad, Prabhakara Somanna, Vishma H Shetty, Rekha Kadabgere Ningappa, Megha Krishnappa","doi":"10.5115/acb.25.211","DOIUrl":"10.5115/acb.25.211","url":null,"abstract":"Gestational diabetes mellitus (GDM) is a condition with hyperglycaemia first seen in pregnancy. GDM is still diagnosed in the late second or early third trimester, because accurate diagnostic approaches in first trimester are still lacking and increasing burden of non-communicable diseases in the country. New diagnostic approaches allow early assessment. To assess the efficacy of glycosylated fibronectin in detecting GDM. In this case control study the pregnant women coming to outpatient department were recruited based on inclusion and exclusion criteria. It was carried out at RajaRajeswari Medical College and Hospital between January 2024 to February 2025. The participant's oral glucose tolerance test (OGTT) was done at 24 to 28 weeks. Diagnostic cut off value based on Diabetes in Pregnancy Study Group India is considered. Based on OGTT value participants were divided into GDM group and control group. Glycosylated fibronectin was estimated by enzyme-linked immunosorbent assay. The concentration of glycosylated fibronectin level between the control and GDM group was analysed using unpaired t-test. The P-value was 0.0001 suggesting significant difference between GDM and control group. The area under the ROC curve equals 0.8096 suggesting that the power of the model to distinguish between two outcomes is excellent. R2 value by the regression analysis in GDM group is 0.9813 whereas in control group it is 0.9991 suggesting that glycosylated fibronectin can be used to make accurate predictions. Glycosylated fibronectin is a very potent biomarker in early diagnosis of GDM.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"182-187"},"PeriodicalIF":1.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epiglottic cartilage calcification: a retrospective study based on computed tomography of a clinical and histological paradox. 会厌软骨钙化：基于临床和组织学悖论的计算机断层扫描的回顾性研究。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2026-01-29 DOI: 10.5115/acb.25.291

Nymfodora Malkidou, Aliki Fiska

{"title":"Epiglottic cartilage calcification: a retrospective study based on computed tomography of a clinical and histological paradox.","authors":"Nymfodora Malkidou, Aliki Fiska","doi":"10.5115/acb.25.291","DOIUrl":"10.5115/acb.25.291","url":null,"abstract":"The epiglottis is a leaf-shaped elastic cartilage structure that guides air into the larynx and prevents food entry into the respiratory tract. Unlike other laryngeal cartilages, it rarely calcifies. Epiglottic calcification is poorly understood, with most data from case reports or postmortem studies, and its prevalence in living individuals remains unclear. This study aims to assess epiglottic calcification on neck computed tomography (CT) and explore associations with age, sex, and medical history. This retrospective observational study evaluated 203 high-resolution neck CT scans from adult patients between 2023 and 2025. Patients with structural abnormalities, prior neck surgery, or poor-quality scans were excluded. Calcification was assessed on the base, body, and stalk of the epiglottis by anatomical location on the epiglottic wall (anterior, posterior, or full thickness) and severity of the lesion (mild, moderate, severe). Two experienced observers independently reviewed all scans, resolving discrepancies by consensus. Only 5 out of 203 patients (2.46%) showed epiglottic calcification, all males aged over 60. Calcifications were primarily located in the body and base, with no involvement of the stalk and no severe or full-thickness cases. No associated epiglottic deformities were observed. Epiglottic calcification is predominantly affecting elderly males. The absence of symptoms suggests a benign, age-related change rather than a pathological condition. Recognition on CT is essential to prevent unnecessary procedures. Further studies integrating imaging, histology, and clinical data are needed to better understand its pathophysiology, and potential clinical implications.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":"59 1","pages":"54-58"},"PeriodicalIF":1.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal development and growth of the human neck axial musculature. 胎儿发育与人颈部轴向肌肉组织的生长。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2025-12-05 DOI: 10.5115/acb.25.186

Sayako Suzuki, Eri Miyamoto, Yuki Yoshihashi, Masahito Yamamoto, Gen Murakami, Shin-Ichi Abe, Jose Francisco Rodríguez-Vázquez

{"title":"Fetal development and growth of the human neck axial musculature.","authors":"Sayako Suzuki, Eri Miyamoto, Yuki Yoshihashi, Masahito Yamamoto, Gen Murakami, Shin-Ichi Abe, Jose Francisco Rodríguez-Vázquez","doi":"10.5115/acb.25.186","DOIUrl":"10.5115/acb.25.186","url":null,"abstract":"Neck epaxial muscles, which are differentiated for suspending the head, occupy a large space posterior to the cervical lordosis. Limited information exists regarding developmental process that determines the muscle fiber direction and bony attachment of neck epaxial muscles. We examined histological sections of 28 human fetuses aged approximately 7-18 weeks (crown-rump length, 20-150 mm). In place of the underdeveloped lordosis, the transverse process of cervical vertebrae was shifted anteriorly at the cervicothoracic junction. The semispinalis and longissimus were distinguished by the direction of muscle fibers connecting between the surface aponeurosis and transverse process. The semispinalis capitis and splenius capitis had a bulky anterior margin without bony attachments. The obliquus capitis inferior continued to both the rectus capitis posterior major and the semispinalis cervicis, but the obliquus capitis superior was consistently independent. Muscle attachments to the scapula were quite different from the final morphology: 1) the levator and rhomboidei usually extended inferiorly along the developing scapula beyond the inferior angle and 2) the splenius capitis or semispinalis cervicis rarely issued an aberrant bundle attaching to the scapula. The scaleni, rhomboidei, levator scapulae, iliocostalis and longissimus were arranged in parallel from the anteromedial to the posterolateral planes and together formed a thick oblique muscle bundle originating from the cervical transverse process and running toward the upper thoracic vertebra and ribcage. The transient oblique muscle bundle seen in early fetuses seemed to provide the so-called intermediate axial muscle between the epaxial-hypaxial muscles: a concept postulated in recent molecular neurology and embryology.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"68-81"},"PeriodicalIF":1.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145675982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficiency of artificial intelligence in identifying histological tissues from microscopic images. 人工智能在显微图像中识别组织学组织的效率。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2026-01-23 DOI: 10.5115/acb.25.295

Mustafa Saad Yousuf, Bashar Issa Almaraziq

{"title":"Efficiency of artificial intelligence in identifying histological tissues from microscopic images.","authors":"Mustafa Saad Yousuf, Bashar Issa Almaraziq","doi":"10.5115/acb.25.295","DOIUrl":"10.5115/acb.25.295","url":null,"abstract":"Histology is an essential, yet difficult, subject to study in medicine. As artificial intelligence (AI) is rapidly evolving with ever-growing image recognition abilities, it presents a great potential to be used in the study of histology. This research aimed to assess the ability of ChatGPT 4o and Google Gemini 2.0 Flash to recognize various histological sections of different tissues and organs from images. The two AI models were presented with high-resolution histological images and prompted with tasks to identify basic tissue types, specific organs, and specific structures indicated by arrows. Scores were given for correct identifications. The test was conducted twice without any training or feedback to assess consistency. McNemar test and Kappa coefficient were used to compare the responses. Both AI models had good image recognition abilities with varying performances. Overall, Google Gemini achieved higher correct scores across both tests (75% and 77.5%, compared to 65% and 65% for ChatGPT). McNemar showed a significant difference between the two models with only fair agreement shown by kappa. No significant difference was found between the repeated tests. Performance across different tissue types varied. Muscular tissue was the easiest to identify and epithelial tissue was the most difficult. AI may have a promising role in histology. Students and histologist can use AI, especially Gemini, to identify histological sections from images. Critical judgment, however, must be utilized as AI can make mistakes.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"59-67"},"PeriodicalIF":1.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal exposure to low-dose tartrazine during lactation induces neurotoxicity in rat pups through oxidative stress, endoplasmic reticulum stress, and autophagy suppression. 哺乳期母鼠暴露于低剂量酒黄石可通过氧化应激、内质网应激和自噬抑制诱导大鼠幼崽神经毒性。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2025-11-14 DOI: 10.5115/acb.25.221

Amal S Sewelam, Bashir Jarrar, Asmaa Mohammed Tolba, Emtethal Mamdouh El-Bestawy

{"title":"Maternal exposure to low-dose tartrazine during lactation induces neurotoxicity in rat pups through oxidative stress, endoplasmic reticulum stress, and autophagy suppression.","authors":"Amal S Sewelam, Bashir Jarrar, Asmaa Mohammed Tolba, Emtethal Mamdouh El-Bestawy","doi":"10.5115/acb.25.221","DOIUrl":"10.5115/acb.25.221","url":null,"abstract":"Tartrazine (TZ) is a synthetic azo dye extensively used as a food colorant, posing potential harm to human health. This study examined whether maternal exposure to TZ at an acceptable daily intake (ADI) dosage during lactation could induce neurotoxicity in male rat pups and to investigate the potential underlying mechanism. Twelve rat dams at postnatal day 2 (PND2) were split equally into control (received vehicle), and TZ-treated (received TZ 7.5 mg/kg) groups. Administration was through oral gavage, once daily for 20 days (from PND2 to PND21). The pups' exposure to TZ was via breastfeeding. On PND22, male pups' brain tissues were collected for histopathological, immunohistochemical, biochemical, and gene expression analyses. Maternal TZ exposure during lactation led to brain tissue damage in rat pups, with resultant neuronal atrophy, nuclear condensation, perineuronal halos, capillary congestion, wide pericapillary spacing, hemorrhage, and neuropil vacuolation in the prefrontal cortex, cerebellar cortex, and hippocampus. Also, lactational TZ exposure was associated with oxidative stress (raised malondialdehyde, reactive oxygen species with total antioxidant capacity decline); oxidative DNA damage (overexpression of 8-OHdG protein); endoplasmic reticulum stress (upregulated XBP-1, BIP, CHOP, and JNK genes); autophagy suppression (upregulated p62 gene, downregulated Beclin-1 gene, decreased LC3-II at both protein and gene levels); synaptogenesis impairment (decreased synaptophysin protein expression and increased acetylcholinesterase activity level); inflammation (raised TNF-α, IL-1β, IL-6 with IL-10 decline). In conclusion, this study highlights neurotoxic alterations in pups associated with low-dose TZ exposure through breastfeeding, focusing on the underlying molecular mechanisms. This is crucial for developing strategies to safeguard public health.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"168-181"},"PeriodicalIF":1.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of mesenchymal stem cells-derived exosomes and conditioned medium as a potential treatment for induced type 1 diabetes mellitus in adult male albino rats. 间充质干细胞来源的外泌体和条件培养基作为成年雄性白化大鼠诱导1型糖尿病的潜在治疗方法的评估。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2025-11-13 DOI: 10.5115/acb.25.159

Walaa E Omar, Asmaa M Tolba, Emtethal M El-Bestawy, Asmaa A Ibrahim, Basma A Ibrahim

{"title":"Evaluation of mesenchymal stem cells-derived exosomes and conditioned medium as a potential treatment for induced type 1 diabetes mellitus in adult male albino rats.","authors":"Walaa E Omar, Asmaa M Tolba, Emtethal M El-Bestawy, Asmaa A Ibrahim, Basma A Ibrahim","doi":"10.5115/acb.25.159","DOIUrl":"10.5115/acb.25.159","url":null,"abstract":"Diabetes mellitus (DM) is a metabolic condition marked by disrupted insulin regulation. Mesenchymal stem cell-derived exosomes and conditioned medium (CM) have emerged as promising therapeutic candidates for DM. This research explored the medical benefits of exosomes and CM in treating streptozotocin-induced type 1 DM (T1DM) in rats, comparing their efficacy to bone marrow-derived mesenchymal stem cells (BM-MSCs). Fifty albino rats were grouped into five groups (n=10 each): healthy controls, untreated T1DM rats, T1DM rats treated with intravenous BM-MSCs, T1DM rats treated with intravenous exosomes, and T1DM rats treated with intravenous CM. Plasma glucose and insulin concentrations were monitored weekly. Pancreatic β-cell regeneration was analyzed via qRT-PCR, focusing on the expression levels of TGF-β, Smad3, Ngn3, Pdx1, MafA, and insulin genes. Histological evaluation of pancreatic tissue regeneration was performed at weeks 2 and 4 using hematoxylin & eosin and Masson's trichrome stains. The exosomes- and CM-treated groups demonstrated significantly higher expression of β-cell regeneration markers (TGF-β, Smad3, Ngn3, Pdx1, MafA, and insulin) than the BM-MSCs group. Additionally, these groups demonstrated a marked rise in the area percentage of pancreatic islets and a significant reduction in pancreatic fibrosis, with more pronounced effects at week 4. Exosomes and CM exhibit superior therapeutic efficiency and regenerative potential over BM-MSCs in T1DM, suggesting their promise as cell-free alternatives for diabetes treatment.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"141-155"},"PeriodicalIF":1.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145501625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double profunda femoris artery: a unique anatomical variation with surgical significance. 双股深动脉：一种独特的解剖变异，具有外科意义。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2025-09-18 DOI: 10.5115/acb.25.213

Punnapa Raviteja, Mrudula Chandrupatla, Alka Vithalrao Bhingardeo

引用次数: 0

Meconium containing intestinal structures: a histological study using human fetuses. 含肠结构的胎便：人类胎儿的组织学研究。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2026-02-13 DOI: 10.5115/acb.25.340

Jun Zhang, Zhe-Wu Jin, Feng Han, Ye Xu, Gen Murakami, Masahito Yamamoto, Shogo Hayashi

{"title":"Meconium containing intestinal structures: a histological study using human fetuses.","authors":"Jun Zhang, Zhe-Wu Jin, Feng Han, Ye Xu, Gen Murakami, Masahito Yamamoto, Shogo Hayashi","doi":"10.5115/acb.25.340","DOIUrl":"10.5115/acb.25.340","url":null,"abstract":"Meconium is changed from defoliated intestinal villi with apoptosis. A meconium corpuscle is a limited architecture in the meconium at the light microscopic level. In histological and immunohistochemical sections of the abdomen from 40 fetuses at 20-31 weeks of gestation, we found 12 fetuses with meconium and examined the architecture. A solid or loose meconium was seen depending on sites. The solid meconium in the colon and rectum contained numerous spherical or rugby ball-like corpuscles comprising of a core with tightly-packed atrophied cells and a laminar fibrous sheath. The solid meconium surrounded and incorporated villi that maintained the original architecture. The loose meconium was seen not only in the stomach and duodenum but also, depending on specimens, in the colon and rectum. It was composed of a large mucosal fold, a single small villus and/or fragmented epithelia. Notably, these mucosal tissues still contained chromogranin-positive gastrointestinal cells and cytokeratin-positive epithelia. A large ring-like meconium was composed of the entirely circular mucosa or epithelia that seemed to be detached along the muscularis mucosae or the basal lamina. A sheath-like fibrous structure in meconium seemed to originate from the lamina propria and basal lamina of villi. A defoliation of villi with apoptosis seemed difficult to explain a detachment of the entirely circular mucosa or epithelia in large fetuses examined. The latter event might require a specific mechanism such as an in utero intussusception in which a proximal side of the colon was invaginated into the distal lumen.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":"105-114"},"PeriodicalIF":1.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aloe vera gel extract and bone marrow mesenchymal stem cells ameliorate thioacetamide-induced liver fibrosis via modulating lincRNA-p21/miR-17-5p axis. 芦荟凝胶提取物和骨髓间充质干细胞通过调节lincRNA-p21/miR-17-5p轴改善硫代乙酰胺诱导的肝纤维化。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-31 Epub Date: 2026-01-29 DOI: 10.5115/acb.25.331

Bassant T Abd Elbaki, Basma A Ibrahim, Walaa E Omar, Sara Ali Kandeel

{"title":"Aloe vera gel extract and bone marrow mesenchymal stem cells ameliorate thioacetamide-induced liver fibrosis via modulating lincRNA-p21/miR-17-5p axis.","authors":"Bassant T Abd Elbaki, Basma A Ibrahim, Walaa E Omar, Sara Ali Kandeel","doi":"10.5115/acb.25.331","DOIUrl":"10.5115/acb.25.331","url":null,"abstract":"Thioacetamide (TAA)-induced liver fibrosis, triggered by inflammation and oxidative stress, is prompted by hepatic stellate cells (HSCs) activation via several pathways. This study explores the hepatoprotective effect of aloe vera gel (AVG) extract and bone marrow mesenchymal stem cells (BM-MSCs) transplantation on regulating long intergenic non-coding RNA (lincRNA-p21) and microRNA (miR-17-5p) expressions and their impact on TGF-β1/Smad-3 and Wnt-10a/β-Catenin cascades in TAA-induced liver damage. The study involved 48 adult male albino rats divided into four groups: control, TAA, TAA treated with BM-MSCs, and TAA treated with BM-MSCs+AVG extract. After 8 weeks, liver enzymes and hepatic oxidative parameters were evaluated alongside lincRNA-p21, miR-17-5p, TGF-β1, Smad-3, Wnt-10a, and β-Catenin expressions. Liver tissue sections were examined by light and electron microscopes and analyzed morphometrically. Group II showed increased aspartate aminotransferase, alanine aminotransferase, malondialdehyde, reduced glutathione levels, and deteriorated hepatocytes with distorted mitochondria and dilated rough endoplasmic reticulum. Group IV restored lincRNA-p21 expression, which downregulated miR-17-5p and suppressed activated HSCs by inhibiting TGF-β1/Smad-3 and Wnt-10a/β-Catenin pathways, and improved hepatic tissue architecture. Additionally, immunohistochemically, alpha-smooth muscle actin and cyclin D1 expressions were markedly decreased in group IV compared to group II. We concluded that AVG suppresses fibrotic pathways, boosts BM-MSCs differentiation, and reduces HSCs activation in liver fibrosis caused by TAA.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":"59 1","pages":"125-140"},"PeriodicalIF":1.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical variation of the sciatic nerve division in the cadaver studies: a systematic review and meta-analysis. 尸体研究中坐骨神经分裂的解剖变异：系统回顾和荟萃分析。

IF 1.2

Anatomy & Cell Biology Pub Date : 2026-03-19 DOI: 10.5115/acb.25.139

Worku Abie Liyew, Soressa Abebe

{"title":"Anatomical variation of the sciatic nerve division in the cadaver studies: a systematic review and meta-analysis.","authors":"Worku Abie Liyew, Soressa Abebe","doi":"10.5115/acb.25.139","DOIUrl":"https://doi.org/10.5115/acb.25.139","url":null,"abstract":"The extent and patterns of variability in the sciatic nerve (SN) division are not well documented in cadaver studies. This review aimed to determine the pooled prevalence and distribution patterns of anatomical variations in the SN division, from existing cadaveric studies, and to explore their potential clinical implications. Articles were searched in PubMed, Google Scholar, ScienceDirect, African Journals Online, and other relevant sources. Stata 14 software was used for data analysis. The prevalence was calculated using a random-effects model. Heterogeneity was assessed using the Cochran Q test and the I2 values of a forest plot. Publication bias was checked using funnel plots and Egger's test. Twenty cadaver studies were used for this systematic review and meta-analysis. In this study, the pooled prevalence of the anatomical variation of the SN division was approximately 31.01% (95% CI: 16.24-45.78). The subgroup analysis demonstrated the highest variability within the popliteal fossa (21.17%; 95% CI: -2.01-44.34), followed by the pelvic region (11.13%; 95% CI: 5.85-16.40), the middle third of the thigh (7.11%; 95% CI: 3.67-10.55), the gluteal region (4.86%; 95% CI: 2.03-7.69), and the upper third of the thigh (4.74%; 95% CI: 1.71-7.76). In this study, the anatomical variation of the SN division was high, and one in three divisions was outside the typical pattern. The variation of SN division may affect intramuscular injections and surgical procedures.","PeriodicalId":7831,"journal":{"name":"Anatomy & Cell Biology","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0