Ancient Science of Life最新文献

{"title":"A randomized double blind controlled study evaluating efficacy & Safety of vatika enriched coconut hair oil on hair health in women with hair fall and dandruff","authors":"M. Kura, Arun Gupta, R. Srivastava, S. Luthra","doi":"10.4103/asl.ASL_142_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_142_17","url":null,"abstract":"Background: Hair loss can be a stressful experience often associated with images of reduced self-worth, more in women than men. Dandruff may be associated with hair loss. Objective: To investigate the safety and efficacy of Vatika Enriched Coconut Hair Oil (VHO) on hair health in women with hair fall and dandruff. Methods: This was a double-blind, controlled study of 8 week duration conducted at Dermatology outpatient department of J.J. Hospital, Mumbai. Forty four (44) healthy female subjects with at least shoulder length hair and complaints of hair fall and dandruff were randomized equally into 2 groups. Members of one group massaged their scalps with VHO twice a week at night followed by washing the hair in morning with a supplied neutral shampoo. Control group used a marketed brand of coconut oil in a similar manner. Main Outcome Measures: Effect of VHO on hair fall, dandruff and hair health parameters such as shininess, blackness, roughness and tensile strength of hair. Secondary outcome assessed was overall subject safety. Subjects were followed up at days 14, 28, 42 and 56 days. Results: VHO was found safe and effective in controlling hair fall, dandruff and improving the overall condition of hair. VHO was found clinically better than coconut oil in controlling hair fall, dandruff, improving the tensile strength of hair and the shininess, blackness and roughness of hair. Global evaluation of therapeutic response by subjects and physician also showed a better efficacy of VHO than coconut hair oil. None of the subjects exhibited sensitivity to any of the study products and no adverse events were reported during the course of the study. Conclusions: Vatika Enriched Coconut Hair Oil is safe and effective in controlling hair fall and dandruff and improving the overall hair-health.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"45 - 50"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marker assay guided standardization of an ayurvedic concentrated polyherbal decoction “CiruvilvāDi KaṣāYam” and its application in industrial quality control","authors":"H. Purushothaman, Ancily Davis, Migy John, Meerabai Palazhy Kalarikkal, A. Bhaskaran, Basil Eldho, T. Antony","doi":"10.4103/asl.ASL_188_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_188_17","url":null,"abstract":"Background: To establish a marker guided standardization technique to assess whether the marketed concentrated kaṣāyam (decoction) prepared in large scale is providing the same phytochemical values of a Laboratory Reference Standard (LRS) kaṣāyam prepared classically from raw materials of Pharmacopoeial quality. Objectives: Manufacturing and standardization of LRS 'Ciruvilvādi kaṣāyam', including marker assays and its comparison with four different marketed samples. Materials and Methods: pH, Brix and Total solids of samples were determined and compared. HPTLC profile comparison and quantitative comparison with HPLC were done with Gallic acid and Piperine as standards. Results and Conclusion: Results of Brix and Total solids imply that, the manufacturing process of sample IV was significantly different from other samples and LRS. pH value of sample III showed a significant difference as compared to other samples and LRS, indicating a difference in phytochemical contents. Quantification of Piperine and Gallic acid revealed that sample III has a very low Gallic acid concentration and zero Piperine concentration. Sample IV showed a very high concentration of Gallic acid when compared to other samples and LRS. Sample I, II and IV had piperine content but significantly lower when compared to the LRS. In conclusion, the samples (1-IV) which showed difference with the LRS should be made phytochemically comparable to in-house LRS or Pharmacopoeial standards by adopting the marker assay standardization technique. This method helps to identify and rectify the problems related to raw material, in process and finished product quality control.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"44 1","pages":"24 - 30"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New triterpenic compounds from Swertia chirata","authors":"S. Bajaj, Vijender Singh, Mohammed Ali","doi":"10.4103/asl.ASL_5_18","DOIUrl":"https://doi.org/10.4103/asl.ASL_5_18","url":null,"abstract":"Aim: To study the Phytochemical constituents of dried aerial parts of Swertia chirata Linn (family Gentianaceae). Methods: The ethanolic extract of the aerial parts of plant S. chirata was subjected to column chromatography and was eluted with petroleum ether and chloroform of various concentrations to yield compound SC-1, 2 and 3 and their structures were elucidated on the basis of chemical methods and spectral techniques such as Ultraviolet (UV), Fourier Transform Infrared (FTIR), Hydrogen Nuclear Magnetic Resonance (1HNMR), Carbon Nuclear Magnetic Resonance (13CNMR), and Mass spectrometry (MS). Results: Three compounds were isolated and their structures were determined as (a) Olean-12-ene-18α H-3-one-9α-ol, (b) Olean-12-ene-18α H-3-one-19β-ol and (c) Olean-12-en-18α H-3-one. Conclusion: Chemical and spectral investigation of extract furnished three novel oleanenone triterpene glycosides from the genus Swertia for the first time.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"37 - 44"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical Screening and Shelf Life Evaluation of <i>Kuṅkumādi Ghṛta</i> Prepared using <i>Kesara</i> and <i>Nāgakesara</i>.","authors":"Pradeep Kumar Prajapati,&nbsp;Rohit Sharma,&nbsp;Amee Amrutia,&nbsp;B J Patgiri","doi":"10.4103/asl.ASL_49_15","DOIUrl":"https://doi.org/10.4103/asl.ASL_49_15","url":null,"abstract":"<p><strong>Introduction: </strong><i>Kuṅkumādi Ghṛta</i> (KG) is an Ayurvedic formulation commonly recommended in skin disorders, especially <i>Mukhadūṣikā</i> (Acne vulgaris). <i>Kesara</i> (stigma of <i>Crocus sativus</i> Linn.) is a prime ingredient in the formulation. However, due to high cost and increased adulteration in Kesara, '<i>Nāgakesara</i>' (<i>Mesua ferrea</i> Linn.) is suggested by Ayurvedic experts as a substitute. <i>Nāgakesara</i> is relatively lower in cost and possesses similar therapeutic attributes to that of <i>Kesara</i>. Recent studies have established standard manufacturing procedures and clinical efficacies of <i>Kesarayukta</i> (with <i>Kesara</i>) <i>Kuṅkumādi Ghṛta</i> (KKG) and <i>Nāgakesara yukta</i> (with <i>Nāgakesara</i>) <i>Kuṅkumādi Ghṛta</i> (NKG) in <i>Mukhadūṣikā</i>. In spite of wide utility of KG in Ayurvedic practice, no published work on its shelf life is available so far.</p><p><strong>Aims and objectives: </strong>To establish the physicochemical profile and evaluate the shelf life of KKG and NKG.</p><p><strong>Materials and methods: </strong>Total three batches of KKG and NKG each were prepared in the laboratory by adopting Ayurvedic classical guidelines and the findings were systematically recorded. Comparative differences in organoleptic characters (colour, odour, taste, touch) and values of different physicochemical parameters (Ash value, pH value, Total solid content, Specific gravity, Refractive index, Loss on drying, Acid value, Iodine value, Saponification value, Peroxide value and Rancidity tests) of raw materials [herbal ingredients, <i>Go Ghṛta</i>, <i>Mūrcchita Ghṛta</i> (MG)] as well as finished products (KKG and NKG) were recorded. Long term (real time) shelf life testing was carried out at the intervals i.e., at 0, 3, 6, 9 and 16 months. High performance thin layer chromatography (HPTLC) analysis of samples was also carried out.</p><p><strong>Results and conclusion: </strong>The average percentage loss in final product was 10.18% in KKG and 7.58% in NKG. The shelf life of MG, KKG and NKG is 16 months. After 16 months, <i>Go Ghṛta</i> showed negative rancidity test, while MG, KKG and NKG showed positive rancidity, indicative of onset of deterioration after 16 months. Present findings validate the Ayurvedic principles stipulating medicated <i>Ghṛta</i> to have a shelf life of 16 months. Chromatographic study showed few differences between KKG and NKG samples. Data obtained by present study may be considered as standard for future researches.</p>","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"36 3","pages":"129-135"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35371187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good Pharmacovigilance Practice: Accountability of Ayurvedic Pharmaceutical Companies.","authors":"Rohit Sharma,&nbsp;R Galib,&nbsp;P K Prajapati","doi":"10.4103/asl.ASL_10_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_10_17","url":null,"abstract":"© 2017 Ancient Science of Life | Published by Wolters Kluwer Medknow Sir, There is a paucity of systematic documentation apropos the occurrence of adverse drug reactions (ADRs) and other safety issues of Ayurveda medicines. National Pharmacovigilance program (NPP) for Ayurvedic drugs is concerned with re‐evaluation of marketed drugs, risk management, promoting rational drug use, and crisis preparedness. However, its successful implementation is a collective responsibility of the stakeholders viz. physicians, pharmacists, patients and pharmaceutical industry, that need to be sensitized towards reporting ADRs. This is a concern, especially in India, where there is below 1% reporting rate of ADRs as against the world rate of 5%.[1] In India, physicians are generally reluctant towards ADR reporting, due to poor awareness or lack of time/ training.[2,3] Furthermore, poor knowledge, attitude and practices of Pharmacovigilance (PV) has been observed in Ayurvedic practitioners.[4‐6] Till date, negligible number of ADRs to Ayurvedic medicines are reported/recorded in the NPP in India. This can be due to either the firm belief among practitioners that Ayurvedic drugs are safe or their lack of knowledge or awareness about the concept and significance of PV.[7] Marketing representatives (MRs) from Ayurvedic pharmaceutical companies approach physicians for the promotion of their drugs. While a new Ayurvedic drug [newly designed formula or new dosage form, which we treat as ‘New Chemical Entities’ (NCEs)] is promoted among physicians, it is important to discuss the reporting of ADRs. But, there is no data on whether such information is disseminated by MRs.","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"36 3","pages":"167-169"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35321716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cyavanaprāśa on Health and Immunity related Parameters in Healthy Children: A Two Arm, Randomized, Open Labeled, Prospective, Multicenter, Clinical Study.","authors":"Arun Gupta,&nbsp;Sunil Kumar,&nbsp;Sanjeeva Dole,&nbsp;Shailesh Deshpande,&nbsp;Vaishali Deshpande,&nbsp;Sudha Singh,&nbsp;V Sasibhushan","doi":"10.4103/asl.ASL_8_17","DOIUrl":"https://doi.org/10.4103/asl.ASL_8_17","url":null,"abstract":"<p><strong>Context: </strong>Cyavanaprāśa (CP) is an Ayurvedic immune booster formulation that confers vigor and vitality while delaying the ageing process. Benefits of CP have been studied widely in adult population.</p><p><strong>Objectives: </strong>Current study assessed beneficial effects of CP on health and immunity related parameters in healthy children.</p><p><strong>Methods: </strong>This study was a 6 month long two armed, randomized, open labeled, prospective clinical study. School going healthy children between ages of 5-12 years were randomized to receive orally daily either CP (approx. 6 g) followed by a cup of milk (100 - 200 ml) or cup of milk only twice a day while continuing with their normal/routine diet. Results were analyzed based on number of episodes, severity, duration of illness (infections and allergies) and number of absent days due to illness during the study duration and changes in levels of energy, physical fitness, strength, stamina and quality of life in children which were recorded in subject diary by their parents/Legally Acceptable Representative (LAR).</p><p><strong>Results: </strong>702 participants were randomized, out of which 627 completed the study (CP n = 313; Control n = 314). Results of immunity (episodes of infections or allergy related conditions) showed more than 2 times protection from immunity related illness in CP Group as compared to the control. CP also showed better percentage improvement in energy levels, physical fitness, strength, stamina and quality of life assessed through KIDSCREEN QOL-27 questionnaires in children.</p><p><strong>Conclusion: </strong>Regular consumption of CP for a period of six months could significantly improve immunity, energy levels, physical fitness, strength, stamina and quality of life in school going healthy children.</p><p><strong>Study registration: </strong>Clinical Trail Registry of India <i>vide</i> CTRI/2015/02/005574, Dated 24 February 2015.</p>","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"36 3","pages":"141-150"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35322805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Need for integration of Yoga in healthcare”: Conference held on 3rd International day of Yoga - 2017 at Kolar, India","authors":"N. Patil, P. Venkatarathnamma, L. Sunitha","doi":"10.4103/ASL.ASL_163_17","DOIUrl":"https://doi.org/10.4103/ASL.ASL_163_17","url":null,"abstract":"","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"53 - 54"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacognostical and Phytochemical Studies of <i>Helleborus niger</i> L Root.","authors":"V Kishor Kumar,&nbsp;K G Lalitha","doi":"10.4103/asl.ASL_57_16","DOIUrl":"https://doi.org/10.4103/asl.ASL_57_16","url":null,"abstract":"<p><strong>Background: </strong><i>Helleborus niger</i> L (Ranunculaceae) is used Ayurvedic and Unani systems and other herbal medicine systems. The roots of <i>H. niger</i> have a good medicinal value.</p><p><strong>Aims: </strong>To conduct a pharmacognostical and phytochemical study of <i>H. niger</i>.</p><p><strong>Materials and methods: </strong>The pharmacognostical studies on roots including parameters such as taxonomical, macroscopic, microscopic characters, physico-chemical, ultra-violet analysis and phytochemical studies are established.</p><p><strong>Results: </strong>Macroscopically, the roots are brownish-black in colour, cylindrical in shape, feeble odour, slightly acrid taste with irregularly branched. Microscopically the root showed the presence of epidermis, air-chambers, fissure periderm, periderm, inner cortex, pith, phloem, xylem, vessels and xylem vessels. Microscopic examination of the powder showed the presence of parenchyma cells, parenchyma mass, periderm, cell inclusion, laticifer, lateral wall pith, perforation, xylem bundle and xylem elements. Ultra-violet and ordinary light analyses with different reagents were conducted to identify the drug in powder form. Physico-chemical evaluation established, Ash values - Total, acid insoluble, water soluble and sulphated ash values were 7.3%, 4.1%, 3.7% and 5.2%, respectively. Extractive values - Alcohol soluble, water soluble and ether soluble extractive values were 22.8%, 7.4% and 5.6%, respectively. Loss on drying was 3.3%. Preliminary phytochemical screening showed the presence of carbohydrate, glycoside, saponins, flavonoid, phytosterols, tannins and phenolic compounds.</p><p><strong>Conclusions: </strong>The results of the study can serve as a valuable resource of pharmacognostic and phytochemical information. This will serve as appropriate, standards for discovery of this plant material in future investigations and applications and also contribute towards establishing pharmacopoeial standards.</p>","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"36 3","pages":"151-158"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35322806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurvedic Management of Recurrent Abortions due to Uterine Fibroid.","authors":"Shailendra Dadarao Katakdound","doi":"10.4103/asl.ASL_189_15","DOIUrl":"https://doi.org/10.4103/asl.ASL_189_15","url":null,"abstract":"<p><p>Uterine fibroids are present in 30-70% of women of reproductive age. Uterine fibroids distort the uterine cavity. Therefore there is consensus of a negative impact on both the clinical pregnancy and delivery rates.[2] In addition, studies have also reported an increased risk of spontaneous miscarriage with submucosal fibroids. In biomedicine, myomectomy is considered the treatment of choice and Assisted Reproductive Technology is advised to overcome infertility. In Hārita Saṃhitā treatment is given for recurrent abortion (<i>Garbhasrāvī</i>). In this study, considering <i>pitta doṣa</i> and altered uterine receptivity (<i>kṣetra duṣṭi</i>) as causative factors, purgation (<i>virecana karma</i>) was done, enema (<i>yoga basti</i>) was given after post purgation protocol (<i>saṃsarjana karma</i>). After body purification (<i>śodhana</i>), <i>garbhasthāpaka</i> drugs were given to the patient for one month. Patient conceived in the second month with this treatment. In Antenatal Care, haematinics and calcium supplements and month wise Ayurvedic medication (<i>Māsānumāsika kaṣāya</i>) were given for nine months. Elective caesarean section ắs done after GA 38 weeks (USG) followed by inj. Wymesone 8 mg. The procedure uneventful. Thus proving Ayurvedic management of recurrent abortion due to uterine fibroid. It is cost effective and improves and normalises uterine receptive environment.</p>","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"36 3","pages":"159-162"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35322808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ayurveda: The way we need","authors":"Aanchal Sharma","doi":"10.4103/ASL.ASL_147_17","DOIUrl":"https://doi.org/10.4103/ASL.ASL_147_17","url":null,"abstract":"","PeriodicalId":7805,"journal":{"name":"Ancient Science of Life","volume":"37 1","pages":"51 - 52"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70684170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}