用Kesara和Nāgakesara制备的Kuṅkumādi Ghṛta的理化筛选及保质期评价。

Pradeep Kumar Prajapati, Rohit Sharma, Amee Amrutia, B J Patgiri
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引用次数: 4

摘要

简介:Kuṅkumādi Ghṛta (KG)是一种阿育吠陀配方,通常推荐用于皮肤疾病,特别是Mukhadūṣikā(寻常痤疮)。Kesara(藏红花的柱头)是配方中的主要成分。然而,由于Kesara的高成本和掺假增加,阿育吠陀专家建议使用“Nāgakesara”(Mesua ferrea Linn.)作为替代品。Nāgakesara的成本相对较低,并且具有与Kesara相似的治疗属性。最近的研究已经在Mukhadūṣikā建立了Kesarayukta(含Kesara) Kuṅkumādi Ghṛta (KKG)和Nāgakesara yukta(含Nāgakesara) Kuṅkumādi Ghṛta (NKG)的标准制造程序和临床疗效。尽管KG在阿育吠陀实践中广泛使用,但迄今为止尚无关于其保质期的出版作品。目的和目标:建立KKG和NKG的理化特性,评估其保质期。材料与方法:采用阿育吠陀经典处方,在实验室制备KKG和NKG各三批,并对实验结果进行系统记录。记录了不同物化参数(灰分值、pH值、总固形物含量、比重、折射率、干燥损失量、酸值、碘值、皂化值、过氧化值和酸败试验)和原料[草药成分,Go Ghṛta, Mūrcchita Ghṛta (MG)]和成品(KKG和NKG)的感官特性(色、嗅、味、触觉)的比较差异。长期(实时)保质期测试在0,3,6,9和16个月的间隔进行。对样品进行了高效薄层色谱(HPTLC)分析。结果与结论:KKG和NKG的平均成品损失率分别为10.18%和7.58%。MG、KKG、NKG的保质期为16个月。16个月后Go Ghṛta酸败试验呈阴性,MG、KKG、NKG酸败试验呈阳性,说明16个月后开始恶化。目前的研究结果证实了阿育吠陀的原则,规定药物Ghṛta的保质期为16个月。色谱分析表明KKG和NKG样品差异不大。本研究获得的数据可作为今后研究的标准。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Physicochemical Screening and Shelf Life Evaluation of <i>Kuṅkumādi Ghṛta</i> Prepared using <i>Kesara</i> and <i>Nāgakesara</i>.

Physicochemical Screening and Shelf Life Evaluation of <i>Kuṅkumādi Ghṛta</i> Prepared using <i>Kesara</i> and <i>Nāgakesara</i>.

Physicochemical Screening and Shelf Life Evaluation of <i>Kuṅkumādi Ghṛta</i> Prepared using <i>Kesara</i> and <i>Nāgakesara</i>.

Physicochemical Screening and Shelf Life Evaluation of Kuṅkumādi Ghṛta Prepared using Kesara and Nāgakesara.

Introduction: Kuṅkumādi Ghṛta (KG) is an Ayurvedic formulation commonly recommended in skin disorders, especially Mukhadūṣikā (Acne vulgaris). Kesara (stigma of Crocus sativus Linn.) is a prime ingredient in the formulation. However, due to high cost and increased adulteration in Kesara, 'Nāgakesara' (Mesua ferrea Linn.) is suggested by Ayurvedic experts as a substitute. Nāgakesara is relatively lower in cost and possesses similar therapeutic attributes to that of Kesara. Recent studies have established standard manufacturing procedures and clinical efficacies of Kesarayukta (with Kesara) Kuṅkumādi Ghṛta (KKG) and Nāgakesara yukta (with Nāgakesara) Kuṅkumādi Ghṛta (NKG) in Mukhadūṣikā. In spite of wide utility of KG in Ayurvedic practice, no published work on its shelf life is available so far.

Aims and objectives: To establish the physicochemical profile and evaluate the shelf life of KKG and NKG.

Materials and methods: Total three batches of KKG and NKG each were prepared in the laboratory by adopting Ayurvedic classical guidelines and the findings were systematically recorded. Comparative differences in organoleptic characters (colour, odour, taste, touch) and values of different physicochemical parameters (Ash value, pH value, Total solid content, Specific gravity, Refractive index, Loss on drying, Acid value, Iodine value, Saponification value, Peroxide value and Rancidity tests) of raw materials [herbal ingredients, Go Ghṛta, Mūrcchita Ghṛta (MG)] as well as finished products (KKG and NKG) were recorded. Long term (real time) shelf life testing was carried out at the intervals i.e., at 0, 3, 6, 9 and 16 months. High performance thin layer chromatography (HPTLC) analysis of samples was also carried out.

Results and conclusion: The average percentage loss in final product was 10.18% in KKG and 7.58% in NKG. The shelf life of MG, KKG and NKG is 16 months. After 16 months, Go Ghṛta showed negative rancidity test, while MG, KKG and NKG showed positive rancidity, indicative of onset of deterioration after 16 months. Present findings validate the Ayurvedic principles stipulating medicated Ghṛta to have a shelf life of 16 months. Chromatographic study showed few differences between KKG and NKG samples. Data obtained by present study may be considered as standard for future researches.

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