Animal Cells and Systems最新文献

Matching developmental timelines of fish, frog, mouse and human brains. 匹配鱼、青蛙、老鼠和人类大脑的发育时间表。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-10-16 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2742604

Hyun Jung Park, Hosung Jung

引用次数: 0

Pharmacological inhibition of REV-ERBα ameliorates motor deficits in the 6-OHDA-lesioned mouse model of Parkinson's disease. rev - erba的药物抑制可改善6- ohda损伤的帕金森病小鼠模型的运动缺陷。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-10-15 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2690728

Jeongah Kim, Mijeong Choe, Sangwon Jang, Inah Park, Sungjoon Oh, Eun-Kyoung Kim, Youngshik Choe, Woong Sun, Kyungjin Kim

{"title":"Pharmacological inhibition of REV-ERBα ameliorates motor deficits in the 6-OHDA-lesioned mouse model of Parkinson's disease.","authors":"Jeongah Kim, Mijeong Choe, Sangwon Jang, Inah Park, Sungjoon Oh, Eun-Kyoung Kim, Youngshik Choe, Woong Sun, Kyungjin Kim","doi":"10.1080/19768354.2026.2690728","DOIUrl":"10.1080/19768354.2026.2690728","url":null,"abstract":"Parkinson's disease (PD) is characterized by nigrostriatal dopaminergic (DAergic) degeneration and motor dysfunction. Many PD patients also show circadian rhythm disturbances. Increasing evidence links circadian clock dysfunction to PD pathology. REV-ERBα is a circadian nuclear receptor that regulates DAergic genes under physiological conditions. However, its role in nigrostriatal dopamine (DA) homeostasis and motor function in PD remains unclear. In this study, we found elevated Rev-erbα mRNA expression in tyrosine hydroxylase (TH)-positive neurons of the substantia nigra (SN) in a 6-hydroxydopamine (6-OHDA) mouse model of PD. To test its functional role, we assessed the acute effects of local SN microinjection of the REV-ERBα antagonist SR8278. We found that SR8278 partially recovered motor performance and improved fine motor function. These effects occurred regardless of circadian timing. SR8278 administration did not restore TH expression or tissue DA levels in the striatum and SN. However, in vivo microdialysis showed enhanced extracellular DA turnover in the striatum. Specifically, while extracellular DA metabolites level increased, basal extracellular DA levels showed no change. Together, these findings identify REV-ERBα as a potential therapeutic target that modulates extracellular nigrostriatal DA dynamics and improves motor function in PD.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"30 1","pages":"558-571"},"PeriodicalIF":3.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic evaluation of AAV administration strategies for targeting Phox2b + primary visceral sensory neurons. 针对Phox2b +初级内脏感觉神经元的AAV给药策略的系统评价。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-10-15 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2749248

Su Young Ki, Ha Kyeong Kim, Hyun Ji Gu, Soo Min Oh, Dong-Hoon Kim, Yong Taek Jeong

{"title":"Systematic evaluation of AAV administration strategies for targeting Phox2b + primary visceral sensory neurons.","authors":"Su Young Ki, Ha Kyeong Kim, Hyun Ji Gu, Soo Min Oh, Dong-Hoon Kim, Yong Taek Jeong","doi":"10.1080/19768354.2026.2749248","DOIUrl":"10.1080/19768354.2026.2749248","url":null,"abstract":"Visceral sensory neurons (VSNs) play an essential role in interoception, but it remains challenging to selectively access them using genetic tools due to their anatomical location and shared molecular markers with central autonomic circuits. Although transgenic models visualizing Phox2b-expressing neurons have been developed to genetically label VSNs, concurrent Phox2b expression in the hindbrain limits their selectivity. To overcome these limitations, we engineered several Phox2b promoter-driven adeno-associated virus (AAV) vectors and evaluated the effects of capsid serotype, delivery route, and injection timing. Using systemic delivery of AAV-PHP.S-Phox2b-Cre, we found that postnatal day 8 is an optimal time window for efficient and selective labeling of VSNs with a relatively low dose. The result contrasts with neonatal administration, which led to extensive ectopic labeling at the same dose. Unexpectedly, lingual submucosal delivery of AAV-retro-Phox2b-Cre, initially intended to label tongue-innervating sensory neurons, also labeled most vagal neurons. These labeled neurons were AAV-retro capsid-specific, because local delivery of AAV-PHP.S-Phox2b-Cre labeled cells only near the injection site. Altogether, this study provides practical parameters for selective genetic access to VSNs using AAV.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"30 1","pages":"572-586"},"PeriodicalIF":3.6,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149215014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZEB1-mediated suppression of circDennd1b promotes the migration and invasion of lung cancer cells. zeb1介导的circDennd1b的抑制促进了肺癌细胞的迁移和侵袭。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-10-06 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2742602

Seongran Cho, Jin-A Choi, Jihye Park, Keunsoo Kang, Young-Ho Ahn

引用次数: 0

Chemical synchronization using household bleach can affect development, behavior and lifespan in Caenorhabditis elegans. 使用家用漂白剂的化学同步可以影响秀丽隐杆线虫的发育、行为和寿命。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-09-30 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2719247

Seung Hyun Kim, Joohong Ahnn, Heon Seok Kim, Sun-Kyung Lee

{"title":"Chemical synchronization using household bleach can affect development, behavior and lifespan in Caenorhabditis elegans.","authors":"Seung Hyun Kim, Joohong Ahnn, Heon Seok Kim, Sun-Kyung Lee","doi":"10.1080/19768354.2026.2719247","DOIUrl":"10.1080/19768354.2026.2719247","url":null,"abstract":"Caenorhabditis elegans, a nematode genetic model, is often synchronized in experiments to accurately observe its unbiased phenotypes. Chemical synchronization, simple bleaching of gravid worms, has been widely used to obtain eggs in bulk because the eggshell is extremely resistant to harsh conditions. While those eggs are considered to preserve their natural properties and are allowed to hatch to obtain synchronized worms, it has not been fully investigated whether chemical synchronization influences embryonic and post-embryonic traits. In this study, we compared some phenotypes observed in worms collected by picking laid eggs and by chemical synchronization. Chemical synchronization decreased hatching and developmental rates and, in some conditions, affected morphological traits, such as body length and head size, and brood size. In contrast, chemical synchronization did not affect the developmental potential of early- or later-stage eggs, or chemosensory behaviors. While the lifespan of wild-type worms did not change, the daf-16 loss-of-function mutant with an extremely short lifespan showed much variation when chemically synchronized. This study clarifies the impacts of chemical synchronization of worms and provides some critical considerations for its use.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"30 1","pages":"20-37"},"PeriodicalIF":3.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria-ER contact sites in neurological disorders. 神经系统疾病中的线粒体-内质网接触部位。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-09-21 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2725542

Eun Jin Jang, Jisoo Lee, Seungha Shin, Tran Diem Nghi, Sang Ki Park

引用次数: 0

Circuit-specific remodeling of synaptic co-transmission in stress-responsive networks. 应激反应网络中突触共传递的电路特异性重构。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-09-18 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2730204

Hoyong Park, Hyogyun Kim, Minsung Sim, Doyeon Ham, ChiHye Chung

{"title":"Circuit-specific remodeling of synaptic co-transmission in stress-responsive networks.","authors":"Hoyong Park, Hyogyun Kim, Minsung Sim, Doyeon Ham, ChiHye Chung","doi":"10.1080/19768354.2026.2730204","DOIUrl":"10.1080/19768354.2026.2730204","url":null,"abstract":"Neurons do not always use a 'one neurotransmitter-one receptor' paradigm to communicate at synapses. Some neurons communicate using more than one neurotransmitter, a phenomenon termed co-transmission. Co-transmission can occur through a few distinct organizational modes at synapses, enabling the integration of excitatory, inhibitory, and modulatory signals in various combinations. Increasingly, evidence suggests that these organizational modes are particularly important in neural circuits functioning in stress response. In monoaminergic nuclei, the lateral habenula, and the hippocampus, stress exposure induces shifts in co-transmission via circuit-specific changes to neurotransmitter balance. Here, we review recent advances in our understanding of co-transmission in these circuits, with an emphasis on evidence that distinct modes of small-molecule co-transmission are employed in circuits that contribute to some of the multidimensional aspects of stress. We further discuss potential mechanisms that may recalibrate multi-transmitter signaling during stress-stimulated co-transmission. Currently, evidence suggests that stress affects not only single-transmitter systems but also multi-transmitter communication across neural circuits. Viewing co-transmission as a dynamic substrate of stress-induced neural plasticity, this review provides new insight into the neural basis of adaptive and maladaptive stress responses and may help identify novel therapeutic opportunities for affective disorders, such as major depressive disorder and bipolar disorder.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"30 1","pages":"39-57"},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual antidiabetic potential of arjunglucoside I and arjunetin from Terminalia chebula via modulation of insulin- and gluconeogenesis-related responses. 通过调节胰岛素和糖异生相关反应，苦姜苷I和苦姜素具有双重降糖潜能。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-09-16 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2725543

Ye-Seul Song, Chen Huo, Alexander Blöchle, Niranjan Parajuli, Ki Hyun Kim, Hyo-Jong Lee

{"title":"Dual antidiabetic potential of arjunglucoside I and arjunetin from Terminalia chebula via modulation of insulin- and gluconeogenesis-related responses.","authors":"Ye-Seul Song, Chen Huo, Alexander Blöchle, Niranjan Parajuli, Ki Hyun Kim, Hyo-Jong Lee","doi":"10.1080/19768354.2026.2725543","DOIUrl":"10.1080/19768354.2026.2725543","url":null,"abstract":"A deciduous tree belonging to the Combretaceae family, Terminalia chebula Retz. has a long history of traditional use in diabetes management. However, it is not fully understood how the extract of T. chebula exerts the antidiabetic effects. To identify the constituents responsible for this activity, we investigated the bark of T. chebula and determined the structures of compounds exhibiting antidiabetic potential. Using molecular networking, LC-MS, and NMR analysis, we identified five phytochemical compounds (1-5): arjunglucoside I (1), arjunetin (2), arjungenin (3), (-)-catechin (4), and (-)-epicatechin (5). We found that arjunglucoside I and arjunetin selectively inhibited α-glucosidase, but not α-amylase, suggesting that they may regulate postprandial glucose levels with few gastrointestinal side effects. Both compounds significantly increased the gene expression of insulin (ins) but decreased that of pck1, which encodes phosphoenolpyruvate carboxykinase (PEPCK), a key enzyme in gluconeogenesis. These effects were also observed under metabolic stress induced by cAMP/dexamethasone, indicating feedback regulation between insulin and gluconeogenesis pathways. Arjunglucoside I and arjunetin protected zebrafish from oxidative damage induced by alloxan, modulated calcium signaling-related gene expression under insulin-resistant conditions, and increased glucose uptake in insulin-resistant C2C12 myotubes. Collectively, these results provide insights into the use of arjunglucoside I and arjunetin for diabetes treatment and the development of novel antidiabetic agents derived from the promising phytochemicals.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"30 1","pages":"471-486"},"PeriodicalIF":3.6,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13587583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium hydroxyapatite suppresses extracellular matrix-related gene expression by modulating Piezo1-associated Ca²⁺ signaling and PKA activity. 羟基磷灰石钙通过调节piezo1相关的Ca2+信号和PKA活性来抑制细胞外基质相关基因表达。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-08-11 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2677272

ChanHui Song, Younjee Jeong, Tae-Jin Kim

{"title":"Calcium hydroxyapatite suppresses extracellular matrix-related gene expression by modulating Piezo1-associated Ca2+ signaling and PKA activity.","authors":"ChanHui Song, Younjee Jeong, Tae-Jin Kim","doi":"10.1080/19768354.2026.2677272","DOIUrl":"10.1080/19768354.2026.2677272","url":null,"abstract":"Fibrosis is characterized by excessive extracellular matrix (ECM) deposition driven by sustained pro-fibrotic signaling and underlies a wide range of pathological conditions. Accordingly, strategies that broadly suppress ECM production are considered promising for the treatment of fibrosis. Although calcium hydroxyapatite (CaHA) is primarily used as a nanoparticle-based dermal filler, previous observations that it affects collagen production suggest its potential repurposing as a regulator of ECM-related programs. Here, we investigated the anti-fibrotic efficacy of CaHA and the signaling mechanisms underlying its effects. CaHA broadly suppressed ECM-related gene expression in fibroblasts, extending beyond collagen to multiple ECM components and associated regulatory factors. Mechanistically, CaHA attenuated Piezo1-associated Ca2+ signaling and was also associated with activation of the PKA pathway. Importantly, CaHA similarly reduced ECM-related gene expression in a fibrotic liver cell model, supporting the broader relevance of its anti-fibrotic activity. Together, these findings identify CaHA as a broad suppressor of ECM-related gene expression through modulation of Piezo1-associated Ca2+ signaling and PKA-associated pathways, and support its potential as an anti-fibrotic therapeutic strategy.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"30 1","pages":"459-470"},"PeriodicalIF":3.6,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De novo whole transcriptome sequencing reveals differentially expressed messenger RNA and MicroRNA in hepatopancreas of Pandalus hypsinotus. 从头开始的全转录组测序揭示了熊猫肝胰腺中mrna和MicroRNA的差异表达。

IF 3.6 2区生物学

Animal Cells and Systems Pub Date : 2026-08-03 eCollection Date: 2026-01-01 DOI: 10.1080/19768354.2026.2692155

Du Hyeong Lee, Woo Ryung Kim, Hae Jin Shin, Jung-Min Kim, Eun Gyung Park, Yun Ju Lee, Hyeon-Su Jeong, Hyun-Young Roh, Yung Hyun Choi, In-Tae Cha, Heui-Soo Kim

{"title":"De novo whole transcriptome sequencing reveals differentially expressed messenger RNA and MicroRNA in hepatopancreas of Pandalus hypsinotus.","authors":"Du Hyeong Lee, Woo Ryung Kim, Hae Jin Shin, Jung-Min Kim, Eun Gyung Park, Yun Ju Lee, Hyeon-Su Jeong, Hyun-Young Roh, Yung Hyun Choi, In-Tae Cha, Heui-Soo Kim","doi":"10.1080/19768354.2026.2692155","DOIUrl":"10.1080/19768354.2026.2692155","url":null,"abstract":"Pandalus hypsinotus (P. hypsinotus), also known as coonstripe shrimp, has high economic value and is widely distributed in Alaska, the Bering Sea and the East Sea of Korea. However, owing to the low catch rates and patchy spatial distribution, transcriptome-based studies on this species remain limited. Transcriptome analyses using PacBio Iso-Seq and Illumina RNA sequencing techniques were performed to establish a de novo unigene set of P. hypsinotus and identify differentially expressed genes (DEGs) in the hepatopancreas compared to the tail muscle. A search of all the unigenes against Gene Ontology (GO), KEGG, Pfam, BLASTN, and UniProt resulted in 46,703 annotated unigenes. A comparison of the sequences in the two tissue-derived libraries revealed 9,429 DEGs in the hepatopancreas. We also investigated the small RNAomes of P. hypsinotus using the Illumina small RNA sequencing technology. Because miRNAs are highly sensitive to stress responses and pathogen infections, they serve as effective indicators of the immune status, thereby acting as crucial tools for enhancing productivity and disease control in the aquaculture industry. The 130 identified microRNA (miRNA) candidates were classified into 32 orthologous and 98 novel miRNAs using BLASTN and miRBase. Through GO analysis and direct interactions between miRNAs and genes, the differentially expressed miRNAs (DEMs) and DEGs related to immune responses showed regulatory relationships based on their sequences. These findings provide a valuable resource for future studies on novel gene detection, gene mapping and biological pathways that may be regulated by miRNAs unique to P. hypsinotus.","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"30 1","pages":"419-444"},"PeriodicalIF":3.6,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0