Animal Cells and Systems最新文献

{"title":"Comparative epigenomics to clinical trials in human breast cancer and canine mammary tumor.","authors":"Su-Jin Jeong, Kang-Hoon Lee, Je-Yoel Cho","doi":"10.1080/19768354.2025.2477024","DOIUrl":"10.1080/19768354.2025.2477024","url":null,"abstract":"<p><p>Epigenetics and epigenomics are captivating fields of molecular biology, dedicated to the exploration of heritable alterations in gene expression and cellular phenotypes, which transpire devoid of any discernible modifications to the fundamental DNA sequence. This intricate regulatory apparatus encompasses multiple mechanisms, prominently featuring DNA methylation, histone modifications, and the involvement of non-coding RNA molecules in pivotal roles. To achieve a comprehensive grasp of these diverse mechanisms, it is imperative to conduct research employing animal models as proxies for human studies. Since experimental animal models like mice and rats struggle to replicate the diverse environmental conditions experienced by humans, this review focuses on comparing common epigenetic alterations in naturally occurring tumors in canine models, which share the human environment, with those in humans. Through this, we emphasize the importance of an epigenetic regulation in the comparative medical approach to a deeper understanding of cancers and further development of cancer treatments. Additionally, we elucidate epigenetic modifications pertinent to specific developmental stages, the ageing process, and the progression of various diseases.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"12-30"},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Germline expression of Imp-L2 in Drosophila females enhances reproductive activity and longevity.","authors":"Sujin Noh, Sungjoon Na, Xinge Song, Seogang Hyun","doi":"10.1080/19768354.2025.2480150","DOIUrl":"10.1080/19768354.2025.2480150","url":null,"abstract":"<p><p>The Imaginal morphogenesis protein-Late 2 (Imp-L2) in <i>Drosophila</i> is recognized as a functional homolog of the insulin-like growth factor (IGF) binding protein family. In this study, we report that Imp-L2 expression in germline cells during oogenesis simultaneously enhances both fecundity and lifespan in female <i>Drosophila</i>. Loss of Imp-L2, either through knockout or germline-specific knockdown, resulted in decreased reproductive activity, as evidenced by reduced ovary size and fecundity, along with a higher proportion of infertile flies. Conversely, overexpression of Imp-L2 specifically in germline cells enhanced reproductive activity. Imp-L2 appears to regulate germline stem cell proliferation and differentiation independently of IGF signaling. Interestingly, germline-specific knockdown of <i>Imp-L2</i> shortened the lifespan of female flies, whereas its overexpression extended it. Thus, Imp-L2 expression in the germline promotes both reproductive activity and longevity, presenting an exception to the typical trade-off between reproduction and lifespan.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"31-40"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRAP1 functions in the morphogenesis of the embryonic kidney.","authors":"Ha Eun Kim, Taejoon Kwon, Hyo Jung Sim, Tae Joo Park","doi":"10.1080/19768354.2025.2477789","DOIUrl":"10.1080/19768354.2025.2477789","url":null,"abstract":"<p><p>TNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology with a cytosolic chaperon HSP90. It has been shown that TRAP1 functions as an inhibitor for apoptosis by preventing cytochrome-c release from mitochondria. In addition, TRAP1 seems to play critical roles in metabolic processes for energy production, such as glycolysis and β-oxidation. It has also been reported that TRAP1 is a direct target of PTEN-induced kinase 1 (PINK1) and may be a cause of Parkinson's disease (PD) in humans. Although the biochemical functions of TRAP1 are under intense study for the physiology and treatment of various cancers, its roles in vertebrate development have not been reported. This study shows that <i>Xenopus</i> TRAP1 is strongly expressed in the developing muscle, kidney, and brain tissues. Perturbation of TRAP1 function by treating TRAP1 inhibiter GTPP or microinjection of antisense-morpholino oligo (MO) caused mild defects in striated muscle fiber formation. Furthermore, the looping patterns of developing kidney tubules were perturbed, indicating that TRAP1 function is necessary for proper kidney development.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"9-18"},"PeriodicalIF":2.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of dasatinib and quercetin promotes osteogenic differentiation and stemness maintenance of hPDLSCs via YAP/TAZ.","authors":"Yunge Qiu, Yajun Zhao, Linglu Jia, Han Xiao, Shaoqing Sun, Weiting Gu, Yong Wen","doi":"10.1080/19768354.2025.2477050","DOIUrl":"10.1080/19768354.2025.2477050","url":null,"abstract":"<p><p>Human periodontal ligament stem cells (hPDLSCs) are candidate seed cells for periodontal tissue regeneration. Enhancing the stemness maintenance and osteogenic differentiation potential of hPDLSCs is conducive to their role in periodontal tissue regeneration. The combination of dasatinib and quercetin, a type of senolytic, has been reported to affect cell senescence. However, whether it can regulate the osteogenic differentiation and stemness maintenance of hPDLSCs, and the related mechanisms, remain unknown. The present study analyzed the optimal concentrations of dasatinib and quercetin in combination for hPDLSCs and found that the combination of dasatinib and quercetin enhanced osteogenic differentiation and promoted the expression of stemness-related markers in hPDLSCs. The expression levels of TAZ and YAP were improved when hPDLSCs were incubated with dasatinib and quercetin. However, the osteogenesis-promoting effects of dasatinib plus quercetin were partly attenuated when TAZ was knocked down, and their effects on stemness-related markers were suppressed when YAP was inhibited. Taken together, the combination of dasatinib and quercetin promotes the osteogenic differentiation and stemness maintenance of hPDLSCs, and YAP/TAZ may be involved in this process. This combination may hold promise for improving hPDLSCs function in periodontal tissue regeneration.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"19-29"},"PeriodicalIF":2.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmenting the human interactome for disease prediction through gene networks inferred from human cell atlas.","authors":"Euijeong Sung, Junha Cha, Seungbyn Baek, Insuk Lee","doi":"10.1080/19768354.2025.2472002","DOIUrl":"10.1080/19768354.2025.2472002","url":null,"abstract":"<p><p>Gene co-expression network inference from bulk tissue samples often misses cell-type-specific interactions, which can be detected through single-cell gene expression data. However, the noise and sparsity of single-cell data challenge the inference of these networks. We developed scNET, a framework for integrative cell-type-specific co-expression network inference from single-cell transcriptome data, demonstrating its utility in augmenting the human interactome for more accurate disease gene prediction. We address the limitations of <i>de novo</i> network inference from single-cell expression data through dropout imputation, metacell formation, and data transformation. Employing this data preprocessing pipeline, we inferred cell-type-specific co-expression links from single-cell atlas data, covering various cell types and tissues, and integrated over 850K of these inferred links into a preexisting human interactome, HumanNet, resulting in HumanNet-plus. This integration notably enhanced the accuracy of network-based disease gene prediction. These findings suggest that with proper data preprocessing, network inference from single-cell gene expression data can be highly effective, potentially enriching the human interactome and advancing the field of network medicine.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"11-20"},"PeriodicalIF":2.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behind the mountains and over the sea: the Changbai Mountain Range provided <i>Rana coreana</i> with a Chinese residence permit all along.","authors":"Amaël Borzée, Tae Eun Um, Abhilasha Shrivastava, Siti N Othman","doi":"10.1080/19768354.2025.2471476","DOIUrl":"10.1080/19768354.2025.2471476","url":null,"abstract":"<p><p>The Changbai Mountain Range is generally perceived as a barrier to amphibian distribution, but it might not be playing this role anymore. <i>Rana coreana</i> was first described as a Korean endemic species, split from <i>Rana amurensis</i>, which ranges at more northern latitude. The species was then found on the Shandong peninsula in China, where it was first described as <i>Rana kunyuensis</i>, before being synonymised with <i>R. coreana</i>. So far, the contact zone with <i>R. amurensis</i> was expected to be in the vicinity of Pyongyang in DPR Korea, west of the Baekdu Mountain Range. However, the species is known from a population further north, and during surveys in Dalian in Liaoning Province, China, we found <i>R. coreana</i> on the southern slopes of the Laoling Mountain Range facing the Yellow Sea. Our phylogenetic analyses based on mitochondrial ribosomal markers showed the individual to cluster with <i>R. coreana</i> samples from the Korean Peninsula. In addition, our ecological niche models showed the presence of suitable habitats outside of the known range of the species, deserving further investigation. The habitat of the species at this new locality is similar to the one known in the three range nations, and highlights the need for more surveys in northeast China as the barrier formed by the Changbai Range is more porous than originally expected.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"21-28"},"PeriodicalIF":2.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulated electro-hyperthermia therapy combined with Korean mistletoe extract treatment exerts a strong anti-tumor activity by enhancing cellular and humoral immune responses in mice.","authors":"Yebeen Kim, Jinwoo Hur, Sung-Chul Hong, Jaewoon Jung, Choon-Ho Park, Joon Beom Park, Taek Joon Yoon, Jong Bae Kim, Seung-Hoon Yang","doi":"10.1080/19768354.2025.2470455","DOIUrl":"10.1080/19768354.2025.2470455","url":null,"abstract":"<p><p>Electro-hyperthermia therapy (EHT) has been known to cause temperature-dependent cell death and enhance the effects of conventional antitumor treatments, such as chemotherapy and radiotherapy. Furthermore, EHT modulates the innate and adaptive immune systems. Mistletoe is one of the most broadly studied complementary and alternative therapeutic agents for cancer treatment due to its ability to stimulate the immune systems. This study aimed to investigate the effects of EHT and mistletoe therapy combination on immune responses. Tumors induced by B16-BL6 melanoma cells were treated twice with modulated EHT (mEHT) (43°C for 10 or 20 min) and with intravenous injection of a Korean mistletoe extract (KME). We examined the level of interferon (IFN)-γ, granzyme, interleukin (IL)-2, IL-10, and tumor-specific antibodies using enzyme-linked immunosorbent assay methods to further study the immunological responses in the combination of mEHT and KME. Additionally, cytotoxic T lymphocyte (CTL) activity is investigated. In this study, we revealed a significant anti-tumor immunological activity elevation in tumor-bearing mice by combined mEHT and KME therapy. Specifically, the combination of mEHT and KME treatment was effective in inhibiting tumor growth in mice. The combination treatment elicited CTL immune response and increased IFN-γ and granzyme secretion. Particularly, the co-treatment appeared to efficiently suppress the immune signal related to tumor-associated macrophage differentiation. Importantly, tumor cell-specific antibodies could be induced in mice after mEHT-treated tumor cell immunization, which represent a promising cancer vaccine strategy. Thus, our results indicate the therapeutic actions of KME as a feasible partner of mEHT, suggesting its potential candidate for cancer immunotherapy. Abbreviations: APC, Antigen-presenting cell; CTL, Cytotoxic T lymphocyte; EHT, Electro-hyperthermia therapy; ELISA, Enzyme-linked immunosorbent assay; HSP, Heat shock protein; KME, Korean mistletoe extract; NK, Natural killer; PBS, Phosphate-buffered saline; QOL, Quality of life; RF, Radio-frequency; TAM, Tumor-associated macrophage.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"163-172"},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lamin B1 regulates RNA splicing factor expression by modulating the spatial positioning and chromatin interactions of the <i>ETS1</i> gene locus.","authors":"Geun-Seup Shin, Ah-Ra Jo, Jinho Kim, Ji-Young Kim, Chul-Hong Kim, Mi-Jin An, Hyun-Min Lee, Yuna Park, Yujeong Hwangbo, Jung-Woong Kim","doi":"10.1080/19768354.2025.2465325","DOIUrl":"10.1080/19768354.2025.2465325","url":null,"abstract":"<p><p>Lamin B1, a crucial component of the nuclear lamina, plays a pivotal role in chromatin organization and transcriptional regulation in eukaryotic cells. While recent studies have highlighted the connection between Lamin B1 and RNA splicing regulation, the precise molecular mechanisms remain elusive. In this study, we demonstrate that Lamin B1 depletion leads to a global reduction in splicing factor expression, as evidenced by analysis of multiple RNA-seq datasets. Motif analysis suggests that members of the ETS transcription factor family likely bind to the promoter regions of these splicing factors. Further analysis using transcription factor databases and ChIP-seq data identified ETS1 as a key regulator of splicing factor expression. Hi-C sequencing revealed that the loss of Lamin B1 disrupts inter-LAD chromatin interactions near the ETS1 gene locus, resulting in its downregulation. These findings suggest that Lamin B1 indirectly regulates RNA splicing by sustaining proper ETS1 expression, uncovering a novel link between nuclear architecture, gene regulation, and RNA splicing.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"149-162"},"PeriodicalIF":2.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian genes and non-coding RNAs: interactions and implications in cancer.","authors":"Goeun Yoon, Jungwook Roh, Wonyi Jang, Wanyeon Kim","doi":"10.1080/19768354.2025.2459622","DOIUrl":"10.1080/19768354.2025.2459622","url":null,"abstract":"<p><p>Circadian rhythms are 24-hour cycles in various biological processes, such as sleep, wake, and hormone secretion, controlled by an internal clock. Disruption of circadian rhythms has been related to various human diseases. Abnormal expression of circadian rhythm-related genes, such as <i>CLOCK</i>, <i>BMAL1</i>, <i>PER1</i>, <i>PER2</i>, <i>CRY1</i>, <i>CRY2</i>, <i>RORα</i>, <i>NPAS2</i>, <i>REV-ERBα</i> and <i>TIMELESS</i> has also been reported to be associated with cancer. <i>CLOCK</i>, <i>CRY1</i>, <i>NPAS2</i> and <i>TIMELESS</i> are related to cancer development. In contrast, <i>BMAL1</i>, <i>PER1</i>, <i>PER2</i>, <i>CRY2</i>, <i>RORα</i> and <i>REV-ERBα</i> related to inhibit cancer development and progression. Furthermore, studies suggest that circadian genes related to cancer can be regulated by ncRNAs such as miRNAs, lncRNAs and circRNAs and that dysregulation of these ncRNAs contributes to cancer development. Here, we summarize the mechanisms whereby ncRNA dysregulation leads to the abnormal expression of circadian genes in several cancers and the ncRNA and circadian gene-associated regulatory mechanisms that contribute to resistance to chemo - and radiotherapy. This review provides insights into the mechanistic involvements of the regulatory network of circadian genes and ncRNAs in cancer development.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"135-148"},"PeriodicalIF":2.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RA-PR058, a novel ramalin derivative, reduces BACE1 expression and phosphorylation of tau in Alzheimer's disease mouse models.","authors":"Yongeun Cho, Jeongmi Lee, Jun-Sik Kim, Yeji Jeon, Sukmin Han, Heewon Cho, Yeongyeong Lee, Tai Kyoung Kim, Ju-Mi Hong, Yujeong Lee, Yujung Byun, Minshik Chae, Sunyoung Park, Leon F Palomera, Sang Yoon Park, Hyunwook Kim, Soyeong Kim, Seongeun Kang, Jun-Goo Jee, Hongchan An, Joung Han Yim, Sung Hyun Kim, Dong-Gyu Jo","doi":"10.1080/19768354.2025.2459649","DOIUrl":"10.1080/19768354.2025.2459649","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by cognitive decline, anxiety-like behavior, β-amyloid (Aβ) accumulation, and tau hyperphosphorylation. BACE1, the enzyme critical for Aβ production, has been a major therapeutic target; however, direct BACE1 inhibition has been associated with adverse side effects. This study investigates the therapeutic potential of RA-PR058, a novel ramalin derivative, as a multi-targeted modulator of AD-related pathologies. The effects of RA-PR058 were evaluated <i>in vitro</i> and <i>in vivo</i>. <i>In vitro</i> studies used SH-SY5Y cells under oxidative stress conditions to assess BACE1 expression, while <i>in vivo</i> effects were studied in 3xTg-AD mice following one month of oral RA-PR058 treatment. Behavioral assessments, biochemical analyses, transcriptomic profiling, and pharmacokinetic evaluations were performed to determine the efficacy of RA-PR058. RA-PR058 significantly reduced oxidative stress-induced BACE1 expression <i>in vitro</i> and decreased cortical BACE1 expression in 3xTg-AD mice. <i>In vivo</i> treatment alleviated anxiety-like behavior and reduced tau phosphorylation at disease-relevant sites (Ser202/Thr205, Thr231, and Ser396). Transcriptomic analysis revealed RA-PR058-mediated gene expression changes related to central nervous system development, response to hypoxia, and neuroactive ligand-receptor interactions, suggesting broader regulatory effects on AD-related pathways. Pharmacokinetic analysis demonstrated that RA-PR058 exhibits high metabolic stability, minimal cytochrome P450 interactions, and moderate blood-brain barrier penetration. RA-PR058 demonstrates potential as a multi-target AD therapeutic by reducing BACE1 expression, tau hyperphosphorylation, and anxiety-like behavior, coupled with favorable pharmacokinetics. Additional studies are needed to assess cognitive effects and clarify molecular mechanisms, but RA-PR058 may represent a promising advancement in addressing AD's complex pathology.</p>","PeriodicalId":7804,"journal":{"name":"Animal Cells and Systems","volume":"29 1","pages":"122-134"},"PeriodicalIF":2.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}