The role of interleukin-17 in neurological disorders.

IF 2.5 2区生物学 Q3 CELL BIOLOGY

Animal Cells and Systems Pub Date : 2025-06-03 eCollection Date: 2025-01-01 DOI:10.1080/19768354.2025.2510994

Seung Eun Park, Ana Flávia F Ferreira, Hyeokbin Kwon, Jeongwoo Yu, Leila Diniz, Henning Ulrich, Luiz R G Britto, Eunha Kim

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引用次数: 0

Abstract

In recent years, the intricate relationship between the immune system and neurological disorders has garnered significant attention. While the central nervous system had long been perceived as immunologically privileged, emerging research has revealed complex interactions among immune cells, inflammatory mediators, and neural components that collectively influence the pathogenesis and progression of various neurological disorders. This comprehensive review explores the crucial role of the cytokine interleukin-17(IL-17) in neurological diseases. It examines the complex contributions of IL-17 to both neurodevelopmental and neurodegenerative disorders, highlighting its diverse mechanisms and its impact on neuro-immune crosstalk. Moreover, we assess the evidence supporting the potential therapeutic role of modulating IL-17, considering its beneficial and detrimental effects. Through a comprehensive analysis of current research, we aim to provide insights into the modulatory role of IL-17 in neurological disorders.

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白细胞介素-17在神经系统疾病中的作用。

近年来，免疫系统和神经系统疾病之间错综复杂的关系引起了人们的极大关注。虽然中枢神经系统长期以来被认为具有免疫特权，但新兴研究揭示了免疫细胞、炎症介质和神经成分之间复杂的相互作用，这些相互作用共同影响着各种神经系统疾病的发病和进展。本文综述了细胞因子白介素-17（IL-17）在神经系统疾病中的重要作用。它研究了IL-17对神经发育和神经退行性疾病的复杂贡献，强调了其多种机制及其对神经免疫串扰的影响。此外，我们评估了支持调节IL-17潜在治疗作用的证据，考虑到其有益和有害的影响。通过对当前研究的综合分析，我们旨在深入了解IL-17在神经系统疾病中的调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animal Cells and Systems 生物-动物学

CiteScore

4.50

自引率

24.10%

发文量

审稿时长

6 months

期刊介绍： Animal Cells and Systems is the official journal of the Korean Society for Integrative Biology. This international, peer-reviewed journal publishes original papers that cover diverse aspects of biological sciences including Bioinformatics and Systems Biology, Developmental Biology, Evolution and Systematic Biology, Population Biology, & Animal Behaviour, Molecular and Cellular Biology, Neurobiology and Immunology, and Translational Medicine.