Angewandte Chemie最新文献_第8页

Outside Front Cover: Click'n ROPISA: One-Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides 外封面：点击'n ROPISA：一锅合成的超亮荧光纳米颗粒制成的多肽

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-08-29 DOI: 10.1002/ange.2026-m2508072800

Amin El Jarroudi Hammou, Juliette Lavainne, Rohit Mangalwedhekar, Jyothis Devasia, Laurent Cognet, Sébastien Lecommandoux, Colin Bonduelle, Chloé Grazon

引用次数: 0

Photoinduzierte Freisetzung maskierter Iridium(III)-Komplexe für die kombinierte photodynamische und photoaktivierte Chemotherapie 光诱导释放掩蔽铱（III）配合物，用于联合光动力和光活化化疗

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-08-12 DOI: 10.1002/ange.9954997

Victoria V. L. Müller, Dominik Moreth, Irene Regeni, Lan Wang, Sylvestre Bonnet, Ulrich Schatzschneider

引用次数: 0

Multidimensional Exploration of Platinum Complexes for Cancer Therapy 铂配合物在癌症治疗中的多维探索

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-08-06 DOI: 10.1002/ange.6256371

Suxing Jin, Xiaoyong Wang

{"title":"Multidimensional Exploration of Platinum Complexes for Cancer Therapy","authors":"Suxing Jin, Xiaoyong Wang","doi":"10.1002/ange.6256371","DOIUrl":"https://doi.org/10.1002/ange.6256371","url":null,"abstract":"<div>\u0000 \u0000 Platinum complexes play an important role in contemporary cancer therapy. The rational design of modern anticancer platinum complexes is largely based on the hallmarks of cancers, such as resistance to cell death, reprogramming of energy metabolism, angiogenesis, metastasis, and immunosuppressive tumor microenvironment (TME). Platinum complexes are evolving from DNA-targeted pure chemotherapeutics to multitarget multifunctional anticancer drugs. Diverse platinum complexes with distinct cellular or molecular targets intervene in cancerous or immune cells through different mechanisms, displaying potent anticancer activities and clinical translation potential. Multimodal platinum complexes that integrate chemotherapy, immunotherapy, photodynamic therapy (PDT), sonodynamic therapy (SDT), or radiotherapy in one molecule provide new options for precise cancer treatment via synergy. This review summarizes a variety of platinum complexes designed according to different mechanisms aiming to improve therapeutic efficacy and minimize side effects of existing platinum drugs. The information is mainly extracted from representative literature published since 2020. These complexes represent the diversified development of platinum anticancer drugs in the present era.\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149099834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside Back Cover: Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication 外封底：前噬菌体激活触发细胞外合成DNA在细菌生物膜通过滚动循环复制

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-09-22 DOI: 10.1002/ange.2026-m1909085800

Gabriel Antonio S. Minero, Line Mørkholt Lund, Lasse Hyldgaard Klausen, Obinna Markraphael Ajunwa, Mingdong Dong, Rikke Louise Meyer, Victoria Birkedal, Kai Thormann

引用次数: 0

Multi-Level Asymmetric Mesoporous Nanochannels for Photothermal-Regulated Dopamine Sensing 光热调节多巴胺传感的多层次非对称介孔纳米通道

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-07-15 DOI: 10.1002/ange.8342567

Abuduheiremu Awati, Xin Zhang, Yeqing Xu, Hui Zeng, Jie Zeng, Chengmin Hu, Runhao Zhang, Yuanbo Song, Huannuo Tao, Lei Xie, Yanjun He, Dazhang Zhu, Mingxian Liu, Kang Liang, Lei Jiang, Biao Kong

{"title":"Multi-Level Asymmetric Mesoporous Nanochannels for Photothermal-Regulated Dopamine Sensing","authors":"Abuduheiremu Awati, Xin Zhang, Yeqing Xu, Hui Zeng, Jie Zeng, Chengmin Hu, Runhao Zhang, Yuanbo Song, Huannuo Tao, Lei Xie, Yanjun He, Dazhang Zhu, Mingxian Liu, Kang Liang, Lei Jiang, Biao Kong","doi":"10.1002/ange.8342567","DOIUrl":"https://doi.org/10.1002/ange.8342567","url":null,"abstract":"<div>\u0000 \u0000 Bioinspired nanochannel systems provide attractive platforms for coupling molecular recognition with ion transport regulation; however, integrating selective binding with efficient signal amplification remains challenging. In this study, we report a multi-level light-responsive asymmetric mesoporous nanochannel constructed via sequential interfacial assembly. The device consists of a dopamine-recognition mesoporous TiO2 (NMTI) layer integrated with a photothermally active mesoporous carbon/γ-Fe2O3 heterostructure on an anodic aluminum oxide scaffold (NMTI/AAO/MC–γ-Fe2O3). Dopamine is selectively captured through strong catechol–Ti coordination accompanied by proton transfer, inducing surface-charge modulation, and ion enrichment within the nanochannels. This recognition process enhances ionic conductance, while the MC–γ-Fe2O3 layer converts optical energy into localized heating, enabling photothermal regulation of ion transport. The synergistic coupling of molecular recognition, surface-charge regulation, and photothermal ion transport enables light-tunable dopamine sensing with an expanded dynamic range and an ultralow detection limit of 10 pM under illumination. The sensing mechanism, spanning molecular adsorption, nanoscale ion redistribution, and macroscopic current amplification, is elucidated through multiscale theoretical analyses, including density functional theory (DFT), molecular dynamics (MD), and finite element simulations. This work establishes a general strategy for integrating molecularly specific recognition and photothermal signal amplification in hierarchical nanochannel systems, providing new design principles for high-performance bioinspired sensing platforms.\u0000 </div>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Click'n ROPISA: One-Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides 点击ROPISA：一锅合成由多肽制成的超亮荧光纳米颗粒

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-07-15 DOI: 10.1002/ange.1373955

Amin El Jarroudi Hammou, Juliette Lavainne, Rohit Mangalwedhekar, Jyothis Devasia, Laurent Cognet, Sébastien Lecommandoux, Colin Bonduelle, Chloé Grazon

{"title":"Click'n ROPISA: One-Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides","authors":"Amin El Jarroudi Hammou, Juliette Lavainne, Rohit Mangalwedhekar, Jyothis Devasia, Laurent Cognet, Sébastien Lecommandoux, Colin Bonduelle, Chloé Grazon","doi":"10.1002/ange.1373955","DOIUrl":"https://doi.org/10.1002/ange.1373955","url":null,"abstract":"Fluorescent nanoparticles are widely used in bioimaging and sensing, yet their preparation relies on multistep synthetic routes that limit scalability and structural control. Here we introduce a one-pot strategy that couples aqueous ring-opening polymerization-induced self-assembly (ROPISA) of γ-propargyl-L-glutamate N-carboxyanhydride with copper-catalyzed azide–alkyne cycloaddition (CuAAC) to produce fluorescent polypeptide nanoparticles. This one-pot “Click'n ROPISA” process enables the simultaneous formation of polypeptide nano-objects and covalent incorporation of diverse azido-functionalized fluorophores. The resulting assemblies exhibit tunable emission across the visible spectrum and are accessible at high solids content while maintaining high brightness and structural uniformity. Dense fluorophore incorporation enables efficient Förster resonance energy transfer (FRET) both within the assemblies and with dye-labeled proteins, supporting sensing applications. The intense brightness of the red-emitting nanoparticles further enables single-particle tracking in microscopy toward advanced bioimaging.","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.1373955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eva Pluhařová

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-08-23 DOI: 10.1002/ange.3525961

Eva Pluhařová

引用次数: 0

Short Sb···Sb Contacts in Polymorphic Tris(p-Tolyl)Antimony: A Hallmark of Organoantimony(III) Solid-State Chemistry? 短Sb···Sb接触在多晶三（p- toyl）锑中：有机锑的标志（III）固态化学？

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-08-12 DOI: 10.1002/ange.5894899

Imogen Suh, Michael Ferguson, Filip Topić, Fu-Qiang Gong, Mihails Arhangelskis, Hatem M. Titi, D. Scott Bohle, Vinko Nemec, Levente Kiss, Andrew J. Morris, Cristian Silvestru, Dominik Cinčić, Tomislav Friščić

{"title":"Short Sb···Sb Contacts in Polymorphic Tris(p-Tolyl)Antimony: A Hallmark of Organoantimony(III) Solid-State Chemistry?","authors":"Imogen Suh, Michael Ferguson, Filip Topić, Fu-Qiang Gong, Mihails Arhangelskis, Hatem M. Titi, D. Scott Bohle, Vinko Nemec, Levente Kiss, Andrew J. Morris, Cristian Silvestru, Dominik Cinčić, Tomislav Friščić","doi":"10.1002/ange.5894899","DOIUrl":"https://doi.org/10.1002/ange.5894899","url":null,"abstract":"Discovery of a polymorph of tris(p-tolyl)antimony(III) reveals solid-state supramolecular dimers connected through short, attractive Sb∙∙∙Sb contacts that, based on theoretical calculations and a systematic screen of the Cambridge Structural Database (CSD), could be an overlooked hallmark of the solid-state and supramolecular chemistry of trivalent organoantimony(III) compounds. While the previously reported crystal structure of tris(p-tolyl)antimony(III) is known to exhibit phenyl embrace motifs, resembling the arsenic or phosphorus analogs, the new polymorph exhibits supramolecular dimers characterized by direct Sb∙∙∙Sb contacts shorter than the sum of the van der Waals radii, and stabilized by a significant dimer dissociation energy of ca. −26 kJ mol−1 established by periodic density-functional calculations. Theoretical analysis indicates that the contacts are attractive and dispersion-dominated, with an overview of the CSD showing that such direct Sb···Sb contacts are not unique to this polymorphic form of tris(p-tolyl)antimony(III) but appear to be a more general feature of trivalent organoantimony in the solid state. Specifically, the CSD shows that dimers based on short Sb···Sb contacts are found across a number of organoantimony structures, including some of the simplest representatives of the series, such as triphenyl- and trimethylantimony, for which the dimer interaction energy is herein calculated to be ca. −13 kJ mol−1.","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.5894899","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seung-Hyeok Kim

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-08-26 DOI: 10.1002/ange.5224426

Seung-Hyeok Kim

引用次数: 0

Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication 前噬菌体激活通过滚动圈复制触发细菌生物膜中DNA的胞外合成

Angewandte Chemie Pub Date : 2026-10-05 Epub Date: 2026-08-26 DOI: 10.1002/ange.3695434

Gabriel Antonio S. Minero, Line Mørkholt Lund, Lasse Hyldgaard Klausen, Obinna Markraphael Ajunwa, Mingdong Dong, Rikke Louise Meyer, Victoria Birkedal, Kai Thormann

{"title":"Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication","authors":"Gabriel Antonio S. Minero, Line Mørkholt Lund, Lasse Hyldgaard Klausen, Obinna Markraphael Ajunwa, Mingdong Dong, Rikke Louise Meyer, Victoria Birkedal, Kai Thormann","doi":"10.1002/ange.3695434","DOIUrl":"https://doi.org/10.1002/ange.3695434","url":null,"abstract":"Extracellular DNA (eDNA) plays crucial roles in biofilm formation and function, yet the role of bacteriophages, which can exist in a dormant state as prophages, in controlling eDNA synthesis, structure, and activity remains obscure. Here, we demonstrate that prophages harbored by environmental bacteria can be exploited for synthesis of programmable eDNA superstructures with a distinct function. We designed a custom circular template and used it to direct rolling circle replication of G-quadruplex (GQ) motifs in Shewanella oneidensis and Bacillus subtilis. Under nutrient-limiting conditions, prophage activation and proliferation triggered cell lysis and subsequent eDNA synthesis, producing multimeric GQ concatemers that self-assembled into spherical (≤10 µm) and wire-like (>50 µm) superstructures in S. oneidensis and B. subtilis, respectively. Real-time monitoring using fluorescent reporter strains revealed that DNA synthesis occurred predominantly after bacterial lysis, coinciding with prophage replication. The resulting eDNA superstructures enhanced the electrochemical properties of S. oneidensis and exhibited peroxidase activity through GQ-hemin DNAzyme formation in S. oneidensis and B. subtilis cocultured biofilm. This work unveils a previously unknown mechanism by which prophages contribute to biofilm architecture and establishes a novel biotechnological platform for engineering functional DNA materials in living bacterial communities with potential applications in synthetic biology.","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":"138 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.3695434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149100480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0