Complement (Basel, Switzerland)最新文献_第2页

Quantification of C3dg/Epstein-Barr virus receptors on human B cells and B cell lines. C3dg/ eb病毒受体在人B细胞和B细胞系上的定量测定。

Complement (Basel, Switzerland) Pub Date : 1988-01-01 DOI: 10.1159/000463040

J M Rasmussen, H V Marquart, R Rask, H H Jepsen, S E Svehag

引用次数: 6

C4-mediated inhibition of immune precipitation and differences in inhibitory action of genetic variants, C4A3 and C4B1. c4介导的免疫沉淀抑制及基因变异C4A3和C4B1抑制作用的差异。

Complement (Basel, Switzerland) Pub Date : 1988-01-01 DOI: 10.1159/000463045

L Paul, V M Skanes, J Mayden, R P Levine

{"title":"C4-mediated inhibition of immune precipitation and differences in inhibitory action of genetic variants, C4A3 and C4B1.","authors":"L Paul, V M Skanes, J Mayden, R P Levine","doi":"10.1159/000463045","DOIUrl":"https://doi.org/10.1159/000463045","url":null,"abstract":"The inhibition of immune precipitation is mediated by the classical complement pathway. We report here that the rate of precipitate formation depends on the genetic form of human C4 present during immune precipitation. C4A3 is more effective than C4B1 in its capacity to inhibit the rate of immune precipitate formation in serum and in serum-free reaction mixtures containing C1 and C4. Immune precipitates form within seconds after antigen is mixed with antibody, and the activation of the classical pathway is known to occur within seconds after C1 binds to antibody molecules. The covalent deposition of C4b on immune complexes is an essential step in the inhibition of immune precipitate formation, and if any of the reactions that lead to covalent C4b deposition become limiting, the rate of immune precipitation could exceed the complement system's inhibitory capacity. Hence, the inhibition of this rate may be an important function underlying the complement-mediated processing of immune complexes, and a decreased ability of the complement system to mediate this process in the presence of C4B1, in contrast to C4A3, could explain, at least in part, the association between the C4A-null phenotype and autoimmune diseases such as systemic lupus erythematosus.","PeriodicalId":77697,"journal":{"name":"Complement (Basel, Switzerland)","volume":"5 3","pages":"110-9"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000463045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14309957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

C4-binding protein prevents spontaneous cleavage of C3 in sera of patients with hereditary angioedema. c4结合蛋白阻止遗传性血管性水肿患者血清中C3的自发裂解。

Complement (Basel, Switzerland) Pub Date : 1988-01-01 DOI: 10.1159/000463026

P Gronski, L Bodenbender, E J Kanzy, F R Seiler

引用次数: 11

Structural basis of the binding specificity of the thioester-containing proteins, C4, C3 and alpha-2-macroglobulin. 含硫酯蛋白、C4、C3和α -2巨球蛋白结合特异性的结构基础。

Complement (Basel, Switzerland) Pub Date : 1988-01-01 DOI: 10.1159/000463039

A W Dodds, S K Law

{"title":"Structural basis of the binding specificity of the thioester-containing proteins, C4, C3 and alpha-2-macroglobulin.","authors":"A W Dodds, S K Law","doi":"10.1159/000463039","DOIUrl":"https://doi.org/10.1159/000463039","url":null,"abstract":"We have previously noted a large difference in the specificity of the covalent binding reaction of human C4-A and C4-B. Here we report data on three other thioester-containing proteins. Human C3 is unreactive with glycine but its reactivity with glycerol (k'/ko = 23.0 M-1) is similar to that of human C4-B (k'/ko = 15.5 M-1). Human alpha 2-macroglobulin reacts with glycine (k'/ko = 206 M-1) in a manner similar to C4-B (k'/ko = 119 M-1) but its reactivity with glycerol (k'/ko = 1.2 M-1) is C4-A like (k'/ko = 1.3 M-1). Mouse C4 is C4-B like in its reaction with both glycine (k'/ko = 136 M-1) and glycerol (k'/ko = 26.0 M-1). Of these proteins, only C4-A shows a very high rate of reaction with glycine (k'/ko = 13,400 M-1). The comparison of the primary structures of these proteins has allowed us to propose the Leu Asp:Ile His substitutions at positions 1105 and 1106 in the human pro-C4 molecule as the residues largely responsible for the binding specificities of these proteins. The Leu:Ile change would not markedly affect the reactivity of these proteins, but may be necessary for allosteric reasons. The Asp in C4-A and His in C4-B seem likely to be the major specificity-defining residues.","PeriodicalId":77697,"journal":{"name":"Complement (Basel, Switzerland)","volume":"5 2","pages":"89-97"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000463039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13600079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Protection against complement-mediated cell damage by Ca2+ and Zn2+. Ca2+和Zn2+对补体介导的细胞损伤的保护。

Complement (Basel, Switzerland) Pub Date : 1988-01-01 DOI: 10.1159/000463048

K J Micklem, G M Alder, C D Buckley, J Murphy, C A Pasternak

引用次数: 18

Molecular basis for the microheterogeneity of human complement factor B. 人补体因子B微异质性的分子基础。

Complement (Basel, Switzerland) Pub Date : 1988-01-01 DOI: 10.1159/000463038

G Garnier, C Davrinche, R Charlionet, M Fontaine

引用次数: 5

Interaction between C3 nephritic factor and erythrocyte membranes. Presence of nephritic factor in patients' erythrocytes. C3肾病因子与红细胞膜的相互作用。患者红细胞中是否存在肾病因子。

Complement (Basel, Switzerland) Pub Date : 1988-01-01 DOI: 10.1159/000463053

M López-Trascasa, M A Marín, G Fontán