Protection against complement-mediated cell damage by Ca2+ and Zn2+.

K J Micklem, G M Alder, C D Buckley, J Murphy, C A Pasternak
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引用次数: 18

Abstract

Ca2+ and Zn2+ prevent antibody-dependent complement-induced permeability changes in tonsil lymphocytes and Lettre cells. Lactate dehydrogenase leaks out from Lettre cells at high complement:cell ratios, under which conditions higher concentrations of Ca2+ and Zn2+ are required for protection. Ca2+ and Zn2+ do not inhibit complement activation or C9 binding to Lettre cells, and prevent leakage through preformed lesions. It is concluded that the extent of complement-induced membrane damage depends on the concentration of extracellular Ca2+, and may be modulated by changes in extracellular Ca2+ or Zn2+.

Ca2+和Zn2+对补体介导的细胞损伤的保护。
Ca2+和Zn2+阻止抗体依赖性补体诱导的扁桃体淋巴细胞和Lettre细胞的通透性变化。乳酸脱氢酶在高补体细胞比例下从字母细胞中泄漏出来,在这种情况下,需要更高浓度的Ca2+和Zn2+来保护。Ca2+和Zn2+不抑制补体激活或C9与letter细胞的结合,并防止通过预先形成的病变渗漏。综上所述,补体诱导的膜损伤程度取决于细胞外Ca2+的浓度,并可能通过细胞外Ca2+或Zn2+的变化来调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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