C3f的结构,C3f是补体第三组分失活时特异性释放的小肽。

R A Harrison, T C Farries, F D Northrop, P J Lachmann, A E Davis
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引用次数: 13

摘要

C3f是一种推测是由因子I和H在液相C3b上共同作用产生的肽,已被分离并测序。该肽有17个残基长,分子量为1847道尔顿。除单个残基外,该氨基末端序列与C3b代iC3b中短暂出现的46千道尔顿多肽的序列相同,并与cDNA分析推断的序列完全一致。此外,高压液相色谱法对因子I消化C3b的结果表明,C3f是iC3b生成过程中唯一释放的肽。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structure of C3f, a small peptide specifically released during inactivation of the third component of complement.

C3f, a peptide presumed to be generated by the combined actions of factors I and H on fluid-phase C3b, has been isolated and sequenced. The peptide is 17 residues long and has a molecular weight of 1,847 daltons. The amino-terminal sequence is, with the exception of a single residue, identical to that deduced for the 46-kilodalton polypeptide seen transiently in the generation of iC3b from C3b, and is in full agreement with the sequence deduced from cDNA analysis. In addition, high-pressure liquid chromatography of the digestion of C3b by factor I has shown that C3f is the sole peptide released during iC3b generation.

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