Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology最新文献_第6页

High incidence of beta-2-microglobulin containing macromolecular complexes in sarcoidosis sera. 含β -2微球蛋白大分子复合物在结节病血清中的高发。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

A Falus, G Glikmann, S E Svehag

引用次数: 0

Characterization of classes of intrathecally synthesized antibodies by imprint immunofixation of electrophoretically separated sera and cerebrospinal fluids. 电泳分离血清和脑脊液印记免疫固定法鉴定鞘内合成抗体的种类。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

F Vartdal, B Vandvik

{"title":"Characterization of classes of intrathecally synthesized antibodies by imprint immunofixation of electrophoretically separated sera and cerebrospinal fluids.","authors":"F Vartdal, B Vandvik","doi":"","DOIUrl":"","url":null,"abstract":"The use of imprint immunofixation (IIF) method to identify IgG, IgA and IgM classes of microbial antibodies in electrophoretically separated sera and cerebrospinal fluids (CSF) is described. The method was applied to the analysis of intrathecal antibody responses in mumps meningitis, subacute sclerosing panencephalitis (SSPE), neurosyphilis and multiple sclerosis (MS). Intrathecally synthesized mumps virus-specific IgG, IgA and IgM antibodies were demonstrated in the CSF of patients with mumps meningitis. The intrathecally synthesized IgG and IgM antibodies displayed oligoclonal characteristics, while the IgA antibodies appeared to be mainly polyclonal. The intrathecal measles antibody responses in SSPE appeared to be confined to IgG antibodies. In neurosyphilis, the intrathecal treponemal antibody response was predominantly of the IgG class, but IgA antibodies were demonstrated in two of nine patients. Intrathecally synthesized IgG antibodies to measles and/or varicella-zoster viruses were demonstrated in 17 of 18 patients with MS; IgA or IgM antibodies to these viruses were not detected.","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 1","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"1983-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17920148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of evidence for granulocyte specific membrane-directed autoantibodies in neutropenic cases of rheumatoid arthritis and in autoimmune neutropenia. 粒细胞特异性膜导向自身抗体在类风湿性关节炎中性粒细胞减少和自身免疫性中性粒细胞减少的病例中缺乏证据。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

J Petersen, A Wiik

{"title":"Lack of evidence for granulocyte specific membrane-directed autoantibodies in neutropenic cases of rheumatoid arthritis and in autoimmune neutropenia.","authors":"J Petersen, A Wiik","doi":"","DOIUrl":"","url":null,"abstract":"With the purpose of detecting granulocyte-specific membrane-directed autoantibodies, IgG was isolated from 14 patients with Felty's syndrome, from 5 patients with rheumatoid arthritis associated with neutropenia, and from 3 rheumatoid factor positive patients with autoimmune neutropenia. By means of indirect immunofluorescence suspensions of leukocytes from healthy controls were tested for their ability to bind whole IgG fractions or F(ab')2 fragments of IgG isolated from the neutropenic patients. By this method, whole IgG preparations from neutropenic patients and normal controls were invariably found to bind to the surface of granulocytes and a minor proportion of lymphocytes. In contrast. F(ab')2 fragments of IgG from the neutropenic patients failed to bind to the surface of granulocytes. Both whole IgG fractions and F(ab')2 fragments displayed displayed antinuclear antibody activity ruling out the possibility of loss of antibody reactivity during the preparation of F(ab')2 fragments. The neutropenia seen in rheumatoid arthritis with or without splenomegaly thus does not seem to be induced by granulocyte-specific membrane-directed IgG autoantibodies, but rather by a non-specific attachment of IgG most probably in immune complex bound form to Fc gamma receptors on neutrophils which thereby acquire surface properties facilitating removal from the circulating blood cell pool.","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"1983-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17406823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complement activation in shock associated with a surgically provoked bacteriaemia. 手术引起的细菌血症引起休克的补体激活。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

I Brandslund, B Teisner, P Hole, J G Grudzinskas, S E Svehag

{"title":"Complement activation in shock associated with a surgically provoked bacteriaemia.","authors":"I Brandslund, B Teisner, P Hole, J G Grudzinskas, S E Svehag","doi":"","DOIUrl":"","url":null,"abstract":"The activation of complement (C) factors in a patient exhibiting an anaphylactoid shock 10 min after the initiation of transurethral coagulation of vesical papillomas was studied. Streptococcus faecalis was cultured from he urine before and after the shock and from the blood on two occasions within 2 days after the shock. The shock was associated with a marked but transient complement activation as judged from serial determinations of C3d and C3c by doubledecker rocket immuno electrophoresis and native C3 and C3c by crossed immuno electrophoresis. Conventional total C3 quantitation by rocket immuno electrophoresis did not reveal the activation. A decrease of native C4 to 20% of normal values and the appearance of C4 split products indicated classical pathway activation. Factor B conversion showed the alternative pathway to be involved as well. Total haemolytic complement activity was temporarily reduced, increasing without reaching normal values within 20 hours. The results indicated that the classical pathway was transiently activated, pointing to an acute antigen-antibody reaction, probably caused by the entrance of bacteria and bacterial products into the circulation of an immunized host.","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 1","pages":"51-7"},"PeriodicalIF":0.0,"publicationDate":"1983-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17659001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and distribution of HLA-DR antigens and Fc gamma receptors in the human thymus. 人胸腺HLA-DR抗原和Fc γ受体的发育和分布。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

N E Gilhus, R Matre

引用次数: 0

Autoantibodies in patients with oral lupus erythematosus, lichen planus and leukoplakia. An aid in diagnosis. 口腔红斑狼疮、扁平苔藓和白斑患者的自身抗体。辅助诊断。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

M Schiødt, H Permin, A Wiik, R Manthorpe

{"title":"Autoantibodies in patients with oral lupus erythematosus, lichen planus and leukoplakia. An aid in diagnosis.","authors":"M Schiødt, H Permin, A Wiik, R Manthorpe","doi":"","DOIUrl":"","url":null,"abstract":"Of 35 patients with oral discoid lupus lesions, 9 (25%) were diagnosed as Systemic (SLE) and 26 as Discoid (dle) lupus erythematosus. Antibodies to whole nuclei (ANAL), dsDNA (anti-DNA ab) and extractable nuclear antigens (anti-RNP ab, anti-Sm ab) as well as serum immunoglobulin levels (Ig) were determined in these patients, in 20 patients with reticular oral lichen planus (LP) and 20 with homogeneous oral leukoplakia (LEUK). High IgG ANA titres were found in the SLE cases, highly increased anti-DNA ab in 6 SLE cases (67%) and one DLE case (4%), slightly increased anti-DNA ab in 9 DLE (35%) but only two (5%) of the LP nd LEUK cases. The prevalence of autoantibodies and increased anti-DNA ab did not differ significantly between DLE cases with oral lesions only and those with cutaneous lesions as well. Increased Ig were present in 6 SLE (67%), 8 DLE (31%), and 3 LEUK (15%) but none of the LP cases. High ANA titres and/or elevated anti-DNA ab disclosed 8 of the 9 SLE and one of 26 DLE cases. Slightly elevated anti-DNA ab and elevated Ig indicated the diagnosis in 9 and 8, respectively, of the 26 DLE cases. It is concluded that determination of ANA, anti-DNA ab and Ig is of diagnostic importance in patients with verified or suspected oral discoid lupus lesions.","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 1","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"1983-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17659002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulocyte specific antinuclear antibodies in ulcerative colitis. Aid in differential diagnosis of inflammatory bowel disease. 溃疡性结肠炎中粒细胞特异性抗核抗体的研究。有助于炎性肠病的鉴别诊断。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

H Nielsen, A Wiik, J Elmgreen

引用次数: 0

Chemotaxis, spreanding nd oxidative metabolism of neutrophils: influence of albumin in vitro. 中性粒细胞的趋化、扩散和氧化代谢:白蛋白在体外的影响。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

N H Valerius

{"title":"Chemotaxis, spreanding nd oxidative metabolism of neutrophils: influence of albumin in vitro.","authors":"N H Valerius","doi":"","DOIUrl":"","url":null,"abstract":"Studies on polymorphonuclear leukocyte (PMN) migration in vitro have shown that albumin increases the speed of the cells without affecting their orientation, i. e. chemokinesis. In order to analyze this phenomenon the effect of albumin on PMN migration in a Boyden chamber towards various chemotactic agents was examined. On attraction with low molecular weight chemotactic factors (a culture filtrate of E. coli (BCF)) or the synthetic peptide N-Formyl-Methionyl-Leucyl-Phenylalanine (F-Met-Leu-Phe) albumin enhanced the migration of PMN. In contrast, albumin did not enhance the migration towards casein, a high molecular weight chemotactic factor, except at very low concentrations. In a direct visual assay, albumin was found to impair PMN spreading on a polystyrene Petri dish. In the presence of BCF or F-Met-Leu-Phe cell spreading remained inversely related to the concentration of albumin, while addition of casein again eliminated the influence of albumin. The effect of albumin on the interaction of PMN with a substrate was studied by measuring the superoxide anion (02-) release by PMN sedimenting on a micropore filter. The 02- release triggered by this stimulus of the PMN membrane was inversely correlated to the concentration of albumin. These results show that one mechanism of the enhancing effect of albumin on PMN migration is to diminish adhesion of the cells to the substratum, so that it remains reversible. It is suggested that the term chemokinesis is equivocal. The chemokinetic activity of chemotactic factors would be the result of specific stimulation of PMN locomotion. In contrast, the chemokinetic activity of albumin is due to changes of the physico-chemical environment which support PMN locomotion.","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 1","pages":"43-9"},"PeriodicalIF":0.0,"publicationDate":"1983-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17368473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of fetal calf serum on the results of the E rosette test. 胎牛血清对E型玫瑰花试验结果的影响。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

A Naess

引用次数: 0

Heterogeneity in electrophoretic mobility of C3-derived molecules expressing D but not C-epitopes following in vivo activation of the complement system. 补体系统激活后，表达D而不表达c表位的c3衍生分子的电泳迁移率的异质性。

Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-02-01

B Teisner, I Brandslund, J Hau, S E Svehag

引用次数: 0