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Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology最新文献

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Effect of antimalarial drugs on human neutrophil chemotaxis in vitro. 抗疟药物对体外人中性粒细胞趋化性的影响。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-08-01
A Kharazmi, N H Valerius, N Høiby
{"title":"Effect of antimalarial drugs on human neutrophil chemotaxis in vitro.","authors":"A Kharazmi,&nbsp;N H Valerius,&nbsp;N Høiby","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of several antimalarial drugs, commonly used for prophylaxis and therapy of human malaria, on polymorphonuclear leukocyte chemotaxis was studied. A modified, reversible Boyden chamber method was used. Various concentrations of each drug was mixed with neutrophils and incubated in the chambers for 2 1/2 hours. After the incubation period percent inhibition of chemotaxis was determined. It was shown that chloroquine, quinine, proguanil, and tetracycline at concentrations frequently obtained in clinical situations significantly inhibited chemotaxis of neutrophils towards casein. There was a direct correlation between increasing drug concentration and percent inhibition of chemotaxis. Drugs such as pyrimethamine and fansidar at any concentration tested had no effect on chemotaxis.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 4","pages":"293-8"},"PeriodicalIF":0.0,"publicationDate":"1983-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17693558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of two strains of selectively bred guinea-pigs. 2. Differences in immune response to synthetic polypeptides. 两株选择性培育豚鼠的特性。2. 合成多肽免疫反应的差异。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-06-01
L Lundberg, C Koch, M Magnusson, C Bertelsen
{"title":"Characterization of two strains of selectively bred guinea-pigs. 2. Differences in immune response to synthetic polypeptides.","authors":"L Lundberg,&nbsp;C Koch,&nbsp;M Magnusson,&nbsp;C Bertelsen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two strains of guinea-pigs selectively bred for either high (IMM/S) or low (IMM/R) responsiveness to ovalbumin-induced respiratory anaphylaxis were examined for their immune response to a copolymer of L-glutamic acid and L-alanine (GA), a copolymer of L-glutamic acid and L-tyrosine (GT), and to a dinitro-phenyl derivative of a homopolymer of L-lysine (DNP-PLL). Considerable differences between the strains in development of cellular hypersensitivity and in the production of antibodies were observed. Guinea-pigs from IMM/S were all responders to GA and DNP-PLL and non-responders to GT, while guinea-pigs from two of three lines from IMM/R were responders to GT and non-responders to GA and DNP-PLL. The third IMM/R line showed an immune response pattern similar to guinea-pigs of strain IMM/S. Preliminary breeding studies confirmed that the immune response to these three antigens is under the control of dominant autosomal genes, since (IMM/S x IMM/R) F1 animals responded to all three antigens. It is concluded that these three antigens may serve as immune response markers in genetic studies of the differences between guinea-pigs from IMM/S and IMM/R in their ability to develop respiratory anaphylaxis.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 3","pages":"187-95"},"PeriodicalIF":0.0,"publicationDate":"1983-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17258033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The determination of natural killer activity of human peripheral blood lymphocytes by measuring the DNA-synthesis of proliferating target cells (K 562 cell line). 通过测定增殖靶细胞(k562细胞系)dna合成来测定人外周血淋巴细胞的自然杀伤活性。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-06-01
K Huttunen, J Ilonen
{"title":"The determination of natural killer activity of human peripheral blood lymphocytes by measuring the DNA-synthesis of proliferating target cells (K 562 cell line).","authors":"K Huttunen,&nbsp;J Ilonen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Natural killer (NK) activity of human peripheral blood lymphocytes was determined by measuring 3H-thymidine incorporation into proliferating highly NK-sensitive K 562 target cells alone and in the presence of effector cells. Although the absolute figures varied, depending mostly on the strength of DNA-synthesis of the target cells on the day of the assay, the results were highly reproducible and compared well with those of the 51Cr-release assay (CRA). The method was extremely simple and less tedious than CRA. The interpretation of the data was facilitated by including known control cells of low and high NK activity. The cells less sensitive to NK activity did not seem to be suited for this kind of assay.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 3","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"1983-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17929775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HLA-DR antigens and Fc gamma receptors in fetal and infant thymus, examined by a double-marker technique. 用双标记技术检测胎儿和婴儿胸腺HLA-DR抗原和Fc γ受体。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-06-01
N E Gilhus, R Matre
{"title":"HLA-DR antigens and Fc gamma receptors in fetal and infant thymus, examined by a double-marker technique.","authors":"N E Gilhus,&nbsp;R Matre","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>HLA-DR antigens and receptors for the Fc part of IgG (Fc gamma R) were examined in cryostat sections and imprints of 12 thymuses from fetuses, infants and children. A double-marker technique, with an anti-T cell serum produced in rabbit and the monoclonal antibody OKIal, was used to study the localization of the thymocytes and the HLA-DR antigens. Membrane-bound HLA-DR antigens were found on about 5% of the thymocytes. A larger proportion of the thymocytes were surrounded by HLA-DR-positive material, probably associated with the thymic epithelial cells. Fc gamma R detected by human aggregated IgG were found on most epithelial cells, but only on a few thymocytes. However, in some areas Fc gamma R were demonstrated on most of the cells stained by the anti-T cell serum. A similar pattern for staining of Fc gamma R was obtained using an anti-Fc gamma R serum produced in rabbit. Fc gamma R were detected on one-third to one-half of the OKT3+ or OKT8+ thymocytes, but only on a few OKT4+ cells. Fc gamma R were present on nearly all the OKT6+ thymocytes at 11 weeks of gestation, whereas in thymuses from older individuals only a few OKT6+ cells had Fc gamma R. The proportions of double-stained cells did not vary much in fetuses older than 14 weeks of gestation, in infants or in children. The results indicate that HLA-DR antigens and Fc gamma R are not correlated to any specific stage of cell maturation.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 3","pages":"227-32"},"PeriodicalIF":0.0,"publicationDate":"1983-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17287181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proliferative human T cell responses to Chlamydia trachomatis in vitro. 增殖性人T细胞对沙眼衣原体的体外反应。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-06-01
E Qvigstad, K Skaug, E Thorsby
{"title":"Proliferative human T cell responses to Chlamydia trachomatis in vitro.","authors":"E Qvigstad,&nbsp;K Skaug,&nbsp;E Thorsby","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The T cell proliferative response to Chlamydia trachomatis was studied in otherwise healthy persons. A suspension of partially purified C. trachomatis subtype LGV-2 particles was used throughout the study. Studies of cord blood lymphocytes demonstrated that the preparation was not mitogenic. The proliferative capacity of peripheral blood mononuclear cells (PBM) and T + non-T cells from adults was tested; in about 70% a proliferative response was observed. The proliferative responses were dependent upon antigen presenting cells (APC) and were mainly mediated by T cells, even though B cells proliferated to a lesser extent. Using antigen-pulsed non-T cells as APC, a significant and consistent specific proliferative response could be obtained. High responders could be separated from low responders with different T cell concentrations. We also found that the T cell response was restricted by the HLA-D/DR determinants of the T cell donor.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 3","pages":"203-9"},"PeriodicalIF":0.0,"publicationDate":"1983-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17659674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human monocyte-mediated antibody dependent cytotoxicity to K-562 cells: an electron microscopic study. 人单核细胞介导的抗体对K-562细胞的依赖性细胞毒性:电镜研究。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-06-01
T Espevik, J Hammerstrøm
{"title":"Human monocyte-mediated antibody dependent cytotoxicity to K-562 cells: an electron microscopic study.","authors":"T Espevik,&nbsp;J Hammerstrøm","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Human monocyte-mediated antibody dependent cytotoxicity (ADCC) to K-562 cells has been examined using 51Cr-release assays and electron microscopy. Non-activated monocytes lysed antibody-coated K-562 cells rapidly, the observed lysis reaching a constant level of 28% after 6 h of co-culture. Lymphokine-activated monocytes mediated ADCC with a similar time course but with higher cytolysis level (42%) compared to non-activated monocytes. The cytolysis was dependent on the amount of antibody on the K-562 cells and on the number of effector cells present in the assay. Scanning electron microscopy revealed that sensitized target cells in contact with monocytes lost their microvilli. Lysis was probably extracellular, but a small number of completely engulfed intact target cells were observed. Lymphokine-activation of the monocytes led to a dissociation of the phagocytic and cytotoxic activity, indicating that phagocytosis is not directly involved in ADCC. Thin section- and freeze-fracture electron microscopy of the contact area between effector and target cells revealed no membrane specializations. The cells were always separated by a gap of 20-30 nm interrupted by characteristic invaginations in the opposing plasma membranes.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 3","pages":"211-9"},"PeriodicalIF":0.0,"publicationDate":"1983-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17929776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of two strains of selectively bred guinea-pigs. I. Skin transplantation experiments and screening for erythrocyte enzyme polymorphism. 两株选择性培育豚鼠的特性。1 .皮肤移植实验及红细胞酶多态性筛选。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-06-01
M Sørensen, P N Jørgensen, L Lundberg
{"title":"Characterization of two strains of selectively bred guinea-pigs. I. Skin transplantation experiments and screening for erythrocyte enzyme polymorphism.","authors":"M Sørensen,&nbsp;P N Jørgensen,&nbsp;L Lundberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two strains of guinea-pigs selectively bred for either high (IMM/S) or low (IMM/R) responsiveness to ovalbumin-induced respiratory anaphylaxis were examined for genetic homogenicity by skin transplantation experiments and screened for polymorphism of erythrocyte enzymes (alkaline phosphatase, carbonic anhydrase, esterase D, and phosphoglucomutase). According to the transplantation data it can be concluded that the brother x sister matings have resulted in lines of guinea-pigs with a high degree of genetic homogenicity. The results from the typing of polymorphic enzymes showed that only phosphoglucomutase exhibited different allelic forms among the tested animals, but no correlation was found between this polymorphism and responsiveness to ovalbumin.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 3","pages":"181-5"},"PeriodicalIF":0.0,"publicationDate":"1983-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17287180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of long-term treatment of rats with ethanol, carbon tetrachloride and high fat-low protein diet on the Kupffer cell distribution with reference to chemical composition of the liver. 乙醇、四氯化碳和高脂低蛋白饮食长期治疗大鼠对库普弗细胞分布的影响(参考肝脏化学成分)
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-06-01
E Kulonen, K Kari, K Franssila
{"title":"Effects of long-term treatment of rats with ethanol, carbon tetrachloride and high fat-low protein diet on the Kupffer cell distribution with reference to chemical composition of the liver.","authors":"E Kulonen,&nbsp;K Kari,&nbsp;K Franssila","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rats were treated for 3-4 months with ethanol or carbon tetrachloride or kept on a high fat-low protein diet. The cell distribution of the liver was investigated with special emphasis on the Kupffer cells with reference to lipids and collagen. Lipids were increased both histologically and chemically in all groups treated. All three treatments caused an increase of Kupffer cells, especially in the high fat-low protein group. The number of Kupffer cells and the content of liver lipids were strongly correlated. Collagen rose in the CCl4- and high fat-low protein groups. Cirrhosis was observed in CCl4--treated rats only.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 3","pages":"221-5"},"PeriodicalIF":0.0,"publicationDate":"1983-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17929777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complement components in 100 newborns and their mothers determined by electroimmunoassay. 用电免疫分析法测定100例新生儿及其母亲的补体成分。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-04-01
U Johnson, L Truedsson, B Gustavii
{"title":"Complement components in 100 newborns and their mothers determined by electroimmunoassay.","authors":"U Johnson,&nbsp;L Truedsson,&nbsp;B Gustavii","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Samples of blood were obtained from 100 healthy full-term women in labour and, after delivery, from the umbilical cord of their infants. By electroimmunoassay, complement components were quantitated in serum (C1q, C1r, C1s, C1 IA, C2, P, D. I, H, C6 and C7) or in EDTA-plasma (C4, C3, B, C5. and C). The concentrations of C7 in cord serum was twice that found by others using a functional assay. Concentrations of C1r, I and C6 in the cord sample were 50-60 per cent of those in healthy blood donors used as reference, and that of D was about 130 per cent. The cord serum and plasma concentrations of the remaining components agreed with previously reported values. The maternal levels of C2, C4, C3, B, H, C5 were 40-60 per cent higher than those of the reference.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 2","pages":"147-50"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17408694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antigen-specific lymphocyte transformation in patients with recent yersiniosis. 近期耶尔森菌病患者抗原特异性淋巴细胞转化。
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Pub Date : 1983-04-01
R Vuento
{"title":"Antigen-specific lymphocyte transformation in patients with recent yersiniosis.","authors":"R Vuento","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphocyte transformation in patients with recent yersiniosis was studied. A micromethod using washed blood cells and Yersinia enterocolitica antigen was employed. The washed blood cells were incubated in the presence of various dilutions of heat-treated whole bacteria; these proved as antigen superior to gentamicin- or formalin-treated bacteria. Patients with recent yersiniosis had a significantly higher response against Yersinia antigen as compared to 20 healthy controls, who had either no response or a low response. No difference could be observed in responses against PPD or streptokinase-streptodornase, or in the mitogen responses between these two groups. A marked cross-reaction was observed between Yersinia and Escherichia coli antigen. The results show that patients with recent yersiniosis develop lymphocyte transformation response against Yersinia. Lymphocyte transformation test can be used in the study of host responses against infecting Yersinia in patients with different clinical pictures of yersiniosis.</p>","PeriodicalId":77653,"journal":{"name":"Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology","volume":"91 2","pages":"89-93"},"PeriodicalIF":0.0,"publicationDate":"1983-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17258032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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