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The Journal of diabetic complications最新文献

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One-day survey of albuminuria in diabetic outpatients in Fukuoka prefecture, Japan 日本福冈县糖尿病门诊患者蛋白尿的为期一天的调查
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90054-S
R. Nomiyama, K. Nunoi, N. Tsutsu, Y. Satho, H. Yoshizumi, H. Himeno, Y. Nakamura, M. Fujishima, Fukuoka Diabetic Clinic Group
{"title":"One-day survey of albuminuria in diabetic outpatients in Fukuoka prefecture, Japan","authors":"R. Nomiyama,&nbsp;K. Nunoi,&nbsp;N. Tsutsu,&nbsp;Y. Satho,&nbsp;H. Yoshizumi,&nbsp;H. Himeno,&nbsp;Y. Nakamura,&nbsp;M. Fujishima,&nbsp;Fukuoka Diabetic Clinic Group","doi":"10.1016/0891-6632(91)90054-S","DOIUrl":"10.1016/0891-6632(91)90054-S","url":null,"abstract":"<div><p>The prevalences and risk factors of micro- and macroalbuminuria were surveyed in all 927 patients with diabetes mellitus who visited outpatient clinics in 27 hospitals in the Fukuoka prefecture on a designated day. The urinary albumin-creatinine ratio (UAI; mg/g Cr) of spot urine was determined in all patients except those with persistent macroproteinuria. The results were as follows: (1) The prevalences of microalbuminuria (UAI 30–299) and macroalbuminuria (UAI ≥ 300) were 26% and 15%, respectively. (2) Hyperglycemia and high blood pressure synergistically increased the prevalences. (3) The independent risk factors of microalbuminuria were severities of retinopathy and neuropathy, duration of diabetes, blood pressure, and HbA<sub>1c</sub>, as determined by logistic regression analysis, although the explanation rate was low.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 155-156"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90054-S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
The etiology of microalbuminuria in early non-insulin-dependent diabetes mellitus 早期非胰岛素依赖型糖尿病患者微量白蛋白尿的病因分析
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90035-N
Fukashi Ishibashi, Kazufumi Ishida, Seiryo Takashina
{"title":"The etiology of microalbuminuria in early non-insulin-dependent diabetes mellitus","authors":"Fukashi Ishibashi,&nbsp;Kazufumi Ishida,&nbsp;Seiryo Takashina","doi":"10.1016/0891-6632(91)90035-N","DOIUrl":"10.1016/0891-6632(91)90035-N","url":null,"abstract":"<div><p>Glomerular or tubular contribution for microalbuminuria was estimated by assessing albumin excretion rate (AER) in glomerular urine obtained by <span>l</span>-arginine infusion (AI) and glomerular filtration rate (GFR) in 20 non-insulin-dependent diabetes mellitus (NIDDM) patients before and after glycemic control, and in 19 age-matched controls. Glycemic control normalized AER during AI, while it decreased AER before AI, though it was still above normal. Glycemic control increased tubular reabsorption rate of albumin, but it was still less than normal. Tubular reabsorption rate of albumin declined in close relation with duration of diabetes mellitus, while AER in glomerular urine had no correlation with the duration. GFR had no correlation with AER before or during AI. In conclusion, impaired tubular reabsorption of albumin plays a key role for microalbuminuria in NIDDM.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 107-109"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90035-N","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Beneficial effect of alacepril, a new angiotensin-converting enzyme inhibitor on albuminuria and glycemic state: An open multicenter trial 新型血管紧张素转换酶抑制剂阿拉西普利对蛋白尿和血糖状态的有益影响:一项开放的多中心试验
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90059-X
K. Utsunomiya, Y. Ikeda, Alacepril Study Group
{"title":"Beneficial effect of alacepril, a new angiotensin-converting enzyme inhibitor on albuminuria and glycemic state: An open multicenter trial","authors":"K. Utsunomiya,&nbsp;Y. Ikeda,&nbsp;Alacepril Study Group","doi":"10.1016/0891-6632(91)90059-X","DOIUrl":"10.1016/0891-6632(91)90059-X","url":null,"abstract":"<div><p>Alacepril is a new angiotensin-converting enzyme (ACE) inhibitor that possesses sympatho-inhibitory action. We evaluated the effect of alacepril on blood pressure and progression of diabetic nephropathy in hypertensive type II diabetics in an open multicenter trial. Eighty-nine type II diabetics with mild hypertension were treated with 50 mg of alacepril daily and observed for 12 weeks. Blood pressure was reduced significantly at 4 weeks; this reduction continued throughout the study. Urinary excretion of albumin also was reduced significantly at 12 weeks. Glycosylated hemoglobin (HbA<sub>1c</sub>) and serum total cholesterol showed significant reduction with alacepril. We confirmed the beneficial effect of alacepril on blood pressure and diabetic nephropathy, and found that glucose and lipid metabolism improves in the diabetic state with this ACE inhibitor.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 165-166"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90059-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Changes in glomerular extracellular matrices components in diabetic nephropathy 糖尿病肾病肾小球细胞外基质成分的变化
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90068-Z
Shuji Ikeda, Hirofumi Makino, Toshinori Haramoto, Kenichi Shikata, Isao Kumagai, Zensuke Ota
{"title":"Changes in glomerular extracellular matrices components in diabetic nephropathy","authors":"Shuji Ikeda,&nbsp;Hirofumi Makino,&nbsp;Toshinori Haramoto,&nbsp;Kenichi Shikata,&nbsp;Isao Kumagai,&nbsp;Zensuke Ota","doi":"10.1016/0891-6632(91)90068-Z","DOIUrl":"10.1016/0891-6632(91)90068-Z","url":null,"abstract":"<div><p>The changes in glomerular extracellular matrices components in diabetic nephropathy were investigated. Indirect immunofluorescence staining, using polyclonal antibodies to heparan sulfate proteoglycan (HS-PG), laminin, type IV collagen, and fibronectin was carried out on renal specimens obtained by needle biopsy. Immunofluorescence intensity and distribution were observed. HS-PG and laminin decreased in the capillary walls; on the other hand, type IV collagen and fibronectin tended to increase in the mesangial area. HS-PG and laminin decreased in inverse proportion to sclerosis grades and proteinuria. These changes seemed to play an important role in progression of diabetic glomerulosclerosis.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 186-188"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90068-Z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Risk factors for development of proteinuria in NIDDM analyzed by poisson regression 用泊松回归分析NIDDM患者蛋白尿的危险因素
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90043-O
Masatoshi Kikuchi , Toeko Matsumoto , Yasuo Ohashi
{"title":"Risk factors for development of proteinuria in NIDDM analyzed by poisson regression","authors":"Masatoshi Kikuchi ,&nbsp;Toeko Matsumoto ,&nbsp;Yasuo Ohashi","doi":"10.1016/0891-6632(91)90043-O","DOIUrl":"10.1016/0891-6632(91)90043-O","url":null,"abstract":"<div><p>To clarify the time dependency of risk factors for the development of diabetic nephropathy, we applied Poisson regression to the analysis of 7167 person-year data in 1447 patients with non-insulin-dependent diabetes mellitus (NIDDM) who were initially free of proteinuria. Significant predictors were found to be annual mean fasting blood glucose (FBG) level, male gender, duration, and age at diagnosis. Hyperglycemia was more influential, while duration was less in the previous year of development of proteinuria than at the initial visit. When more information during longer-year data was used as average, the contribution of FBG level was enhanced. Current age was less associated than was age at diagnosis. Thus, Poisson regression seems to be useful for the analysis of risk variables in chronic diseases.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 128-130"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90043-O","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Recent advance in the treatment of diabetic nephropathy: Low-protein diet 糖尿病肾病治疗的新进展:低蛋白饮食
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90027-M
GianCarlo Viberti
{"title":"Recent advance in the treatment of diabetic nephropathy: Low-protein diet","authors":"GianCarlo Viberti","doi":"10.1016/0891-6632(91)90027-M","DOIUrl":"10.1016/0891-6632(91)90027-M","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Page 87"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90027-M","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Recent advance in the treatment of diabetic nephropathy: Angiotensin I converting enzyme (ACE) inhibitors 糖尿病肾病治疗的最新进展:血管紧张素I转换酶(ACE)抑制剂
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90029-O
Michel Marre
{"title":"Recent advance in the treatment of diabetic nephropathy: Angiotensin I converting enzyme (ACE) inhibitors","authors":"Michel Marre","doi":"10.1016/0891-6632(91)90029-O","DOIUrl":"10.1016/0891-6632(91)90029-O","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Page 91"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90029-O","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical significance of urinary enzymes in diabetic nephropathy 尿酶在糖尿病肾病中的临床意义
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90056-U
Emiko Morita , Kazo Kaizu , Kohei Uriu , Osamu Hashimoto , Norikuni Komine , Sumiya Eto
{"title":"Clinical significance of urinary enzymes in diabetic nephropathy","authors":"Emiko Morita ,&nbsp;Kazo Kaizu ,&nbsp;Kohei Uriu ,&nbsp;Osamu Hashimoto ,&nbsp;Norikuni Komine ,&nbsp;Sumiya Eto","doi":"10.1016/0891-6632(91)90056-U","DOIUrl":"10.1016/0891-6632(91)90056-U","url":null,"abstract":"<div><p>Urinary enzyme activities (<em>N</em>-acetyl-β-<span>d</span>-glucosaminidase [NAG], alkaline phosphatase [ALP], leucine aminopeptidase [LAP], γ-glutamyl transpeptidase [γ-GTP]) were investigated to determine their clinical significance in diabetic nephropathy. There were correlations among ALP, LAP, and γ-GTP, though no correlation existed between NAG and the other three enzymes. Activities of NAG isozymes (both A and B) were higher than in normal controls. It has been reported that NAG isozyme A might be associated with glomerular diseases, and isozyme B might be associated with proximal tubular damage. The results of our study suggest that NAG reflects lysosomal dysfunction of both glomerular and proximal tubular epithelial cells, which may be caused by poor glycemic control, and that ALP, LAP, and γ-GTP reflect brush border damage of proximal tubules, which may be caused by diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 158-159"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90056-U","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12850389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Effect of proteinase inhibitor Camostat Mesilate on nephrotic syndrome with diabetic nephropathy 蛋白酶抑制剂甲磺酸卡莫他对肾病综合征合并糖尿病肾病的影响
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90060-3
T. Onbe, H. Makino, I. Kumagai, T. Haramoto, K. Murakami, Z. Ota
{"title":"Effect of proteinase inhibitor Camostat Mesilate on nephrotic syndrome with diabetic nephropathy","authors":"T. Onbe,&nbsp;H. Makino,&nbsp;I. Kumagai,&nbsp;T. Haramoto,&nbsp;K. Murakami,&nbsp;Z. Ota","doi":"10.1016/0891-6632(91)90060-3","DOIUrl":"10.1016/0891-6632(91)90060-3","url":null,"abstract":"<div><p>The effect of serine protease inhibitor Camostat Mesilate on nephrotic syndrome with diabetic nephropathy was evaluated. Eight patients with nephrotic syndrome associated with diabetic nephropathy were orally administered 600 mg of Camostat Mesilate per day. Three patients showed a reduction of urinary protein excretion promptly at 4 weeks. Serum protein and degree of edema improved significantly at 4 weeks. Camostat Mesilate had no effect on renal function assessed by creatinine clearance. During the observation period there were no significant changes in blood pressure, level of blood sugar, or HbA<sub>1</sub>c. Camostat Mesilate would be beneficial for the treatment of diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 167-168"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90060-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of a somatostatin analogue (SMS 201–995) on renal function and urinary protein excretion in diabetic rats 生长抑素类似物(SMS 201-995)对糖尿病大鼠肾功能和尿蛋白排泄的影响
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90066-X
Kazumasa Igarashi, Asao Nakazawa, Nagayuki Tani, Masatoshi Yamazaki, Seiki Ito, Akira Shibata
{"title":"Effect of a somatostatin analogue (SMS 201–995) on renal function and urinary protein excretion in diabetic rats","authors":"Kazumasa Igarashi,&nbsp;Asao Nakazawa,&nbsp;Nagayuki Tani,&nbsp;Masatoshi Yamazaki,&nbsp;Seiki Ito,&nbsp;Akira Shibata","doi":"10.1016/0891-6632(91)90066-X","DOIUrl":"10.1016/0891-6632(91)90066-X","url":null,"abstract":"<div><p>We evaluated the effect of a somatostatin analogue (SMS 201–995) on diabetic nephropathy using urinary albumin excretion as a marker in a streptozocin-induced diabetic unilateral nephrectomized rat model. Nondiabetic rats were injected with either 0.9% sodium chloride (NaCl) (n = 10) or SMS (n = 10). Diabetic rats were also injected with either 0.9% NaCl (n = 10) or SMS (n = 10). The control saline and SMS groups showed significant increases in urinary albumin excretion (UAE) and albumin clearance. The diabetic saline-treated rats showed no significant changes in UAE or albumin clearance. The diabetic SMS-treated rats showed significant decreases in UAE (151 ± 76 mg/day/kg to 98 ± 46, <em>P</em> &lt; .005) and albumin clearance (5.85 ± 3.34 mL/day/kg to 3.63 ± 1.73, <em>P</em> &lt; .01). There was no significant difference in kidney weight between the two control groups, but a significant difference was found between the two diabetic groups (3.35 ± 0.39 g vs. 2.68 ± 0.26 g, <em>P</em> &lt; .001). The results suggest that in early diabetes with renal hyperfiltration and hypertrophy, the administration of SMS may prevent progression to late diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 181-183"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90066-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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