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The Journal of diabetic complications最新文献

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Introductory notes on diabetic nephropathy: A diabetologist's view 糖尿病肾病导论:糖尿病专家的观点
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90013-F
Harry Keen (Emeritus Professor)
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引用次数: 0
Kidney disease of diabetes mellitus (diabetic nephropathy): Perspectives in the United States 糖尿病肾病(糖尿病肾病):在美国的观点
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90014-G
Gary E. Striker , Lawrence L. Agodoa , Phillip Held , Toshio Doi , Francesco Conti , Liliane J. Striker
{"title":"Kidney disease of diabetes mellitus (diabetic nephropathy): Perspectives in the United States","authors":"Gary E. Striker , Lawrence L. Agodoa , Phillip Held , Toshio Doi , Francesco Conti , Liliane J. Striker","doi":"10.1016/0891-6632(91)90014-G","DOIUrl":"10.1016/0891-6632(91)90014-G","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 51-52"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90014-G","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
The molecular biologic study of the expression of thrombospondin in vascular smooth muscle cells and mesangial cells 血栓反应蛋白在血管平滑肌细胞和系膜细胞表达的分子生物学研究
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90040-V
Sentaro Kobayashi , Tadashi Yamamoto
{"title":"The molecular biologic study of the expression of thrombospondin in vascular smooth muscle cells and mesangial cells","authors":"Sentaro Kobayashi ,&nbsp;Tadashi Yamamoto","doi":"10.1016/0891-6632(91)90040-V","DOIUrl":"10.1016/0891-6632(91)90040-V","url":null,"abstract":"<div><p>Thrombospondin (TS) is a high-molecular-weight glycoprotein (MW 450,000) that is stored in alpha-granules of platelets and secreted by a wide variety of mesenchymal cells, including vascular smooth muscle cells (SMCs) and mesangial cells. TS binds to cell surfaces and to matrix macromolecules such as collagen, fibronectin, and heparin (heparan sulfate). We have isolated one of the complementary DNA (cDNA) clones of TS from human endothelial cell cDNA libraries. With the TS cDNA as a probe, we used Northern blot analysis to look at TS messenger RNA (mRNA) levels of rat aortic SMCs in a quiescent state and cultured under different stimuli. Treatment with platelet-derived growth factor (PDGF) caused a rapid increase of TS mRNA at 2 to 4 hours. This induction was enhanced by the addition of cycloheximide, suggesting that the induction of TS by PDGF does not require the synthesis of new protein species. Transforming growth factor beta (TGF-β) also induced mRNA of TS at 8 hours after stimulation and the induction was blocked by cycloheximide, suggesting that TGF-β requires the mediation of new protein synthesis to induce a TS gene. In measangial cells, we observed the same type of gene expression of TS using an in-situ hybridization study. We conclude that during SMC and mesangial cell proliferation, the induction of TS mRNA is regulated in a specific manner by PDGF and TGF-β.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 121-123"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90040-V","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Structural-functional relationships in type I insulin-dependent diabetes mellitus in humans 人类I型胰岛素依赖型糖尿病的结构-功能关系
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90021-G
Pascale Lane , Michael W. Steffes , S.Michael Mauer
{"title":"Structural-functional relationships in type I insulin-dependent diabetes mellitus in humans","authors":"Pascale Lane ,&nbsp;Michael W. Steffes ,&nbsp;S.Michael Mauer","doi":"10.1016/0891-6632(91)90021-G","DOIUrl":"10.1016/0891-6632(91)90021-G","url":null,"abstract":"<div><p>The major renal pathologic changes of diabetes include thickening of all renal extracellular basement membranes and mesangial matrix and, to a lesser extent, mesangial cell expansion. Two renal lesions appear critical in diabetic nephropathy. Mesangial expansion out of proportion to the size of the glomerulus is closely and inversely related to measures of peripheral capillary wall filtration surface and to clinical features of proteinuria, hypertension, and decreasing glomerular filtration rate (GFR). Arteriolar hyalinosis is related to global glomerulosclerosis, and both are correlated with the clinical features of nephropathy. These lesions are markedly advanced by the time renal dysfunction is clinically detectable. Relationships of structure and function early in the course of the diabetes have not been examined satisfactorily.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 69-71"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90021-G","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Recent progress in the treatment of diabetic nephropathy: Importance of strict glycemic control on the regression of diabetic nephropathy 糖尿病肾病治疗的最新进展:严格控制血糖对糖尿病肾病病情好转的重要性
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90028-N
Ryuzo Kawamori, Keiji Kamado, Takenobu Kamada
{"title":"Recent progress in the treatment of diabetic nephropathy: Importance of strict glycemic control on the regression of diabetic nephropathy","authors":"Ryuzo Kawamori,&nbsp;Keiji Kamado,&nbsp;Takenobu Kamada","doi":"10.1016/0891-6632(91)90028-N","DOIUrl":"10.1016/0891-6632(91)90028-N","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 88-90"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90028-N","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Recent advance in the treatment of diabetic nephropathy: Anticoagulant therapy 糖尿病肾病治疗的最新进展:抗凝治疗
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90030-S
Kazo Kaizu , Kohei Uriu , Osamu Hashimoto , Sumiya Eto
{"title":"Recent advance in the treatment of diabetic nephropathy: Anticoagulant therapy","authors":"Kazo Kaizu ,&nbsp;Kohei Uriu ,&nbsp;Osamu Hashimoto ,&nbsp;Sumiya Eto","doi":"10.1016/0891-6632(91)90030-S","DOIUrl":"10.1016/0891-6632(91)90030-S","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 92-94"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90030-S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Clinical significance of urinary laminin P1 in diabetic patients 尿层粘连蛋白P1在糖尿病患者中的临床意义
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90073-X
Chiaki Nakajima , Nobuo Shimojo , Kei-ichi Naka , Kiyoshi Okuda , Masaki Yamamoto , Satoru Fujii
{"title":"Clinical significance of urinary laminin P1 in diabetic patients","authors":"Chiaki Nakajima ,&nbsp;Nobuo Shimojo ,&nbsp;Kei-ichi Naka ,&nbsp;Kiyoshi Okuda ,&nbsp;Masaki Yamamoto ,&nbsp;Satoru Fujii","doi":"10.1016/0891-6632(91)90073-X","DOIUrl":"10.1016/0891-6632(91)90073-X","url":null,"abstract":"<div><p>The urinary concentrations of laminin fragment P1 (L-P1), a major component of laminin, were determined in diabetic patients without diabetic nephropathy and healthy controls. In the control subjects, urinary L-P1 increased with age, especially over 60 years of age. A significant increase of urinary L-P1 was observed in diabetics aged less than 50 years. Neither urinary albumin nor <em>N</em>-acetyl-β-<span>d</span>-glucosaminidase correlated to the urinary L-P1 level. We used immunohistochemistry to locate L-P1 in the cortex of human kidneys. In nondiabetic kidneys, the glomerular and tubular basement membranes, mesangium, and Bowman's capsule were stained. In the diabetic kidney, more was stained, including the mesangial expansion and the thickened capillary basement membranes.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 197-198"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90073-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Frequency of diabetic nephropathy in childhood diabetics in southern districts of Kyusyu 九州南部地区儿童糖尿病患者糖尿病肾病的发病率
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90045-Q
K. Ishikawa , M. Nagayoshi , S. Higa , K. Murakami , Y. Kono , T. Jinnouchi , G. Mimura
{"title":"Frequency of diabetic nephropathy in childhood diabetics in southern districts of Kyusyu","authors":"K. Ishikawa ,&nbsp;M. Nagayoshi ,&nbsp;S. Higa ,&nbsp;K. Murakami ,&nbsp;Y. Kono ,&nbsp;T. Jinnouchi ,&nbsp;G. Mimura","doi":"10.1016/0891-6632(91)90045-Q","DOIUrl":"10.1016/0891-6632(91)90045-Q","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Page 134"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90045-Q","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the clinical course of 130 Japanese non-insulin-dependent diabetic patients undergoing dialysis 130例日本非胰岛素依赖型糖尿病透析患者临床过程分析
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90062-T
Chieko Takahashi, Norko Ujihara, Tetsuya Babazono, Hiroki Yokoyama, Katsue Nakanishi, Osamu Tomonaga, Tsutomu Sanaka, Yukimasa Hirata
{"title":"Analysis of the clinical course of 130 Japanese non-insulin-dependent diabetic patients undergoing dialysis","authors":"Chieko Takahashi,&nbsp;Norko Ujihara,&nbsp;Tetsuya Babazono,&nbsp;Hiroki Yokoyama,&nbsp;Katsue Nakanishi,&nbsp;Osamu Tomonaga,&nbsp;Tsutomu Sanaka,&nbsp;Yukimasa Hirata","doi":"10.1016/0891-6632(91)90062-T","DOIUrl":"10.1016/0891-6632(91)90062-T","url":null,"abstract":"<div><p>To clarify the characteristics of diabetic nephropathy (DN) in Japanese patients with non-insulin-dependent diabetes (NIDDM), we analyzed the clinical course of 130 such patients who began dialysis treatment due to DN between 1978 and 1988 at the Diabetes Center of Tokyo Women's Medical College. Analysis of the clinical course prior to attending the Diabetes Center revealed that 64 (49.2%) of the patients neglected or discontinued their initial treatment for diabetes until the development of diabetic complications because of the lack of symptoms. The average duration of untreated diabetes in these patients was 10.7 ± 4.6 years. The biggest problem for NIDDM patients was the absence of symptoms until the development of diabetic complications.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 171-172"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90062-T","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Glomerular charge selectivity in non-insulin-dependent diabetes mellitus 非胰岛素依赖型糖尿病的肾小球电荷选择性
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90046-R
Yasuko Chiba, Nagayuki Tani, Masatoshi Yamazaki, Hiroshi Nakamura, Seiki Ito, Akira Shibata
{"title":"Glomerular charge selectivity in non-insulin-dependent diabetes mellitus","authors":"Yasuko Chiba,&nbsp;Nagayuki Tani,&nbsp;Masatoshi Yamazaki,&nbsp;Hiroshi Nakamura,&nbsp;Seiki Ito,&nbsp;Akira Shibata","doi":"10.1016/0891-6632(91)90046-R","DOIUrl":"10.1016/0891-6632(91)90046-R","url":null,"abstract":"<div><p>To elucidate the stage of the charge selectivity defect in diabetic nephropathy, urinary excretions of IgG1 and IgG4 were measured in patients with non-insulin-dependent diabetes mellitus (NIDDM) and healthy controls. The molecular weights of IgG1 and IgG4 were the same but their isoelectric points were different. Therefore, by measuring both urinary IgG1 and IgG4 excretions, the stage of charge selectivity impairment in the nephropathy of NIDDM may be elucidated. Results were expressed as urinary excretion rate (IgG1 ER, IgG4 ER) and compared between diabetic patients with different urinary excretion rates of albumin (AER). IgG4 ER increased to the stage in which AER was more than 10 μg/min, whereas IgG1 ER did not increase to the stage of AER between 10 and 100 μg/min. This finding suggests that the charge selectivity defect in the kidney of the NIDDM patient is present at the stage when AER is more than 10 μg/min.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 135-137"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90046-R","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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