The Journal of diabetic complications最新文献_第8页

Changes in the glomerular pore size selectivity in patients with type II diabetes mellitus 2型糖尿病患者肾小球孔径选择性的变化

The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90047-S

Masatoshi Yamazaki, Nagayuki Tani, Kazumasa Igarashi, Hiroshi Nakamura, Takeshi Momotsu, Seiki Ito, Akira Shibata

{"title":"Changes in the glomerular pore size selectivity in patients with type II diabetes mellitus","authors":"Masatoshi Yamazaki, Nagayuki Tani, Kazumasa Igarashi, Hiroshi Nakamura, Takeshi Momotsu, Seiki Ito, Akira Shibata","doi":"10.1016/0891-6632(91)90047-S","DOIUrl":"10.1016/0891-6632(91)90047-S","url":null,"abstract":"<div><p>We measured the urinary excretion rate and clearance of three plasma proteins, albumin, transferrin, and IgG4, each of which has a similar isoelectric point, but a different molecular weight. This study consisted of 86 patients with type II diabetes mellitus and 15 healthy subjects. In the patients, the degree of the urinary excretion rate and clearance of both transferrin (TER and Ctrans) and IgG4 (IgG4 ER and CIgG4) closely correlated with that of the urinary excretion rate of albumin (AER). Although significant increases in the medians of TER and Ctrans were found even in the patients with AER of less than 5 μg/min, significant increases in the medians of IgG4 ER and CIgG4 were observed only in the patients with AER of more than 10 μg/min, in comparison with age-matched healthy subjects. Considering the biochemical properties of these proteins, our results indicate that an alteration in the glomerular size selectivity may appear even in patients with normoalbuminuria, and in patients with AER of more than 10 μg/min, more extensive damage in glomerular size selectivity may occur.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 138-139"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90047-S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Natural history and pathogenesis of diabetic nephropathy 糖尿病肾病的自然历史和发病机制

The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90022-H

GianCarlo Viberti , James D. Walker

引用次数: 11

Natural history of diabetic nephropathy in non-insulin-dependent diabetes mellitus 非胰岛素依赖型糖尿病患者糖尿病肾病的自然病史

The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90023-I

Robert G. Nelson , William C. Knowler , Peter H. Bennett

引用次数: 12

Renal metabolism of amino acids in early insulin-dependent diabetes mellitus 早期胰岛素依赖型糖尿病中氨基酸的肾脏代谢

The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90033-L

Giacomo Deferrari, Giacomo Garibotto , Cristina Robaudo , Stefano Saffioti , Roberto Pontremoli , Alberto Tizianello

{"title":"Renal metabolism of amino acids in early insulin-dependent diabetes mellitus","authors":"Giacomo Deferrari, Giacomo Garibotto , Cristina Robaudo , Stefano Saffioti , Roberto Pontremoli , Alberto Tizianello","doi":"10.1016/0891-6632(91)90033-L","DOIUrl":"10.1016/0891-6632(91)90033-L","url":null,"abstract":"<div><p>Renal metabolism of amino acids (AAs) was evaluated in 5 patients with early IDDM, and in 7 controls (C) in the basal state for 80 minutes after the ingestion of an AA mixture simulating an animal protein meal. Insulin was withdrawn 20 hours before the study. Renal metabolism of AAs was evaluated by the arterial-venous difference technique. In the basal state in IDDM, as in C, the kidney takes up large amounts of a few nonessential AAs (NEAAs): it releases many NEAAs and a few essential AAs (EAAs). After AA ingestion in C, renal extraction of most EAAs, mainly BCAAs, Lys, and Thr, occurs; Pro extraction also increases and a significant uptake of Gly, Glu, Asp, Orn, and Tyr takes place. EAA extraction accounts for 30–40% of total AA uptake. In IDDM, after AA ingestion, a) renal uptake of total AAs is significantly lower, owing mainly to a markedly lower uptake of BCAAs, Lys, and also of Pro, Orn, and Ala; b) renal EAA uptake accounts for less than 20% of total AA extraction. These results indicate that in IDDM postprandial renal N repletion is impaired and unbalanced.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 101-103"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90033-L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial derangement: Possible initiator of microalbuminuria in NIDDM 线粒体紊乱:NIDDM患者微量白蛋白尿的可能引发者

The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90034-M

Shigeo Takebayashi, Koji Kaneda

引用次数: 17

Risk factors for retardation of renal function in IDDM and NIDDM with nephropathy IDDM和NIDDM合并肾病肾功能迟缓的危险因素

The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90044-P

Shigeko Hara , Kenji Arizono , Yosifumi Ubara , Takasi Morita , Yosio Suzuki , Yousuke Ogura , Ryouko Hagura , Yasuo Akanuma

引用次数: 3

Tamm-Horsfall-Protein excretion as a marker of ascending limb transport indicates early renal tubular damage in diabetes mellitus type I tamm - horsfall蛋白排泄作为升肢运输的标志提示I型糖尿病早期肾小管损伤

The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90037-P

L.B. Zimmerhackl , S. Pfleiderer , R. Kinne , F. Manz , G. Schuler , M. Brandis

引用次数: 32

Role of mesangial cells in glomerulosclerosis 系膜细胞在肾小球硬化中的作用

The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90018-K

Liliane J. Striker, Toshio Doi, Francesco Conti, Gary E. Striker

引用次数: 1

Measuring subclinical neuropathy: Does it relate to clinical neuropathy? Pittsburgh epidemiology of diabetes complications study-V 测量亚临床神经病变:它与临床神经病变有关吗?匹兹堡糖尿病并发症流行病学研究v

The Journal of diabetic complications Pub Date : 1991-01-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90003-8

Raelene E. Maser , Viggo K. Nielsen , Janice S. Dorman , Allan L. Drash , Dorothy J. Becker , Trevor J. Orchard

{"title":"Measuring subclinical neuropathy: Does it relate to clinical neuropathy? Pittsburgh epidemiology of diabetes complications study-V","authors":"Raelene E. Maser , Viggo K. Nielsen , Janice S. Dorman , Allan L. Drash , Dorothy J. Becker , Trevor J. Orchard","doi":"10.1016/0891-6632(91)90003-8","DOIUrl":"10.1016/0891-6632(91)90003-8","url":null,"abstract":"<div><p>We report results from 120 (25- to 34-year-old) participants in a neuropathy substudy of subjects with insulin-dependent diabetes mellitus (IDDM) taking part in a cohort follow-up study. Diabetic neuropathy was evaluated by quantitative sensory testing, nerve conduction studies, and clinical examination. Mean quantitative sensory thresholds differed significantly by clinical category of abnormal sensation and ankle reflex activity. Mean sural and peroneal amplitudes and conduction velocities were also significantly lower for subjects classified as having abnormal ankle reflex activity. Modeling potential correlates in logistic analyses showed glycemic control, triglyceride levels, and hypertension status to be independently associated with clinically overt neuropathy. Similar lipid and hemodynamic parameters were associated with abnormality by any single assessment method used to define neuropathy. Although follow-up is needed to resolve the best assessment methods for determining neuropathy, these results suggest that good glycemic control as well as control of blood pressure and lipids is advisable.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 1","pages":"Pages 6-12"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90003-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13016977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Parotid salivary secretion in diabetic autonomic neuropathy 糖尿病自主神经病变的腮腺唾液分泌

The Journal of diabetic complications Pub Date : 1991-01-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90008-D

P.G. Newrick , C. Bowman , D. Green , I.A.D. O'Brien , S.R. Porter , C. Scully , R.J.M. Corrall

引用次数: 64