The Journal of diabetic complications最新文献_第8页

Changes in the glomerular pore size selectivity in patients with type II diabetes mellitus 2型糖尿病患者肾小球孔径选择性的变化

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90047-S

Masatoshi Yamazaki, Nagayuki Tani, Kazumasa Igarashi, Hiroshi Nakamura, Takeshi Momotsu, Seiki Ito, Akira Shibata

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引用次数: 8

Renal metabolism of amino acids in early insulin-dependent diabetes mellitus 早期胰岛素依赖型糖尿病中氨基酸的肾脏代谢

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90033-L

Giacomo Deferrari, Giacomo Garibotto , Cristina Robaudo , Stefano Saffioti , Roberto Pontremoli , Alberto Tizianello

{"title":"Renal metabolism of amino acids in early insulin-dependent diabetes mellitus","authors":"Giacomo Deferrari, Giacomo Garibotto , Cristina Robaudo , Stefano Saffioti , Roberto Pontremoli , Alberto Tizianello","doi":"10.1016/0891-6632(91)90033-L","DOIUrl":"10.1016/0891-6632(91)90033-L","url":null,"abstract":"<div><p>Renal metabolism of amino acids (AAs) was evaluated in 5 patients with early IDDM, and in 7 controls (C) in the basal state for 80 minutes after the ingestion of an AA mixture simulating an animal protein meal. Insulin was withdrawn 20 hours before the study. Renal metabolism of AAs was evaluated by the arterial-venous difference technique. In the basal state in IDDM, as in C, the kidney takes up large amounts of a few nonessential AAs (NEAAs): it releases many NEAAs and a few essential AAs (EAAs). After AA ingestion in C, renal extraction of most EAAs, mainly BCAAs, Lys, and Thr, occurs; Pro extraction also increases and a significant uptake of Gly, Glu, Asp, Orn, and Tyr takes place. EAA extraction accounts for 30–40% of total AA uptake. In IDDM, after AA ingestion, a) renal uptake of total AAs is significantly lower, owing mainly to a markedly lower uptake of BCAAs, Lys, and also of Pro, Orn, and Ala; b) renal EAA uptake accounts for less than 20% of total AA extraction. These results indicate that in IDDM postprandial renal N repletion is impaired and unbalanced.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 101-103"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90033-L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial derangement: Possible initiator of microalbuminuria in NIDDM 线粒体紊乱:NIDDM患者微量白蛋白尿的可能引发者

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90034-M

Shigeo Takebayashi, Koji Kaneda

引用次数: 17

Risk factors for retardation of renal function in IDDM and NIDDM with nephropathy IDDM和NIDDM合并肾病肾功能迟缓的危险因素

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90044-P

Shigeko Hara , Kenji Arizono , Yosifumi Ubara , Takasi Morita , Yosio Suzuki , Yousuke Ogura , Ryouko Hagura , Yasuo Akanuma

引用次数: 3

Natural history and pathogenesis of diabetic nephropathy 糖尿病肾病的自然历史和发病机制

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90022-H

GianCarlo Viberti , James D. Walker

引用次数: 11

Natural history of diabetic nephropathy in non-insulin-dependent diabetes mellitus 非胰岛素依赖型糖尿病患者糖尿病肾病的自然病史

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90023-I

Robert G. Nelson , William C. Knowler , Peter H. Bennett

引用次数: 12

Role of mesangial cells in glomerulosclerosis 系膜细胞在肾小球硬化中的作用

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90018-K

Liliane J. Striker, Toshio Doi, Francesco Conti, Gary E. Striker

引用次数: 1

Tamm-Horsfall-Protein excretion as a marker of ascending limb transport indicates early renal tubular damage in diabetes mellitus type I tamm - horsfall蛋白排泄作为升肢运输的标志提示I型糖尿病早期肾小管损伤

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90037-P

L.B. Zimmerhackl , S. Pfleiderer , R. Kinne , F. Manz , G. Schuler , M. Brandis

引用次数: 32

Parotid salivary secretion in diabetic autonomic neuropathy 糖尿病自主神经病变的腮腺唾液分泌

The Journal of diabetic complications Pub Date : 1991-01-01 DOI: 10.1016/0891-6632(91)90008-D

P.G. Newrick , C. Bowman , D. Green , I.A.D. O'Brien , S.R. Porter , C. Scully , R.J.M. Corrall

引用次数: 64

Albuminuria and associated medical risk factors: A cross-sectional study in 476 type I (insulin-dependent) diabetic patients. Part 1 蛋白尿及相关医疗危险因素:476例I型(胰岛素依赖)糖尿病患者的横断面研究第1部分

The Journal of diabetic complications Pub Date : 1991-01-01 DOI: 10.1016/0891-6632(91)90006-B

O. Torffvit , E. Agardh , C-D. Agardh

{"title":"Albuminuria and associated medical risk factors: A cross-sectional study in 476 type I (insulin-dependent) diabetic patients. Part 1","authors":"O. Torffvit , E. Agardh , C-D. Agardh","doi":"10.1016/0891-6632(91)90006-B","DOIUrl":"10.1016/0891-6632(91)90006-B","url":null,"abstract":"<div><p>Albumin concentration in a morning urine sample was analyzed in a cross-sectional study in 476 insulin-dependent diabetic patients. The following groups of patients were defined: A) normal urinary albumin (urine albumin <12.5 mg/L); B) high normal albuminuria (12.5–30 mg/L); C) microalbuminuria, ie, incipient nephropathy (31–299 mg/L); and D) clinical nephropathy (≥300 mg/L). The prevalences of incipient and clinical diabetic nephropathy were 24.8 and 14.4%, respectively. There were no differences in clinical parameters such as age, age at onset or duration of diabetes, blood pressure, serum creatinine, or HbA<sub>1c</sub> levels between groups A and B. The frequency of retinopathy in these groups was 55 and 50%, respectively. In group C, there were increases in age, duration of diabetes, blood pressure, serum creatinine, and HbA<sub>1c</sub> levels. The frequency of retinopathy was higher (80%), and more patients had severe forms (47%). In group D, there were further increases in all parameters and, in addition, younger age at onset of diabetes. The frequency of retinopathy was 97%, and severe forms of retinopathy were more common (86%). Seventeen percent of the patients were treated for hypertension. These patients were older, had longer duration of diabetes, and had higher levels of blood pressure, serum creatinine, and urinary albumin, as well as a younger age at onset of diabetes than patients not requiring antihypertensive treatment.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 1","pages":"Pages 23-28"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90006-B","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12991915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4