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The Journal of diabetic complications最新文献

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Renal hypertrophy in experimental diabetes 实验性糖尿病的肾肥大
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90019-L
Allan Flyvbjerg , Carl Erik Mogensen , Ruth Østerby , Hans Ørskov
{"title":"Renal hypertrophy in experimental diabetes","authors":"Allan Flyvbjerg , Carl Erik Mogensen , Ruth Østerby , Hans Ørskov","doi":"10.1016/0891-6632(91)90019-L","DOIUrl":"10.1016/0891-6632(91)90019-L","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 62-64"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90019-L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Diabetic nephropathy in insulin-dependent diabetes mellitus patients: How to measure progression of disease and effect of treatment 胰岛素依赖型糖尿病患者的糖尿病肾病:如何衡量疾病进展和治疗效果
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90020-P
Carl Erik Mogensen
{"title":"Diabetic nephropathy in insulin-dependent diabetes mellitus patients: How to measure progression of disease and effect of treatment","authors":"Carl Erik Mogensen","doi":"10.1016/0891-6632(91)90020-P","DOIUrl":"10.1016/0891-6632(91)90020-P","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 65-68"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90020-P","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of vanadate on renal function in rats with streptozotocin-induced diabetes 钒酸盐对链脲佐菌素所致糖尿病大鼠肾功能的影响
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90065-W
Asao Nakazawa, Kazumasa Igarashi, Nagayuki Tani, Takeshi Momotsu, Seiki Ito, Akira Shibata
{"title":"Effect of vanadate on renal function in rats with streptozotocin-induced diabetes","authors":"Asao Nakazawa,&nbsp;Kazumasa Igarashi,&nbsp;Nagayuki Tani,&nbsp;Takeshi Momotsu,&nbsp;Seiki Ito,&nbsp;Akira Shibata","doi":"10.1016/0891-6632(91)90065-W","DOIUrl":"10.1016/0891-6632(91)90065-W","url":null,"abstract":"<div><p>The effects of vanadate on glycemic control (HbA<sub>1</sub>c) and renal function was assessed in streptozotocin-induced diabetic rats (STZ-D) with heminephrectomy. Vanadate-treated rats had a significantly lower HbA<sub>1</sub>c level compared with STZ-D rats without vanadate at 8 weeks after initiation of this study. In the STZ-D rats with vanadate, there were significant decreases in the urinary albumin and IgG excretion rates. The present findings suggest that glycemic control by oral administration of vanadate, which does not cause insulin release, improves diabetic renal function.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 179-180"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90065-W","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Acute loading with proteins from different sources in healthy volunteers and diabetic patients 健康志愿者和糖尿病患者不同来源蛋白质的急性负荷
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90048-T
Hiroshi Nakamura , Masatoshi Yamazaki , Yasuko Chiba , Nagayuki Tani , Takeshi Momotsu , Kyuzi Kamoi , Seiki Ito , Tohru Yamaji , Akira Shibata
{"title":"Acute loading with proteins from different sources in healthy volunteers and diabetic patients","authors":"Hiroshi Nakamura ,&nbsp;Masatoshi Yamazaki ,&nbsp;Yasuko Chiba ,&nbsp;Nagayuki Tani ,&nbsp;Takeshi Momotsu ,&nbsp;Kyuzi Kamoi ,&nbsp;Seiki Ito ,&nbsp;Tohru Yamaji ,&nbsp;Akira Shibata","doi":"10.1016/0891-6632(91)90048-T","DOIUrl":"10.1016/0891-6632(91)90048-T","url":null,"abstract":"<div><p>To evaluate the effects of protein loading on glomerular filtration rate (GFR), urinary excretion rate of albumin (AER), and plasma concentration of amino acids, 10 healthy volunteers and six diabetics were studied before and after eating tuna fish, egg white, cheese, or tofu. Furthermore, to study the possible role of glucagon, growth hormone (GH), atrial natriuretic peptide (ANP), or kallikrein in the responses of GFR, these substances were measured before and after protein loading. GFR increased significantly (<em>p</em> &lt; .001) after ingestion of tuna fish. No significant differences were seen between the GFR before and that after ingestion of the other foods. AER was unchanged following protein loading. Plasma concentrations of alanine, glycine, and arginine increased to a greater degree after ingestion of tuna fish than after digestion of the other foods. This result suggests that the response of GFR after protein loading may differ from one protein to another, and that these responses may not be directly mediated by glucagon, GH, ANP, or kallikrein.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 140-142"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90048-T","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Insulin-like growth factor I (IGF-I) stimulates glucose and amino acid uptake in cultured glomerular mesangial cells 胰岛素样生长因子I (IGF-I)刺激培养肾小球系膜细胞对葡萄糖和氨基酸的摄取
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90067-Y
Masaki Togawa, Ryuichi Kikkawa, Masakazu Haneda, Daisuke Koya, Naoki Horide, Nobuyuki Kajiwara, Yukio Shigeta
{"title":"Insulin-like growth factor I (IGF-I) stimulates glucose and amino acid uptake in cultured glomerular mesangial cells","authors":"Masaki Togawa,&nbsp;Ryuichi Kikkawa,&nbsp;Masakazu Haneda,&nbsp;Daisuke Koya,&nbsp;Naoki Horide,&nbsp;Nobuyuki Kajiwara,&nbsp;Yukio Shigeta","doi":"10.1016/0891-6632(91)90067-Y","DOIUrl":"10.1016/0891-6632(91)90067-Y","url":null,"abstract":"<div><p>Cultured measangial cells possess a large number of receptors specific to IGF-I with a small number of insulin receptors. Physiological concentrations of IGF-I increased the uptakes of aminoisobutyric acid and 2-deoxyglucose in mesangial cells, while insulin exhibited similar effects only with unphysiologically high concentration. These findings suggest that, in cultured mesangial cells, IGF-I may regulate cellular metabolic functions such as glucose and amino acid uptakes through its own receptors rather than insulin receptors.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 184-185"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90067-Y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Glucose-induced overproduction of type IV collagen in cultured glomerular mesangial cells 葡萄糖诱导培养肾小球系膜细胞IV型胶原的过量产生
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90074-Y
Masakazu Haneda, Ryuichi Kikkawa, Naoki Horide, Masaki Togawa, Daisuke Koya, Nobuyuki Kajiwara, Shiro Maeda, Yukio Shigeta
{"title":"Glucose-induced overproduction of type IV collagen in cultured glomerular mesangial cells","authors":"Masakazu Haneda,&nbsp;Ryuichi Kikkawa,&nbsp;Naoki Horide,&nbsp;Masaki Togawa,&nbsp;Daisuke Koya,&nbsp;Nobuyuki Kajiwara,&nbsp;Shiro Maeda,&nbsp;Yukio Shigeta","doi":"10.1016/0891-6632(91)90074-Y","DOIUrl":"10.1016/0891-6632(91)90074-Y","url":null,"abstract":"<div><p>Type IV collagen production by cultured rat glomerular mesangial cells was evaluated quantitatively by measuring type IV collagen secreted into culture media and associated with the cells using enzyme-linked immunosorbent assay (ELISA). The majority of type IV collagen was secreted into culture media; type IV collagen increased with cell growth in the early log phase and decreased in the late log phase and after cofluency. By exposing the cells to high concentrations of glucose (27.8 mM), both secreted and cell-associated type IV collagens increased significantly compared with the cells cultured under normal glucose concentrations (5.6 mM) or under equivalent concentrations of mannitol, resulting in a significant increase in total type IV collagen accumulation.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 199-200"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90074-Y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Renal metabolism of C peptide in type I (insulin-dependent) diabetic patients I型(胰岛素依赖)糖尿病患者C肽的肾脏代谢
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90036-O
I. Zavaroni, C. Robaudo , S. Mazza, L. Gnudi, S. Saffioti , R. Lugari , A. Gnudi , G. Deterrari
{"title":"Renal metabolism of C peptide in type I (insulin-dependent) diabetic patients","authors":"I. Zavaroni,&nbsp;C. Robaudo ,&nbsp;S. Mazza,&nbsp;L. Gnudi,&nbsp;S. Saffioti ,&nbsp;R. Lugari ,&nbsp;A. Gnudi ,&nbsp;G. Deterrari","doi":"10.1016/0891-6632(91)90036-O","DOIUrl":"10.1016/0891-6632(91)90036-O","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 110-111"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90036-O","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetic study of glomerular cells of diabetic rats in relation to the development of irreversible glomerular sclerosis 糖尿病大鼠肾小球细胞动力学与不可逆肾小球硬化发生的关系
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90038-Q
Gengo Osawa, Tamaki Sasaki, Tetsuya Sato, Masahiko Yamada, Yuichi Kitano
{"title":"Kinetic study of glomerular cells of diabetic rats in relation to the development of irreversible glomerular sclerosis","authors":"Gengo Osawa,&nbsp;Tamaki Sasaki,&nbsp;Tetsuya Sato,&nbsp;Masahiko Yamada,&nbsp;Yuichi Kitano","doi":"10.1016/0891-6632(91)90038-Q","DOIUrl":"10.1016/0891-6632(91)90038-Q","url":null,"abstract":"<div><p>In order to clarify the cellular kinetics involved in progression of diabetic glomerulosclerosis, the epithelial cells of spontaneously diabetic <span><math><mtext>WBN</mtext><mtext>Kob</mtext></math></span> rats were investigated by labeling with the DNA precursor bromodeoxyuridine, which was histochemically stained using monoclonal antibody. The labeling index (number of labeled cells/number of cells counted) of glomeruli was constantly low (approximately 0.15%) and no significant variation could be demonstrated in control rats of the Wistar strain. In both control and diabetic rats, podocytes showed no evidence of mitosis. In contrast to capillary podocytes, the Bowman epithelial cells of diabetic rats showed increased labeling, often surrounding sclerotic capillaries. These observations suggest a critical role of Bowman's epithelial cells in the development of irreversibly sclerotic glomeruli in diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 115-117"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90038-Q","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effect of proteinase inhibitor camostat mesilate on nephrotic syndrome with diabetic nephropathy. 蛋白酶抑制剂甲磺酸卡莫他对肾病综合征合并糖尿病肾病的影响。
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1007/978-1-4615-3884-4_4
T. Onbe, H. Makino, I. Kumagai, T. Haramoto, K. Murakami, Z. Ota
{"title":"Effect of proteinase inhibitor camostat mesilate on nephrotic syndrome with diabetic nephropathy.","authors":"T. Onbe, H. Makino, I. Kumagai, T. Haramoto, K. Murakami, Z. Ota","doi":"10.1007/978-1-4615-3884-4_4","DOIUrl":"https://doi.org/10.1007/978-1-4615-3884-4_4","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"54 1","pages":"167-8"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80794742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
A cell biology approach to the study of diabetic vascular complications 用细胞生物学方法研究糖尿病血管并发症
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90016-I
George L. King, H. Ohashi, R. Najak
{"title":"A cell biology approach to the study of diabetic vascular complications","authors":"George L. King,&nbsp;H. Ohashi,&nbsp;R. Najak","doi":"10.1016/0891-6632(91)90016-I","DOIUrl":"10.1016/0891-6632(91)90016-I","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 56-57"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90016-I","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12828636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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