{"title":"钒酸盐对链脲佐菌素所致糖尿病大鼠肾功能的影响","authors":"Asao Nakazawa, Kazumasa Igarashi, Nagayuki Tani, Takeshi Momotsu, Seiki Ito, Akira Shibata","doi":"10.1016/0891-6632(91)90065-W","DOIUrl":null,"url":null,"abstract":"<div><p>The effects of vanadate on glycemic control (HbA<sub>1</sub>c) and renal function was assessed in streptozotocin-induced diabetic rats (STZ-D) with heminephrectomy. Vanadate-treated rats had a significantly lower HbA<sub>1</sub>c level compared with STZ-D rats without vanadate at 8 weeks after initiation of this study. In the STZ-D rats with vanadate, there were significant decreases in the urinary albumin and IgG excretion rates. The present findings suggest that glycemic control by oral administration of vanadate, which does not cause insulin release, improves diabetic renal function.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 179-180"},"PeriodicalIF":0.0000,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90065-W","citationCount":"4","resultStr":"{\"title\":\"Effect of vanadate on renal function in rats with streptozotocin-induced diabetes\",\"authors\":\"Asao Nakazawa, Kazumasa Igarashi, Nagayuki Tani, Takeshi Momotsu, Seiki Ito, Akira Shibata\",\"doi\":\"10.1016/0891-6632(91)90065-W\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effects of vanadate on glycemic control (HbA<sub>1</sub>c) and renal function was assessed in streptozotocin-induced diabetic rats (STZ-D) with heminephrectomy. Vanadate-treated rats had a significantly lower HbA<sub>1</sub>c level compared with STZ-D rats without vanadate at 8 weeks after initiation of this study. In the STZ-D rats with vanadate, there were significant decreases in the urinary albumin and IgG excretion rates. The present findings suggest that glycemic control by oral administration of vanadate, which does not cause insulin release, improves diabetic renal function.</p></div>\",\"PeriodicalId\":77636,\"journal\":{\"name\":\"The Journal of diabetic complications\",\"volume\":\"5 2\",\"pages\":\"Pages 179-180\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0891-6632(91)90065-W\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of diabetic complications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/089166329190065W\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of diabetic complications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/089166329190065W","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of vanadate on renal function in rats with streptozotocin-induced diabetes
The effects of vanadate on glycemic control (HbA1c) and renal function was assessed in streptozotocin-induced diabetic rats (STZ-D) with heminephrectomy. Vanadate-treated rats had a significantly lower HbA1c level compared with STZ-D rats without vanadate at 8 weeks after initiation of this study. In the STZ-D rats with vanadate, there were significant decreases in the urinary albumin and IgG excretion rates. The present findings suggest that glycemic control by oral administration of vanadate, which does not cause insulin release, improves diabetic renal function.
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