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The Journal of diabetic complications最新文献

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Serum concentrations of intact type IV collagen in diabetics 糖尿病患者完整IV型胶原蛋白的血清浓度
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90069-2
Eisaku Matsumoto, Gensaku Matsumoto, Hiroto Bessho, Hiroyoshi Kikuoka, Kishio Nanjo
{"title":"Serum concentrations of intact type IV collagen in diabetics","authors":"Eisaku Matsumoto,&nbsp;Gensaku Matsumoto,&nbsp;Hiroto Bessho,&nbsp;Hiroyoshi Kikuoka,&nbsp;Kishio Nanjo","doi":"10.1016/0891-6632(91)90069-2","DOIUrl":"10.1016/0891-6632(91)90069-2","url":null,"abstract":"<div><p>We developed a sandwich enzyme immunoassay for intact type IV collagen (IV-C) using two monoclonal antibodies as a marker of basement membrane metabolism, and examined the relationship between serum IV-C and diabetic complications. Serum IV-C was measured in 186 diabetics with or without clinical signs of retinopathy, neuropathy, and/or nephropathy, and 328 healthy subjects. Serum IV-C was significantly (<em>P</em> &lt; .01) higher in diabetics (mean ± SE: 124.83 ± 2.94 ng/ml) than in healthy subjects (73.32 ± 1.42 ng/ml). In diabetics with microangiopathy, serum IV-C became higher as clinical signs worsened. Especially in diabetics with nephropathy, serum IV-C became higher with the elevation of blood urea nitrogen (BUN), serum creatinine, and β<sub>2</sub>-microglobulin. Serum IV-C level seems to be a useful marker for assessment of the activity or progression of diabetic microangiopathy, and for evaluation of therapeutic effects.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 189-190"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90069-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
High glucose concentration suppresses mesangial laminin B2 gene expression 高葡萄糖抑制系膜层粘连蛋白B2基因表达
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90039-R
Shigehiro Katayama, Mari Abe, Kiyoshi Tanaka, Akira Omoto, Kiyohiko Negishi, Akira Itabashi, Jun Ishii
{"title":"High glucose concentration suppresses mesangial laminin B2 gene expression","authors":"Shigehiro Katayama,&nbsp;Mari Abe,&nbsp;Kiyoshi Tanaka,&nbsp;Akira Omoto,&nbsp;Kiyohiko Negishi,&nbsp;Akira Itabashi,&nbsp;Jun Ishii","doi":"10.1016/0891-6632(91)90039-R","DOIUrl":"10.1016/0891-6632(91)90039-R","url":null,"abstract":"<div><p>To study the role of laminin in the rat mesangial cell attachment, cell adhesion to laminin-coated dishes was assayed by adding various amounts of a pentapeptide (YIGSR). YIGSR (20–100 μg/mL) inhibited the cell attachment to laminin-coated dishes. Mesangial laminin B<sub>2</sub> messenger RNA (mRNA) levels were attenuated during exposure to 30 mM glucose or high osmolarity achieved by the addition of 25 mM choline chloride to 5 mM glucose (310 mOsm/kg H<sub>2</sub>O) for 3 hours. These results suggest that laminin, which may have a physiologic role in mesangial cell attachment, is produced in mesangial cells, and that the decrease of laminin B<sub>2</sub> mRNA during hyperglycemia or exposure to high osmolarity may have some pathophysiologic significance in the development of diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 118-120"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90039-R","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Glomerular hyperfiltration in insulin-dependent diabetes mellitus: No evidence for enhanced activity of the renin-angiotensin-aldosterone system 胰岛素依赖型糖尿病的肾小球高滤过:没有证据表明肾素-血管紧张素-醛固酮系统的活性增强
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90042-N
Daniel Carvalho-Braga , Raulina Almeida , Maria Azevedo , Izolett Amaral , José Medina , Manuel Hargreaves
{"title":"Glomerular hyperfiltration in insulin-dependent diabetes mellitus: No evidence for enhanced activity of the renin-angiotensin-aldosterone system","authors":"Daniel Carvalho-Braga ,&nbsp;Raulina Almeida ,&nbsp;Maria Azevedo ,&nbsp;Izolett Amaral ,&nbsp;José Medina ,&nbsp;Manuel Hargreaves","doi":"10.1016/0891-6632(91)90042-N","DOIUrl":"10.1016/0891-6632(91)90042-N","url":null,"abstract":"<div><p>Glomerular hyperfiltration is a characteristic functional abnormality in insulin-dependent diabetes mellitus (IDDM) patients, but the underlying mechanisms remain controversial. Supine and ambulant plasma renin activity (PRA) and aldosterone were measured in ten IDDM patients with normal glomerular filtration rate (GFR), in ten IDDM patients with elevated GFR and in ten nondiabetic controls. Basal and stimulated PRA or aldosterone did not differ significantly between the three groups. These results suggest that in insulin-dependent diabetes the glomerular hyperfiltration is not causally related to hyperactivity of the renin-angiotensin-aldosterone system.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 126-127"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90042-N","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Nondiabetic renal disease complicating diabetic nephropathy 非糖尿病肾病并发糖尿病肾病
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90051-P
Kazue Hironaka, Hirofumi Makino, Shuji Ikeda, Toshinori Haramoto, Zensuke Ota
{"title":"Nondiabetic renal disease complicating diabetic nephropathy","authors":"Kazue Hironaka,&nbsp;Hirofumi Makino,&nbsp;Shuji Ikeda,&nbsp;Toshinori Haramoto,&nbsp;Zensuke Ota","doi":"10.1016/0891-6632(91)90051-P","DOIUrl":"10.1016/0891-6632(91)90051-P","url":null,"abstract":"<div><p>The clinicopathological and laboratory findings for 35 diabetic patients who had undergone renal biopsy from 1982 to 1990 were reviewed. Ten of these patients (28.6%) were found to have nondiabetic renal diseases. Five of those patients (14.3%) suffered from nondiabetic renal disease complicated by diabetic nephropathy. Nondiabetic renal diseases included IgA nephropathy, idiopathic membranous nephropathy, membranoproliferative glomerulonephritis (types I and III), minimal change disease, and toxemia of pregnancy. The diagnosis of nondiabetic renal diseases complicated by diabetes is important for the treatment of renal disease. Urinary abnormalities and/or deterioration in renal function inconsistent with the natural history of diabetic nephropathy were suggestive of the presence of nondiabetic renal disease.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 148-149"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90051-P","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Morphologic study of the kidney in Japanese non-insulin-dependent patients 日本非胰岛素依赖患者肾脏形态学研究
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90024-J
Yoshiki Suzuki, Mitsuhiro Ueno, Hiroshi Hayashi, Shinichi Nishi, Ryou Karasawa, Hian Inn, Hirokazu Satou, Satoru Suzuki, Yuuichirou Maruyama, Yutaka Ninomiya, Masaaki Arakawa
{"title":"Morphologic study of the kidney in Japanese non-insulin-dependent patients","authors":"Yoshiki Suzuki,&nbsp;Mitsuhiro Ueno,&nbsp;Hiroshi Hayashi,&nbsp;Shinichi Nishi,&nbsp;Ryou Karasawa,&nbsp;Hian Inn,&nbsp;Hirokazu Satou,&nbsp;Satoru Suzuki,&nbsp;Yuuichirou Maruyama,&nbsp;Yutaka Ninomiya,&nbsp;Masaaki Arakawa","doi":"10.1016/0891-6632(91)90024-J","DOIUrl":"10.1016/0891-6632(91)90024-J","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 79-81"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90024-J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Influence of glycemic control and hypertension on urinary microprotein excretion in non-insulin-dependent diabetes mellitus 血糖控制和高血压对非胰岛素依赖型糖尿病患者尿微量蛋白排泄的影响
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90057-V
H. Wainai, F. Katsukawa, I. Takei, H. Maruyama, K. Kataoka, T. Saruta
{"title":"Influence of glycemic control and hypertension on urinary microprotein excretion in non-insulin-dependent diabetes mellitus","authors":"H. Wainai,&nbsp;F. Katsukawa,&nbsp;I. Takei,&nbsp;H. Maruyama,&nbsp;K. Kataoka,&nbsp;T. Saruta","doi":"10.1016/0891-6632(91)90057-V","DOIUrl":"10.1016/0891-6632(91)90057-V","url":null,"abstract":"<div><p>In order to evaluate the influence of glycemic control and hypertension on the development of diabetic nephropathy, we measured urinary excretion of albumin (AER) and other microproteins in non-insulin-dependent diabetes mellitus (NIDDM), and reexamined the 103 patients who had had AER &lt; 300 μg/min at the initial study 12–18 months later. AER in the patients with HbA<sub>1</sub>c ≧ 7.5% increased significantly in both the normoalbuminuric (AER &lt; 30 μg/min) and microalbuminuric (30–300 μg/min) groups, whereas no significant change in AER was observed in the patients with HbA<sub>1</sub>c &lt; 7.5%. In the microalbuminuric group, AER in both hypertensive and normotensive patients increased significantly. In this group, the change in AER correlated positively with the change in <em>α</em><sub>1</sub>-microglobulin (α 1M). These results indicate that glycemic control has a greater influence on the development of nephropathy in its early stage than hypertension and that α 1M is as a good predictor of nephropathy as albumin.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 160-161"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90057-V","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12886488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Hypercalciuria and hematuria in non-insulin-dependent diabetes mellitus 非胰岛素依赖型糖尿病的高钙尿和血尿
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90052-Q
Yasuko Chiba, Naoko Arakawa, Nagayuki Tani, Hiroshi Nakamura, Takeshi Momotsu, Seiki Ito, Akira Shibata
{"title":"Hypercalciuria and hematuria in non-insulin-dependent diabetes mellitus","authors":"Yasuko Chiba,&nbsp;Naoko Arakawa,&nbsp;Nagayuki Tani,&nbsp;Hiroshi Nakamura,&nbsp;Takeshi Momotsu,&nbsp;Seiki Ito,&nbsp;Akira Shibata","doi":"10.1016/0891-6632(91)90052-Q","DOIUrl":"10.1016/0891-6632(91)90052-Q","url":null,"abstract":"<div><p>This study was undertaken to examine whether patients with non-insulin-dependent diabetes (NIDDM) are hypercalciuric and whether there is a pathophysiologic relationship between urinary calcium excretion (UCE) and the degree of diabetic nephropathy. Although UCE did not parallel the increase of urinary albumin excretion rate (AER) and the presence of hematuria was not corrected with the degree of UCE, we confirmed that 36% of diabetic patients have hypercalciuria and that the prevalence of hypercalciuria is more frequent in diabetic patients with normo- or microalbuminuria than in the controls. In 6 months, the AER of two hypercalciuric patients increased. However, the blood pressure and HbA<sub>1c</sub> of these two patients increased during the same 6 months. Therefore, it remains unclear whether hypercalciuria induced an increase in the AER of these patients.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 150-152"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90052-Q","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased urinary excretion of kappa light chains in diabetic patients 糖尿病患者尿中kappa轻链排泄增加
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90055-T
K. Ohsawa, E. Takazakura
{"title":"Increased urinary excretion of kappa light chains in diabetic patients","authors":"K. Ohsawa,&nbsp;E. Takazakura","doi":"10.1016/0891-6632(91)90055-T","DOIUrl":"10.1016/0891-6632(91)90055-T","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Page 157"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90055-T","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The range of urinary albumin index in normoalbuminuria 正常蛋白尿尿白蛋白指数的变化范围
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90053-R
S. Okada, K. Ichiki, S. Tanokuchi, K. Ishii, Y. Ogino, Z. Ota
{"title":"The range of urinary albumin index in normoalbuminuria","authors":"S. Okada,&nbsp;K. Ichiki,&nbsp;S. Tanokuchi,&nbsp;K. Ishii,&nbsp;Y. Ogino,&nbsp;Z. Ota","doi":"10.1016/0891-6632(91)90053-R","DOIUrl":"10.1016/0891-6632(91)90053-R","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 153-154"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90053-R","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Glomerular hemodynamic function in early diabetes 早期糖尿病肾小球血流动力学功能
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90015-H
Timothy W. Meyer
{"title":"Glomerular hemodynamic function in early diabetes","authors":"Timothy W. Meyer","doi":"10.1016/0891-6632(91)90015-H","DOIUrl":"10.1016/0891-6632(91)90015-H","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 53-55"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90015-H","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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