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The Journal of diabetic complications最新文献

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Serum concentrations of intact type IV collagen in diabetics 糖尿病患者完整IV型胶原蛋白的血清浓度
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90069-2
Eisaku Matsumoto, Gensaku Matsumoto, Hiroto Bessho, Hiroyoshi Kikuoka, Kishio Nanjo
{"title":"Serum concentrations of intact type IV collagen in diabetics","authors":"Eisaku Matsumoto,&nbsp;Gensaku Matsumoto,&nbsp;Hiroto Bessho,&nbsp;Hiroyoshi Kikuoka,&nbsp;Kishio Nanjo","doi":"10.1016/0891-6632(91)90069-2","DOIUrl":"10.1016/0891-6632(91)90069-2","url":null,"abstract":"<div><p>We developed a sandwich enzyme immunoassay for intact type IV collagen (IV-C) using two monoclonal antibodies as a marker of basement membrane metabolism, and examined the relationship between serum IV-C and diabetic complications. Serum IV-C was measured in 186 diabetics with or without clinical signs of retinopathy, neuropathy, and/or nephropathy, and 328 healthy subjects. Serum IV-C was significantly (<em>P</em> &lt; .01) higher in diabetics (mean ± SE: 124.83 ± 2.94 ng/ml) than in healthy subjects (73.32 ± 1.42 ng/ml). In diabetics with microangiopathy, serum IV-C became higher as clinical signs worsened. Especially in diabetics with nephropathy, serum IV-C became higher with the elevation of blood urea nitrogen (BUN), serum creatinine, and β<sub>2</sub>-microglobulin. Serum IV-C level seems to be a useful marker for assessment of the activity or progression of diabetic microangiopathy, and for evaluation of therapeutic effects.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 189-190"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90069-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Serum or urinary concentration of type IV collagen in diabetics 糖尿病患者血清或尿中IV型胶原蛋白的浓度
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90070-6
Toshiro Watanabe , Kiyohiko Negishi , Shigehiro Katayama , Jun Ishii , Shoji Kawazu
{"title":"Serum or urinary concentration of type IV collagen in diabetics","authors":"Toshiro Watanabe ,&nbsp;Kiyohiko Negishi ,&nbsp;Shigehiro Katayama ,&nbsp;Jun Ishii ,&nbsp;Shoji Kawazu","doi":"10.1016/0891-6632(91)90070-6","DOIUrl":"10.1016/0891-6632(91)90070-6","url":null,"abstract":"<div><p>Concentrations of serum or urinary type IV collagen, determined by sandwich enzyme immunoassay, were significantly elevated in diabetics compared to controls (<em>P</em>&lt;.01). Serum or urinary levels of type IV collagen were significantly increased in patients with microangiopathy compared to those without microvascular disease (<em>P</em> &lt; .05). Serum type IV collagen levels were also augmented in diabetics who showed an increased albumin index for 1 year. Serum levels of type IV collagen were not affected by any conditions of metabolic control.</p><p>The measurement of serum or urinary type IV collagen may be a useful indicator for monitoring the development of diabetic microangiopathy, especially in early diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 191-192"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90070-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Nondiabetic renal disease complicating diabetic nephropathy 非糖尿病肾病并发糖尿病肾病
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90051-P
Kazue Hironaka, Hirofumi Makino, Shuji Ikeda, Toshinori Haramoto, Zensuke Ota
{"title":"Nondiabetic renal disease complicating diabetic nephropathy","authors":"Kazue Hironaka,&nbsp;Hirofumi Makino,&nbsp;Shuji Ikeda,&nbsp;Toshinori Haramoto,&nbsp;Zensuke Ota","doi":"10.1016/0891-6632(91)90051-P","DOIUrl":"10.1016/0891-6632(91)90051-P","url":null,"abstract":"<div><p>The clinicopathological and laboratory findings for 35 diabetic patients who had undergone renal biopsy from 1982 to 1990 were reviewed. Ten of these patients (28.6%) were found to have nondiabetic renal diseases. Five of those patients (14.3%) suffered from nondiabetic renal disease complicated by diabetic nephropathy. Nondiabetic renal diseases included IgA nephropathy, idiopathic membranous nephropathy, membranoproliferative glomerulonephritis (types I and III), minimal change disease, and toxemia of pregnancy. The diagnosis of nondiabetic renal diseases complicated by diabetes is important for the treatment of renal disease. Urinary abnormalities and/or deterioration in renal function inconsistent with the natural history of diabetic nephropathy were suggestive of the presence of nondiabetic renal disease.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 148-149"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90051-P","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Asymptomatic ischemic heart disease and diabetic nephropathy: Relationship between prevalence of asymptomatic ischemic heart disease and urinary albumin excretion rate 无症状缺血性心脏病与糖尿病肾病:无症状缺血性心脏病患病率与尿白蛋白排泄率的关系
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90061-S
Nagayuki Tani , Asako Hiroshima , Yutaka Kobayashi , Kazumasa Igarashi , Masatoshi Yamazaki , Hiroshi Nakamura , Asao Nakazawa , Seiki Ito , Akira Shibata
{"title":"Asymptomatic ischemic heart disease and diabetic nephropathy: Relationship between prevalence of asymptomatic ischemic heart disease and urinary albumin excretion rate","authors":"Nagayuki Tani ,&nbsp;Asako Hiroshima ,&nbsp;Yutaka Kobayashi ,&nbsp;Kazumasa Igarashi ,&nbsp;Masatoshi Yamazaki ,&nbsp;Hiroshi Nakamura ,&nbsp;Asao Nakazawa ,&nbsp;Seiki Ito ,&nbsp;Akira Shibata","doi":"10.1016/0891-6632(91)90061-S","DOIUrl":"10.1016/0891-6632(91)90061-S","url":null,"abstract":"<div><p>To examine whether prevalences of asymptomatic ischemic heart diseases in type II diabetic patients are correlated with the degree of diabetic nephropathy, <sup>201</sup>Tl scintigraphies with dipyridamole loading were performed in 28 type II diabetic patients without any chest discomforts. Positive findings of ischemic changes were found in 5 (28%) of 18 patients with normoalbuminuria (urinary albumin excretion rate, AER &lt; 20 μg/min) and 5 (50%) of 10 patients with micro- or macroalbuminuria (AER &gt; 20 μg/min). Coronary angiography (CAG) was performed in 6 of 10 patients with positive findings of <sup>201</sup>Tl scintigraphy. No stenotic findings were found in any patients, but wall motion was decreased in some patients and pulmonary artery pressure was increased in one patient. As stenosis of arteries with diameter of more than 0.3 mm can be detected by CAG, it seems likely that microangiopathy may play some role in the pathogenesis of asymptomatic ischemic heart disease detected with <sup>201</sup>Tl scintigraphy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 169-170"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90061-S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
High glucose concentration suppresses mesangial laminin B2 gene expression 高葡萄糖抑制系膜层粘连蛋白B2基因表达
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90039-R
Shigehiro Katayama, Mari Abe, Kiyoshi Tanaka, Akira Omoto, Kiyohiko Negishi, Akira Itabashi, Jun Ishii
{"title":"High glucose concentration suppresses mesangial laminin B2 gene expression","authors":"Shigehiro Katayama,&nbsp;Mari Abe,&nbsp;Kiyoshi Tanaka,&nbsp;Akira Omoto,&nbsp;Kiyohiko Negishi,&nbsp;Akira Itabashi,&nbsp;Jun Ishii","doi":"10.1016/0891-6632(91)90039-R","DOIUrl":"10.1016/0891-6632(91)90039-R","url":null,"abstract":"<div><p>To study the role of laminin in the rat mesangial cell attachment, cell adhesion to laminin-coated dishes was assayed by adding various amounts of a pentapeptide (YIGSR). YIGSR (20–100 μg/mL) inhibited the cell attachment to laminin-coated dishes. Mesangial laminin B<sub>2</sub> messenger RNA (mRNA) levels were attenuated during exposure to 30 mM glucose or high osmolarity achieved by the addition of 25 mM choline chloride to 5 mM glucose (310 mOsm/kg H<sub>2</sub>O) for 3 hours. These results suggest that laminin, which may have a physiologic role in mesangial cell attachment, is produced in mesangial cells, and that the decrease of laminin B<sub>2</sub> mRNA during hyperglycemia or exposure to high osmolarity may have some pathophysiologic significance in the development of diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 118-120"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90039-R","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12933674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Hypercalciuria and hematuria in non-insulin-dependent diabetes mellitus 非胰岛素依赖型糖尿病的高钙尿和血尿
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90052-Q
Yasuko Chiba, Naoko Arakawa, Nagayuki Tani, Hiroshi Nakamura, Takeshi Momotsu, Seiki Ito, Akira Shibata
{"title":"Hypercalciuria and hematuria in non-insulin-dependent diabetes mellitus","authors":"Yasuko Chiba,&nbsp;Naoko Arakawa,&nbsp;Nagayuki Tani,&nbsp;Hiroshi Nakamura,&nbsp;Takeshi Momotsu,&nbsp;Seiki Ito,&nbsp;Akira Shibata","doi":"10.1016/0891-6632(91)90052-Q","DOIUrl":"10.1016/0891-6632(91)90052-Q","url":null,"abstract":"<div><p>This study was undertaken to examine whether patients with non-insulin-dependent diabetes (NIDDM) are hypercalciuric and whether there is a pathophysiologic relationship between urinary calcium excretion (UCE) and the degree of diabetic nephropathy. Although UCE did not parallel the increase of urinary albumin excretion rate (AER) and the presence of hematuria was not corrected with the degree of UCE, we confirmed that 36% of diabetic patients have hypercalciuria and that the prevalence of hypercalciuria is more frequent in diabetic patients with normo- or microalbuminuria than in the controls. In 6 months, the AER of two hypercalciuric patients increased. However, the blood pressure and HbA<sub>1c</sub> of these two patients increased during the same 6 months. Therefore, it remains unclear whether hypercalciuria induced an increase in the AER of these patients.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 150-152"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90052-Q","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glomerular hemodynamic function in early diabetes 早期糖尿病肾小球血流动力学功能
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90015-H
Timothy W. Meyer
{"title":"Glomerular hemodynamic function in early diabetes","authors":"Timothy W. Meyer","doi":"10.1016/0891-6632(91)90015-H","DOIUrl":"10.1016/0891-6632(91)90015-H","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 53-55"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90015-H","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Renal hypertrophy in experimental diabetes 实验性糖尿病的肾肥大
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90019-L
Allan Flyvbjerg , Carl Erik Mogensen , Ruth Østerby , Hans Ørskov
{"title":"Renal hypertrophy in experimental diabetes","authors":"Allan Flyvbjerg ,&nbsp;Carl Erik Mogensen ,&nbsp;Ruth Østerby ,&nbsp;Hans Ørskov","doi":"10.1016/0891-6632(91)90019-L","DOIUrl":"10.1016/0891-6632(91)90019-L","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 62-64"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90019-L","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Diabetic nephropathy in insulin-dependent diabetes mellitus patients: How to measure progression of disease and effect of treatment 胰岛素依赖型糖尿病患者的糖尿病肾病:如何衡量疾病进展和治疗效果
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90020-P
Carl Erik Mogensen
{"title":"Diabetic nephropathy in insulin-dependent diabetes mellitus patients: How to measure progression of disease and effect of treatment","authors":"Carl Erik Mogensen","doi":"10.1016/0891-6632(91)90020-P","DOIUrl":"10.1016/0891-6632(91)90020-P","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 65-68"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90020-P","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased urinary excretion of kappa light chains in diabetic patients 糖尿病患者尿中kappa轻链排泄增加
The Journal of diabetic complications Pub Date : 1991-04-01 Epub Date: 2004-04-15 DOI: 10.1016/0891-6632(91)90055-T
K. Ohsawa, E. Takazakura
{"title":"Increased urinary excretion of kappa light chains in diabetic patients","authors":"K. Ohsawa,&nbsp;E. Takazakura","doi":"10.1016/0891-6632(91)90055-T","DOIUrl":"10.1016/0891-6632(91)90055-T","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Page 157"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90055-T","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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