The Journal of diabetic complications最新文献_第3页

Pathogenesis of diabetic nephropathy in non-insulin-dependent diabetes mellitus 非胰岛素依赖型糖尿病肾病的发病机制

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90025-K

Hiroshi Kida, Mituhiro Yoshimura, Kenzo Ikeda, Yafumi Saitou, Yutaka Noto

{"title":"Pathogenesis of diabetic nephropathy in non-insulin-dependent diabetes mellitus","authors":"Hiroshi Kida, Mituhiro Yoshimura, Kenzo Ikeda, Yafumi Saitou, Yutaka Noto","doi":"10.1016/0891-6632(91)90025-K","DOIUrl":"10.1016/0891-6632(91)90025-K","url":null,"abstract":"<div>To elucidate the characteristics of diabetic nodular lesions and the process of progression of diabetic glomerulosclerosis, kidney specimens obtained from 185 patients with non-insulin-dependent diabetes mellitus (NIDDM) were observed using light, electron, and immunofluorescence microscopes. The results suggest the following. First, there are two distinct subtypes of nodular lesions: One is formed by the progression and expansion of diffuse lesions; the other, showing a concentrically layered structure, is probably formed in the process of reconstruction of mesangiolysis. Second, there are three phases in the process of progression of diabetic glomerulosclerosis: In the first phase, arteriolosclerosis and diffuse lesions appear; in the second phase, mesangiolysis and nodular lesions develop in association with moderately advanced arteriolosclerosis; and in the third phase, exudative lesions and hyalinized glomeruli appear in association with advanced arteriolosclerosis together with advanced interstitial lesions. In the progression of the phases and in the development of mesangiolysis and layered nodular lesions, disturbed blood flow into glomeruli in consequence of diabetic arteriolosclerosis could be essential.</div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 82-83"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90025-K","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Comparison of renal hemodynamics in early non-insulin-dependent and insulin-dependent diabetes mellitus 早期非胰岛素依赖型糖尿病与胰岛素依赖型糖尿病肾脏血流动力学比较

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90049-U

Kazufumi Ishida, Fukashi Ishibashi, Seiryo Takashina

{"title":"Comparison of renal hemodynamics in early non-insulin-dependent and insulin-dependent diabetes mellitus","authors":"Kazufumi Ishida, Fukashi Ishibashi, Seiryo Takashina","doi":"10.1016/0891-6632(91)90049-U","DOIUrl":"10.1016/0891-6632(91)90049-U","url":null,"abstract":"<div>The differences in deranged renal hemodynamics in non-insulin-dependent diabetes mellitus (NIDDM) and insulin-dependent diabetes mellitus (IDDM) have never been fully investigated. Whether or not autoregulatory mechanism of renal hemodynamics in NIDDM and IDDM is preserved remains to be clarified.In the present study we directly compared renal hemodynamics and its autoregulatory function in the early stage of NIDDM and IDDM before and after short-term glycemic control. Before glycemic control, mildly exaggerated glomerular filtration rate (GFR), subnormal renal plasma flow (RPF), and elevated filtration fraction (FF) were found in NIDDM as well as in IDDM; but there were no differences in these parameters of renal hemodynamics between the two types of diabetics. Glycemic control decreased GFR, whereas it did not alter RPF, resulting in normalization of FF in NIDDM and in IDDM. Before glycemic control, mean blood pressure was significantly correlated with GFR, but was not correlated after glycemic control in either type of diabetes. In conclusion, hyperglycemia induced glomerular hyperfiltration evenly and disturbed autoregulation of renal hemodynamics in NIDDM and in IDDM.</div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 143-145"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90049-U","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Effects of angiotensin-converting enzyme inhibitor (alacepril) and calcium antagonist (nicardipine) in hypertensive non-insulin-dependent diabetic patients with microalbuminuria 血管紧张素转换酶抑制剂(阿拉西普利)和钙拮抗剂(尼卡地平)在高血压非胰岛素依赖型糖尿病合并微量白蛋白尿患者中的作用

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90058-W

S. Haisa , T. Norii , E. Takatori , A. Goto , S. Morioka , K. Uchida , H. Himei

{"title":"Effects of angiotensin-converting enzyme inhibitor (alacepril) and calcium antagonist (nicardipine) in hypertensive non-insulin-dependent diabetic patients with microalbuminuria","authors":"S. Haisa , T. Norii , E. Takatori , A. Goto , S. Morioka , K. Uchida , H. Himei","doi":"10.1016/0891-6632(91)90058-W","DOIUrl":"10.1016/0891-6632(91)90058-W","url":null,"abstract":"<div>The influence of alacepril (50 mg/day) on arterial blood pressure and microproteinuria in 26 hypertensive non-insulin-dependent diabetic patients was studied for 16 weeks. Alacepril reduced blood pressure gradually from <math><mtext>175</mtext><mtext>88</mtext></math> (standard error of mean [SEM] <math><mtext>2.6</mtext><mtext>1.7</mtext></math>) to <math><mtext>152</mtext><mtext>81</mtext></math> (<math><mtext>3.3</mtext><mtext>2.0</mtext></math>) mm Hg (P < .005) and albuminuria from 160.6 (SEM 29.1) to 98.1 (14.1) mg/g Cr (P < .05), while serum blood urea nitrogen, creatinine, HbA1c, and fructosamine (FRA) remained stable. No significant changes occurred in the urinary β2 microglobulin and N-acetyl-β-d-glucosaminidase levels. As compared with the effects of a calcium antagonist (nicardipine, 60 mg/day) that reduced blood pressure from <math><mtext>170</mtext><mtext>92</mtext></math> (SEM <math><mtext>2.5</mtext><mtext>1.4</mtext></math>) to <math><mtext>154</mtext><mtext>84</mtext></math> (<math><mtext>2.5</mtext><mtext>1.5</mtext></math>) mm Hg (P < .001) and albuminuria from 162.2 (SEM 33.9) to 95.4 (25.0) mg/g Cr (not significant), it is suggested that the angiotensin-converting enzyme inhibitor (alacepril) may have an advantageous renal effect in spite of its mild antihypertensive effect.</div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 162-164"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90058-W","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Diabetes mellitus in Japan: Past, present, and future 日本的糖尿病:过去、现在和未来

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90012-E

Akira Eboshida

引用次数: 0

Elevated endogenous Na-K-ATPase inhibitor activity in hypertensive diabetic patients with a family history of hypertension 有高血压家族史的高血压糖尿病患者内源性na - k - atp酶抑制剂活性升高

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90050-Y

S. Okamoto, M. Ikeda, T. Morise, I. Miyamori, R. Takeda

引用次数: 5

Three-dimensional architecture of glomerular extracellular matrices in diabetic glomerulosclerosis 糖尿病肾小球硬化肾小球细胞外基质的三维结构

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90041-M

Hirofumi Makino, Shigeaki Nishimura, Toshinori Haramoto, Yasushi Yamasaki, Shuji Ikeda, Zensuke Ota

引用次数: 0

Glucose-induced production of type IV collagen and laminin P1 from cultured human umbilical vein endothelial cells 葡萄糖诱导培养的人脐静脉内皮细胞产生IV型胶原和层粘连蛋白P1

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90075-Z

Shigeki Moritani , Kiyohiko Negishi , Toshiro Watanabe , Shunichiro Shunto , Naoki Serizawa , Masao Suzuki , Masaki Takahashi , Shigehiro Katayama , Jun Ishii , Shoji Kawazu

{"title":"Glucose-induced production of type IV collagen and laminin P1 from cultured human umbilical vein endothelial cells","authors":"Shigeki Moritani , Kiyohiko Negishi , Toshiro Watanabe , Shunichiro Shunto , Naoki Serizawa , Masao Suzuki , Masaki Takahashi , Shigehiro Katayama , Jun Ishii , Shoji Kawazu","doi":"10.1016/0891-6632(91)90075-Z","DOIUrl":"10.1016/0891-6632(91)90075-Z","url":null,"abstract":"<div>To study the effect of high glucose on the production of type IV collagen and laminin P1 from the cultured human umbilical vein endothelial cells (HUVEC), we measured type N collagen and laminin P1 from HUVEC that were cultured under different conditions. The concentrations of type IV collagen in the cultured medium for high glucose (30 mM d-glucose), l-glucose (30 mM), or mannitol (30 mM). The increase of type IV collagen was dependent on the glucose concentration in the medium. The contents of type IV collagen in the cultured cells were also increased in high-glucose incubation compared with low glucose or l-glucose incubation. In contrast, the levels of laminin P1 in the medium cultured with high glucose were similar to those with low glucose or l-glucose. These results suggest that the increased production of type IV collagen may contribute to the thickening of basement membranes and may be linked to the development of diabetic nephropathy.</div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 201-203"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90075-Z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Clinical significance of microalbuminuria in Japanese subjects with non-insulin-dependent diabetes 日本非胰岛素依赖型糖尿病患者微量白蛋白尿的临床意义

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90026-L

Yukio Shigeta, Masakazu Haneda, Ryuichi Kikkawa

引用次数: 9

Serum or urinary concentration of type IV collagen in diabetics 糖尿病患者血清或尿中IV型胶原蛋白的浓度

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90070-6

Toshiro Watanabe , Kiyohiko Negishi , Shigehiro Katayama , Jun Ishii , Shoji Kawazu

引用次数: 11

Asymptomatic ischemic heart disease and diabetic nephropathy: Relationship between prevalence of asymptomatic ischemic heart disease and urinary albumin excretion rate 无症状缺血性心脏病与糖尿病肾病:无症状缺血性心脏病患病率与尿白蛋白排泄率的关系

The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90061-S

Nagayuki Tani , Asako Hiroshima , Yutaka Kobayashi , Kazumasa Igarashi , Masatoshi Yamazaki , Hiroshi Nakamura , Asao Nakazawa , Seiki Ito , Akira Shibata

{"title":"Asymptomatic ischemic heart disease and diabetic nephropathy: Relationship between prevalence of asymptomatic ischemic heart disease and urinary albumin excretion rate","authors":"Nagayuki Tani , Asako Hiroshima , Yutaka Kobayashi , Kazumasa Igarashi , Masatoshi Yamazaki , Hiroshi Nakamura , Asao Nakazawa , Seiki Ito , Akira Shibata","doi":"10.1016/0891-6632(91)90061-S","DOIUrl":"10.1016/0891-6632(91)90061-S","url":null,"abstract":"<div>To examine whether prevalences of asymptomatic ischemic heart diseases in type II diabetic patients are correlated with the degree of diabetic nephropathy, 201Tl scintigraphies with dipyridamole loading were performed in 28 type II diabetic patients without any chest discomforts. Positive findings of ischemic changes were found in 5 (28%) of 18 patients with normoalbuminuria (urinary albumin excretion rate, AER < 20 μg/min) and 5 (50%) of 10 patients with micro- or macroalbuminuria (AER > 20 μg/min). Coronary angiography (CAG) was performed in 6 of 10 patients with positive findings of 201Tl scintigraphy. No stenotic findings were found in any patients, but wall motion was decreased in some patients and pulmonary artery pressure was increased in one patient. As stenosis of arteries with diameter of more than 0.3 mm can be detected by CAG, it seems likely that microangiopathy may play some role in the pathogenesis of asymptomatic ischemic heart disease detected with 201Tl scintigraphy.</div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 169-170"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90061-S","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2