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The Journal of diabetic complications最新文献

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Factors associated with diabetic microangiopathy: A study of 157 type I (insulin-dependent) diabetic patients 与糖尿病微血管病变相关的因素:157例I型(胰岛素依赖)糖尿病患者的研究
The Journal of diabetic complications Pub Date : 1991-10-01 DOI: 10.1016/0891-6632(91)90083-2
Bernadette M. Billault , Philippe L. Passa
{"title":"Factors associated with diabetic microangiopathy: A study of 157 type I (insulin-dependent) diabetic patients","authors":"Bernadette M. Billault ,&nbsp;Philippe L. Passa","doi":"10.1016/0891-6632(91)90083-2","DOIUrl":"10.1016/0891-6632(91)90083-2","url":null,"abstract":"<div><p>The relation between poor glycemic control and the development of diabetic microangiopathy has long been recognized. However hyperglycemia alone cannot account for the striking heterogeneity of diabetic patients regarding the presence or absence of microangiopathic lesions. This study was therefore designed to determine the prevalence of retinopathy, nephropathy, and neuropathy, and to identify the factors respectively associated with these lesions. In 157 patients with type I (insulin-dependent) diabetes, the following parameters were recorded: sex, age, duration of diabetes, body mass index, fasting plasma glucose, HbA<sub>1c</sub>, blood pressure, antihypertensive treatment, tobacco consumption, urinary albumin excretion, plasma creatinine, and presence of retinopathy and neuropathy. One-half of these patients had retinopathy, 32% neuropathy, and 29% nephropathy. Patients with nephropathy exhibited concomitantly high prevalences of retinopathy (69%) and neuropathy (49%). Among patients with retinopathy, 39% had nephropathy; 79% of those with neuropathy had concomitant retinopathy. For each microangiopathic localization, patients with the disease had significantly higher values (<em>p</em> &lt; 0.05) than those without for duration of diabetes, prevalence of hypertension, and systolic blood pressure. Stepwise logistic regression analysis showed that the following were independent predictive factors of each localization: for nephropathy, systolic blood pressure; for retinopathy, duration of diabetes; and for neuropathy, duration of diabetes, age, and HbA<sub>1c</sub>.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 4","pages":"Pages 238-243"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90083-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12941445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Rapid development of extensive macrovascular calcifications in a type I diabetic patient 1型糖尿病患者广泛大血管钙化的快速发展
The Journal of diabetic complications Pub Date : 1991-10-01 DOI: 10.1016/0891-6632(91)90086-5
Patricia B. Carroll , Horacio L.R. Rilo , Yijun Zeng , Camillo Ricordi , Ron Shapiro , Andreas G. Tzakis
{"title":"Rapid development of extensive macrovascular calcifications in a type I diabetic patient","authors":"Patricia B. Carroll ,&nbsp;Horacio L.R. Rilo ,&nbsp;Yijun Zeng ,&nbsp;Camillo Ricordi ,&nbsp;Ron Shapiro ,&nbsp;Andreas G. Tzakis","doi":"10.1016/0891-6632(91)90086-5","DOIUrl":"10.1016/0891-6632(91)90086-5","url":null,"abstract":"<div><p>This is a case report of a 35-year-old woman with a 15-year history of type I diabetes mellitus, who developed extensive macrovascular calcifications of the abdominal aorta and all its tributaries within 7 months of developing renal insufficiency. The patient was maintained on hemodialysis and peritoneal dialysis for a total of 3 months, then underwent combined cadaveric renal and pancreatic islet transplantation. Although some vascular calcifications are known to occur in elderly patients and in patients with long-standing uremia, it was the rapidity and extent of development of these lesions in this young woman that is astonishing.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 4","pages":"Pages 252-254"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90086-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12941337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Author index, volume 5 作者索引，第五卷
The Journal of diabetic complications Pub Date : 1991-10-01 DOI: 10.1016/0891-6632(91)90088-7
{"title":"Author index, volume 5","authors":"","doi":"10.1016/0891-6632(91)90088-7","DOIUrl":"https://doi.org/10.1016/0891-6632(91)90088-7","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 4","pages":"Pages 258-259"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90088-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137441032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of urokinase on preservation of renal function in patients with diabetic nephropathy 尿激酶对糖尿病肾病患者肾功能保存的影响
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90031-J
Hideto Sakai, Seiichi Watanabe, Itaru Inoue, Kurumi Tanaka, Mitsunori Yagame, Hideo Machimura, Hideaki Kaneshige, Yasuo Nomoto
{"title":"Effect of urokinase on preservation of renal function in patients with diabetic nephropathy","authors":"Hideto Sakai,&nbsp;Seiichi Watanabe,&nbsp;Itaru Inoue,&nbsp;Kurumi Tanaka,&nbsp;Mitsunori Yagame,&nbsp;Hideo Machimura,&nbsp;Hideaki Kaneshige,&nbsp;Yasuo Nomoto","doi":"10.1016/0891-6632(91)90031-J","DOIUrl":"10.1016/0891-6632(91)90031-J","url":null,"abstract":"<div><p>Long-term effects of urokinase on the preservation of renal function in patients with diabetic nephropathy were evaluated. Twenty-nine adult patients with non-insulin-dependent diabetes mellitus and overt proteinuria were randomly divided into two groups. One group was treated with daily oral administration of dipyridamole or dilazep dihydrochloride and weekly intravenous administration of urokinase; the other group was treated with dipyridamole alone. There was a significant decrease in the amount of proteinuria in the first group after 3 months of the treatment compared with the second group. There was also a significant preservation of renal function in the first group after three years of treatment compared with the second group. It was concluded that continuous administration of urokinase in addition to antiplatelet agents is useful in the treatment of patients with diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 95-97"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90031-J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Exercise regimen for patients with diabetic nephropathy 糖尿病肾病患者的运动方案
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90032-K
Kempei Matsuoka, Toshiyuki Nakao, Yoshihito Atsumi, Hiroshi Takekoshi
{"title":"Exercise regimen for patients with diabetic nephropathy","authors":"Kempei Matsuoka,&nbsp;Toshiyuki Nakao,&nbsp;Yoshihito Atsumi,&nbsp;Hiroshi Takekoshi","doi":"10.1016/0891-6632(91)90032-K","DOIUrl":"10.1016/0891-6632(91)90032-K","url":null,"abstract":"<div><p>To elucidate the relationship between physical activity and the progress of diabetic nephropathy, patients were divided into two groups with physical activity maintained (G) or restricted (R). The period between the onset of 1+ and 3+ proteinuria was 56 ± 25 months in G and 68 ± 25 months in R. But the period between 3+ proteinuria and the serum creatinine exceeding 2.0 mg/dl was 29 ± 19 and 23 ± 22 months, respectively. Duration of the nephrotic stage before the entry to dialysis was about 27 months in each group. After initiation of hemodialysis or continuous ambulatory peritoneal dyalysis (CAPD), postural hypotension tended to be less in G and Karnofsky score for fitness in daily physical activity was significantly better in G. Even after macroalbuminuria emerged, it was concluded that a strict restriction of exercise is of little benefit.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 98-100"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90032-K","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Clinical implications of serum levels of basement membrane components in diabetic patients with and without albuminuria 伴有和不伴有蛋白尿的糖尿病患者血清基底膜成分水平的临床意义
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90071-V
Shoichi Tomono, Shoji Kawazu, Norihiro Kato, Tomio Ohno, Toshihiro Utsugi, Kazuhiko Murata
{"title":"Clinical implications of serum levels of basement membrane components in diabetic patients with and without albuminuria","authors":"Shoichi Tomono,&nbsp;Shoji Kawazu,&nbsp;Norihiro Kato,&nbsp;Tomio Ohno,&nbsp;Toshihiro Utsugi,&nbsp;Kazuhiko Murata","doi":"10.1016/0891-6632(91)90071-V","DOIUrl":"10.1016/0891-6632(91)90071-V","url":null,"abstract":"<div><p>Serum levels of type IV collagen (7S-IV) and laminin P1 in 185 non-insulin-dependent diabetes mellitus patients were significantly higher than those in normal subjects. Furthermore, they were significantly elevated in relation to the excretion of urinary albumin, showing their increases even at the stage of microalbuminuria, although they were not correlated with HbA<sub>1</sub>c or age in diabetic patients. Thus, the determination of serum levels of basement membrane components, 7S-IV and laminin, could be beneficial as the early indices of diabetic microangiopathy, including diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 193-194"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90071-V","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Increased concentrations of the basement membrane component type IV collagen in sera and urine of diabetics 糖尿病患者血清和尿液中基底膜成分IV型胶原浓度升高
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90072-W
Y. Hayashi, H. Makino, K. Shikata, T. Haramoto, Y. Yamasaki, I. Kumagai, Z. Ota
{"title":"Increased concentrations of the basement membrane component type IV collagen in sera and urine of diabetics","authors":"Y. Hayashi,&nbsp;H. Makino,&nbsp;K. Shikata,&nbsp;T. Haramoto,&nbsp;Y. Yamasaki,&nbsp;I. Kumagai,&nbsp;Z. Ota","doi":"10.1016/0891-6632(91)90072-W","DOIUrl":"10.1016/0891-6632(91)90072-W","url":null,"abstract":"<div><p>We measured serum and urinary concentrations of type IV collagen by radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) in diabetics. Serum and urinary concentrations of type IV collagen measured by RIA and ELISA were increased compared to those of control subjects. In diabetics with macroproteinuria or with renal insufficiency, serum and urinary concentrations of type IV collagen were higher than in diabetics without nephropathy or with early renal damage as determined by the presence of microproteinuria. These results suggest that serum and urinary concentrations of type IV collagen are increased in patients with advanced diabetic nephropathy. These increases may indicate that alteration of basement membrane metabolism has occurred in diabetics.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 195-196"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90072-W","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Mesangial cell dysfunction 系膜细胞功能障碍
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90017-J
Ryuichi Kikkawa, Masakazu Haneda, Daisuke Koya, Yukio Shigeta
{"title":"Mesangial cell dysfunction","authors":"Ryuichi Kikkawa,&nbsp;Masakazu Haneda,&nbsp;Daisuke Koya,&nbsp;Yukio Shigeta","doi":"10.1016/0891-6632(91)90017-J","DOIUrl":"10.1016/0891-6632(91)90017-J","url":null,"abstract":"","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 58-59"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90017-J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12934007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of sulfated carbohydrate from the glomerular podocyte as a cause of albuminuria in experimental diabetic rats: Ultrastructural histochemical study 实验性糖尿病大鼠肾小球足细胞中硫酸碳水化合物的丢失是引起蛋白尿的原因:超微结构组织化学研究
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90063-U
K. Ina , H. Kitamura , M. Nakamura , J. Ono , R. Takaki
{"title":"Loss of sulfated carbohydrate from the glomerular podocyte as a cause of albuminuria in experimental diabetic rats: Ultrastructural histochemical study","authors":"K. Ina ,&nbsp;H. Kitamura ,&nbsp;M. Nakamura ,&nbsp;J. Ono ,&nbsp;R. Takaki","doi":"10.1016/0891-6632(91)90063-U","DOIUrl":"10.1016/0891-6632(91)90063-U","url":null,"abstract":"<div><p>Decrease of anionic sites and heparan sulfate proteoglycan has been demonstrated in diabetic glomerular basement membrane (GBM) and causally related to albuminuria. The HID-TCH-SP-PD technique is a sensitive histochemical method for negatively charged sulfated carbohydrates. In this study, we examined the localization of HID-TCH-SP-PD reaction in the glomeruli of diabetic and control rats. In both rats, the reaction was found in assciation with the surface of podocytes and with GBM. In diabetic rats, the former-associated reaction was markedly reduced. By contrast, the latter-associated reaction did not show any differences between both animal groups. Urinary albumin excretion (UAE) increased significantly in alloxanized rats. It is suggested that a decrease of podocyte-associated sulfated carbohydrates, the primary observed change, gives rise to albuminuria in alloxan diabetic rats.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 173-175"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90063-U","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Phosphate depletion with phosphate binder arrests the development of nephropathy in spontaneously hypertensive rats with non-insulin-dependent diabetes mellitus fed a high-protein diet 磷酸盐结合物的磷酸盐耗竭阻止了高蛋白饮食喂养的非胰岛素依赖型糖尿病自发性高血压大鼠肾病的发展
The Journal of diabetic complications Pub Date : 1991-04-01 DOI: 10.1016/0891-6632(91)90064-V
K. Nunoi, Y. Satho, N. Tsutsu, M. Iwase, M. Wakisaka, M. Fujishima
{"title":"Phosphate depletion with phosphate binder arrests the development of nephropathy in spontaneously hypertensive rats with non-insulin-dependent diabetes mellitus fed a high-protein diet","authors":"K. Nunoi,&nbsp;Y. Satho,&nbsp;N. Tsutsu,&nbsp;M. Iwase,&nbsp;M. Wakisaka,&nbsp;M. Fujishima","doi":"10.1016/0891-6632(91)90064-V","DOIUrl":"10.1016/0891-6632(91)90064-V","url":null,"abstract":"<div><p>The protective effect of phosphate binder (PB) on nephropathy was examined in spontaneously hypertensive rats with non-insulin-dependent diabetes mellitus (NIDDM) fed a high-protein diet. The rats were treated with vehicle or streptozocin neonatally. After 14 weeks, all rats were fed a high-protein diet (50% protein content), and in half of the diabetic rats the diets were supplemented with PB. At 24 weeks, the urinary excretion rate of albumin and kidney weight increased in diabetic rats, but decreased or tended to decrease in diabetic rats treated with PB. The elevation of urinary excretion rate of <em>N</em>-acetyl-β-<span>d</span>-glucosaminidase, probably due to protein load, was also abolished with PB.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 176-178"},"PeriodicalIF":0.0,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90064-V","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12932184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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