{"title":"Clinical significance of urinary enzymes in diabetic nephropathy","authors":"Emiko Morita , Kazo Kaizu , Kohei Uriu , Osamu Hashimoto , Norikuni Komine , Sumiya Eto","doi":"10.1016/0891-6632(91)90056-U","DOIUrl":null,"url":null,"abstract":"<div><p>Urinary enzyme activities (<em>N</em>-acetyl-β-<span>d</span>-glucosaminidase [NAG], alkaline phosphatase [ALP], leucine aminopeptidase [LAP], γ-glutamyl transpeptidase [γ-GTP]) were investigated to determine their clinical significance in diabetic nephropathy. There were correlations among ALP, LAP, and γ-GTP, though no correlation existed between NAG and the other three enzymes. Activities of NAG isozymes (both A and B) were higher than in normal controls. It has been reported that NAG isozyme A might be associated with glomerular diseases, and isozyme B might be associated with proximal tubular damage. The results of our study suggest that NAG reflects lysosomal dysfunction of both glomerular and proximal tubular epithelial cells, which may be caused by poor glycemic control, and that ALP, LAP, and γ-GTP reflect brush border damage of proximal tubules, which may be caused by diabetic nephropathy.</p></div>","PeriodicalId":77636,"journal":{"name":"The Journal of diabetic complications","volume":"5 2","pages":"Pages 158-159"},"PeriodicalIF":0.0000,"publicationDate":"1991-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0891-6632(91)90056-U","citationCount":"13","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of diabetic complications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/089166329190056U","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
Abstract
Urinary enzyme activities (N-acetyl-β-d-glucosaminidase [NAG], alkaline phosphatase [ALP], leucine aminopeptidase [LAP], γ-glutamyl transpeptidase [γ-GTP]) were investigated to determine their clinical significance in diabetic nephropathy. There were correlations among ALP, LAP, and γ-GTP, though no correlation existed between NAG and the other three enzymes. Activities of NAG isozymes (both A and B) were higher than in normal controls. It has been reported that NAG isozyme A might be associated with glomerular diseases, and isozyme B might be associated with proximal tubular damage. The results of our study suggest that NAG reflects lysosomal dysfunction of both glomerular and proximal tubular epithelial cells, which may be caused by poor glycemic control, and that ALP, LAP, and γ-GTP reflect brush border damage of proximal tubules, which may be caused by diabetic nephropathy.
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