Hermes Melo Teixeira Batista, Solange Kelly Lima Araújo, Galba Matos Cardoso de Alencar Júnior, Luiz Carlos de Abreu, Italla Maria Pinheiro Bezerra, Andrés Ricardo Pérez Riera
{"title":"Effect of clonidine on heart rate variability during spinal anaesthesia: randomized clinical trial.","authors":"Hermes Melo Teixeira Batista, Solange Kelly Lima Araújo, Galba Matos Cardoso de Alencar Júnior, Luiz Carlos de Abreu, Italla Maria Pinheiro Bezerra, Andrés Ricardo Pérez Riera","doi":"10.5114/ait.2023.130821","DOIUrl":"https://doi.org/10.5114/ait.2023.130821","url":null,"abstract":"<p><strong>Introduction: </strong>Spinal anaesthesia consists of administering a local anaesthetic in the subarachnoid space, thus causing sensory, motor, and autonomic nerve conduction block. Currently, recovery from spinal anaesthesia is evaluated by the return of motor function, without considering the autonomic blockade, which is responsible for most complications of the technique. Heart rate variability (HRV) is an indirect method to measure the autonomic nervous system and may be useful in assessing autonomic recovery after spinal anaesthesia. The study objective was to evaluate the autonomic function, through HRV, at the moment of return of motor function in patients who received spinal anaesthesia when clonidine is used as an adjuvant.</p><p><strong>Material and methods: </strong>This was a randomised, double-blind clinical trial. The sample consisted of 64 ASA I-II patients who underwent spinal anaesthesia and were divided into 2 groups. Group C received 20 mg of bupivacaine with 75 mcg of clonidine, and group B received 20 mg of bupivacaine. HRV was evaluated at rest (T1) and at the time of motor function recovery (T2). Data were collected using a Polar V800® heart rate monitor and then analysed and filtered using Kubios 3.0® software.</p><p><strong>Results: </strong>There was no difference in the values of the low-frequency/high-frequency (LF/HF) ratio, Poincaré plot standard deviation (SD2/SD1), detrended fluctuation analysis (DFAα1, DFAα2), or correlation dimension (D2) indices in any of the groups between the 2 moments. In the clonidine group, there was a difference only in approximate entropy (ApEn), where a P of 0.0124 was obtained considering a 95% confidence interval ranging from 17.83 to 141.47.</p><p><strong>Conclusions: </strong>There was no significant difference between the duration of sympathetic blockade and motor blockade in spinal anaesthesia.</p>","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"55 3","pages":"218-222"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/08/AIT-55-51318.PMC10496102.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41098157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zbigniew Putowski, Natalia Rachfalska, Karolina Majewska, Katarzyna Megger, Łukasz Krzych
{"title":"Identification of risk factors for post-intensive care syndrome in family members (PICS-F) among adult patients: a systematic review.","authors":"Zbigniew Putowski, Natalia Rachfalska, Karolina Majewska, Katarzyna Megger, Łukasz Krzych","doi":"10.5114/ait.2023.130831","DOIUrl":"https://doi.org/10.5114/ait.2023.130831","url":null,"abstract":"<p><strong>Introduction: </strong>Relatives of critically ill patients who either die or survive the intensive care unit (ICU) may develop substantial mental health problems that are collectively defined as post-intensive care syndrome in family (PICS-F).</p><p><strong>Material and methods: </strong>By using a systematised search strategy we included studies that focused on PICS-F in relatives of adult ICU patients and reported the risk factors associated with its development. The search was conducted within PubMed, Embase, SCOPUS, clinicaltrials.gov, and Cochrane Library on the 23 August 2022. PRISMA 2020 guidelines were implemented for appropriate reporting. The objective was to document all possible risk factors associated with the development of PICS-F.</p><p><strong>Results: </strong>We included 51 papers covering 9302 relatives. The frequency of PICS-F varied between 2.5 and 69%. We identified 51 different risk factors of PICS-F, among which we distinguished patient-related ( n = 16), relative-related ( n = 27), and medical staff-related ( n = 8) risk factors. Among 21 studies of the highest quality, we identified the 33 variables associated with the development of PICS-F, of which younger age of a patient, death of a patient, depression in relatives during the ICU stay, history of mental disorders in relatives, being a female relative, being a spouse, and having low satisfaction with communication and care in the ICU were the most commonly reported risk factors.</p><p><strong>Conclusions: </strong>PICS-F is a highly frequent phenomenon that can be exacerbated by several risk factors. Special attention should be paid to relatives of younger patients with worse prognosis and with the following relative-related risk factors: female sex, being a spouse, and history of mental health disorders. Finally, the medical staff play a role in preventing the PICS-F development, not only by maintenance of proper communication, but also by early identification of relatives prone to PICS-F.</p>","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"55 3","pages":"168-178"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5e/d4/AIT-55-51319.PMC10496103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41111959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prospective, randomised comparison of two intravenous sedation methods for magnetic resonance imaging in children.","authors":"Viktor Mark Brzózka, Andrzej Jerzy Piotrowski","doi":"10.5114/ait.2023.128715","DOIUrl":"https://doi.org/10.5114/ait.2023.128715","url":null,"abstract":"<p><strong>Background: </strong>Children usually need sedation or even anaesthesia for magnetic resonance imaging (MRI) studies. As there is no universally accepted method for this purpose we undertook a prospective, randomised comparison of propofol and dexmedetomidine in children aged 1 to 10 years.</p><p><strong>Methods: </strong>After Institutional Board approval and parents' informed consent 64 ASA status I or II children scheduled for MRI scan were enrolled. Patients were premedicated with intravenous (IV) midazolam (0.1 mg kg -1 ) and ketamine (1 mg kg -1 ) and randomised to propofol (P) or dexmedetomidine (D) group. A propofol bolus of 1 mg kg -1 followed by infusion of 4 mg kg -1 h -1 , or dexmedetomidine 1 µg kg -1 followed by 2 µg kg -1 h-1 infusion were used. Heart rate, SpO 2 and non-invasive blood pressure were monitored and recorded at 5 min intervals. Results were compared by means of standard statistical methods.</p><p><strong>Results: </strong>Both dexmedetomidine and propofol after premedication with ketamine and midazolam are suitable for MRI sedation, although propofol use results in shorter recovery time. Less interventions are needed when dexmedetomidine is used.</p>","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"55 2","pages":"81-86"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/99/AIT-55-50864.PMC10415600.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10446666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing general anaesthesia versus sedation for endoscopic submucosal dissection: results from a systematic review and meta-analysis.","authors":"Choy-May Leung, Rex Wan-Hin Hui","doi":"10.5114/ait.2023.125416","DOIUrl":"https://doi.org/10.5114/ait.2023.125416","url":null,"abstract":"<p><p>Endoscopic submucosal dissection (ESD) is an advanced endoscopic procedure for management of gastrointestinal tumours. ESD is usually performed under sedation. However, the use of general anaesthesia (GA) has been hypothesised to improve ESD outcomes. We performed a systematic review and meta-analysis to compare GA against sedation in ESD. A systematic literature search was performed on Cochrane Library, EMBASE and MEDLINE using the terms \"General Anaesthesia\", \"Sedation\" and \"Endoscopic submucosal dissection\". Original articles comparing GA versus sedation in ESD were included. The risk of bias and level of evidence were assessed by validated methods. This review is registered in PROSPERO (CRD42021275813). 176 articles were found in the initial literature search, and 7 articles (comprising 518 patients receiving GA and 495 receiving sedation) were included. Compared with sedation, GA was associated with higher en-bloc resection rates in oesophageal ESD (RR 1.05; 95% CI: 1.00-1.10; I 2 = 65%; P = 0.05). GA patients also trended towards lower rates of gastrointestinal perforation in all ESD procedures (RR 0.62; 95% CI: 0.21-1.82; I 2 = 52%; P = 0.06). Rates of intra- procedural desaturation and post-procedural aspiration pneumonia were lower in GA patients than in patients under sedation. The included studies had a moderate to high risk of bias, and the overall level of evidence was low. GA appears safe and feasible for ESD, yet high-quality trials will be required before GA can be regularly implemented for ESD.</p>","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"55 1","pages":"9-17"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b7/9d/AIT-55-50200.PMC10156556.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of positive pressure extubation with traditional extubation in critically ill patients - a randomised control study.","authors":"Ajeetviswanath Thanjavur Prabhakaran, Darlong Vanalal, Kapil Soni, Dalim Baidya, Richa Aggarwal, Harsha Binu, Shivanand Gamanagatti, Maya Dehran, Anjan Trikha","doi":"10.5114/ait.2023.125584","DOIUrl":"https://doi.org/10.5114/ait.2023.125584","url":null,"abstract":"<p><strong>Background: </strong>Two extubation methods are commonly used in the intensive care unit (ICU): the traditional method with endotracheal suctioning and the positive- pressure method without suctioning. Better physiological outcomes were found in lab studies using the latter, as the air passing between the endotracheal tube and the larynx pushes out the collected subglottic secretions, which can be suctioned.</p><p><strong>Methods: </strong>70 mechanically ventilated patients in a tertiary ICU were randomised into 2 groups of 35 patients each. At the end of the spontaneous breathing trial (SBT), the positive pressure extubation (PPE) group was given a pressure support of 15 cm H 2 O and a positive end expiratory pressure of 10 cm H 2 O for 5 minutes while the other group (traditional extubation - TE) was extubated directly. We compared the lung ultrasound scores (LUS), chest X-ray findings, alveolar arterial oxygen gradient changes, adverse clinical events, ICU-free days and reintubation rates between the two groups.</p><p><strong>Results: </strong>Median LUS at the end of the SBT was similar between the two groups. However, the median post-extubation LUS at 30 minutes, 6 hours, 24 hours in the PPE group [5 (4-8) ( P = 0.04), 5 (3-8) ( P = 0.02), 4 (3-7) ( P = 0.02), respectively] were significantly lower compared to the TE group [6 (6-8), 6 (5-7.5), 6 (5-7.5), respectively]. There was a persistent lowering of the scores even at the end of 24 hours in the PPE group, while the percentage of patients without adverse clinical events was significantly higher (80% vs. 57.14%, P = 0.04).</p><p><strong>Conclusions: </strong>The study shows that positive pressure extubation is a safe procedure which improves aeration and reduces adverse events.</p>","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"55 1","pages":"38-45"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/bf/AIT-55-50250.PMC10156539.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dipasri Bhattacharya, Mohanchandra Mandal, Antonio Esquinas
{"title":"Commentary: Barotrauma in critically ill patients with COVID-19: miles to go to unwrap the pathophysiology.","authors":"Dipasri Bhattacharya, Mohanchandra Mandal, Antonio Esquinas","doi":"10.5114/ait.2023.126223","DOIUrl":"https://doi.org/10.5114/ait.2023.126223","url":null,"abstract":"Dear Editor, We read with great interest the retrospective case-control study of Venkateswaran et al. [1]. However, we consider that there are certain points that need further clarification, and that the provision of more data in the methodology would make it even more interesting. Firstly, the authors did not mention what flow was used during use of a high-flow nasal cannula (HFNC) for their patients. Lower flow rates (35–40 L min-1) may be advantageous for better patient comfort and initial adaptation, while a higher flow rate (60 L min-1) can provide a faster relief of dyspnoea. One might start with 60 L min-1 and individualise the flow to the highest value tolerated by the patient [2]. The decrease of transoesophageal pressure fluctuations can be used as a measure of patient effort and work of breathing. HFNC may be a fruitful therapy when personalised bedside titration to optimum flow is ensured. Secondly, we are curious to know about the level of positive end-expiratory pressure (PEEP) (the PEEP maximum) used during invasive mechanical ventilation, and whether they utilised any lung-protective strategy and ventilator modes in their cases. Low tidal volume lung protective ventilation remains the cornerstone of supportive therapy in patients with acute respiratory distress syndrome (ARDS), thereby yielding a considerable improvement in outcomes [3]. Higher maximum PEEP has been observed among patients who suffered barotrauma compared with non-barotrauma patients [4]. Finally, in the present study, the authors relied on clinical examination findings and utilised chest radiography, computed tomography, ultrasonography, or a combination thereof to diagnose pneumothorax. It would be interesting to know the details of how many patients were diagnosed using which diagnostic modality. In any study assessing barotrauma, a plausible cause of reported higher incidence of pneumothorax could be the broader use of chest CT with its higher sensitivity to detect extra-alveolar gas collections [5].","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"55 1","pages":"68"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/d5/AIT-55-50435.PMC10156551.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9625540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-dose caudal versus dorsal penile nerve block for postoperative analgesia after circumcision: a randomized comparative study.","authors":"Mayar Hassan El Sersi, Mohamed Sidky Mahmoud Zaki, Samar Sobhi Elnaggar, Ramy Mahrose","doi":"10.5114/ait.2023.132869","DOIUrl":"https://doi.org/10.5114/ait.2023.132869","url":null,"abstract":"<p><strong>Introduction: </strong>Paediatric male circumcision is a painful surgical procedure, which is usually carried out under general anaesthesia. Regional analgesic techniques, including dorsal penile nerve block (DPNB) and caudal nerve block (CNB), are superior to opioid and non-opioid systemic analgesia for postoperative pain control after circumcision.</p><p><strong>Material and methods: </strong>The purpose of our study was to compare the efficacy, duration of postoperative analgesia, and complications of DPNB, CNB, and the combination of 2 blocks. Eighty-one male patients aged from 3 to 12 years scheduled for circumcision were distributed into 3 groups, each consisting of 27 patients; group 1 (DPNB group), group 2 (CNB group), and group 3 for combined blockade. This study compared the 3 groups in terms of intraoperative vital signs: heart rate and blood pressure, postoperative Wong-Baker score, and complications (nausea, vomiting, pruritus, urinary retention, and constipation).</p><p><strong>Results: </strong>The intraoperative haemodynamics did not differ between the 3 groups of the study. There is significant difference in the Wong-Baker scale postoperatively at 1, 3, and 24 hours, being significantly less in the CNB group and combined blockade group than in the DPNB group, but there was no significant difference between the CNB group and the combined blockade group. The incidence of complications showed no significant intergroup difference, except for urinary retention being lower with DPNB.</p><p><strong>Conclusions: </strong>Both caudal and combined blockade were superior to DPNB for intraoperative and postoperative analgesia after circumcision. CNB and combined blockade was associated with significantly higher incidence of urinary retention compared to DPNB. Also, there was no additional benefit to the analgesic efficacy from combining both blocks.</p>","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"55 4","pages":"297-303"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10691451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agata Hanych, Paweł Kutnik, Przemysław Pasiak, Aleksandra Zakrzewska-Szalak, Oksana Wichowska, Mariusz Jednakiewicz, Adam Nogalski, Paweł Piwowarczyk, Michał Borys
{"title":"Continuous lumbar erector spinae plane block as an alternative to epidural analgesia in pain treatment in patients undergoing hip replacement surgery – a prospective pilot study","authors":"Agata Hanych, Paweł Kutnik, Przemysław Pasiak, Aleksandra Zakrzewska-Szalak, Oksana Wichowska, Mariusz Jednakiewicz, Adam Nogalski, Paweł Piwowarczyk, Michał Borys","doi":"10.5114/ait.2023.132517","DOIUrl":"https://doi.org/10.5114/ait.2023.132517","url":null,"abstract":"Background Postoperative pain associated with hip replacement surgery can be severe, decreasing the patient’s mobility and satisfaction with perioperative treatment. Regional techniques are commonly used as postoperative analgesia in hip surgery patients. Methods We performed a prospective pilot study on patients undergoing hip replacement surgery. We anesthetized each participant with spinal technique and allocated patients according to postoperative analgesia to the continuous epidural group and the continuous lumbar erector spinae plane block (ESPB) group. We measured postope-rative oxycodone consumption with patient-controlled analgesia (PCA) demands. At several points, we evaluated the patients’ pain at rest and during activity on the visual analog scale (VAS, 0–10), their quadriceps femoris’ muscle strength on the Lovett scale (0–5), and their ability to sit, stand upright, and walk on the Timed Up and Go test. Moreover, we assessed the patients’ recovery through the Quality of Recovery 40 (QoR-40) questionnaire on the first postoperative day. Results We found lower oxycodone consumption via PCA in the epidural than in the ESPB group (9.1 (mean) mg (5.2–13.0) (confidence interval) vs. 15.5 mg (9.8–21.3), P = 0.049). Patients in the ESPB group had more demands with PCA than participants in the epidural group (10.5 (median) (6–16) (interquartile range) vs. 25 (16–51), P = 0.016). We did not find differences between the groups in the other outcomes or in terms of postoperative complications. Conclusions The results suggest that the continuous lumbar ESPB group is equivalent to epidural analgesia as a pain treatment technique in patients undergoing hip replacement surgery.","PeriodicalId":7750,"journal":{"name":"Anaesthesiology intensive therapy","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135706375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}