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Spectrokinetic characteristics of two types of fluorescence of refractive granules in native individual cells from ascitic tumours. 腹水肿瘤原生细胞中两种折射颗粒荧光的光谱动力学特征。
Biomedical science Pub Date : 1991-01-01
P M Shvartsburd, K B Aslanidi
{"title":"Spectrokinetic characteristics of two types of fluorescence of refractive granules in native individual cells from ascitic tumours.","authors":"P M Shvartsburd,&nbsp;K B Aslanidi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The spectrokinetic parameters of two different types of fluorescence of lipid-containing refractory granules (RG1 and RG2) specific to native single cells from rat ovarian tumour and Zaidela ascites hepatoma were studied. With these parameters it was possible for the first time to reveal and estimate the contribution of fluorescent lipid peroxidation products to the total fluorescence band (430-470 nm) of RG1 as well as to reveal another fluorescent component with parameters similar to those of NAD(P)H. The phenomenon of 'photoinflammation' of RG2 fluorescence under UV light, reported previously for lipofuscin granules, was observed in vitro for four retinal derivatives, but only in the absence of their contact with air.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 4","pages":"391-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogenicity of a polypeptide fragment of the streptococcal group A M protein conjugated with an acrylic acid N-vinylpyrrolidone copolymer. 与丙烯酸- n -乙烯基吡咯烷酮共聚物偶联的链球菌a组M蛋白多肽片段的免疫原性。
Biomedical science Pub Date : 1991-01-01
I M Lyampert, E N Semenova, Sanina VYu, N G Puchkova, A V Nekrasov
{"title":"Immunogenicity of a polypeptide fragment of the streptococcal group A M protein conjugated with an acrylic acid N-vinylpyrrolidone copolymer.","authors":"I M Lyampert,&nbsp;E N Semenova,&nbsp;Sanina VYu,&nbsp;N G Puchkova,&nbsp;A V Nekrasov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunization of animals with a polypeptide fragment of the streptococcal group A M protein (pep M) conjugated with a synthetic copolymer caused a significant increase in the titres of bactericidal type-specific antibodies. In some cases bactericidal antibodies to streptococci of other types were also induced.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 4","pages":"410-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12959062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteins of human chorionic villi tissue: construction of a protein map based upon fractionation by two-dimensional gel electrophoresis. 人绒毛膜绒毛组织的蛋白质:基于二维凝胶电泳分离的蛋白质图谱的构建。
Biomedical science Pub Date : 1991-01-01
Kornienko YuA, S S Shishkin, B A Kaurov
{"title":"Proteins of human chorionic villi tissue: construction of a protein map based upon fractionation by two-dimensional gel electrophoresis.","authors":"Kornienko YuA,&nbsp;S S Shishkin,&nbsp;B A Kaurov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Proteins of human chorionic villi from the first trimester of pregnancy were studied by high-resolution two-dimensional gel electrophoresis. One hundred and ninety-eight proteins spots were identifiable and allowed the plotting of a two-dimensional map of the proteins of human chorionic villi from the eighth week of pregnancy. The proteins of human chorionic villi from the twelfth week of gestation and of villi from term placenta were also studied. A comparison of protein compositions at different gestational ages was made. The findings from two-dimensional electrophoretic analysis of villi proteins have been summarized and stored in a computer data base.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 6","pages":"590-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13002795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venezuelan equine encephalitis virus propagation in the olfactory tract of normal and immunized mice. 委内瑞拉马脑炎病毒在正常小鼠和免疫小鼠嗅道中的传播。
Biomedical science Pub Date : 1991-01-01
A B Ryzhikov, N V Tkacheva, A N Sergeev, E I Ryabchikova
{"title":"Venezuelan equine encephalitis virus propagation in the olfactory tract of normal and immunized mice.","authors":"A B Ryzhikov,&nbsp;N V Tkacheva,&nbsp;A N Sergeev,&nbsp;E I Ryabchikova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The role of virus spread in the induction of damage to the central nervous system (CNS) of mice infected with Venezuelan equine encephalitis virus (VEEV) via the respiratory route was studied. The virus concentration in various organs and in the blood, the sensitivity to different doses of virus, and ultrastructural lesions in various tissues were examined. It is concluded that VEEV can enter the CNS of nonimmunized mice both by vascular and by olfactory pathways, whereas in immunized mice the olfactory pathway is the main route.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 6","pages":"607-14"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13002798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Participation of macrophages in the mechanism mediating the enhancement of metastasis formation after tumour resection. 巨噬细胞参与肿瘤切除后促进转移形成的机制。
Biomedical science Pub Date : 1991-01-01
V M Yunker, N P Taraskina, A S Ustinov
{"title":"Participation of macrophages in the mechanism mediating the enhancement of metastasis formation after tumour resection.","authors":"V M Yunker,&nbsp;N P Taraskina,&nbsp;A S Ustinov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The number of spontaneous lung metastases and the frequency of metastasis formation in the lymph nodes of mice were studied following the induction of tumour growth by injection of tumour cells. A syngeneic transplantable mammary adenocarcinoma, MMT 1, from C3H/He mice, and a cloned strain, MMTV4, obtained by treating MMT1 cells with 5-azacytidine in vitro, were used. No differences between MMT1 and MMTV4 were detected in the number of spontaneous metastases in the lungs of mice. An in vitro cytotoxic test and an adoptive transfer test were used to measure cytotoxic activity and the antimetastatic activity of spleen macrophages. The macrophages from mice bearing the MMT1 tumour exhibited antimetastatic activity in the adoptive transfer test, and specific and nonspecific cytotoxic activity in the in vitro test. Macrophages from mice carrying the MMTV4 tumour possessed nonspecific cytotoxic activity in vitro but did not exhibit antimetastatic activity in the adoptive transfer test. Tumours were surgically removed 13-15 days after their induction. Two weeks after the MMT1 tumour was resected, an abrupt increase in the number of spontaneous metastases in the lungs and in the lymph nodes was observed, whereas after removal of the MMTV4 tumour there were no changes in the number of lung metastases. When mice with the MMT1 tumour were given the cyclooxygenase inhibitor, indomethacin, in their drinking water, there was a significant decrease in the number of spontaneous lung metastases. Spleen macrophages from mice operated on after injection with MMT1 or MMTV4 did not possess specific cytotoxicity in the in vitro test.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 6","pages":"569-75"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13002888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of T lymphocytes in the immunotherapy of tumours. T淋巴细胞在肿瘤免疫治疗中的作用。
Biomedical science Pub Date : 1991-01-01
B D Brondz, K E Balashov
{"title":"The role of T lymphocytes in the immunotherapy of tumours.","authors":"B D Brondz,&nbsp;K E Balashov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The interactions of tumour cells with membrane molecules of T-cell subsets, as well as methods directed towards the enhancement of antitumour immunity, are reviewed in this paper. Special attention is given to the cytotoxic function of lymphokine-activated tumour-infiltrating lymphocytes, to tumour-specific suppressor T cells, and to various causes of decreased expression of histocompatibility antigens on the surface of tumour cells. The different mechanisms underlying selective antitumour immunodeficiencies and possible approaches to the correction of immunodeficiency, to the enhancement of tumour immunogenicity, and to specific immunotherapy are considered in more detail.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 5","pages":"441-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13003022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of the predictive abilities of different methods based on information theory: searching for receptor-binding sites. 基于信息论的不同方法预测能力的比较:寻找受体结合位点。
Biomedical science Pub Date : 1991-01-01
A E Gabrielian, A N Nekrasov, M P Kirpichnikov
{"title":"Comparison of the predictive abilities of different methods based on information theory: searching for receptor-binding sites.","authors":"A E Gabrielian,&nbsp;A N Nekrasov,&nbsp;M P Kirpichnikov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A comparison of a new method of searching for functionally important sites in proteins and peptide hormones with a previously published method is presented. All methods are based on information theory that holds that rare oligomers contain much information and, thus, are likely to be important for specific functional activity. Twenty-five proteins and peptide hormones with known receptor-binding sites were studied; the new method showed good predictive ability. However, taking into account short-range sequential preferences in protein structures, the predictive ability of methods based on information theory, at least for the receptor-binding site predictions, was not greatly improved.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 5","pages":"481-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13003026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viral chimeric protein including a determinant of myelin basic protein is capable of inducing allergic encephalomyelitis in guinea pigs. 含有髓鞘碱性蛋白决定因子的病毒嵌合蛋白能够诱导豚鼠过敏性脑脊髓炎。
Biomedical science Pub Date : 1991-01-01
S N Shchelkunov, S B Stavitskii, L I Batenko, P V Gashnikov, G A Shchelkunova, O A Kostyrev, L S Sandakhchiev
{"title":"Viral chimeric protein including a determinant of myelin basic protein is capable of inducing allergic encephalomyelitis in guinea pigs.","authors":"S N Shchelkunov,&nbsp;S B Stavitskii,&nbsp;L I Batenko,&nbsp;P V Gashnikov,&nbsp;G A Shchelkunova,&nbsp;O A Kostyrev,&nbsp;L S Sandakhchiev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A hybrid vaccinia virus expressing a chimeric protein consisting of thymidine kinase and the encephalitogenic determinant, S1, from guinea pig myelin basic protein was constructed. Infection of guinea pigs with the virus resulted in the development of allergic encephalomyelitis.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 5","pages":"493-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12889886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural correlate of mental error detection in the human brain cortex. 人脑皮层心理错误检测的神经关联。
Biomedical science Pub Date : 1991-01-01
N P Bechtereva, S V Medvedev, Y G Abdullaev
{"title":"Neural correlate of mental error detection in the human brain cortex.","authors":"N P Bechtereva,&nbsp;S V Medvedev,&nbsp;Y G Abdullaev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The use of long-term intracerebral electrodes combined with advances in stereotaxic neurosurgery and a complex multimethodological approach to brain research has made possible a study of the neurophysiological mechanisms of higher mental functions in the course of diagnosis and/or treatment of some chronic cerebral diseases. Investigations in which both local oxygen tension and neuronal impulse activity were recorded while the patients were performing psychological tasks have revealed selective responses in some neuronal populations of the thalamus and of the striopallidal complex, which occur only during erroneous task performance. So-called 'error detector' neurons were also found in the perirolandic and parietotemporal regions of the human brain cortex.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 3","pages":"301-5"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet-induced hypercholesterolaemia in the rabbit. 家兔饮食性高胆固醇血症。
Biomedical science Pub Date : 1991-01-01
A S Ivanov, T I Torkhovskaya, E M Khalilov, A I Archakov
{"title":"Diet-induced hypercholesterolaemia in the rabbit.","authors":"A S Ivanov,&nbsp;T I Torkhovskaya,&nbsp;E M Khalilov,&nbsp;A I Archakov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Intraspecies variation in diet-induced hypercholesterolaemia in rabbits, simulating atherosclerosis, was studied. The chinchilla rabbit population examined contained several subpopulations, as indicated by polymodal forms of histograms of plasma cholesterol levels. This finding indicates that the inclusion of subpopulations in an investigation can lead to erroneous conclusions, and that subpopulations should be identified before such work is undertaken. The relationship between the molar cholesterol/phospholipid ratio in rabbit erythrocyte membranes and the plasma cholesterol level in experimental atherosclerosis was also studied. A correlation was evident only over the range of 1-5 g cholesterol per litre of plasma.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 3","pages":"285-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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