含有髓鞘碱性蛋白决定因子的病毒嵌合蛋白能够诱导豚鼠过敏性脑脊髓炎。

Biomedical science Pub Date : 1991-01-01

S N Shchelkunov, S B Stavitskii, L I Batenko, P V Gashnikov, G A Shchelkunova, O A Kostyrev, L S Sandakhchiev

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引用次数: 0

摘要

从豚鼠髓鞘碱性蛋白中构建了一种表达胸苷激酶与致脑性决定因子S1嵌合蛋白的杂交痘苗病毒。豚鼠感染该病毒导致过敏性脑脊髓炎的发展。

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Viral chimeric protein including a determinant of myelin basic protein is capable of inducing allergic encephalomyelitis in guinea pigs.

A hybrid vaccinia virus expressing a chimeric protein consisting of thymidine kinase and the encephalitogenic determinant, S1, from guinea pig myelin basic protein was constructed. Infection of guinea pigs with the virus resulted in the development of allergic encephalomyelitis.

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Biomedical science

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