Proteins of human chorionic villi tissue: construction of a protein map based upon fractionation by two-dimensional gel electrophoresis.

Proteins of human chorionic villi from the first trimester of pregnancy were studied by high-resolution two-dimensional gel electrophoresis. One hundred and ninety-eight proteins spots were identifiable and allowed the plotting of a two-dimensional map of the proteins of human chorionic villi from the eighth week of pregnancy. The proteins of human chorionic villi from the twelfth week of gestation and of villi from term placenta were also studied. A comparison of protein compositions at different gestational ages was made. The findings from two-dimensional electrophoretic analysis of villi proteins have been summarized and stored in a computer data base.