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LDL-apheresis on affine haemosorbents. 仿射吸附剂的ldl分离。
Biomaterials, artificial cells, and artificial organs Pub Date : 1990-01-01 DOI: 10.3109/10731199009117323
Lopukhin YuM, V V Zuevsky, S S Markin, E S Nalivaiko, A B Rabovsky
{"title":"LDL-apheresis on affine haemosorbents.","authors":"Lopukhin YuM,&nbsp;V V Zuevsky,&nbsp;S S Markin,&nbsp;E S Nalivaiko,&nbsp;A B Rabovsky","doi":"10.3109/10731199009117323","DOIUrl":"https://doi.org/10.3109/10731199009117323","url":null,"abstract":"<p><p>There were synthesized new hemosorbents for selective removal of LDL, based on macroporous silica, immobilised by heparine (sorbent 1) and chytozane-sulphate (sorbent 2). Experimental data showed satisfactory hemo- and biocompatibility of the new sorbents. No significant alterations in biochemical parameters were observed. Sorption cholesterol (Ch) capacity of the sorbents was equal and accounted for 15 mg of Ch per 1 g of the sorbent. Pilot clinical studies in familial hypercholesterolemia (FH) patients have shown the satisfactory hemo- and biocompatibility of the sorbent 1, and its significant Ch withdrawal. We conclude that the hemosorbents can be used in the FH patients treatment.</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"18 5","pages":"571-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199009117323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13125111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Induction of leukotriene B4 formation by dialyzer membranes. 透析膜诱导白三烯B4的形成。
Biomaterials, artificial cells, and artificial organs Pub Date : 1990-01-01 DOI: 10.3109/10731199009117325
H Schiffl, T Strasser
{"title":"Induction of leukotriene B4 formation by dialyzer membranes.","authors":"H Schiffl,&nbsp;T Strasser","doi":"10.3109/10731199009117325","DOIUrl":"https://doi.org/10.3109/10731199009117325","url":null,"abstract":"<p><p>Interactions between blood and dialysis membranes lead to activation of the 5-lipoxygenase pathway of the arachiodonic acid metabolism during hemodialysis. Newly generated leukotriene B4 (LTB4) may contribute to the multifaceted granulocyte abnormalities of uremic patients.</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"18 5","pages":"585-90"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199009117325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13125113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional measurements on carboxymethylated hemoglobin, a potential blood substitute: effects of sodium chloride on pH values that influence the alkaline Bohr effect. 羧甲基化血红蛋白(一种潜在的血液替代品)的功能测量:氯化钠对影响碱性玻尔效应的pH值的影响。
Biomaterials, artificial cells, and artificial organs Pub Date : 1990-01-01 DOI: 10.3109/10731199009117296
L R Manning, W J Fantl, J M Manning
{"title":"Functional measurements on carboxymethylated hemoglobin, a potential blood substitute: effects of sodium chloride on pH values that influence the alkaline Bohr effect.","authors":"L R Manning,&nbsp;W J Fantl,&nbsp;J M Manning","doi":"10.3109/10731199009117296","DOIUrl":"https://doi.org/10.3109/10731199009117296","url":null,"abstract":"<p><p>The leakage of chloride from electrodes during measurements of the alkaline Bohr effect of hemoglobin (by the proton release method) amounted to 1-5 mM concentration of the anion depending on the type of electrode employed. This concentration, together with the amount of chloride found to be intrinsically bound to hemoglobin (0.2-0.6 mM), could mask the contribution of chloride to various hemoglobin functions. In addition, the concentration of chloride was found to affect the pH of buffers as measured either with a pH meter or with the dye, cresol red. Thus, for 20 mM phosphate buffer, the pH was lowered almost 0.4 pH units in the presence of 0.30 M chloride. For Tris-acetate buffer, the same concentration of chloride led to an increase in pH of about 0.05 units.</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"18 2","pages":"133-41"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199009117296","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13516722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Haemoglobin pyridoxalation in phosphate buffer: comparison of results with those obtained with Tris-HCl buffer. 磷酸缓冲液中血红蛋白吡啶羟化:与Tris-HCl缓冲液所得结果的比较。
Biomaterials, artificial cells, and artificial organs Pub Date : 1990-01-01 DOI: 10.3109/10731199009117298
P Menu, C Geschier, P Labrude, C Vigneron
{"title":"Haemoglobin pyridoxalation in phosphate buffer: comparison of results with those obtained with Tris-HCl buffer.","authors":"P Menu,&nbsp;C Geschier,&nbsp;P Labrude,&nbsp;C Vigneron","doi":"10.3109/10731199009117298","DOIUrl":"https://doi.org/10.3109/10731199009117298","url":null,"abstract":"<p><p>Most workers studying haemoglobin solutions re-establish a P50 close to physiological values by covalent fixation of pyridoxal phosphate (PLP) using the method first described by Benesch. This is performed with deoxyhaemoglobin in a Tris-HCl buffer, considered to be necessary for transimination. To simplify the chemical procedure of the conjugation of a macromolecule to Hb-PLP we have performed the pyridoxalation in a phosphate buffer. Physico-chemical analysis of pyridoxalated haemoglobin solutions show a slight degradation of the protein, a amount of fixed PLP to the haemoglobin and a right-shift of the dissociation curve similar whether the coupling is performed in the phosphate or the Tris buffer. The pharmacological evaluation by total and isovolumic exchange transfusion in rats, of solutions prepared from both methods of pyridoxalation show identical survival times, vascular persistence and stability of the conjugates. Thus the pyridoxalation takes place with a comparable yield whatever reagent is used, proving that Tris is not essential to haemoglobin pyridoxalation.</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"18 2","pages":"157-68"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199009117298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13518752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generation of free oxygen radicals and the toxicity of hemoglobin solutions. 自由基的产生和血红蛋白溶液的毒性。
Biomaterials, artificial cells, and artificial organs Pub Date : 1990-01-01 DOI: 10.3109/10731199009117301
J Simoni, M Feola, P C Canizaro
{"title":"Generation of free oxygen radicals and the toxicity of hemoglobin solutions.","authors":"J Simoni,&nbsp;M Feola,&nbsp;P C Canizaro","doi":"10.3109/10731199009117301","DOIUrl":"https://doi.org/10.3109/10731199009117301","url":null,"abstract":"<p><p>The observed toxicity of hemoglobin solutions (HbS) might depend, at least in part, on the tendency of Hb to autoxidation with generation of oxygen free-radicals. Aims of this study were: (1) to quantitate plasma elevations of H2O2 and lipid peroxides after replacement of 1/3 of calculated blood volume in various groups of rabbits with different Hb solutions; (2) to correlate these elevations with parameters of brain, heart, lung, liver and kidney injury or dysfunction; and (3) investigate the protective effect of mannitol as a radical scavenger. One Hb solution contaminated with stromal phospholipids raised H2O2 from 31.2 +/- 1.9 to 166 +/- 20 mumol/ml, lipid peroxides from 1.62 +/- 0.5 to 7.29 +/- 0.3 nmol/ml, CK-BB (brain isoenzyme) from 250 +/- 25 to 470 +/- 50 IU/L, CK-MB (myocardial isoenzyme) from 2.98 +/- 0.03 to 10.73 +/- 1.3 IU/L and SGPT from 38.1 +/- 5 to 167 +/- 45 IU/L, and reduced PaO2 from 87 +/- 10 to 57.5 +/- 2.5 mm Hg and creatinine clearance from 1.5 +/- 0.3 to 0.13 +/- 0.03 mg/min/Kg. These changes were progressively less severe with pure unmodified Hb, pure Hb crosslinked with \"o-ATP\", and pure crosslinked Hb + mannitol (4 mg/ml). These observations indicate a significant role for oxygen-derived radicals in the toxicity of Hb solutions.</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"18 2","pages":"189-202"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199009117301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13518755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
Long-term plasma exchange via Cimino fistula in patients with hypercholesterolemia. 高胆固醇血症患者经Cimino瘘长期血浆置换。
Biomaterials, artificial cells, and artificial organs Pub Date : 1990-01-01 DOI: 10.3109/10731199009117329
J Passfall, F Keller, H R Arntz
{"title":"Long-term plasma exchange via Cimino fistula in patients with hypercholesterolemia.","authors":"J Passfall,&nbsp;F Keller,&nbsp;H R Arntz","doi":"10.3109/10731199009117329","DOIUrl":"https://doi.org/10.3109/10731199009117329","url":null,"abstract":"<p><p>Two patients with familial hypercholesterolemia were treated by long-term plasma exchange via an arteriovenous Cimino shunt using unselective membrane separation. Cholesterol was lowered to 40 percent (+/-3) of peak levels by each procedure. Sieving coefficient was 0.76 (+/-0.12). With a mean exchange interval of 11 days (+/-2), the peak cholesterol levels decreased from 406 mg per dl (+/-28) to 322 mg per dl (+/-27), the LDL fraction from 338 mg per dl (+/-9) to 265 mg per dl (+/-25) whereas the HDL fraction remained unchanged at 28 mg per dl (+/-4). Electrocardiographic stress testing improved in the first patient after treatment for 12 months.</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"18 5","pages":"617-21"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731199009117329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13254710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Bilirubin removal by the pseudoperoxidase activity of free and immobilized hemoglobin and hemoglobin co-immobilized with glucose oxidase. 游离和固定化血红蛋白及与葡萄糖氧化酶共固定化血红蛋白的假过氧化物酶活性去除胆红素。
Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909117636
J N Daka, T M Chang
{"title":"Bilirubin removal by the pseudoperoxidase activity of free and immobilized hemoglobin and hemoglobin co-immobilized with glucose oxidase.","authors":"J N Daka,&nbsp;T M Chang","doi":"10.3109/10731198909117636","DOIUrl":"https://doi.org/10.3109/10731198909117636","url":null,"abstract":"<p><p>We report a process for oxidizing bilirubin. Hemoglobin in the presence of an oxidizing agent can effectively oxidize bilirubin. Hemoglobin can be used either in free form or immobilized. Immobilisation includes microencapsulation, covalent linkage to carriers, intermolecular crosslinking into polyhemoglobin and others. The oxidizing agent can be added in the form of a peroxide. However, no external peroxide is required when hemoglobin is co-immobilized with glucose oxidase. In this case, the oxidation reaction takes place in the presence of glucose which is normally available in the blood stream and the presence of other oxidizing agents becomes unnecessary. In cases where bilirubin is conjugated to large proteins such as albumin, oxidation can be accomplished by using hemoglobin either in free form, adsorbed or bound on a suitable surface. Polyhemoglobin or cross-linked hemoglobins can also be used as oxidation catalysts in this case.</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"17 5","pages":"553-62"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198909117636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13769114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Preparation and characterisation of xanthine oxidase immobilised by microencapsulation in artificial cells for the removal of hypoxanthine. 人工细胞微胶囊固定化黄嘌呤氧化酶的制备与表征。
Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909117640
T M Chang
{"title":"Preparation and characterisation of xanthine oxidase immobilised by microencapsulation in artificial cells for the removal of hypoxanthine.","authors":"T M Chang","doi":"10.3109/10731198909117640","DOIUrl":"https://doi.org/10.3109/10731198909117640","url":null,"abstract":"Artificial cells are microscopic structures of cellular dimensions. This paper reports the preparation and in vitro charaterisation of artificial cells containing xanthine oxidase for use in clinical trial for the removal of hypoxanthine in Lesch-Nyhan Disease","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"17 5","pages":"611-6"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198909117640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13769807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Extracorporeal immunoadsorption with IM-PH or IM-TR column. 体外免疫吸附IM-PH或IM-TR柱。
Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118273
Z Yamazaki, Y Idezuki, N Inoue, H Yoshizawa, N Yamawaki, K Inagaki, N Tsuda
{"title":"Extracorporeal immunoadsorption with IM-PH or IM-TR column.","authors":"Z Yamazaki,&nbsp;Y Idezuki,&nbsp;N Inoue,&nbsp;H Yoshizawa,&nbsp;N Yamawaki,&nbsp;K Inagaki,&nbsp;N Tsuda","doi":"10.3109/10731198909118273","DOIUrl":"https://doi.org/10.3109/10731198909118273","url":null,"abstract":"<p><p>In order to selectively remove pathogenic macromolecular reactants, a biological affinity type adsorbent (a DNA colloidin charcoal column or protein A sepharose CL4B = Prosorba) has been developed and used for the treatment of immune disorders, alloimmunization and cancer. However, because physiologically active materials are required in this procedure, it is difficult to ensure an adequate supply of raw materials (and their handling, sterilization and preservation as an immunoadsorbent. To overcome the above-mentioned problems, we developed physicochemical type immunoadsorbents IM-TR and IM-PH, which consist of polyvinyl alcohol gel where tryptophan, in the former, and phenylalanine, in the latter, is used as a ligand. IM-PH has a better selectivity than IM-TR, however, IM-TR is a more efficient adsorbent of anti-acethylcholine receptor antibody than IM-PH. IM-PH plasma perfusion has been successfully used with patients with rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis (MS).</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"17 2","pages":"117-24"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198909118273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13813834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Plasmapheresis in overall treatment of renal immune diseases. 血浆置换术在肾免疫性疾病综合治疗中的应用。
Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118284
M D Dzhavad-Zade, M M Agaev, V M Feldman
{"title":"Plasmapheresis in overall treatment of renal immune diseases.","authors":"M D Dzhavad-Zade,&nbsp;M M Agaev,&nbsp;V M Feldman","doi":"10.3109/10731198909118284","DOIUrl":"https://doi.org/10.3109/10731198909118284","url":null,"abstract":"<p><p>Polymorphism of the clinical picture manifested in pregnancy induced nephropathies necessitates the development of special immune methods of diagnosis, prevention and overall treatment. The changes in cellular and humoral immunity disclosed in this group of patients may serve as a starting point for elucidating the mechanism underlying pathogenesis of the disease and complications. Complex therapy, including medicinal preparations, dietotherapy and plasmapheresis contributes to normalizing the clinical course of pregnancy, correcting the immunologic status and decreasing the incidence of complications in the postpartum period.</p>","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"17 3","pages":"263-70"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198909118284","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13957969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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