Biomaterials, artificial cells, and artificial organs最新文献_第8页

The effect of moderately severe hemodilution with Fluosol-DA on cytochrome P-450 mediated antipyrine metabolism. 氟索- da中重度血液稀释对细胞色素P-450介导的安替比林代谢的影响。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118854

R P Shrewsbury, S R Oliver, L G White

引用次数: 2

Eighth Southern Biomedical Engineering Conference. Richmond, Virginia, October 15-16, 1989. Abstracts. 第八届南方生物医学工程会议。1989年10月15日至16日，弗吉尼亚州里士满。摘要。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01

引用次数: 0

Tumoricidal effect of controlled-release polymeric needle devices containing adriamycin HCl in tumor-bearing mice. 盐酸阿霉素聚合物控释针具对荷瘤小鼠的杀瘤作用。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118280

S Y Lin, L F Cheng, W Y Lui, C F Chen, S H Han

{"title":"Tumoricidal effect of controlled-release polymeric needle devices containing adriamycin HCl in tumor-bearing mice.","authors":"S Y Lin, L F Cheng, W Y Lui, C F Chen, S H Han","doi":"10.3109/10731198909118280","DOIUrl":"https://doi.org/10.3109/10731198909118280","url":null,"abstract":"Controlled-release polymeric needle devices containing adriamycin HCL (ADH) were investigated by an in vitro dissolution study in normal saline solution and an in vivo antitumor activity in C3H mice bearing mammary carcinoma and nude mice bearing brain tumor. HPMC was used as a release rate regulator. The ADH released from needle devices was controlled by the types of polymer used and the addition of HPMC. EVA needle devices exhibit a zero order release behavior better than that of PLA needle devices. Tumor growth was markedly inhibited by treatment with needle devices after locally inserted into the solid tumor. The rank of antitumor activity of the needle devices is EVA greater than PLA greater than EVA-HPMC greater than PLA-HPMC. No significant changes in body weight of mice after treatment were found in treated groups as compared to controlled groups. The preliminary results of our study suggest that needle device dosage form shows a controlled release behavior and may be applicable as a drug carrier for delivery of antitumor drug in cancer chemotherapy.","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"17 2","pages":"189-203"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198909118280","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13916059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Development of methodology for recording colonic myoelectrical activity in the infant primate. 幼龄灵长类动物结肠肌电活动记录方法的发展。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118271

R A Cannon, A T Cheung

{"title":"Development of methodology for recording colonic myoelectrical activity in the infant primate.","authors":"R A Cannon, A T Cheung","doi":"10.3109/10731198909118271","DOIUrl":"https://doi.org/10.3109/10731198909118271","url":null,"abstract":"In order to study developmental aspects of colonic motility, we have developed a miniaturized electrophysiologic recording system for use in the infant primate rhesus (Macaca mulatta). Technical considerations including absence of rectal valves, decreased tissue thickness and small colonic diameter limit application of standard non-surgical recording methodology in this model. In-vivo testing with 4 different bipolar electrode probe configurations yielded satisfactory quality recordings only with silver chloride suction electrodes. Using this system, colonic slow waves and spike action potentials were studied in 6 infant primates (ages 1 to 7 months) both fasting and following a standard liquid meal of 10 cc/kg. In response to feeding, colonic spike potentials increased from 7.8 +/- 1.7 to 14.2 +/- 4.1 within 15 minutes (mean spikes +/- SEM/5 min interval). The observed response of the distal colon to a meal in this model is similar to the response reported in adult humans using intraluminal recording techniques. Utilizing the described methodology, the infant primate appears to be a suitable model for investigation of developmental aspects of gastrointestinal motility and electrophysiology. These techniques have important direct applications for investigation in the human infant.","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"17 1","pages":"81-92"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198909118271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13916140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Effects of oral administration of artificial cells immobilized phenylalanine ammonia-lyase on intestinal amino acids of phenylketonuric rats. 人工细胞固定化苯丙氨酸解氨酶对苯酮尿酸大鼠肠道氨基酸的影响。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118278

L Bourget, T M Chang

引用次数: 23

Computer-aided sperm analysis (CASA): image digitization and processing. 计算机辅助精子分析(CASA):图像数字化和处理。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118272

R O Davis, D F Katz

{"title":"Computer-aided sperm analysis (CASA): image digitization and processing.","authors":"R O Davis, D F Katz","doi":"10.3109/10731198909118272","DOIUrl":"https://doi.org/10.3109/10731198909118272","url":null,"abstract":"The active undulations of a sperm flagellum are a basic expression of cell vitality. They reflect a number of intracellular processes, and also reveal the interaction between the sperm and its environment. The pattern of sperm-head motion during locomotion is a hydrodynamic consequence of the behavior of the flagellum. Hence, studies of sperm-head motion should provide insights into cellular function and membrane integrity. Because of its importance in fertility, considerable attention is devoted to the analysis of sperm-head motion at both a clinical and basic biological level. Historically, such work has been done by hand. Recently, new, computer-aided sperm analysis (CASA) systems have become available to automate this process. These new systems promise to advance the study of cell behavior because they facilitate the objective collection of large amounts of data at relatively low cost. At present, however, few workers understand the relative strengths and limitations of such systems. There is a tendency to uncritically accept CASA results because they are computer generated. In this article, we describe how CASA systems work, and discuss several technological and methodological problems which can produce spurious results. We argue for the development of optical, machine, and specimen preparation standards which will facilitate inter-laboratory comparisons of CASA data.","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"17 1","pages":"93-116"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198909118272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13916142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Peritoneal oxygenation. A feasibility analysis. 腹膜氧化。可行性分析。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118856

F B Bilge, P H Bedenbaugh, A F von Recum

引用次数: 8

Reactivity and stability improvement of immobilized glucose oxidase. 固定化葡萄糖氧化酶的反应性及稳定性提高。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01

L X Li, C Z Chen, Y T Yu

引用次数: 0

Effects of pyridoxalated polyhemoglobin and stroma-free hemoglobin on ADP-induced platelet aggregation. 吡哆醛化多血红蛋白和无基质血红蛋白对adp诱导的血小板聚集的影响。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118292

F R Lalla, J Ning, T M Chang

{"title":"Effects of pyridoxalated polyhemoglobin and stroma-free hemoglobin on ADP-induced platelet aggregation.","authors":"F R Lalla, J Ning, T M Chang","doi":"10.3109/10731198909118292","DOIUrl":"https://doi.org/10.3109/10731198909118292","url":null,"abstract":"Although polyhemoglobin produced from homologous sources is not immunogenic when utilized in vivo (1), effects on hemostasis and thrombosis have not been documented. In this study, we use rat platelet rich plasma (PRP) and light transmission aggregometry to measure the possible influence of stroma-free hemoglobin (SFHb) and pyridoxalated polyhemoglobin (PP-PolyHb) on platelet aggregation in response to various levels of adenosine triphosphate (ADP) activation in vitro. Our study demonstrates that PP-PolyHb and SFHb solutions, when added to PRP in volumes and concentrations likely to be administered to patients requiring perfusant therapy, do not initiate or facilitate platelet activation. Both solutions induce similar levels of aggregation (and presumably activation) inhibition, but do so only at high or maximal levels of ADP activator stimulation, late in the aggregation sequence. The apparent inability of the purified hemoglobins to stimulate platelets is a necessary characteristic if such preparations are to be used as clinical perfusants in hemorrhagic emergencies.","PeriodicalId":77498,"journal":{"name":"Biomaterials, artificial cells, and artificial organs","volume":"17 3","pages":"363-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10731198909118292","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13957230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Thromboresistant polymers: a new approach. 抗血栓聚合物:一种新方法。

Biomaterials, artificial cells, and artificial organs Pub Date : 1989-01-01 DOI: 10.3109/10731198909118858

J E Wilson, C E Jones

引用次数: 2