Anaesthesia最新文献

{"title":"Association between glucagon-like peptide-1 receptor agonist use and peri-operative pulmonary aspiration: a systematic review and meta-analysis","authors":"Jasmin Elkin, Siddharth Rele, Priya Sumithran, Michael Hii, Sharmala Thuraisingam, Tim Spelman, Tuong Phan, Peter Choong, Michelle Dowsey, Cade Shadbolt","doi":"10.1111/anae.16601","DOIUrl":"https://doi.org/10.1111/anae.16601","url":null,"abstract":"Glucagon-like peptide-1 receptor agonists are known to delay gastric emptying; however, the association between glucagon-like peptide-1 receptor agonist use and peri-operative pulmonary aspiration risk is not known. This systematic review and meta-analysis aimed to summarise the evidence on whether glucagon-like peptide-1 receptor agonist exposure is associated with pulmonary aspiration or increased residual gastric content in fasted patients undergoing procedures requiring anaesthesia or sedation.","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"72 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-operative reference ranges for ROTEM® sigma in patients undergoing cardiac surgery: a secondary analysis of two prospective trial cohorts","authors":"Maite M. T. van Haeren, Meike Brouwers, Jimmy Schenk, Jennifer S. Breel, Sijm H. Noteboom, Eline Kho, Susanne Eberl, Denise P. Veelo, Alexander P. J. Vlaar, Marcella C. A. Müller, Henning Hermanns","doi":"10.1111/anae.16608","DOIUrl":"https://doi.org/10.1111/anae.16608","url":null,"abstract":"Rotational thromboelastometry (ROTEM^®) is used widely in cardiac surgery. Reference ranges are derived from healthy volunteers but may not be interchangeable with those from patients undergoing cardiac surgery. Furthermore, sex and age seem to influence rotational thromboelastometry profiles. We performed a secondary analysis of two prospective observational study cohorts from a single centre in the Netherlands, which establishes pre-operative ROTEM^® sigma reference ranges for adult patients undergoing cardiac surgery and examines sex- and age-specific variations.","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"108 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best anaesthetic technique for prevention of postoperative cognitive dysfunction in older patients after hip fracture surgery – is the debate over?","authors":"Ana Kowark, Mark Coburn","doi":"10.1111/anae.16609","DOIUrl":"https://doi.org/10.1111/anae.16609","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"74 5 Pt 1 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143832025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information – Editorial Board","authors":"","doi":"10.1111/anae.16336","DOIUrl":"https://doi.org/10.1111/anae.16336","url":null,"abstract":"","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"80 5","pages":"469"},"PeriodicalIF":7.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anae.16336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Videolaryngoscopy vs. direct laryngoscopy in class 2 and 3 obesity: a systematic review, meta-analysis and trial sequential analysis of randomised controlled trials*","authors":"Zhi Jie Goh,&nbsp;Aaron Ang,&nbsp;Si-Xian Nicole Ang,&nbsp;Shermaine See,&nbsp;Jinbin Zhang,&nbsp;Kumaresh Venkatesan,&nbsp;Wan-Ling Alyssa Chiew","doi":"10.1111/anae.16578","DOIUrl":"10.1111/anae.16578","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The 7th National Audit Project of the Royal College of Anaesthetists revealed an increase in rates of tracheal intubation over the last decade, partially contributed to by the rise in people living with obesity. Notably, airway and respiratory complications were over-represented in patients living with class 2 or 3 obesity (BMI ≥ 35 kg.m^-2). Hence, it is timely to evaluate if videolaryngoscopy might improve tracheal intubation-related outcomes when compared with direct laryngoscopy in this high-risk patient group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a systematic review and meta-analysis of randomised controlled trials published in the last 15 years. We searched five databases for trials comparing videolaryngoscopy with direct laryngoscopy in adult patients living with class 2 or 3 obesity undergoing elective general surgery. Primary outcomes were the incidence of failed tracheal intubation; hypoxaemia; and first attempt tracheal intubation failure. Secondary outcomes were glottic visualisation; time to tracheal intubation; incidence of sore throat; and intubation difficulty scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 10 trials with 955 patients, of whom 481 received videolaryngoscopy and 474 direct laryngoscopy. Videolaryngoscopy significantly reduced failed tracheal intubation (relative risk (95%CI) 0.15 (0.05–0.35), p &lt; 0.001, nine studies); hypoxaemia (relative risk (95%CI) 0.21 (0.10–0.43), p &lt; 0.001, seven studies); and first attempt failure (relative risk (95%CI) 0.44 (0.25–0.76), p = 0.004, seven studies). While glottic visualisation was also significantly improved, there was no significant difference in time to tracheal intubation, incidence of sore throat or intubation difficulty scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In patients living with class 2 or 3 obesity, videolaryngoscopy significantly reduced failed tracheal intubation incidence, first-attempt failure incidence, incidence of hypoxaemia and poor glottic visualisation. Patients living with class 2 or 3 obesity are likely to benefit from the use of videolaryngoscopy compared with direct laryngoscopy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"80 6","pages":"684-693"},"PeriodicalIF":7.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-theatre TIVA rapid sequence induction: what are we doing?","authors":"William Musselbrook","doi":"10.1111/anae.16613","DOIUrl":"10.1111/anae.16613","url":null,"abstract":"&lt;p&gt;Discussions around the use of total intravenous anaesthesia (TIVA) when performing a rapid sequence induction (RSI) have increased recently due to the publication of a coroner's report [&lt;span&gt;1&lt;/span&gt;], which highlighted “&lt;i&gt;Lack of ‘updated’ national guidelines to support the use of TIVA for RSI&lt;/i&gt;” as one of the eight areas of concern within the reported case. A review of practice is pertinent, as we have seen developments within TIVA since the last large-scale survey of RSI practice within the UK [&lt;span&gt;2&lt;/span&gt;], such as the increased use of newer models such as Eleveld and updated pumps, which change the dynamics in drug delivery. The Association of Anaesthetists' guideline on the safe practice of TIVA [&lt;span&gt;3&lt;/span&gt;] mentions a few approaches to performing an RSI using target-controlled infusions (TCI) or manual bolus then TCI, but does not offer definitive advice as to the safest method. Other authors have suggested several viable approaches [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;We created a survey on Google Forms and the link was distributed via email and WhatsApp to anaesthetists within our UK region. The link was sent out to the trainees via the anaesthesia co-ordinator for the region. College tutors and Staff grade and Associate Specialist (SAS) representatives for each hospital were emailed to gather responses from consultants and SAS doctors, respectively. The survey gathered data on a variety of topics, including clinician grade; hospital; preferred method of in-theatre RSI; approach to RSI when using TIVA; preferences of drugs used; preferred pump programming; use of equipment checks; and monitoring.&lt;/p&gt;&lt;p&gt;We received 122 responses out of approximately 900 clinicians, from a variety of hospitals and physician seniority (response rate 13.5%). Some did not answer all the questions. There was a noticeable variation among anaesthetists. The majority 78/122 (64%) stated their preferred RSI method to be propofol and rocuronium, followed by inhalational anaesthesia. A ‘TIVA RSI’ methodology was preferred by 30/122 clinicians (25%). There was a significant variation in the approach to TIVA RSI (Table 1). The method of remifentanil TCI with use of 3-way tap bolus on propofol TCI and a neuromuscular blocking drug (NMBD) was preferred by 30/111 (27%) clinicians. There were 30/111 (27%) who used only the TCI pumps then a NMBD. Twenty-four out of 111 (21.6%) used a separate propofol bolus with an opioid and NMBD, then started TCI, while 10/111 (9%) started remifentanil TCI, used a separate propofol bolus and NMBD, then started TCI propofol. There were several other variances in approach (including explicit refusal to use TIVA RSI), but the significant split in the most frequent techniques is worth highlighting. Of those who responded to the question, 61/117 (52%) stated their preferred propofol TCI model as Eleveld, although this is not available in all TCI pumps yet.&lt;/p&gt;&lt;p&gt;The most cited reservation against using TIVA RSI was ‘speed of RSI’ (75/118, 63","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"80 6","pages":"728-729"},"PeriodicalIF":7.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anae.16613","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal characteristics of remimazolam-induced sedation in paediatric anaesthesia: observations from a multicentre trial","authors":"Xiaoyu Li,&nbsp;Bo Lu","doi":"10.1111/anae.16614","DOIUrl":"10.1111/anae.16614","url":null,"abstract":"<p>The multicentre trial by Fang et al. is the first controlled trial assessing both the efficacy and safety of remimazolam in children [<span>1</span>], providing useful data for paediatric sedation practice. However, we wish to explore a pharmacokinetic observation regarding the pharmacokinetic-temporal relationship between drug administration and loss of consciousness. While the Methods specify 60-s administration for both drugs, median loss of consciousness occurred at 45 s (remimazolam) and 25 s (propofol). For remimazolam, this implies an effective administration rate of 0.4 mg.kg.min^-1 (0.3 mg.kg^-1 ÷ 0.75 min), 33% faster than the 0.3 mg.kg.min^-1 specified in the protocol. This temporal compression creates a paradox: achieving loss of consciousness before completing drug administration. Using updated paediatric parameters (clearance 15.9 ml.kg^-1.min^-1, volume of distribution 0.58 l.kg^-1) [<span>2</span>], our simulations show that 0.3 mg.kg^-1 achieves 93% of adult exposure (AUC 0.314 vs. 0.336 mg.h.l^-1) [<span>3</span>]. The observed efficacy could be explained by either enhanced paediatric pharmacodynamic sensitivity (a lower half maximal effective concentration) or actual administration rates exceeding the protocol – a 10 kg child receiving 0.3 mg.kg^-1 over 45 s would attain plasma concentrations comparable with 0.4 mg.kg^-1 over 60 s.</p><p>Three non-exclusive mechanisms merit consideration. Modified Observer's Alertness/Sedation scale might have detected transitional sedation states as full loss of consciousness; accelerated drug redistribution may occur in paediatric patients; and secondary dosing may have influenced initial loss of consciousness recordings (6/140 received rescue doses). The 99% success rate, despite sub-theoretical exposure, suggests possible supratherapeutic levels from faster administration – a phenomenon requiring verification through time-stamped infusion logs and pharmacokinetic modelling using the reported parameters [<span>4, 5</span>].</p><p>The trial by Fang et al. represents an important advancement in paediatric anaesthesia. By addressing these chrono-pharmacological considerations, the authors could transform temporal biomarkers into precision-dosing tools, ultimately providing safer sedation protocols.</p>","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"80 6","pages":"731"},"PeriodicalIF":7.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anae.16614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking point or turning point? Harnessing artificial intelligence to combat burnout","authors":"Cathriona Murphy","doi":"10.1111/anae.16610","DOIUrl":"10.1111/anae.16610","url":null,"abstract":"&lt;p&gt;I read with interest the article by Gale et al. which identifies several factors that contribute to the high levels of stress and burnout among anaesthesia residents [&lt;span&gt;1&lt;/span&gt;]. Burnout, as outlined by the World Health Organisation's International Classification of Diseases, is recognised as an occupational phenomenon and is characterised by three key domains: energy depletion; job-related negativity and reduced professional efficacy [&lt;span&gt;2&lt;/span&gt;]. Fatigue among anaesthetists has been shown to affect both clinician well-being and patient safety negatively. It results in diminished alertness, slower decision-making and a higher risk of errors, all of which compromise patient safety [&lt;span&gt;3&lt;/span&gt;]. With the rapid advancement of artificial intelligence (AI) in healthcare, one must question whether there is now a unique and unprecedented opportunity to combat the impending global crisis of burnout and workforce attrition in the healthcare system, specifically among anaesthesia residents.&lt;/p&gt;&lt;p&gt;A major concern raised by Gale et al. was difficulty with rostering, including limited flexibility and challenges in accommodating leave for important life events, even when requests were made in advance, resulting in unnecessary stress and anxiety for residents [&lt;span&gt;1&lt;/span&gt;]. The introduction of a ‘request rota’ was a positive adjunct for residents where implemented, although, notably, added an increased rostering workload. A recent initiative has highlighted the instrumental role that AI can play in generating a fair and balanced roster, addressing the specific requirements of an anaesthetic department promptly [&lt;span&gt;4&lt;/span&gt;]. Therefore, could AI potentially reduce the stress linked to rostering and service provision by creating a reliable and supportive schedule in a timely manner that benefits residents? Artificial intelligence has the potential to allocate working hours and training time appropriately whilst facilitating requested leave, ensuring residents have the necessary time with their support networks [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;A common issue among healthcare providers is low morale from the perception of being overworked and burdened excessively in the workplace [&lt;span&gt;1&lt;/span&gt;]. Residents often face difficulty in balancing clinical commitments with non-clinical tasks, such as completing examinations and expanding their portfolios, which can leave them feeling overwhelmed and undervalued. Artificial intelligence enhances documentation by using speech recognition and natural language processing to capture physician-patient interactions and summarise them in electronic patient records automatically. Artificial intelligence-driven diagnostic tools enhance the accuracy and efficiency of patient care. They also reduce the cognitive load on healthcare providers when making decisions, helping to lower workplace stress [&lt;span&gt;5&lt;/span&gt;]. Artificial intelligence has the potential to unburden a massive cognitive load through its unparalleled ab","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"80 6","pages":"730-731"},"PeriodicalIF":7.5,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/anae.16610","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising peri-operative intravenous lidocaine dosing regimens","authors":"Angela Tognolini, Jason A. Roberts, Victoria A. Eley","doi":"10.1111/anae.16611","DOIUrl":"https://doi.org/10.1111/anae.16611","url":null,"abstract":"<p>We thank Dr Hansel for his interest and comments [<span>1</span>] related to our publication [<span>2</span>]. This discussion highlights the ongoing debate regarding dosing of intravenous lidocaine infusions and ongoing concerns with the lack of safety data. The aim of our observational pharmacokinetic study and dosing simulations was to improve the understanding of intravenous lidocaine pharmacokinetics and, ultimately, to improve safety and efficacy of dosing of this commonly used (albeit ‘off-label’) peri-operative drug.</p>\u0000<p>We acknowledge this is a simulated regimen that requires external validation and evaluation in the clinical setting for safety and efficacy. Our proposed simulated dose regimen is specific to our studied population, carefully considers covariates and body weight metrics, and shows (simulated) concentrations &lt; 5 μg.ml^-1. Our proposed dosing aligns with other regimens used clinically, with infusions ranging from 1–5 mg.kg^-1.h^-1 [<span>3, 4</span>]. Importantly, in patients with obesity, dosing should be adjusted based on lean body weight. We have not examined infusions &gt; 3 h and have not made any comments regarding postoperative dosing and administration.</p>\u0000<p>The use of intravenous lidocaine for peri-operative pain management is common in Australia and parts of the UK. We agree that it requires careful individual patient assessment of risk vs. benefit, should consider the clinical context, and close monitoring is required to pick up adverse events. Consensus statements, such as that published by Foo et al. [<span>5</span>] and focused on postoperative lidocaine infusions, can be a useful guide for clinicians. Ensuring patient safety is paramount and, with intra-operative administration, intravenous lidocaine can be delivered carefully and monitored by the anaesthetist. Large anaesthesia incident reporting systems, such as WebAIRS in Australia, remain important in identifying safety data related to infrequent anaesthesia-related events, but are limited by reliance on self-reporting.</p>\u0000<p>We agree with Hansel and others [<span>6</span>] that robust evidence is needed through large clinical trials with carefully considered safety and outcome measures. We believe dosing strategies such as those proposed in this study may help enable optimal peri-operative use of intravenous lidocaine infusions and look forward to prospective evaluation.</p>","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"34 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising mechanical ventilation: integrating clinical needs with mechanical power reduction strategies","authors":"Wei Cao","doi":"10.1111/anae.16612","DOIUrl":"https://doi.org/10.1111/anae.16612","url":null,"abstract":"<p>The study by Buiteman-Kruizinga et al. provides valuable insights into the determinants of mechanical power during mechanical ventilation [<span>1</span>]. The authors highlight the importance of limiting respiratory rate and peak pressures to reduce mechanical power and, potentially, ventilator-induced lung injury. We would like to discuss some aspects that merit further exploration.</p>\u0000<p>First, the study suggests that reducing respiratory rate may be a viable strategy to lower mechanical power. However, the potential trade-off between reduced mechanical power and increased carbon dioxide retention remains underexplored [<span>2</span>]. In patients with impaired carbon dioxide clearance, such as those with chronic obstructive pulmonary disease or a metabolic acidosis, a lower respiratory rate might exacerbate hypercapnia, leading to respiratory acidosis and haemodynamic instability [<span>3</span>]. Future studies could investigate optimal mechanical power thresholds that balance lung protection with adequate carbon dioxide elimination.</p>\u0000<p>Second, while mechanical power is linked to lung injury, its direct contribution to alveolar stress and strain was not assessed explicitly. In addition to pressure- and volume-related parameters, lung compliance plays a crucial role in determining the actual stress imposed on the lung parenchyma [<span>4</span>]. A stratified analysis based on compliance levels could provide a more granular understanding of how mechanical power interacts with lung mechanics, particularly in heterogeneous conditions such as acute respiratory distress syndrome.</p>\u0000<p>Lastly, the study focuses primarily on short-term ICU outcomes. However, the impact of mechanical power modulation on long-term respiratory function and weaning success is unknown. Given that prolonged exposure to high mechanical power may contribute to persistent lung fibrosis or impaired ventilatory mechanics, follow-up studies assessing post-ICU pulmonary function could enhance our understanding of its clinical consequences [<span>5</span>].</p>\u0000<p>In conclusion, while this study is an important step toward optimising mechanical ventilation strategies, addressing the interplay between mechanical power, gas exchange and long-term respiratory outcomes could further refine lung-protective ventilation strategies.</p>","PeriodicalId":7742,"journal":{"name":"Anaesthesia","volume":"23 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}