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Plastic rearrangement of basal forebrain parvalbumin-immunoreactive neurons in the kainite model of epilepsy 癫痫kainite模型中基底前脑小蛋白免疫反应神经元的可塑性重排
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/neuroscience.2023023
Ruben Carvalho, Alisa N. Lukoyanova, João Casalta-Lopes, Nikolay V. Lukoyanov, Joana Isabel Soares
{"title":"Plastic rearrangement of basal forebrain parvalbumin-immunoreactive neurons in the kainite model of epilepsy","authors":"Ruben Carvalho, Alisa N. Lukoyanova, João Casalta-Lopes, Nikolay V. Lukoyanov, Joana Isabel Soares","doi":"10.3934/neuroscience.2023023","DOIUrl":"https://doi.org/10.3934/neuroscience.2023023","url":null,"abstract":"<abstract> <p>Temporal lobe epilepsy (TLE) is the most prevalent form of epilepsy, through the neuronal mechanisms of this syndrome remain elusive. In addition to the temporal lobe structures, it was found that the basal forebrain cholinergic cells are also involved in epileptogenesis. However, little is known about the involvement of the basal forebrain GABAergic neurons in epilepsy; despite this, they largely project to the temporal lobe and are crucial for the regulation of the hippocampal circuitry. In this study, we assessed epilepsy-induced changes in parvalbumin (PARV) immunoreactive neurons of the medial septum (MS) and of the magnocellular preoptic nucleus (MCPO) using the kainic acid (KA) model in rats. In addition, we estimated the respective changes in the cholinergic varicosities in the MS, where we observed a significant reduction in the PARV cell number (12849 ± 2715 vs. 9372 ± 1336, <italic>p</italic> = .029) and density (16.2 ± 2.62 vs. 10.5 ± 1.00 per .001 mm<sup>3</sup>, <italic>p</italic> =.001), and an increase in the density of cholinergic varicosities (47.9 ± 11.1 vs. 69.4 ± 17.8 per 30,000 µm<sup>2</sup>, <italic>p</italic> =.036) in KA-treated animals. In the MCPO, these animals showed a significant increase in somatic volume (827.9 ± 235.2 µm<sup>3</sup> vs. 469.9 ± 79.6 µm<sup>3</sup>, <italic>p</italic> = .012) and total cell number (2268.6 ± 707.1 vs. 1362.4 ± 262.0, <italic>p</italic> =.028). These results show that the basal forebrain GABAergic cell populations undergo numerical and morphological changes in epileptic animals, which may contribute to an increased vulnerability of brain circuits to epilepsy and epilepsy-related functional impairments.</p> </abstract>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"305 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flavonoid glycoside fraction of Ginkgo biloba extract modulates antioxidants imbalance in vanadium-induced brain damage. 银杏叶提取物类黄酮苷组分对钒脑损伤抗氧化剂失衡的调节作用。
IF 2.7
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/Neuroscience.2023015
Adeshina O Adekeye, Adedamola A Fafure, Morayo M Omodele, Lawrence D Adedayo, Victor O Ekundina, Damilare A Adekomi, Ephraim Samuel Jen, Thomas K Adenowo
{"title":"Flavonoid glycoside fraction of <i>Ginkgo biloba</i> extract modulates antioxidants imbalance in vanadium-induced brain damage.","authors":"Adeshina O Adekeye,&nbsp;Adedamola A Fafure,&nbsp;Morayo M Omodele,&nbsp;Lawrence D Adedayo,&nbsp;Victor O Ekundina,&nbsp;Damilare A Adekomi,&nbsp;Ephraim Samuel Jen,&nbsp;Thomas K Adenowo","doi":"10.3934/Neuroscience.2023015","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023015","url":null,"abstract":"<p><p>Human and animal diseases have always been reported to be treated by medicinal herbs owing to their constituents. Excess sodium metavanadate is a potential environmental toxin when consumed and could induce oxidative damage leading to various neurological disorders and Parkinsons-like diseases. This study is designed to investigate the impact of the flavonoid Glycoside Fraction of Ginkgo Biloba Extract (GBE) (at 30 mg/kg body weight) on vanadium-treated rats. Animals were divided randomly into four groups: Control (Ctrl, normal saline), Ginkgo Biloba (GIBI, 30mg/kg BWT), Vanadium (VANA, 10 mg/kg BWT) and Vanadium + Ginkgo biloba (VANA + GIBI). Markers of oxidative stress (Glutathione Peroxidase and Catalase) were assessed and found to be statistically increased with GIBI when compared with CTRL and treatment groups. Results from routine staining revealed that the control and GIBI group had a normal distribution of cells and a pronounced increase in cell count respectively compared to the VANA group. When compared to the VANA group, the NeuN photomicrographs revealed that the levels of GIBI were within the normal range (***p < 0.001; ** p < 001). The treatment with GIBI showed a better response by increasing the neuronal cells in the VANA+GIBI when compared with the VANA group. The NLRP3 Inflammasome photomicrographs denoted that there was a decrease in NLRP3-positive cells in the control and GIBI groups. The treatment group shows fewer cells compared to that of the VANA group. The treatment group shows fewer cells compared to that of the VANA group. The findings of the study confirmed that ginkgo biloba extract via its flavonoid glycoside fraction has favorable impacts in modulating vanadium-induced brain damage with the potential ability to lower antioxidant levels and reduce neuroinflammation.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"178-189"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10187520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep brain stimulation, lesioning, focused ultrasound: update on utility. 脑深部刺激，病变，聚焦超声:效用更新。
IF 2.7
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/Neuroscience.2023007
Akshay Reddy, Mohammad Reza Hosseini, Aashay Patel, Ramy Sharaf, Vishruth Reddy, Arman Tabarestani, Brandon Lucke-Wold
{"title":"Deep brain stimulation, lesioning, focused ultrasound: update on utility.","authors":"Akshay Reddy,&nbsp;Mohammad Reza Hosseini,&nbsp;Aashay Patel,&nbsp;Ramy Sharaf,&nbsp;Vishruth Reddy,&nbsp;Arman Tabarestani,&nbsp;Brandon Lucke-Wold","doi":"10.3934/Neuroscience.2023007","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023007","url":null,"abstract":"<p><p>Procedures for neurological disorders such as Parkinsons Disease (PD), Essential Tremor (ET), Obsessive Compulsive Disorder (OCD), Tourette's Syndrome (TS), and Major Depressive Disorder (MDD) tend to overlap. Common therapeutic procedures include deep brain stimulation (DBS), lesioning, and focused ultrasound (FUS). There has been significant change and innovation regarding targeting mechanisms and new advancements in this field allowing for better clinical outcomes in patients with severe cases of these conditions. In this review, we discuss advancements and recent discoveries regarding these three procedures and how they have led to changes in utilization in certain conditions. We further discuss the advantages and drawbacks of these treatments in certain conditions and the emerging advancements in brain-computer interface (BCI) and its utility as a therapeutic for neurological disorders.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"87-108"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10168760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A rare case of basilar artery dissection. 基底动脉夹层1例。
IF 2.7
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/Neuroscience.2023008
Sahibjot Bhatia, Nimrit Gahoonia, Jeffrey Stenger, Forshing Lui
{"title":"A rare case of basilar artery dissection.","authors":"Sahibjot Bhatia,&nbsp;Nimrit Gahoonia,&nbsp;Jeffrey Stenger,&nbsp;Forshing Lui","doi":"10.3934/Neuroscience.2023008","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023008","url":null,"abstract":"<p><p>This case describes a 30-year-old Hispanic male who presented with a significant headache that started after a period of weightlifting and squatting. The patient was diagnosed with a basilar artery dissection. His only complaint was a headache that was exacerbated with exertion and sexual activity; there were no neurologic deficits. The diagnosis of basilar artery dissection was established and supported by findings on the CT angiogram of his head and neck. Basilar artery dissections are rarely seen, as they are likely underrecognized due to their varying clinical presentations; however, it is important to consider these phenomena due to the risk of progression and high morbidity rates.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"109-117"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9811188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transitioning from PET/MR to trimodal neuroimaging: why not cover the temporal dimension with EEG? 从PET/MR到三模态神经成像的过渡:为什么不用脑电图覆盖时间维度?
IF 2.7
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/Neuroscience.2023001
Arosh S Perera Molligoda Arachchige
{"title":"Transitioning from PET/MR to trimodal neuroimaging: why not cover the temporal dimension with EEG?","authors":"Arosh S Perera Molligoda Arachchige","doi":"10.3934/Neuroscience.2023001","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023001","url":null,"abstract":"<p><p>The possibility of multimodality imaging with PET/MR and the availability of ultra-high field MRI has allowed to investigate novel aspects of neuropsychiatric conditions. One of the major barriers in current studies is the lack of an instrument that allows to accurately cover the temporal aspect under the same physiological conditions. The aim of this commentary is to provide our perspective on how the integration of EEG-PET-MR could be a solution to the current challenge in molecular imaging and seems to hold great promise in future pharmacological challenging-based studies, understanding different functional states of the brain, and could furthermore aid in the diagnostic and prognostic evaluations of neurocognitive disorders.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 1","pages":"1-4"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9383973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The blue brain project: pioneering the frontier of brain simulation 蓝脑计划:开拓大脑模拟的前沿
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/neuroscience.2023024
Arosh S. Perera Molligoda Arachchige
{"title":"The blue brain project: pioneering the frontier of brain simulation","authors":"Arosh S. Perera Molligoda Arachchige","doi":"10.3934/neuroscience.2023024","DOIUrl":"https://doi.org/10.3934/neuroscience.2023024","url":null,"abstract":"<jats:p xml:lang=\"fr\" />","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of Lego® Therapy on cognitive skills in Autism Spectrum Disorders: a brief discussion. 乐高®疗法对自闭症谱系障碍患者认知技能的影响:简要讨论。
IF 2.7
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/Neuroscience.2023016
Nicoletta Vegni, Caterina D'Ardia, Gloria Di Filippo, Francesco Maria Melchiori
{"title":"The impact of Lego® Therapy on cognitive skills in Autism Spectrum Disorders: a brief discussion.","authors":"Nicoletta Vegni,&nbsp;Caterina D'Ardia,&nbsp;Gloria Di Filippo,&nbsp;Francesco Maria Melchiori","doi":"10.3934/Neuroscience.2023016","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023016","url":null,"abstract":"<p><p>Over the years, several interventions have been implemented, including Lego® Therapy, with the aim of supporting and implementing social and communication skills impairments in Autism Spectrum Disorders (ASD). Although recent studies have shown that the ability to learn implicitly is preserved in ASDs, no study related to Lego® Therapy has analyzed whether and how this training can also affect aspects not directly treated. In this study, we report a first attempt of assessment of Lego® Therapy's effect on the specific area of cognitive skills in an ASD child. Over a period of 12 months, a child with ASD had weekly meetings with an expert operator of Lego® aiming to improve the child's ability to communicate, reduce impulsiveness and hyper verbalism, and encourage pro-social behavior. The intervention resulted in positive outcomes that were assessed after 12 months.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"190-199"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10187522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marijuana's potential in neurodegenerative diseases: an editorial. 大麻在神经退行性疾病中的潜力:一篇社论。
IF 2.7
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/Neuroscience.2023014
Arosh S Perera Molligoda Arachchige
{"title":"Marijuana's potential in neurodegenerative diseases: an editorial.","authors":"Arosh S Perera Molligoda Arachchige","doi":"10.3934/Neuroscience.2023014","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023014","url":null,"abstract":"<jats:p xml:lang=\"fr\" />","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 2","pages":"175-177"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10323256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10187524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
How can nanomicelle-curcumin modulate aluminum phosphide-induced neurotoxicity?: Role of SIRT1/FOXO3 signaling pathway. 纳米颗粒姜黄素如何调节磷酸铝诱导的神经毒性?SIRT1/FOXO3信号通路的作用。
IF 2.7
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/Neuroscience.2023005
Milad Khodavysi, Nejat Kheiripour, Hassan Ghasemi, Sara Soleimani-Asl, Ali Fathi Jouzdani, Mohammadmahdi Sabahi, Zahra Ganji, Zahra Azizi, Akram Ranjbar
{"title":"How can nanomicelle-curcumin modulate aluminum phosphide-induced neurotoxicity?: Role of SIRT1/FOXO3 signaling pathway.","authors":"Milad Khodavysi,&nbsp;Nejat Kheiripour,&nbsp;Hassan Ghasemi,&nbsp;Sara Soleimani-Asl,&nbsp;Ali Fathi Jouzdani,&nbsp;Mohammadmahdi Sabahi,&nbsp;Zahra Ganji,&nbsp;Zahra Azizi,&nbsp;Akram Ranjbar","doi":"10.3934/Neuroscience.2023005","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023005","url":null,"abstract":"<p><p>Aluminum phosphide (ALP) is among the most significant causes of brain toxicity and death in many countries. Curcumin (CUR), a major turmeric component, is a potent protective agent against many diseases, including brain toxicity. This study aimed to examine the probable protection potential of nanomicelle curcumin (nanomicelle-CUR) and its underlying mechanism in a rat model of ALP-induced brain toxicity. A total of 36 Wistar rats were randomly divided into six groups (n = 6) and exposed to ALP (2 mg/kg/day, orally) + CUR or nanomicelle-CUR (100 mg/kg/day, orally) for 7 days. Then, they were anesthetized, and brain tissue samples were dissected to evaluate histopathological alterations, oxidative stress biomarkers, gene expression of SIRT1, FOXO1a, FOXO3a, CAT and GPX in brain tissue via hematoxylin and eosin (H&E) staining, biochemical and enzyme-linked immunosorbent assay (ELISA) methods and Real-Time PCR analysis. CUR and nanomicelle-CUR caused significant improvement in ALP-induced brain damage by reducing the MDA levels and induction of antioxidant capacity (TTG, TAC and SOD levels) and antioxidant enzymes (CAT, GPX), modulation of histopathological changes and up-regulation of gene expression of SIRT1 in brain tissue. It was concluded that nanomicelle-CUR treatment ameliorated the harmful effects of ALP-induced brain toxicity by reducing oxidative stress. Therefore, it could be considered a suitable therapeutic choice for ALP poisoning.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 1","pages":"56-74"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9383977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimaging with SPECT-MRI: a myth or reality? SPECT-MRI神经成像:神话还是现实?
IF 2.7
AIMS Neuroscience Pub Date : 2023-01-01 DOI: 10.3934/Neuroscience.2023004
Arosh S Perera Molligoda Arachchige
{"title":"Neuroimaging with SPECT-MRI: a myth or reality?","authors":"Arosh S Perera Molligoda Arachchige","doi":"10.3934/Neuroscience.2023004","DOIUrl":"https://doi.org/10.3934/Neuroscience.2023004","url":null,"abstract":"","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"10 1","pages":"52-55"},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10106334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9385186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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