AIMS Neuroscience最新文献

{"title":"Current landscape for the management of facioscapulohumeral muscular dystrophy and emerging treatment modalities: A literature review.","authors":"Ubaid Ansari, Dawnica Nadora, Lauren Ong, Romteen Sedighi, Ethan Tabaie, Zaid Ansari, Meraj Alam, Burhaan Syed, Noorhan Amani, Sarah Preiss-Farzanegan","doi":"10.3934/Neuroscience.2025016","DOIUrl":"10.3934/Neuroscience.2025016","url":null,"abstract":"<p><p>Facioscapulohumeral Muscular Dystrophy (FSHD) is a genetic disorder characterized by progressive muscle weakness, primarily affecting the facial, shoulder, and upper arm muscles. In this literature review, we examined the available treatments for FSHD, covering established methods and experimental approaches. We began with an overview of pharmacological treatments, emphasizing the importance of physical therapy and rehabilitation in maintaining muscle strength, improving mobility, preventing contractures, and respiratory therapy for severe cases. We also explored exercise interventions, addressing the debate surrounding exercise in FSHD patients, and highlight the possible benefits of aerobic and strength training, as well as ongoing research into safe exercise protocols. Additionally, the use of assistive devices and orthotics, such as braces and mobility aids, is discussed, along with surgical interventions like scapular fixation surgery and corrective procedures for foot drop. Emerging therapeutic strategies, including gene therapy focusing on DUX4 silencing and CRISPR-Cas9 technology, were evaluated. The potential of antisense oligonucleotides and myostatin inhibitors was reviewed, along with the challenges and ethical considerations associated with cell-based therapies. We aimed to inform researchers and advance treatment strategies for FSHD patients.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"291-311"},"PeriodicalIF":2.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Transglutaminase 2 mRNA expression in peripheral blood mononuclear cells in patients with Radiologically Isolated Syndrome as a neuroinflammation biomarker: A preliminary study.","authors":"Rosa Giacca, Miriana Conte, Alessandro d'Ambrosio, Alvino Bisecco, Renato Docimo, Mario Risi, Manuela Altieri, Riccardo Borgo, Rosario Domenico Melisi, Vittorio Gentile, Antonio Gallo","doi":"10.3934/Neuroscience.2025015","DOIUrl":"10.3934/Neuroscience.2025015","url":null,"abstract":"<p><p>The calcium-dependent enzyme Transglutaminase 2 (TG2) (E.C. 2.3.2.13), which can promote post-translational modifications of proteins, is involved in several physiological processes, including development, neuronal cell death, and differentiation, as well as synaptic plasticity and transmission in the central nervous system (CNS). Several studies highlight the potential role of the TG2/NF-κB activation pathway in neurodegenerative diseases, including Multiple Sclerosis (MS), and the neuroinflammation that is associated with these conditions. The cross-linking activity of TG2, facilitating the formation of isopeptide bonds between glutamine and lysine residues, appears to be involved in forming protein aggregate deposits in these pathological conditions. Specifically, in the chronic neuroinflammation of MS, TG2 seems to play a central role in the fibrotic process of the lesion. Several potential biomarkers have been investigated for the prognosis and monitoring of MS, but no researchers have explored the presence of potential inflammatory signals in peripheral blood mononuclear cells (PBMCs) during the presymptomatic stage of MS, known as Radiologically Isolated Syndrome (RIS), on account of the lack of information regarding its pathological aspects. Since researchers have demonstrated a correlation between TG2 mRNA levels in PBMCs and the clinical and radiological progression of MS, we aimed to evaluate the expression levels of TG2 in RIS patients, comparing them with those in relapsing-remitting MS (RRMS) patients and healthy controls (HCs) using real-time PCR analysis. Preliminary data showed that RIS patients exhibit lower TG2 mRNA expression levels compared to RRMS patients, while no difference in TG2 mRNA expression being observed between RIS patients and HCs. This suggests that RIS patients exhibit a lower neuroinflammation grade than RRMS patients and that TG2 may represent a potential biochemical marker for assessing neuroinflammation associated with this disease. Future investigations may include longitudinal assessments of the potential role of TG2 mRNA blood levels in predicting or monitoring the progression from RIS to MS.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"284-290"},"PeriodicalIF":2.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 7 Muses of Neuro-Creative Cycle: How some patients with Parkinson's disease can unleash latent creativity.","authors":"Kyung Hee Kim","doi":"10.3934/Neuroscience.2025014","DOIUrl":"10.3934/Neuroscience.2025014","url":null,"abstract":"<p><p>Although dopamine therapy is known to enhance creativity in some artists with Parkinson's disease (PD), similar creative changes have been observed in individuals with other neurological conditions, even without such treatment. This suggests that broader neurological and psychological factors beyond dopamine alone may influence creativity in PD. In this paper, I examined these influences through the lens of the <i>7 Muses of the Neuro-Creative Cycle</i>: independence, curiosity, playfulness, confidence, openness, interdependence, and passion. Originally developed to support creativity in healthy individuals, the 7 Muses framework aligns closely with the structural and functional brain changes, as well as psychological shifts, commonly seen in PD. These changes may unlock latent creative potential, enabling PD artists to express themselves more authentically. By promoting a dynamic balance between top-down (goal-directed) and bottom-up (emotion-driven) processing across the creative cycle, preparation, imagination, and verification, PD-related changes may help reduce self-censorship, foster originality, and support the creation of meaningful, valuable work. Ultimately, beyond the effects of dopamine, some PD patients may awaken their dormant muses by following their intrinsic drives, listening more to their heart than their head.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"250-283"},"PeriodicalIF":2.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccines and neurological disorders: A narrative review of immune responses and adverse reactions.","authors":"Mehran Joodaki, Farhad Seif, Azadeh Afzalnia, Nikoo Emtiazi, Mona Merati Shirazi, Behnaz Ashtari, Seyed Mohamad Hosseinian, Nasrin Hosseini","doi":"10.3934/Neuroscience.2025013","DOIUrl":"10.3934/Neuroscience.2025013","url":null,"abstract":"<p><p>COVID-19 vaccines have been effective in providing strong immunity within a relatively short time frame, significantly reducing both the severity of the disease and associated mortality. However, post-vaccination complications, particularly neurological disorders, have been reported. Among the more frequently documented neurological complications are acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), transverse myelitis (TM), optic neuritis (ON), Bell's palsy (BP), and Guillain-Barré syndrome (GBS). The precise role of COVID-19 vaccines in triggering the onset or relapse of these conditions remains uncertain. Immunological processes involving cytokines, chemokines, antibodies, and immune cells are believed to contribute to the pathogenesis of these neurological side effects. This review examines the immune responses triggered by COVID-19 vaccines and their potential role in the development of such complications. Despite reports of neurological side effects, these cases remain rare, and the overall benefits of vaccination in curbing the pandemic and preventing severe illness far exceed the risks. It is vital to sustain the progress of global vaccination efforts while continuously evaluating the risk-benefit ratio, particularly for individuals with underlying conditions. Ongoing research and surveillance are crucial for creating safer vaccines and identifying individuals who may be more susceptible to adverse reactions, ensuring broader protection against COVID-19.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"222-249"},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global patterns linking total meat supply to dementia incidence: A population-based ecological study.","authors":"Wenpeng You","doi":"10.3934/Neuroscience.2025012","DOIUrl":"10.3934/Neuroscience.2025012","url":null,"abstract":"<p><p>Dementia cases are projected to triple globally by 2050, largely driven by an aging population. While aging remains the primary risk factor, emerging evidence suggests that diet, including total meat supply, may influence dementia risk. This study investigates the relationship between total meat supply (red and white meat) and dementia incidence using data from 204 countries. Bivariate correlations revealed a significant positive association between total meat supply and dementia incidence globally (r = 0.59, p < 0.001), with a stronger effect observed in low- and middle-income countries (z = 3.92, p < 0.001). Partial correlation analyses and multiple regression models, controlling for aging, economic status, genetic predisposition, and urbanization, confirmed that meat supply remained a significant predictor of dementia (Beta = 0.20, p < 0.001). Aging showed the strongest influence (Beta = 0.79, p < 0.001), underscoring its dominant role. Regional analyses suggested socio-economic disparities, dietary habits, and limited access to diverse nutrition as factors amplifying the association in developing regions. These findings identify total meat supply as a modifiable dietary factor contributing to dementia risk, particularly in resource-constrained settings. Implementing tailored dietary interventions may help reduce dementia incidence globally, especially in vulnerable populations.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"203-221"},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infantile neuroaxonal dystrophy: Molecular mechanisms and pathogenesis of PLA2G6-associated neurodegeneration.","authors":"María González-Sánchez, María Jesús Ramírez-Expósito, José Manuel Martínez-Martos","doi":"10.3934/Neuroscience.2025011","DOIUrl":"10.3934/Neuroscience.2025011","url":null,"abstract":"<p><p>Infantile neuroaxonal dystrophy (INAD), also known as <i>PLA2G6</i>-associated neurodegeneration (PLAN), is a rare, early-onset, autosomal recessively inherited neurodegenerative disease belonging to the group of neurodegenerations with brain iron accumulation (NBIA). The main cause of this disease is bi-allelic mutations in the <i>PLA2G6</i> gene, which codes for the enzyme phospholipase A2 type VI. Clinically, it manifests with progressive neurodevelopmental impairment, psychomotor regression, movement disorders, and pyramidal signs. Initially described in the 1950s, the classical form presents in the first two years of life, although later-onset variants are recognized. At the neuropathological level, INAD is characterized by the presence of neuroaxonal spheroids, which are dilations of degenerated axons, located mainly in the white matter, basal ganglia, and cerebellum. INAD is considered a rare or ultra-rare disease, with an estimated prevalence of approximately 1 per million individuals. Diagnosis requires a comprehensive evaluation combining clinical with neuroimaging studies, mainly magnetic resonance imaging (MRI), and genetic analysis. MRI may reveal early cerebellar atrophy and a low-intensity signal in the globus pallidus on iron-sensitive sequences, indicative of iron accumulation. Currently, there is no curative treatment for INAD, so management focuses on providing palliative care and symptom control using a multidisciplinary approach. However, various therapeutic strategies are being investigated, including gene therapy to correct the genetic defect, as well as approaches to modulate pathological pathways such as lipid peroxidation and iron accumulation.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"180-202"},"PeriodicalIF":2.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct neural mechanisms of alpha binaural beats and white noise for cognitive enhancement in young adults.","authors":"Aini Ismafairus Abd Hamid, Nurfaten Hamzah, Siti Mariam Roslan, Nur Alia Amalin Suhardi, Muhammad Riddha Abdul Rahman, Faiz Mustafar, Hazim Omar, Asma Hayati Ahmad, Elza Azri Othman, Ahmad Nazlim Yusoff","doi":"10.3934/Neuroscience.2025010","DOIUrl":"10.3934/Neuroscience.2025010","url":null,"abstract":"<p><p>Young adulthood is a critical period marked by significant cognitive demands, requiring efficient brain function to manage academic, professional, and social challenges. Many young adults struggle with focus, stress management, and information processing. Emerging research suggests that auditory stimulation, specifically binaural beats and white noise, may enhance cognitive abilities and address these challenges. This exploratory study investigates the immediate effects of alpha binaural beats (ABB) and alpha binaural beats combined with white noise (AWN) on brain connectivity in young adults using functional magnetic resonance imaging (fMRI). Twenty-nine participants (n = 14 ABB, n = 15 AWN; mean age ≈ 22.14 years) were randomly assigned to receive either ABB or AWN during fMRI scans. Using dynamic independent component analysis (dyn-ICA), we examined the modulation of functional brain circuits during auditory stimulation. Preliminary findings revealed distinct and overlapping patterns of brain connectivity modulation of ABB and AWN. ABB primarily modulated connectivity within circuits involving frontoparietal, visual-motor, and multisensory regions, potentially enhancing cognitive flexibility, attentional control, and multisensory processing. Conversely, AWN primarily modulated connectivity in salience and default mode networks, with notable effects in limbic or reward regions, suggesting enhancements in focused attention and emotional processing. These preliminary results demonstrate that ABB and AWN differentially modulate brain networks on an immediate timescale. ABB may promote cognitive adaptability, while AWN enhances focused attention and emotional stability. Although behavioral effects were not assessed, these findings provide a neurobiological basis for understanding how these stimuli impact brain circuits. These preliminary findings may aid the development of personalized strategies for cognitive and emotional well-being. Given the exploratory nature, small sample size, and lack of concurrent behavioral data, these findings should be interpreted cautiously. Future research with rigorous designs, including control groups and behavioral measures, is needed to explore the long-term effects and applications of these interventions in various settings.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"147-179"},"PeriodicalIF":2.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation techniques in combination for a short-intensive treatment of depression and anxiety: a case report.","authors":"Fiammetta Iannuzzo, Federica Donia, Lorenzo Bette, Fabrizio Turiaco, Antonio Bruno","doi":"10.3934/Neuroscience.2025009","DOIUrl":"10.3934/Neuroscience.2025009","url":null,"abstract":"<p><p>Neuromodulation techniques have emerged as valuable strategies for patients with depression and anxiety who do not respond to traditional therapies. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) treatments are heterogeneous; however, they all share an average duration of at least 10 days, thus requiring significant patient commitment to maintain adequate compliance. Here we describe a 68-year-old woman who suffered from depression and generalized anxiety disorder and underwent a short-intensive combined protocol, thus highlighting its effectiveness and good tolerability.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"140-146"},"PeriodicalIF":2.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-6 targeting antibodies for the treatment of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD): A review of current literature.","authors":"Siddarth R Ganesh, Orion Yedidia, Krupa Pandey, Carmenrita Infortuna, Charitha Madiraju, Florian P Thomas, Fortunato Battaglia","doi":"10.3934/Neuroscience.2025008","DOIUrl":"10.3934/Neuroscience.2025008","url":null,"abstract":"<p><p>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune inflammatory demyelinating disorder that can manifest as optic neuritis, transverse myelitis, and acute disseminated encephalomyelitis. Although typically monophasic, relapsing cases are more common in adults. Current treatments include corticosteroids, intravenous immunoglobulin, immune-suppressive drugs, and plasma exchange, but there is emerging interest in the use of interleukin-6 (IL-6) inhibitors to prevent relapses such as tocilizumab and satralizumab. This review analyzed 24 studies on IL-6 inhibitors for MOGAD, including case reports, case series, and retrospective studies with at least one MOGAD patient. Tocilizumab demonstrated significant efficacy, with most studies reporting reduced annualized relapse rates (ARR), prolonged relapse-free periods, and improved neurological outcomes, including stabilization or recovery of vision, motor function, and magnetic resonance imaging (MRI) lesion resolution. Satralizumab also showed potential, though data were more limited. While IL-6 inhibitors appear beneficial for steroid-dependent or treatment-resistant MOGAD, the existing data are limited to small, observational studies. Larger controlled trials are needed to establish their long-term efficacy and safety.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"113-139"},"PeriodicalIF":2.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing cognition and well-being by treating the malocclusion unilateral posterior crossbite: preliminary evidence by a single case study.","authors":"Laura Mandolesi, Noemi Passarello, Eillyn Leiva Ramirez, Deny Menghini, Patrizia Turriziani, Teresa Vallelonga, Francesco Aristei, Angela Galeotti, Stefano Vicari, Vito Crincoli, Maria Grazia Piancino","doi":"10.3934/Neuroscience.2025007","DOIUrl":"10.3934/Neuroscience.2025007","url":null,"abstract":"<p><p>Scientific investigations have increasingly revealed the intricate connection between masticatory function and cognitive functioning, as well as psychological well-being. Addressing malocclusions, such as the common unilateral posterior crossbite, during early developmental stages, emerges as an effective strategy for gaining health. This study aims to evaluate the efficacy of treating unilateral posterior crossbite by utilizing a function generating bite (FGB) appliance in a 12-year-old child, focusing on its impact on specific cognitive domains. Through meticulous pre- and post-treatment assessments, encompassing global cognitive activity (Colored Progressive Matrices), verbal and spatial working memory (Digit Span and Corsi Block-Tapping Test), and graphic fluency (modified Five Points Test), this research aims to elucidate the cognitive benefits associated with FGB treatment. Results unveil that a mere seven-month application of FGB effectively rectified the malocclusion while concurrently yielding notable improvements in the cognitive abilities under scrutiny. Additionally, post-treatment observations revealed enhanced well-being and sleep quality, further emphasizing the multifaceted benefits of such interventions. Although this study presents findings from a singular case, it serves as a catalyst for further exploration into the intricate interplay between masticatory function and cognitive performance. Such endeavors are vital for advancing holistic healthcare practices that integrate dental care with cognitive and psychological considerations, thereby fostering comprehensive well-being and optimal development.</p>","PeriodicalId":7732,"journal":{"name":"AIMS Neuroscience","volume":"12 2","pages":"95-112"},"PeriodicalIF":2.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}