Estimation of white matter hyperintensities with synthetic MRI myelin volume fraction in patients with multiple sclerosis and non-multiple-sclerosis white matter hyperintensities: A pilot study among the Indian population.

IF 3.1 Q2 NEUROSCIENCES
Nisha Syed Nasser, Krish Sharma, Parv Mahendra Mehta, Vidur Mahajan, Harsh Mahajan, Vasantha Kumar Venugopal
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引用次数: 0

Abstract

Aim: Synthetic MRI (SyMRI) works on the MDME sequence, which acquires the relaxation properties of the brain and helps to measure the accurate tissue properties in 6 minutes. The aim of this study was to evaluate the synthetic MRI (SyMRI)-generated myelin (MyC) to white matter (WM) ratio, the WM fraction (WMF), MyC partial maps performing normative brain volumetry to investigate MyC loss in multiple sclerosis (MS) patients with white-matter hyperintensites (WMHs) and non-MS patients with WMHs in a clinical setting.

Materials and methods: Synthetic MRI images were acquired from 15 patients with MS, and from 15 non-MS patients on a 3T MRI scanner (Discovery MR750w; GE Healthcare; Milwaukee, USA) using MAGiC, a customized version of SyntheticMR's SyMRI® IMAGE software marketed by GE Healthcare under a license agreement. Fast multi-delay multi-echo acquisition was performed with a 2D axial pulse sequence with different combinations of echo time (TEs) and saturation delay times. The total image acquisition time was 6 minutes. SyMRI image analysis was done using SyMRI software (SyMRI Version: 11.3.6; Synthetic MR, Linköping, Sweden). SyMRI data were used to generate the MyC partial maps and WMFs to quantify the signal intensities of test group and control group, andcontrol group , and their mean values were recorded. All patients also underwent conventional diffusion-weighted imaging, i.e., T1w and T2w imaging.

Results: The results showed that the WMF was significantly lower in the test group than in the control group (38.8% vs 33.2%, p < 0.001). The Mann-Whitney U nonparametric t-test revealed a significant difference in the mean myelin volume between the test group and the control group (158.66 ± 32.31 vs. 138.29 ± 29.28, p = 0.044). Also, there were no significant differences in the gray matter fraction and intracranial volume between the test group and the control group.

Conclusions: We observed MyC loss in test group using quantitative SyMRI. Thus, myelin loss in MS patients can be quantitatively evaluated using SyMRI.

Abstract Image

Abstract Image

用合成MRI髓磷脂体积分数评估多发性硬化症和非多发性硬化症患者白质高信号:一项针对印度人群的初步研究。
目的:合成磁共振成像(synmri)对MDME序列进行研究,获得大脑的放松特性,有助于准确测量6分钟内的组织特性。本研究的目的是评估合成MRI (SyMRI)生成的髓磷脂(MyC)与白质(WM)之比,WM分数(WMF), MyC部分图执行规范的脑容量测定,以调查多发性硬化症(MS)伴白质高强度(wmh)患者和非MS伴wmh患者在临床环境中的MyC损失。材料和方法:通过3T MRI扫描仪(Discovery MR750w;通用电气医疗集团;MAGiC是通用电气医疗集团根据许可协议销售的SyntheticMR公司SyMRI®IMAGE软件的定制版本。采用不同回波时间(TEs)和饱和延迟时间组合的二维轴向脉冲序列进行快速多延迟多回波采集。总图像采集时间为6分钟。使用SyMRI软件(SyMRI Version: 11.3.6;合成MR, Linköping,瑞典)。采用SyMRI数据生成MyC局部图和WMFs,量化实验组、对照组和对照组的信号强度,并记录其平均值。所有患者均行常规弥散加权成像,即T1w和T2w成像。结果:试验组WMF明显低于对照组(38.8% vs 33.2%, p < 0.001)。Mann-Whitney U非参数t检验显示,实验组和对照组的平均髓磷脂体积差异有统计学意义(158.66±32.31比138.29±29.28,p = 0.044)。实验组和对照组在脑灰质分数和颅内体积上也没有显著差异。结论:通过定量SyMRI观察到实验组MyC丢失。因此,髓磷脂损失在MS患者可以定量评估使用SyMRI。
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来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
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