Science China Chemistry最新文献_第6页

Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer 新血液生物标志物在胃癌早期诊断中的研究进展

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-25 DOI: 10.1007/s11426-024-2189-1

Xinyu Peng, Qian Ma, Da Han

{"title":"Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer","authors":"Xinyu Peng, Qian Ma, Da Han","doi":"10.1007/s11426-024-2189-1","DOIUrl":"10.1007/s11426-024-2189-1","url":null,"abstract":"<div><p>Gastric cancer (GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and carbohydrate antigen 72-4 (CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells (CTCs), circulating tumor cell DNA (ctDNA), and circulating free RNA (cfRNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"35 - 45"},"PeriodicalIF":10.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphorus incorporation-induced adsorption behavior modulation for carbon cathodes enables ultrastable and high-energy aqueous Zn-ion hybrid capacitors

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-25 DOI: 10.1007/s11426-024-2293-9

Lai Yu, Xiaoyue He, Rong Liu, Guanglin Wan, Xinyi Ma, Anqiang Pan, Liang Shi, Genqiang Zhang

{"title":"Phosphorus incorporation-induced adsorption behavior modulation for carbon cathodes enables ultrastable and high-energy aqueous Zn-ion hybrid capacitors","authors":"Lai Yu, Xiaoyue He, Rong Liu, Guanglin Wan, Xinyi Ma, Anqiang Pan, Liang Shi, Genqiang Zhang","doi":"10.1007/s11426-024-2293-9","DOIUrl":"10.1007/s11426-024-2293-9","url":null,"abstract":"<div><p>The aqueous zinc ions hybrid capacitors (ZHCs) have great potential for future energy storage devices by their high safety and low cost merits, more importantly, it could combine the advantages of batteries and supercapacitors with high energy density and power output, respectively. However, the development of reliable cathodes is still a challenge with the unsatisfactory cycling stability and limited reaction kinetic, severely restricting its further commercial applications. Herein, we present phosphorus functionalized nitrogen-doped hierarchical porous carbon nanosheets (PN-HPCNS), where the P incorporation could effectively enhance the electronic transfer kinetics and ion adsorption capability to achieve superior zinc-ion storage properties. The as-prepared PN-HPCNS cathode-based ZHC exhibits a high energy and power density (169.1 Wh kg<sup>−1</sup>/68 W kg<sup>−1</sup>, 15,840 W kg<sup>−1</sup>/30.8 Wh kg<sup>−1</sup>) and long cycling lifespans more than 20,000 cycles with 92.0% capacity retention. Systematic characterizations coupled with kinetics studies indicate that phosphorus modification is crucial to superior zinc ion storage, enabling PN-HPCNS with favorable reaction kinetics, promoting ion adsorption by providing more active sites. Moreover, the theoretical calculation reveals that the phosphorus modification could enhance the adsorption ability, contributing to the superior ZHCs performance of PN-HPCNS.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 3","pages":"900 - 907"},"PeriodicalIF":10.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accurate regulation of carbon skeletons bonded to Fe-N4 single atom nanozymes for efficient generation of reactive oxygen species

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-18 DOI: 10.1007/s11426-024-2268-7

Fuchun Nan, Qilin Wei, Tongtong Kou, Yuxuan Zhao, Lanbo Shen, Dawei Li, Tong Chang, Lingyun Wang, Fangfang Lang, William W. Yu

{"title":"Accurate regulation of carbon skeletons bonded to Fe-N4 single atom nanozymes for efficient generation of reactive oxygen species","authors":"Fuchun Nan, Qilin Wei, Tongtong Kou, Yuxuan Zhao, Lanbo Shen, Dawei Li, Tong Chang, Lingyun Wang, Fangfang Lang, William W. Yu","doi":"10.1007/s11426-024-2268-7","DOIUrl":"10.1007/s11426-024-2268-7","url":null,"abstract":"<div><p>Rational design of single atom nanozymes (SAzymes) could be achieved through the accurate configuration regulation of metal coordination sites, nevertheless, the un-defined carbon environment of traditional SAzymes synthesized by high-temperature pyrolysis makes it difficult to unveil the influence of carbon skeletons with enzyme mimicking activities of SAzymes. Herein, we investigated the relationship between the carbon skeletons and the enzyme mimicking activities through the construction of a series of fully <i>π</i>-conjugated covalent organic polymer (COP)-based SAzymes with analogous Fe-N<sub>4</sub> sites. The experimental results and theoretical calculations demonstrated that carbon skeletons bonded to the Fe-N<sub>4</sub> catalytic sites strongly affect the enzyme mimicking activities of COP SAzymes. When the number of benzene rings in carbon skeletons was 1, the COP SAzyme possessed much more remarkable oxidase (OXD) and peroxidase (POD) mimicking activities, and further reducing or increasing the benzene rings would dramatically inhibit the enzyme mimicking activity. Additionally, the fantastic enzyme mimicking activity of COP-1 could be applied to colorimetric detection of biological molecules and degradation of pollutants. These results provide a new perspective for the rational fabrication of SAzymes with high catalytic efficiency.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 3","pages":"1067 - 1077"},"PeriodicalIF":10.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-induced surface amorphization of Cu2(OH)2CO3 catalyst promotes multi-carbon products selectivity of CO2 electroreduction

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-18 DOI: 10.1007/s11426-024-2326-7

Jie Wang, Min Wang, Yang Wang, Zixuan Wei, Xin He, Haojie Zang, Xixiong Jin, Lingxia Zhang

{"title":"Microwave-induced surface amorphization of Cu2(OH)2CO3 catalyst promotes multi-carbon products selectivity of CO2 electroreduction","authors":"Jie Wang, Min Wang, Yang Wang, Zixuan Wei, Xin He, Haojie Zang, Xixiong Jin, Lingxia Zhang","doi":"10.1007/s11426-024-2326-7","DOIUrl":"10.1007/s11426-024-2326-7","url":null,"abstract":"<div><p>For CO<sub>2</sub> electroreduction, efficient catalysts with superior selectivity toward multi-carbon (C<sub>2+</sub>) products (such as C<sub>2</sub>H<sub>4</sub>, C<sub>2</sub>H<sub>5</sub>OH, etc.) are intensely desired. Amorphous Cu-based catalysts show appealing performance on the crucial C–C coupling, but their synthesis procedures are complicated and their actual mechanisms are still unclear. In this work, surface amorphization has been implemented on Cu<sub>2</sub>(OH)<sub>2</sub>CO<sub>3</sub> catalysts by a very simple microwave-induction method, improving the Faradaic efficiency for C<sub>2+</sub> products (<span>({rm FE}_{{rm C}_{2+}})</span>) up to 86% (increased by ∼26% than that on Cu<sub>2</sub>(OH)<sub>2</sub>CO<sub>3</sub>) at a partial current density of 258 mA cm<sup>−2</sup>, and a high <span>({rm FE}_{{rm C}_{2+}})</span> of 75% at 500 mA cm<sup>−2</sup> in a flow cell. Moreover, the catalyst exhibits good stability. <i>In situ</i> investigations disclose that the amorphous surface optimizes the adsorption state (binding mode and coverage) of key intermediate *CO and stabilizes Cu<sup>+</sup> pieces, facilitating the dimerization of *CO into *OCCO and hydrogenation to *OC<sub>2</sub>H<sub>5</sub>, ultimately achieving high yields of C<sub>2+</sub> products. This work highlights a simple microwave approach for surface amorphization and the roles of amorphous features in CO<sub>2</sub> reduction to C<sub>2+</sub> products, which could be valuable references for designing high-performance catalysts for CO<sub>2</sub> electroreduction.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 4","pages":"1597 - 1607"},"PeriodicalIF":10.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance single-component white light-emitting diodes based on donor-acceptor integrated carbon nitride

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-18 DOI: 10.1007/s11426-024-2339-8

Ning Wu, Fangxu Dai, Kunpeng Wang, Yunhu Wang, Xinyi Wang, Kai Zhang, Mingming Zhang, Kang Liu, Jixiang Xu, Lei Wang, Jun Xing

{"title":"High-performance single-component white light-emitting diodes based on donor-acceptor integrated carbon nitride","authors":"Ning Wu, Fangxu Dai, Kunpeng Wang, Yunhu Wang, Xinyi Wang, Kai Zhang, Mingming Zhang, Kang Liu, Jixiang Xu, Lei Wang, Jun Xing","doi":"10.1007/s11426-024-2339-8","DOIUrl":"10.1007/s11426-024-2339-8","url":null,"abstract":"<div><p>White light-emitting diodes (WLEDs) as energy-saving light sources are widely used to alleviate the rising electric consumption. Most commercial WLEDs are blue/yellow-mixed emitting devices, which have some disadvantages, such as physiological damages of rich blue light, complex device structure and color aging. It is essential to develop single-component WLEDs with quasi-solar spectrum to overcome these problems. Here we demonstrate a high-performance single-component WLED based on donor-acceptor integrated carbon nitride (DACN) material. The donor-acceptor simultaneously increases the photoluminescence efficiency and the carrier mobility of graphitic carbon nitride (g-CN), hence, the DACN-based WLED reaches a milestone in maximum luminance of 2,045 cd m<sup>−2</sup> and maximum external quantum efficiency of 2.2%, which are one order of magnitude higher than pristine g-CN-based LED. Furthermore, the DACN-based WLED emits broadband white light with color coordinates of (0.34, 0.44) and a color temperature of 5,163 K. Our works open a way to boost optoelectronic properties of g-CN materials and show their promising application in single-component WLEDs.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 3","pages":"1136 - 1143"},"PeriodicalIF":10.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-dependent color-tunable room temperature phosphorescence from unusual conformational transitions in phenothiazine polymers under UV irradiation

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-18 DOI: 10.1007/s11426-024-2270-x

Jiwen Lu, Yifan Niu, Chanjuan Jin, Chengheng Wu, Hanyu Wang, Yan Guan, Ping Wang, Xinghe Fan

{"title":"Time-dependent color-tunable room temperature phosphorescence from unusual conformational transitions in phenothiazine polymers under UV irradiation","authors":"Jiwen Lu, Yifan Niu, Chanjuan Jin, Chengheng Wu, Hanyu Wang, Yan Guan, Ping Wang, Xinghe Fan","doi":"10.1007/s11426-024-2270-x","DOIUrl":"10.1007/s11426-024-2270-x","url":null,"abstract":"<div><p>Achieving color-tunable room-temperature phosphorescence (RTP), especially including blue RTP from a single-component polymer still faces a formidable challenge. Herein, we wisely choose conformation-dependent phenothiazine with trifluoromethyl substituent as the side group of the phosphor monomer (CzPT) and then copolymerize it with <i>N</i>-isopropylacrylamide (NIPAM) through photopolymerization to obtain polymers PPCzPTs. Time-dependent color-tunable phosphorescence from unusual quasi-equatorial (eq) to quasi-axial (ax) conformers are obtained, and the RTP color changes from orange (550 nm) to blue (470 nm) with phosphorescence lifetime up to 0.96 s. The theoretical calculations confirm that the quasi-axial conformer is the preferred structure that facilitates the formation of intramolecular hydrogen bonds on the trifluoromethyl group. The EPR spectra illustrate that the persistent UV irradiation generates radical cations to induce the conformational transitions first, followed by photopolymerization immobilizing the ax conformation in PPCzPTs. Applications of data encryption and anti-counterfeiting are fabricated to show prompt and delayed multicolor information. This work affords a simple and feasible avenue for two-dimensional color tunable room temperature phosphorescence from a single-component polymer.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 3","pages":"1091 - 1098"},"PeriodicalIF":10.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11426-024-2270-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recyclable selenoviologen-based D-A porous ionic polymer: from dual-channels photocatalytic degradation to plant growth

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-18 DOI: 10.1007/s11426-024-2327-5

Chenjing Liu, Guoping Li, Yujing Gao, Yawen Li, Wenxi He, Lei Zhang, Wenxin Wei, Gang He

{"title":"Recyclable selenoviologen-based D-A porous ionic polymer: from dual-channels photocatalytic degradation to plant growth","authors":"Chenjing Liu, Guoping Li, Yujing Gao, Yawen Li, Wenxi He, Lei Zhang, Wenxin Wei, Gang He","doi":"10.1007/s11426-024-2327-5","DOIUrl":"10.1007/s11426-024-2327-5","url":null,"abstract":"<div><p>Antibiotic contamination in water systems poses significant environmental concerns, finding efficient photocatalysts that utilize visible light is still a challenge in the field of antibiotic degradation. The selenoviologen-based D-A porous ionic polymer (<b>SeV-PIP</b>) was synthesized by selenoviologen (SeV<sup>2+</sup>) acceptor units with triazine donor units using the Sonogashira reaction. The <b>SeV-PIP</b> exhibits remarkable visible light absorption, effective charge separation and excellent radical cation stability, enabling both photogenerated electrons and holes to participate in dual-channel degradation and demonstrating great recyclability. The efficient degradation of tetracycline antibiotics under visible-light conditions achieves a degradation rate of up to 96% and a recovery rate of 97%, even in the presence of common wastewater contaminants, leading to the eventual mineralization of the contaminant molecules. A flowing sun-light-degradation tandem plant-growth device was designed and assembled, which verified that the degraded wastewater has plant-growth promoting abilities through bean seedling growth experiments and realized further application. This research contributes to sustainable wastewater treatment strategies, emphasizing the importance of advanced photocatalysis for environmental remediation.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 4","pages":"1511 - 1521"},"PeriodicalIF":10.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress on photoactive nonprecious transition-metal complexes 光活性非贵重过渡金属配合物的研究进展

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-15 DOI: 10.1007/s11426-024-2345-0

Zhong-Liang Gong, Hong-Jie Zhang, Yan Cheng, Jianxun Liu, Yuhan Ai, Yaqin Li, Zhihui Feng, Qiong Zhang, Shaolong Gong, Yong Chen, Chang-Jiang Yao, Yuan-Yuan Zhu, Liang-Jin Xu, Yu-Wu Zhong

{"title":"Recent progress on photoactive nonprecious transition-metal complexes","authors":"Zhong-Liang Gong, Hong-Jie Zhang, Yan Cheng, Jianxun Liu, Yuhan Ai, Yaqin Li, Zhihui Feng, Qiong Zhang, Shaolong Gong, Yong Chen, Chang-Jiang Yao, Yuan-Yuan Zhu, Liang-Jin Xu, Yu-Wu Zhong","doi":"10.1007/s11426-024-2345-0","DOIUrl":"10.1007/s11426-024-2345-0","url":null,"abstract":"<div><p>Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"46 - 95"},"PeriodicalIF":10.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting photocatalytic CO2-to-CO conversion using a biomimetic dinuclear Co(II) complex through an HCO3−-mediated pathway

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-15 DOI: 10.1007/s11426-024-2280-8

Yuchen Wang, Wenjie Shi, Weixue Tao, Jihong Zhang, Di-Chang Zhong, Tongbu Lu

{"title":"Boosting photocatalytic CO2-to-CO conversion using a biomimetic dinuclear Co(II) complex through an HCO3−-mediated pathway","authors":"Yuchen Wang, Wenjie Shi, Weixue Tao, Jihong Zhang, Di-Chang Zhong, Tongbu Lu","doi":"10.1007/s11426-024-2280-8","DOIUrl":"10.1007/s11426-024-2280-8","url":null,"abstract":"<div><p>Dinuclear metal synergistic catalysis (DMSC) has been evidenced to be effective in enhancing the catalytic activity for CO<sub>2</sub> reduction. However, the reaction kinetics of CO<sub>2</sub> reduction is still limited by the local CO<sub>2</sub> concentration around the dinuclear catalytic centers. Inspired by the structure of carbonic anhydrase, we have designed and synthesized a dinuclear cobalt(II) complex with an –OH group. This complex not only exhibits DMSC for CO<sub>2</sub> reduction but also possesses excellent capture capacity for CO<sub>2</sub> molecules. Consequently, the complex demonstrates high efficiency for the photocatalytic reduction of CO<sub>2</sub> to CO, with turnover number reaching as high as 43,400 and a selectivity of 97%. Even in 10% CO<sub>2</sub>, the complex still shows state-of-the-art catalytic activity. The results of experiments and theoretical calculations reveal that besides the DMSC contributing to the enhanced catalytic activity, the –OH group in the dinuclear cobalt(II) complex facilitates the capture of CO<sub>2</sub> by the formation of HCO<sub>3</sub><sup>−</sup> intermediates, thereby enhancing the affinity towards CO<sub>2</sub> and boosting the catalytic activity for CO<sub>2</sub>-to-CO conversion.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 3","pages":"974 - 979"},"PeriodicalIF":10.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-controllable multiple and orthogonal regulation of gene expression by chemically modified oligonucleotides

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-14 DOI: 10.1007/s11426-024-2285-7

Yang Wang, Qiu-Long Zhang, Yan Liu, Liang-Liang Wang, Chao-Qun Wu, Ming Shao, Xiwen Xing, Juan Du, Liang Xu

{"title":"Photo-controllable multiple and orthogonal regulation of gene expression by chemically modified oligonucleotides","authors":"Yang Wang, Qiu-Long Zhang, Yan Liu, Liang-Liang Wang, Chao-Qun Wu, Ming Shao, Xiwen Xing, Juan Du, Liang Xu","doi":"10.1007/s11426-024-2285-7","DOIUrl":"10.1007/s11426-024-2285-7","url":null,"abstract":"<div><p>Gene expression must be precisely regulated in cells and functional nucleic acids are the most widely utilized tools for gene manipulation. Photocontrol of how these nucleic acid tools work in the cellular environment can precisely manipulate gene expression through a non-invasive way. Here we report a methodology on multiplex photocontrol of functional nucleic acids to achieve totally temporal and orthogonal regulation of gene expression in living cells. We select two functional nucleic acid systems as examples, DNAzyme and CRISPR/Cas9, and demonstrate the power of light control for precise gene manipulation by rational design of chemically modified oligonucleotides through introduction of two photocleavable linkers. Unlike the previous modulation of functional nucleic acids by simply activating or deactivating, we successfully achieve versatile controlling patterns using light as the governing factor. This design represents a generalized pathway towards the photo-controllable functional nucleic acids, which greatly enriches the toolbox for optogenetic studies.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 2","pages":"694 - 704"},"PeriodicalIF":10.4,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11426-024-2285-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0