Science China Chemistry最新文献_第6页

Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response 肿瘤炎症特异性自扩增荧光分子探针诱导抗肿瘤免疫反应

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-10 DOI: 10.1007/s11426-024-2130-1

Shuguang Yang, Lijun Hu, Hong Xiao, Zecong Xiao, Xintao Shuai

{"title":"Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response","authors":"Shuguang Yang, Lijun Hu, Hong Xiao, Zecong Xiao, Xintao Shuai","doi":"10.1007/s11426-024-2130-1","DOIUrl":"10.1007/s11426-024-2130-1","url":null,"abstract":"<div><p>Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTP-ICG, for photodynamic therapy (PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase (MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and MPO. Meanwhile, PDT efficiently incites immunogenic cell death (ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells (DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils (TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels, potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"273 - 287"},"PeriodicalIF":10.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification and progress of extraction technologies for nonferrous metal resources

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-09 DOI: 10.1007/s11426-024-2196-x

Fangqin Cheng, Na Zhou, Nazeer Muhammad Nouman, Li Cui, Caixia Yin

{"title":"Classification and progress of extraction technologies for nonferrous metal resources","authors":"Fangqin Cheng, Na Zhou, Nazeer Muhammad Nouman, Li Cui, Caixia Yin","doi":"10.1007/s11426-024-2196-x","DOIUrl":"10.1007/s11426-024-2196-x","url":null,"abstract":"<div><p>In recent years, the demand for strategic metal resources, essential for scientific and technological progress and industrial development, has multiplied. Ensuring a stable supply of these metals is critical to national security and the well-being of the population. As global industrialization accelerates, the daily demand for nonferrous metals continues to rise. Consequently, extracting and recovering strategic metals from low-grade raw materials, such as solid waste, has become crucial for maintaining their supply and economic development. However, the extraction process is fraught with challenges, including mineral phase stability and complex composition. This review focuses on key strategic metals such as lithium, aluminum, gallium, and vanadium. It introduces and examines various methods for extracting nonferrous metals from different raw materials, including traditional mining technologies applied to low-grade solid wastes. It also outlines future development opportunities and challenges in this field.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 2","pages":"458 - 474"},"PeriodicalIF":10.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Folding encapsulation toward Lindqvist polyoxometalates within adaptive coordination cages for catalysis

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-09 DOI: 10.1007/s11426-024-2168-4

Ying-Mei Zhong, Jin-Jin Xuan, Xujie Qin, Han Xiao, Zi-Jun Xia, Li-Peng Zhou, Xiao-Qing Guo, Yu-Hang Hu, Lu Zhang, Chunsen Li, Li-Xuan Cai, Qing-Fu Sun

{"title":"Folding encapsulation toward Lindqvist polyoxometalates within adaptive coordination cages for catalysis","authors":"Ying-Mei Zhong, Jin-Jin Xuan, Xujie Qin, Han Xiao, Zi-Jun Xia, Li-Peng Zhou, Xiao-Qing Guo, Yu-Hang Hu, Lu Zhang, Chunsen Li, Li-Xuan Cai, Qing-Fu Sun","doi":"10.1007/s11426-024-2168-4","DOIUrl":"10.1007/s11426-024-2168-4","url":null,"abstract":"<div><p>In nature, enzymes at specific folded conformations exhibit high substrate complementarity, enabling them to efficiently and selectively catalyze biochemical reactions. Inspired by enzymes, coordination cages with conformational dynamics have been designed and are receiving increasing attention due to their versatile applications in allosteric guest binding and catalysis. We present here two enzyme-mimicking adaptive macrocycle-based coordination cages, Pd<sub>2</sub>L<sup>1</sup><sub>2</sub> and Pd<sub>2</sub>L<sup>2</sup><sub>2</sub>, from macrocycle-based ligands (L<sup>1</sup> and L<sup>2</sup>) and the encapsulation and stabilization of Lindqvist polyoxometalates anions M<sub>6</sub>O<sub>19</sub><sup>2−</sup> (M = W or Mo) in neutral aqueous solution. X-ray crystallographic studies have verified the formation of 1:1 host-guest complexes of two Pd<sub>2</sub>L<sub>2</sub> cages and the W<sub>6</sub>O<sub>19</sub><sup>2−</sup>. anion, via an induced-fit folding mechanism. Compared with the free host, Pd<sub>2</sub>L<sup>1</sup><sub>2</sub> exhibited an induced-fit semi-folded conformation in the inclusion complex, while Pd<sub>2</sub>L<sup>2</sup><sub>2</sub> adopted an induced-fit fully-folded conformation. Moreover, the Mo<sub>6</sub>O<sub>19</sub>⊂Pd<sub>2</sub>L<sub>2</sub> host-guest complexes demonstrate high yield and selectivity in the oxidative decontamination reaction of the sulfur mustard simulant, 2-chloroethyl ethyl sulfide. This work not only sheds light on the importance of conformational adaptability in enzyme-like systems but also paves the way for protecting labile POM clusters via host-guest encapsulation toward enhanced catalytic performance in aqueous solution.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 2","pages":"561 - 569"},"PeriodicalIF":10.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming waste particles into valuable adsorbents via amyloid-mediated molecular engineering 通过淀粉样蛋白介导的分子工程将废物颗粒转化为有价值的吸附剂

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-09 DOI: 10.1007/s11426-024-2164-x

Qingmin Yang, Jian Zhao, Yujia Zhang, Xingyu Zhou, Hao Ren, Bowen Hu, Zhongli Lei, Lixin Chen, Peng Yang

{"title":"Transforming waste particles into valuable adsorbents via amyloid-mediated molecular engineering","authors":"Qingmin Yang, Jian Zhao, Yujia Zhang, Xingyu Zhou, Hao Ren, Bowen Hu, Zhongli Lei, Lixin Chen, Peng Yang","doi":"10.1007/s11426-024-2164-x","DOIUrl":"10.1007/s11426-024-2164-x","url":null,"abstract":"<div><p>The high-value utilization of industrial solid waste using a facile and eco-friendly process is of great interest and significance in reducing environmental pollution and developing a green circular economy. Herein, we propose an amyloid-mediated molecular engineering strategy to transform particulate waste into valuable adsorbents for metal ions. Our method has the advantage of aqueous solution fabrication under mild conditions without the use of high-temperature hydrothermal methods and toxic chemical reagents. Amyloid-mediated molecular engineering manipulates the phase transition of bovine serum albumin (BSA) on particulate waste surfaces, resulting in a remarkable ~3.1 times improvement in the adsorption capacity of fly ash, a typical industrial solid waste for gold ions after modification with the phase-transitioned BSA (PTB). The resultant adsorption ability was 69–1,980 times higher than those of conventional and emerging adsorbent materials such as ion exchange resins, activated carbon (AC), covalent organic frameworks (COFs), and metal-organic frameworks (MOFs). We further demonstrated the application of our PTB-modified materials in the recovery of precious metals from low-grade gold ore and electronic waste leachates. Consequently, this strategy could increase the value of waste materials nearly 27 times. In addition, this method is generally extendable to other conventional industrial adsorbents such as resin, clay, and Al<sub>2</sub>O<sub>3</sub>, and enhances their adsorption capabilities at least twofold. Overall, this work provides a simple and green approach for improving the adsorption performance of solid particles, and is expected to develop into a universal strategy for transforming waste particles into high-value-added products.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"317 - 328"},"PeriodicalIF":10.4,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress of photocatalytic CO2 reduction toward multi-carbon products 光催化CO2还原多碳产物研究进展

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-08 DOI: 10.1007/s11426-024-2148-2

Jiaojiao Fang, Chengyang Zhu, Huiling Hu, Jiaqi Li, Licheng Li, Haiyan Zhu, Junjie Mao

{"title":"Progress of photocatalytic CO2 reduction toward multi-carbon products","authors":"Jiaojiao Fang, Chengyang Zhu, Huiling Hu, Jiaqi Li, Licheng Li, Haiyan Zhu, Junjie Mao","doi":"10.1007/s11426-024-2148-2","DOIUrl":"10.1007/s11426-024-2148-2","url":null,"abstract":"<div><p>The photocatalytic CO<sub>2</sub> reduction reaction (CO<sub>2</sub>RR) represents a promising solution to alleviate environmental and energy issues stemming from CO<sub>2</sub> emissions while simultaneously enabling the production of high-value multi-carbon fuels. However, the efficient generation of multi-carbon products remains challenging due to high kinetic barriers, sluggish C–C coupling processes, and intricate reaction pathways. This review provides a comprehensive overview of the latest advancements in synthesizing C<sub>2+</sub> products through CO<sub>2</sub> photoreduction, highlighting the crucial role of active site design and the C–C coupling mechanism. Specifically, we emphasize the correlation between the structure of active sites and the key intermediates of C–C coupling, which is fundamental for achieving deep photoconversion of CO<sub>2</sub>. Finally, we offer a glimpse into future challenges and prospects, outlining potential directions for the development of CO<sub>2</sub>-to-multicarbon photoconversion, aiming to contribute novel insights to this exciting field.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"67 12","pages":"3994 - 4013"},"PeriodicalIF":10.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder 直接和快速检测血清氨基酸和单胺类神经递质以协助诊断惊恐障碍

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-08 DOI: 10.1007/s11426-024-2150-5

Shiwen Liu, Xuerui Wan, Meng Zhao, Jiaqi Wang, Weilan Wu, Linlin You, Yonggui Yuan, Qian Xu, Rong Gao

{"title":"Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder","authors":"Shiwen Liu, Xuerui Wan, Meng Zhao, Jiaqi Wang, Weilan Wu, Linlin You, Yonggui Yuan, Qian Xu, Rong Gao","doi":"10.1007/s11426-024-2150-5","DOIUrl":"10.1007/s11426-024-2150-5","url":null,"abstract":"<div><p>The measurement of amino acid and monoamine neurotransmitters (NTs) in serum plays a central role in the identification and monitoring of clinical panic disorder (PD). However, the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely challenging. Herein, we developed a strategy that integrated solid phase extraction based on magnetic Fe<sub>3</sub>O<sub>4</sub> coated with polydopamine (Fe<sub>3</sub>O<sub>4</sub>@PDA) and direct analysis of mass spectrometry in real time (DART-MS) for quantification of 10 NTs. We systematically investigated the optimal conditions of this strategy to achieve good accuracy and precision. Compared with existing magnetic solid phase extraction methods for NTs detection in biological samples, this strategy could adsorb more targets while having similar adsorption efficiencies, and the total process time was reduced by an average of 69.42%. We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic accuracy. In addition, an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this strategy. Our results highlighted the potential ability of Fe<sub>3</sub>O<sub>4</sub>@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"377 - 384"},"PeriodicalIF":10.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nitrogen-rich halogen-bonded organic framework (XOF) for efficient iodine capture and security printing

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-08 DOI: 10.1007/s11426-024-2204-8

Qi Zhao, Penghao Sun, Guanfei Gong, Yi Chen, Lingzhi Luo, Yongfei Yin, Chunsheng Li, Jike Wang, Lu Wang, Shigui Chen

{"title":"A nitrogen-rich halogen-bonded organic framework (XOF) for efficient iodine capture and security printing","authors":"Qi Zhao, Penghao Sun, Guanfei Gong, Yi Chen, Lingzhi Luo, Yongfei Yin, Chunsheng Li, Jike Wang, Lu Wang, Shigui Chen","doi":"10.1007/s11426-024-2204-8","DOIUrl":"10.1007/s11426-024-2204-8","url":null,"abstract":"<div><p>The escalating utilization of nuclear energy and nuclear medicine raises concerns about the environmental impact of radioactive iodine, necessitating the development of effective iodine adsorbents, especially under a real-world scenario with extremely low iodine concentration and elevated temperature. Herein, we have presented the construction of a nitrogen-abundant two-dimensional (2D) halogen-bonded organic framework, <b>XOF-TNP</b>, characterized by exceptional crystallinity, thermal stability, and nitrogen-rich structures. <b>XOF-TNP</b> exhibits strong binding to iodine, thanks to the fact that iodine can be pre-enriched into the framework through N⋯I interactions. The nitrogen-rich framework and I<sup>+</sup> synergistically have extremely high binding force to iodine, enabling the rapid and efficient capture of iodine in both vapor and solution phases, with significant recyclability. Further flow-through adsorption experiments using an <b>XOF-TNP</b>-packed column achieve 99% iodine removal from hexane and aqueous solutions, surpassing traditional activated carbon. This highlights its potential for environmental remediation. <b>XOF-TNP</b> enables the development of a novel rewritable security paper, utilizing its iodine adsorption properties to encrypt and decrypt QR codes. This research expands the application scope of halogen-bonded organic frameworks, providing insights into the design of materials for environmental remediation and security applications.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 2","pages":"631 - 640"},"PeriodicalIF":10.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel photoresponsive dinuclear nickel catalysts for ethylene (co)polymerization

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-08 DOI: 10.1007/s11426-024-2201-6

Chenlong Nan, Tong Pang, Jiaxing Zhao, Lijia Fan, Chen Zou, Xin-Qi Hao, Mao-Ping Song, Jun-Fang Gong, Changle Chen, Hui Jiang

{"title":"Novel photoresponsive dinuclear nickel catalysts for ethylene (co)polymerization","authors":"Chenlong Nan, Tong Pang, Jiaxing Zhao, Lijia Fan, Chen Zou, Xin-Qi Hao, Mao-Ping Song, Jun-Fang Gong, Changle Chen, Hui Jiang","doi":"10.1007/s11426-024-2201-6","DOIUrl":"10.1007/s11426-024-2201-6","url":null,"abstract":"<div><p>Compared with the conventional strategies of electronic and/or steric perturbation, catalytic olefin polymerization modulated by light irradiation or metal-metal cooperativity effect is a fascinating challenge that attracts considerable attention in the academic community. In this context, we design a strategy that could employ both effects to influence the polymerization process. Some dinuclear salicylaldimine and <i>α</i>-imino-ketone nickel complexes bearing a stiff-stilbene bridge were prepared, which could transfer between (<i>E</i>)-isomers and (<i>Z</i>)-isomers under ultraviolet irradiation. This isomerization can tune the electronic, steric and metal-metal cooperativity effects of the nickel catalysts. In this way, the catalytic activity, as well as polymer microstructures including molecular weight and branching density can be modulated in ethylene polymerization and copolymerization reactions. This strategy is generally applicable to other olefin polymerization catalytic systems and other types of transition metal mediated catalysis.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 2","pages":"714 - 722"},"PeriodicalIF":10.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s11426-024-2201-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantioselective iridium-catalyzed allylic substitution with a Reformatsky reagent: direct construction of β-stereogenic homoallylic esters 铱催化烯丙基取代与 Reformatsky 试剂的对映选择性：直接构建 β-立体同源烯丙基酯

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-09-30 DOI: 10.1007/s11426-024-2284-x

Debasis Pal, Kirana D. Veeranna, Yuk Fai Wong, P. Andrew Evans

{"title":"Enantioselective iridium-catalyzed allylic substitution with a Reformatsky reagent: direct construction of β-stereogenic homoallylic esters","authors":"Debasis Pal, Kirana D. Veeranna, Yuk Fai Wong, P. Andrew Evans","doi":"10.1007/s11426-024-2284-x","DOIUrl":"10.1007/s11426-024-2284-x","url":null,"abstract":"<div><p>The Reformatsky reagent derived from ethyl bromoacetate circumvents the challenge associated with the direct regio- and enantioselective iridium-catalyzed allylic alkylation with an unstabilized aliphatic ester enolate. Notably, this work represents the first example of using a Reformatsky reagent in a metal-allyl reaction, which permits the direct construction of enantioenriched β-stereogenic homoallylic esters without preactivation of the pronucleophile or post-reaction modification of the product (e.g., thermal decarboxylation of a 1,3-dicarbonyl). Moreover, the process allows the coupling of a broad range of sterically and electronically diverse electrophiles bearing aryl, heteroaryl and alkenyl derivatives, including the significantly more challenging alkyl-substituted allylic carbonates. The versatility of the ester product is exemplified by a series of functional group manipulations and the development of a concise and efficient enantioselective total synthesis of the natural product, (+)-descurainolide A. Finally, mechanistic studies indicate that the zinc enolate behaves as a soft nucleophile that undergoes outer-sphere alkylation.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"67 11","pages":"3791 - 3797"},"PeriodicalIF":10.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thioredoxin pathway regulated live-cell synthesis of CdSe quantum dots in Saccharomyces cerevisiae 硫氧还蛋白途径调控酿酒酵母中硒化镉量子点的活细胞合成

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-09-29 DOI: 10.1007/s11426-024-2261-x

Xu Li, Cai-Qin Wu, Jia-Wei Tu, Juan Kong, Ling-Ling Yang, Zhi-Xiong Xie, Dai-Wen Pang

{"title":"Thioredoxin pathway regulated live-cell synthesis of CdSe quantum dots in Saccharomyces cerevisiae","authors":"Xu Li, Cai-Qin Wu, Jia-Wei Tu, Juan Kong, Ling-Ling Yang, Zhi-Xiong Xie, Dai-Wen Pang","doi":"10.1007/s11426-024-2261-x","DOIUrl":"10.1007/s11426-024-2261-x","url":null,"abstract":"<div><p>Currently, the application of synthetic biology to artificially manipulate and utilize organisms for the synthesis of desired products such as nanomaterials with excellent fluorescence properties is attracting considerable attention. However, it is still difficult to obtain designed products efficiently due to insufficient knowledge of the biosynthetic mechanisms. The thioredoxin (TRX) and glutathione (GSH) pathways are generally conserved thiol-reductase systems that protect organisms from oxidative stress and are involved in selenium (Se) metabolism. In this study, we revealed the pivotal role of cytoplasmic TRX pathway in regulating the metabolism of Na<sub>2</sub>SeO<sub>3</sub> during the live-cell synthesis of cadmium-selenium quantum dots (CdSe QDs) in <i>Saccharomyces cerevisiae</i> by regulating the expression level of genes related to TRX pathway and measuring the intracellular content of selenocysteine (SeCys). The determination of SeCys metabolism in yeast with GSH pathway-related genes deleted demonstrated that the TRX pathway played a more significant role in SeCys metabolism than GSH pathway. A 6.4-fold enhancement in the synthetic yield of CdSe QDs was achieved through the overexpression of TRX pathway-related genes, improvement of synthetic procedure, and supplementation of GSH based on the understanding of biological metabolism. Exploring the mechanism of CdSe QDs live-cell synthesis facilitates the precise manipulation of biological processes for the synthesis of inorganic nanomaterials.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"67 11","pages":"3851 - 3860"},"PeriodicalIF":10.4,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0