German journal of ophthalmology最新文献_第6页

Functional prognosis in A and V patterns: a retrospective analysis of surgery on oblique muscles. A型和V型的功能预后:斜肌手术的回顾性分析。

German journal of ophthalmology Pub Date : 1996-09-01

A L Ali, K P Boergen, A B el Naggar, H D Schworm

引用次数: 0

Prediction of visual acuity after early vitrectomy in diabetics. 糖尿病患者早期玻璃体切除术后视力的预测。

German journal of ophthalmology Pub Date : 1996-09-01

L Hesse, S Bodanowitz, M Hühnermann, P Kroll

{"title":"Prediction of visual acuity after early vitrectomy in diabetics.","authors":"L Hesse, S Bodanowitz, M Hühnermann, P Kroll","doi":"","DOIUrl":"","url":null,"abstract":"In proliferative diabetic retinopathy the indication of early vitrectomy remains controversial. At present, no decision rule exists for the assessment of the various factors predicting the postoperative visual outcome. We reviewed 75 vitrectomies in 68 diabetics from our clinic. All vitrectomies were done by one surgeon. In all cases, vitrectomy was indicated because of nonclearing vitreous hemorrhage and/or fibrovascular proliferation. A linear regression model was used to identify factors correlating with the visual outcome. By means of univariate analysis, six of nine clinical variables were found to be associated with the final visual outcome. Dividing the patients into two groups according to their preoperative visual acuity (group 1 hand movement, group 2 better than hand movement), we identified two predictors that were independently associated with the postoperative visual acuity: group 1-the visual acuity of the fellow eye (P < 0.05) and rubeosis iridis (P < 0.05); group 2-the visual acuity of the fellow eye (P < 0.001) and preexisting systemic diabetic vascular disorders (P < 0.01). Based on this model, a formula was derived to predict the visual acuity at 6 months postsurgery. For easier handling the prognostic factors of a poor visual outcome (less than 0.1) were summarized in a flow chart. The test is a useful tool for the preoperative evaluation of various risk factors and, hence, for more reliable prediction of a poor visual outcome. Thus, it may be especially useful to objectify the risk-benefit ratio for early vitrectomy in diabetics.","PeriodicalId":77146,"journal":{"name":"German journal of ophthalmology","volume":"5 5","pages":"257-61"},"PeriodicalIF":0.0,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19876876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelial ingrowth: a study of 207 histopathologically proven cases. 上皮向内生长:207例组织病理学证实病例的研究。

German journal of ophthalmology Pub Date : 1996-07-01

M Küchle, W R Green

{"title":"Epithelial ingrowth: a study of 207 histopathologically proven cases.","authors":"M Küchle, W R Green","doi":"","DOIUrl":"","url":null,"abstract":"Epithelial ingrowth is a major complication of penetrating trauma or intraocular surgery. The present study was undertaken to analyze the clinical and histopathologic findings in a large series of consecutive patients. All cases of epithelial ingrowth on file in the Eye Pathology Laboratory of the Wilmer Ophthalmological Institute, Johns Hopkins Hospital, were included. Histopathologic slides of 207 consecutive cases of epithelial ingrowth were reviewed and, where necessary, additional sectioning and staining was performed. Transmission electron microscopy was performed in 15 cases and immunohistochemistry, in 28 cases. The histopathologic specimens included globes (46), corneal buttons (64), iris tissue (87), and block excisions (7). The causes of epithelial ingrowth were penetrating trauma (48), cataract surgery (123), keratoplasty (21), and others (15). There was a wide spectrum of presenting signs and symptoms, most frequently glaucoma (35), fistula (34), retrocorneal membrane (31), \"uveitis\" (29), iris cyst formation (28), pain (25), bullous keratopathy (20), and corneal graft failure (19). Glaucoma was present in 43.1% of eyes and fistula and/or wound dehiscence was present in 29 eyes. Epithelial ingrowth was cystic in 40 cases and diffuse in 167 and was not suspected prior to histopathologic examination in 36% of cases. Histologically a multilayer of surface epithelium was present on intraocular surfaces such as the cornea, iris, chamber angle, ciliary body, lens capsule, and Bruch's membrane. Epithelial ingrowth may present with a wide variety of often uncharacteristic signs and symptoms and should always be included in the differential diagnosis of unusual posttraumatic or postoperative findings.","PeriodicalId":77146,"journal":{"name":"German journal of ophthalmology","volume":"5 4","pages":"211-23"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leaving the eyelid to its own devices. 让眼睑顺其自然。

German journal of ophthalmology Pub Date : 1996-07-01

T M Wohlrab, J M Rohrbach, H J Thiel

引用次数: 0

German Ophthalmological Society 94th Congress. Mannheim/Heidelberg 21-24 September 1996. Abstracts. 德国眼科学会第94届大会。1996年9月21日至24日曼海姆/海德堡。摘要。

German journal of ophthalmology Pub Date : 1996-07-01

引用次数: 0

Results of adjuvant radiation therapy after surgical excision of pterygium. 翼状胬肉手术切除后辅助放射治疗的结果。

German journal of ophthalmology Pub Date : 1996-07-01

J Schultze, M Hinrichs, B Kimmig

{"title":"Results of adjuvant radiation therapy after surgical excision of pterygium.","authors":"J Schultze, M Hinrichs, B Kimmig","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the present study was the evaluation of the role of adjuvant radiation therapy in the prevention of recurrence after excision. Between July 1, 1985, and April 1, 1993, 64 patients (43 men, 21 women) were referred for radiation therapy after excision of a nasal pterygium. All patients were followed for 1-9 years (median 5.5 years). Radiation therapy was done with a strontium 90 eye applicator at a total dose of 30 Gy fractionated into six fractions of 5 Gy each. In all, 49 patients were treated after their first excision and 15 patients had undergone multiple prior excisions. In 8 of 64 irradiated patients, recurrent pterygium was detected (12.5%); 4 recurrences developed after first excision and adjuvant radiation therapy (8.16%) and the other 4, following multiple former reexcisions and radiotherapy (26.7%). Pterygium did not recur in any of the primarily treated patients who were irradiated within 3 days of surgery. In contrast, 3 of 7 accordingly treated patients (42.9%) who started radiation therapy at between 7 and 10 days after surgery developed recurrent pterygium. Adjuvant radiation therapy after excision of pterygium lowers the overall rate of recurrence to 12.5%. In an adjuvant situation after first excision, radiation therapy should be initiated within 3 days of surgery, the result being freedom from recurrence.","PeriodicalId":77146,"journal":{"name":"German journal of ophthalmology","volume":"5 4","pages":"207-10"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Results of occlusion therapy in anisomyopic amblyopia with myelinated nerve fibers. 有髓神经纤维性屈光性弱视的闭塞治疗效果。

German journal of ophthalmology Pub Date : 1996-07-01

B Käsmann, H Höh, K W Ruprecht

{"title":"Results of occlusion therapy in anisomyopic amblyopia with myelinated nerve fibers.","authors":"B Käsmann, H Höh, K W Ruprecht","doi":"","DOIUrl":"","url":null,"abstract":"The combination of anisomyopia and myelinated nerve fibers in the highly myopic eye is often correlated with severe and therapy-resistant amblyopia. There are very few reports on successful amblyopia therapy in patients with this constellation of symptoms. We report on six patients aged 6, 7, 9 (two cases), and 28 years (two cases) who presented with anisomyopia, myelinated nerve fibers, and severe amblyopia in the highly myopic eye. The four younger patients took part in a therapeutic trial with contact lens correction and occlusion. The six patients suffered from varying degrees of anisomyopia, which ranged between -3.5 and -18.5 D. Four patients underwent strict occlusion therapy. The best visual improvement was from 1/25 to 0.2 (factor of 5) and the best final visual acuity was 0.4. Two patients had microstrabismus, three displayed exotropia, and one patient showed no strabismus. The combination of unilateral high-grade myopia and myelinated nerve fibers represents a special conjunction that is usually correlated with severe amblyopia. The amblyopia is practically resistant to therapy, even under strict treatment regimen with contact lenses and forced occlusion. The goal must be to diagnose this constellation in the first 2 years of life. As case reports show in the literature, consistent therapy at this age can lead to good visual acuity.","PeriodicalId":77146,"journal":{"name":"German journal of ophthalmology","volume":"5 4","pages":"241-5"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leber's hereditary optic neuropathy: clinical and molecular genetic results obtained in a family with a new point mutation at nucleotide position 14498 in the ND 6 gene. Leber遗传性视神经病变:在ND 6基因14498位点出现新的点突变的家族中获得的临床和分子遗传学结果。

German journal of ophthalmology Pub Date : 1996-07-01

B Leo-Kottler, M Christ-Adler, B Baumann, E Zrenner, B Wissinger

{"title":"Leber's hereditary optic neuropathy: clinical and molecular genetic results obtained in a family with a new point mutation at nucleotide position 14498 in the ND 6 gene.","authors":"B Leo-Kottler, M Christ-Adler, B Baumann, E Zrenner, B Wissinger","doi":"","DOIUrl":"","url":null,"abstract":"Mitochondrial DNA mutations at nucleotide position (np) 3460 in the ND 1 gene, np 11778 in the ND 4 gene, and np 14484 in the ND 6 gene are commonly considered to be associated with the clinical features of Leber's hereditary optic neuropathy (LHON) and account for the majority of LHON cases. Recently, a further mutation in the mtDNA at np 14459 was detected. Herein we report the clinical and the most relevant molecular genetic findings obtained in a LHON family with a new mitochondrial DNA mutations at np 14498 in the ND 6 gene. Clinical and historical data were collected over four generations on three affected and five yet unaffected relatives of the maternal line in this family. All three patients and four of their relatives underwent molecular genetic examination. Two patients and five relatives were also studied clinically. All patients exhibited typical clinical features of LHON. In all yet unaffected relatives, various degrees of peripapillary microangiopathy were found. Molecular analysis did not reveal any of the common LHON mutations. Sequence analysis of the mtDNA of one patient was performed and showed a thymine-to-cytosine exchange at np 14498 in the ND 6 gene, leading to the replacement of an evolutionary highly conserved tyrosine by a cysteine residue. The mutation was not found among 70 other LHON lineages and 180 controls. The new mutation at np 14498 lies in the vicinity of the LHON-related mutations at np 14484 and of the recently described mutation at np 14459, in a region constituting the most evolutionarily conserved part of this polypeptide. That the new mutation at np 14498 is found within this highly conserved region and was not present in any controls implies that this mutation is responsible for LHON in this family.","PeriodicalId":77146,"journal":{"name":"German journal of ophthalmology","volume":"5 4","pages":"233-40"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclosporin-A and its metabolites in the anterior chamber after topical and systemic application as determined with high-performance liquid chromatography-electrospray mass spectrometry. 采用高效液相色谱-电喷雾质谱法测定局部和全身应用环孢素a及其代谢物在前房中的含量。

German journal of ophthalmology Pub Date : 1996-07-01

C Althaus, E Dagres, T Reinhard, U Christians, R Sundmacher

{"title":"Cyclosporin-A and its metabolites in the anterior chamber after topical and systemic application as determined with high-performance liquid chromatography-electrospray mass spectrometry.","authors":"C Althaus, E Dagres, T Reinhard, U Christians, R Sundmacher","doi":"","DOIUrl":"","url":null,"abstract":"Penetration of cyclosporin A (CSA) into the anterior chamber through the intact cornea after topical application is difficult due to its hydrophobic structure. Following systemic application the anterior-chamber levels of CSA are reported to be higher. CSA metabolites are more hydrophilic than CSA. Only high-performance liquid chromatography-electrospray mass spectrometry allows exact quantification of the CSA level and the identification of all CSA metabolites. We studied the anterior-chamber levels of CSA and different CSA metabolites after topical and systemic application. CSA and CSA-metabolite anterior-chamber levels were measured in 49 patients after topical application of CSA 2% eye drops preceding routine cataract surgery with 2 different application schemes and in 7 patients receiving systemic CSA after high-risk penetrating keratoplasty. After topical application the average CSA level measured in the anterior chamber was 81 ng/ml. The CSA-metabolite levels were much higher, reaching an average of 378 ng/ml. After systemic therapy the anterior-chamber levels of CSA and of the metabolites were much more balanced at 256 and 317 ng/ml, respectively. CSA penetrates into the anterior chamber after topical eye-drop application, but these levels are much lower than those measured after systemic CSA therapy. After topical application the CSA metabolites might play an important role; they are found in the anterior chamber in much higher concentrations than is CSA, and the metabolite pattern differs from that seen after systemic therapy. The relevance of these findings to the immunosuppressive activity of the CSA metabolites, however, remains unclear.","PeriodicalId":77146,"journal":{"name":"German journal of ophthalmology","volume":"5 4","pages":"189-94"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical experience with the Ben-Sira teledioptric system for use in age-related macular degeneration. 本-西拉远视系统用于老年性黄斑变性的临床经验。

German journal of ophthalmology Pub Date : 1996-07-01

A Mayer

引用次数: 0