IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.02.006

Dongil Keum, Alexandre E. Medina

{"title":"The effect of developmental alcohol exposure on multisensory integration is larger in deeper cortical layers","authors":"Dongil Keum, Alexandre E. Medina","doi":"10.1016/j.alcohol.2024.02.006","DOIUrl":"10.1016/j.alcohol.2024.02.006","url":null,"abstract":"<div><div>Fetal Alcohol Spectrum Disorders (FASD) are one of the most common causes of mental disability in the world. Despite efforts to increase public awareness of the risks of drinking during pregnancy, epidemiological studies indicate a prevalence of 1–6% in all births. There is growing evidence that deficits in sensory processing may contribute to social problems observed in FASD. Multisensory (MS) integration occurs when a combination of inputs from two sensory modalities leads to enhancement or suppression of neuronal firing. MS enhancement is usually linked to processes that facilitate cognition and reaction time, whereas MS suppression has been linked to filtering unwanted sensory information. The rostral portion of the posterior parietal cortex (PPr) of the ferret is an area that shows robust visual-tactile integration and displays both MS enhancement and suppression. Recently, our lab demonstrated that ferrets exposed to alcohol during the “third trimester equivalent” of human gestation show less MS enhancement and more MS suppression in PPr than controls. Here we complement these findings by comparing <em>in vivo</em> electrophysiological recordings from channels located in shallow and deep cortical layers. We observed that while the effects of alcohol (less MS enhancement and more MS suppression) were found in all layers, the magnitude of these effects was more pronounced in putative layers V-VI. These findings extend our knowledge of the sensory deficits of FASD.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 193-198"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139992080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

22. Decreases in microbial derived butyrate may contribute to intestinal inflammation in combined ethanol intoxication and burn injury 22. 微生物衍生丁酸盐的减少可能有助于乙醇中毒和烧伤合并肠道炎症

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.10.025

M.G. Murray, C.J. Herrnreiter, X. Li, M.A. Choudhry

引用次数: 0

1. Alcohol exacerbates neuroinflammation in traumatic brain injury 1. 酒精会加重创伤性脑损伤的神经炎症

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.10.004

S.M. Abazari , M.G. Murray , A. Sullivan , M.A. Choudhry , A.R. Cannon

引用次数: 0

37. Investigating the C5 complosome in Kupffer cell inflammatory activation in alcohol-associated liver disease 37. 酒精相关性肝病库普弗细胞炎症活化中C5复合物的研究

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.10.040

S. Twardy, R. McCullough

引用次数: 0

8. The role of neutrophil activation in binge alcohol-induced intestinal leakage 8. 嗜中性粒细胞活化在狂饮酒精引起的肠漏中的作用

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.10.011

S.E. Cohen, M. Donovan, D.J. Gardner, P.M. McTernan, R.W. Siggins, J. Paloczi

引用次数: 0

27. Aging promotes liver injury: studies on C57Bl/6 mice 27. 衰老促进肝损伤：C57Bl/6小鼠的研究

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.10.030

S.K. Perumal , R. Rajamanickam , P. Sagar , N.A. Osna , K.Rasineni , K.K. Kharbanda

引用次数: 0

28. Liver-specific loss of betaine-homocysteine methyltransferase promotes alcohol-induced liver injury 28. 甜菜碱-同型半胱氨酸甲基转移酶的肝脏特异性丧失促进酒精诱导的肝损伤

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.10.031

R. Rajamanickam , S.K. Perumal , P. Sagar , N.A. Osna , K. Rasineni , K.K. Kharbanda

引用次数: 0

13. Alterations in hematopoietic stem and progenitor cells mediate alcohol-induced osteoclastogenesis 13. 造血干细胞和祖细胞的改变介导酒精诱导的破骨细胞发生

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.10.016

H. Hemati , M. Blanton , R. Khadka , K.A. Grant , I. Messaoudi

引用次数: 0

26. Ethanol and HBV: unraveling the pathogenic interactions 26. 乙醇和HBV：揭示致病相互作用

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.10.029

A.S. Pathania, M. Ganesan, G.A. Bybee, L.A. Adepoju, S. Bhat, H. Chava, L.Y. Poluektova, N.A. Osna

引用次数: 0

Alcohol treatment preferences and the acceptability of virtual reality therapy for treating alcohol misuse in adult drinkers 酒精治疗偏好与虚拟现实疗法治疗成年饮酒者酒精滥用的可接受性。

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 DOI: 10.1016/j.alcohol.2024.03.004

Rigina Skeva , Caroline Jay , Steve Pettifer , Lynsey Gregg

{"title":"Alcohol treatment preferences and the acceptability of virtual reality therapy for treating alcohol misuse in adult drinkers","authors":"Rigina Skeva , Caroline Jay , Steve Pettifer , Lynsey Gregg","doi":"10.1016/j.alcohol.2024.03.004","DOIUrl":"10.1016/j.alcohol.2024.03.004","url":null,"abstract":"<div><div>Alcohol misuse affects a large part of the population worldwide, with high relapse rates reported even post-treatment. Treatments are also not always available, for example during the COVID-19 pandemic when social distancing measures affected the availability of in-person approaches. Novel treatments like Virtual Reality Therapy (VRT), delivered via a standard VR headset or a mobile device, may offer a flexible alternative for reducing drinking and assisting relapse prevention, but little is known about their acceptability. We therefore explored the acceptability of VRT alongside the treatment preferences of adult drinkers in an online survey. Participants were asked to consider and rank order a range of treatments typically offered by healthcare services alongside standard and mobile VRT in order to determine their relative preferences. Acceptability of each treatment was also established. Additional questions addressed potential predictors of VRT's acceptability including familiarity with each treatment option presented, prior experience of VR, hazardous drinking, perceived stigma, treatment uptake attitudes, gender, ethnicity, and mental health. Of 259 participants, more than half (52.9%) were drinking at hazardous levels. The majority of respondents (86.9%) expressed a preference for in-person treatments. Cognitive Behavioral Therapy, Counseling, and 12-Step Facilitation Therapy were considered the most acceptable treatments, whereas VRT, and particularly mobile VRT, were perceived as less acceptable than traditional treatments. Treatment familiarity and preferences, prior VR experience, mental health, treatment uptake attitudes, and perceived stigma were all associated with the acceptability of VRT. Psychoeducation and familiarization processes in delivery protocols, and in-person delivery of VRT, could increase the acceptability of VRT, particularly for people who are not regular technology users, or who require concurrent mental health support.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 185-192"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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