Alcohol最新文献

{"title":"Impact of parental ethanol exposure on offspring memory: Sex differences in spatial and passive avoidance tasks","authors":"Amirhossein Heidari ,&nbsp;Arman Hajikarim-Hamedani ,&nbsp;MohammadBasir Asefi ,&nbsp;Haniyeh Soltani ,&nbsp;Mohammad Saber Zamani ,&nbsp;Yekta Ghane ,&nbsp;Setareh Rassa ,&nbsp;Mitra Sadat-Shirazi ,&nbsp;Mohammad-Reza Zarrindast","doi":"10.1016/j.alcohol.2025.01.009","DOIUrl":"10.1016/j.alcohol.2025.01.009","url":null,"abstract":"<div><div>The impact of parental alcohol exposure on subsequent generations recently gained significant attention. Ethanol, widely consumed by humans, is known for its anxiolytic effects upon initial use. However, repeated ethanol consumption leads to cognitive dysfunction, dependence, and other physical abnormalities. In line with recent publications from our group, this study investigated the role of parental ethanol exposure—10 days prior to gestation—on learning and memory, which are critical cognitive abilities, in male and female offspring.</div><div>Adult male and female Wistar rats (n = 12) were exposed to ethanol (in drinking water) for 30 days, followed by a 10-day ethanol-free period. Each rat was then paired to mate with either an ethanol-naïve (control, n = 12) or ethanol-exposed rat, resulting in four distinct groups: (1) control male and female, (2) ethanol-exposed male and control female (P.EE), (3) ethanol-exposed female and control male (M.EE), and (4) ethanol-exposed male and female (P + M.EE). Adult male and female offspring were tested for spatial learning and memory (Morris Water Maze) and passive avoidance memory. Additionally, brain-derived neurotrophic factor (BDNF) levels in the cerebrospinal fluid were evaluated.</div><div>Results showed that spatial memory was negatively affected by parental ethanol consumption in both male and female offspring, while spatial learning was impaired only in female offspring of ethanol-exposed dams. In the passive avoidance paradigm, memory retrieval was impaired in ethanol-exposed male offspring, whereas in females, only the P + M.EE group showed a deficit in memory retention. While BDNF levels decreased in male offspring, an enhancement in BDNF was observed in female offspring of the P. EE group.</div><div>In conclusion, our findings suggest that parental ethanol exposure before conception has differential impacts on learning and memory, depending on the offspring's sex and the type of memory tested. Spatial memory was affected in both sexes (except for females in the P. EE group), while memory retrieval in the passive avoidance task remained unaffected in female offspring of the P. EE and M. EE groups. Conversely, male offspring of ethanol-exposed sires and dams exhibited deficits in passive avoidance memory. This may suggest that in memory tasks involving inhibitory cues, such as passive avoidance, female offspring of ethanol-exposed dams or sires are more resilient to memory deficits compared to male offspring. This resilience could possibly be attributed to their higher anxiety levels relative to males.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 13-21"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sleep health, negative reinforcement learning, and alcohol use among South Florida college students with elevated internalizing symptoms","authors":"Nathan A. Sollenberger,&nbsp;Logan R. Cummings,&nbsp;Josefina Freitag,&nbsp;Elisa M. Trucco,&nbsp;Sthefany Gomez,&nbsp;Melanie Giraldo,&nbsp;Gabriela Muse,&nbsp;Aaron T. Mattfeld,&nbsp;Dana L. McMakin","doi":"10.1016/j.alcohol.2024.04.006","DOIUrl":"10.1016/j.alcohol.2024.04.006","url":null,"abstract":"<div><div>Negative reinforcement is proposed to mediate associations between sleep and alcohol use, especially among people with depression and/or anxiety symptoms. Worse sleep (e.g., shorter duration, less efficiency, more irregular timing) exacerbates negative emotions, which alcohol may temporarily relieve. Not yet examined, we propose sleep indirectly impacts early stages of alcohol use via differences in negative reinforcement learning (NRL), since sleep impacts emotion, reward response, and learning. The current study aimed to replicate associations between sleep and alcohol use, test associations with NRL, and examine indirect associations between sleep health and alcohol use via NRL among 60 underage college students (ages 18–20 years, 77% female) varying in depression and anxiety symptoms. Participants wore Fitbit smartwatches and completed daily diaries measuring sleep and substance use for ∼14 days before completing two computer tasks assessing social (SNRL) and monetary (MNRL) negative reinforcement learning. Robust generalized linear models tested direct associations within the proposed model. SNRL performance was positively associated with alcohol use, but no other associations were observed. Statistical mediation models failed to indicate indirect effects of sleep on alcohol use via SNRL or MNRL performance. Post-hoc exploratory models examining depression and anxiety symptoms as moderators of direct associations indicated several interactions. Positive associations between sleep timing variability and alcohol use were weakened at higher anxiety symptom severity and stronger at higher depression symptom severity. The positive association between SNRL performance and alcohol use was also stronger at higher depression symptom severity. Among students with elevated depression symptoms, variable sleep timing and stronger SNRL performance were independently associated with more alcohol use, but indirect effects were not supported. Future research should replicate findings, confirm causality of interactions, and examine sleep timing and behavioral responses to negative social stimuli as targets for improving alcohol-related outcomes among underage college students with elevated depressive symptoms.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 23-34"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between sleep medication use and alcohol consumption over 36 years in Finnish twins","authors":"Viola Helaakoski ,&nbsp;Stephanie Zellers ,&nbsp;Christer Hublin ,&nbsp;Hanna M. Ollila ,&nbsp;Antti Latvala","doi":"10.1016/j.alcohol.2023.12.004","DOIUrl":"10.1016/j.alcohol.2023.12.004","url":null,"abstract":"<div><h3>Background</h3><div>Sleep medication use is an indicator of underlying sleep problems that might be induced by various factors such as alcohol use. However, the longitudinal relationship between drinking and sleep problems remains poorly understood. We investigated associations between sleep medication and alcohol use throughout adulthood, and examined the role of familial and potential confounding factors contributing to these associations.</div></div><div><h3>Methods</h3><div>We used information of zygosity and self-report questionnaire data over a follow-up period of 36 years from the Older Finnish Twin Cohort (N = 13 851).</div></div><div><h3>Results</h3><div>Logistic regression analyses suggested consistent associations between sleep medication use and heavy/binge drinking at all four time points (OR range = 1.36–3.18, P &lt; 0.05), implying that increased drinking is associated with increased sleep medication use over time. Cross-lagged path analyses suggested that moderate/heavy and binge drinking predict sleep medication use at most time points (OR range = 1.15–1.94, P &lt; 0.05), whilst sleep medication use predicts subsequent abstaining from alcohol (OR range = 2.26–2.47, P &lt; 0.05). Within-pair analyses implied that familial factors play a role, and quantitative genetic modelling estimated genetic factors to explain approximately 80 % of the lifetime association of sleep medication use with moderate/heavy and binge drinking.</div></div><div><h3>Conclusions</h3><div>Drinking is associated with sleep medication use throughout adulthood. Further, our results suggest that drinking is likely to predict sleep medication use, thereby potentially constituting a risk factor for sleep problems, and that genetic factors contribute to the association. These findings are important in terms of better understanding the development of sleep and alcohol use disorders.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 79-88"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138688100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of impulsivity on suicidal behaviour among higher education students with depression and substance abuse disorders","authors":"Rachel McHugh ,&nbsp;Margaret McLafferty ,&nbsp;Natasha Brown ,&nbsp;Caoimhe Ward ,&nbsp;Colum P. Walsh ,&nbsp;Anthony J. Bjourson ,&nbsp;Louise McBride ,&nbsp;John Brady ,&nbsp;Siobhan O'Neill ,&nbsp;Elaine K. Murray","doi":"10.1016/j.alcohol.2025.01.002","DOIUrl":"10.1016/j.alcohol.2025.01.002","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol and drug dependent individuals have consistently exhibited elevated impulsivity and some studies have indicated that impulsivity recorded in young adults predicts future alcohol abuse. Research also indicates that depressed individuals with higher impulsivity are more likely to report suicidal ideation even when they are less depressed, which may indicate that impulsivity could more strongly predict suicidality than severity of depressive symptoms.</div></div><div><h3>Objective</h3><div>The aim of this study was to investigate the mediating role of impulsivity on suicidal behaviour and self-harm among students with depression, alcohol and substance abuse disorders.</div></div><div><h3>Materials and methods</h3><div>Participants were first-year undergraduate students (n = 1829) across Ulster University (NI) and Letterkenny Institute of Technology - now known as Atlantic Technological University Donegal (ROI), who were recruited as part of the World Mental Health International College Student Initiative. Participants completed an online survey utilising the WMH-Composite International Diagnostic Interview Screening Scales (CIDI-SC). Mediation analyses were conducted in three different stages.</div></div><div><h3>Results</h3><div>A high prevalence of depression and substance use disorders, suicidal ideation, plans, attempts and self-harm were observed. Impulsivity was found to partially mediate the association between depression and suicidal behaviours and substance use disorders and suicidal behaviours. Impulsivity was significantly associated with suicide ideation, attempts and self-harm, but not suicide plans. Males were more likely to be impulsive, and higher levels of depression and substance use disorders were related to higher impulsivity.</div></div><div><h3>Conclusions</h3><div>The main findings of this study reinforce the role of impulsivity in mediating the relationship between depression and suicidality and substance use and suicidality. College wellbeing services may consider whether screening for impulsivity, rather than for example substance abuse, could be more beneficial and less prone to under-reporting, when assessing for suicide risk among vulnerable students.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 89-96"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal, paternal, and dual-parental alcohol exposures result in both overlapping and distinct impacts on behavior in adolescent offspring","authors":"Kara N. Thomas ,&nbsp;Alison Basel ,&nbsp;Hayden Reitz ,&nbsp;Rachel Toler ,&nbsp;Kelly R. Thomas ,&nbsp;Luke J. Dotson ,&nbsp;Tyler Brown ,&nbsp;Alan Nguyen Pham ,&nbsp;Siara K. Rouzer ,&nbsp;Rajesh C. Miranda ,&nbsp;Michael C. Golding","doi":"10.1016/j.alcohol.2025.01.004","DOIUrl":"10.1016/j.alcohol.2025.01.004","url":null,"abstract":"<div><div>Emerging research reveals that alcohol use by fathers before conception can affect the growth and development of their offspring. Here, we used a C57BL/6J mouse model to study the effects of alcohol exposure on the behavior of the first-generation (F1) offspring, comparing the impacts of alcohol exposure by mothers, fathers, and both parents. Our goal was to determine how alcohol exposure by each parent or both parents influences the behavior of the offspring. We found that adolescent male offspring of alcohol-exposed fathers showed reduced anxiety-like behaviors as they spent more time in the center of the testing arena during the open field test. Both maternal and paternal alcohol exposure caused sex-specific increases in the nestlet shredding test while decreasing the number of buried marbles in the marble burying test. Interestingly, dual-parental alcohol exposure did not produce any significant changes in these same tests. However, during novel object recognition testing, we found that dual-parental male and female offspring exhibit an increased preference for novel objects, suggesting an increased risk preference. Finally, at sixteen weeks, male offspring of dual-exposed parents exhibited decreased voluntary physical activity on running wheels during the active phase, suggesting alterations in their circadian rhythms. Although differences in parental exposure histories between treatment groups make interpretation challenging, our findings suggest that exposure to alcohol by both parents may have unique effects on behavior and that studying both maternal and paternal alcohol use is essential for understanding the full range of factors influencing the penetrance and severity of alcohol-related phenotypes.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 65-77"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of alcohol and its prevention strategies on adolescent school students","authors":"Emmanuel Janagan Johnson ,&nbsp;Jessica Evangelin Emmanuel Janagan","doi":"10.1016/j.alcohol.2024.03.009","DOIUrl":"10.1016/j.alcohol.2024.03.009","url":null,"abstract":"<div><div>Substance use continues to be recognized as one of the major health and social issues in the Caribbean. This study focusses on the risks and consequences of adolescent school student's exposure to alcohol and prevention strategies. Participants were selected from the age group of 13–19 years old, who are attending Secondary School. Five schools were chosen according to the prevalence of alcohol. Students were purposively selected from each school based on the recommendations from the school social workers. Students completed the Adolescent Drug Involvement Scale (ADIS) to understand the extent of involvement in alcohol use. The study recommends that there is a need for effective parenting where training in awareness, skills, and techniques around engaging young adolescent students with age-appropriate information on alcohol abuse can be disbursed and reinforced as they enter various stages of their development.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 7-11"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140320118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between 5-HTRs gene polymorphism and alcohol use disorder in Han males from Yunnan, China","authors":"Kuan Li ,&nbsp;Wei Wei ,&nbsp;Yue Wang ,&nbsp;Ning Zhang ,&nbsp;Jianjun Bao ,&nbsp;Xulan Zhang ,&nbsp;Xinjian Zheng ,&nbsp;Fei Zhao ,&nbsp;Xiaopei Yang ,&nbsp;Jiahui Peng ,&nbsp;Changqing Gao ,&nbsp;Shurong Zhong","doi":"10.1016/j.alcohol.2025.01.008","DOIUrl":"10.1016/j.alcohol.2025.01.008","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) has become a very serious medical and social problem. It is found that genetic polymorphisms of the 5-hydroxytryptamine receptors (<em>5-HTRs</em>) genes were associated with the risk of AUD. However, the results are controversial among different ethnic groups. At present, the correlation between <em>5-HTRs</em> gene polymorphism and AUD in Han population from Yunnan Province remains unclear. In this study, 13 single nucleotide polymorphisms (SNPs) of <em>HTR1B</em>, <em>HTR2A</em>, <em>HTR3A, HTR3B</em> and <em>HTR7</em> were detected by universal fluorescent probe technique. The CT genotype frequency of <em>HTR3A</em> rs1062613 was significantly higher in AUD case group than that in control group (<em>P</em> = 0.037, OR = 2.193, 95% CI: 1.048–4.366). The study indicated that the genetic polymorphisms of <em>5-HTRs</em> were significantly associated with risk of AUD in Han male from Yunnan, China. In addition, this study further demonstrated the impact of alcohol on human health, especially liver damage, by analyzing the blood biochemical indicators of patients with AUD and combining them with their medical history.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 55-63"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain predicts past-month co-use of alcohol and cannabis among emerging adults: Results from the Population Assessment of Tobacco and Health (PATH) Study","authors":"Callon M. Williams ,&nbsp;Nadine R. Mastroleo ,&nbsp;Mark F. Lenzenweger ,&nbsp;Emily L. Zale","doi":"10.1016/j.alcohol.2025.02.003","DOIUrl":"10.1016/j.alcohol.2025.02.003","url":null,"abstract":"<div><div>Alcohol use, cannabis use, and pain are public health concerns among emerging adults (18–24 years old). Co-use of alcohol and cannabis is of particular concern since individuals who co-use alcohol and cannabis use more of each substance and experience greater substance-related harm. Pain and substance use frequently co-occur, and a growing body of literature indicates pain is unique risk factor for substance use. The goal of the current study was to examine moderate/severe pain (vs. no/low pain) as a prospective predictor of engaging in co-use of alcohol and cannabis among emerging adults, and to test sex as a moderator of this hypothesized relationship. Data were drawn from Waves 1–5 of the Population Assessment of Tobacco and Health Study (<em>n</em> = 3544). Unadjusted logistic regression revealed that those with moderate/severe pain at baseline were 1.4 times more likely to engage in past-month co-use of alcohol and cannabis over the next four years (<em>p</em> = .046). The effects of pain on co-use were no longer significant after inclusion of covariates and a pain∗sex interaction term, which was also nonsignificant (<em>ps</em> &gt; .05). These findings provide initial support for pain as a risk factor for engaging in co-use of alcohol and cannabis during emerging adulthood. Future research should continue investigating how pain may motivate co-use of alcohol and cannabis, exploring how pain is associated with other measures of co-use, and determining how providers can incorporate pain-substance use psychoeducation for emerging adults in clinical settings.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 111-119"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KCa2 channel positive modulation reduces alcohol drinking in female C57BL/6J mice","authors":"Kathy L. Lindquist,&nbsp;Audrey E. Padula,&nbsp;Natalie S. Katzenmeyer,&nbsp;Hannah N. Potts,&nbsp;Jennifer A. Rinker,&nbsp;Patrick J. Mulholland","doi":"10.1016/j.alcohol.2025.01.005","DOIUrl":"10.1016/j.alcohol.2025.01.005","url":null,"abstract":"<div><div>Although men have historically exhibited higher levels of alcohol use disorder (AUD) diagnosis, the gap between men and women has been diminishing quickly. Preclinical screening for pharmacological treatments for AUD has typically focused solely on males, ignoring the possibility that males and females may differ mechanistically for the same behavioral phenotype. To ensure the efficacy of treatment targets across the sexes, it is crucial to study the pharmacological effects of AUD treatments in males and females. While positive K_Ca2 channel modulation can reduce ethanol consumption and seeking behaviors, withdrawal-induced hyperexcitability, and negative affective behaviors in male rodents, the effect of K_Ca2 channel modulation on female ethanol consumption has not been reported. To determine the efficacy of K_Ca2 channel positive modulation in female C57BL/6J mice, we assessed the ability of the K_Ca2 channel positive modulator 1-EBIO to affect locomotor activity, voluntary home cage ethanol intake prior to and following chronic intermittent ethanol (CIE) exposure, and voluntary home cage sucrose drinking. There were no significant changes to distance traveled in an open field apparatus following administration of 1-EBIO in our locomotor assay. In ethanol drinking mice, 1-EBIO significantly reduced ethanol consumption in air controls and CIE exposed mice, without altering water consumption. While administration of 1-EBIO did not affect consumption of sucrose in male mice, 1-EBIO significantly increased sucrose intake in females. Together, these data provide further evidence that K_Ca2 channel positive modulation is a promising therapeutic target to reduce ethanol drinking in males and females alike.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 97-103"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coping-strategies as a mediator between emotional disorders and problematic alcohol use","authors":"Celia Antuña-Camblor ,&nbsp;Gabriel Esteller-Collado ,&nbsp;Joel Juarros-Basterretxea ,&nbsp;Roger Muñoz-Navarro ,&nbsp;Francisco Javier Rodríguez-Díaz","doi":"10.1016/j.alcohol.2024.07.008","DOIUrl":"10.1016/j.alcohol.2024.07.008","url":null,"abstract":"<div><h3>Background</h3><div>Epidemiological studies reveal a high prevalence of alcohol use and comorbidity rates with emotional disorders. This study aims to explore the possible mediational effect of stress-coping strategies on the relationship between symptoms of emotional disorders and problematic alcohol use.</div></div><div><h3>Methods</h3><div>The sample included 1014 participants (33.82% male, 66.17% female) aged 18–75 years (<em>M</em> = 33.0, <em>SD</em> = 15.15). Three mediation analyzes were carried out, for depressive, anxious and somatization symptomatology measured with the LSB-50 in which they acted as an independent variable, the coping strategies of the CSQ as a mediating variable and the problematic alcohol use, measured with AUDIT, as a dependent variable. Additionally, sex, age, educational level, and socioeconomic status were entered as covariates.</div></div><div><h3>Results</h3><div>In all the models, problematic alcohol use was mediated by Problem-Solving Focus and Open Emotional Expression. However, while in depressive symptoms was a fully mediation, in anxious and somatization symptomatology was partially mediated.</div></div><div><h3>Conclusions</h3><div>The similarities found may be due to shared variance between emotional disorders. Interventions focused on Problem-Solving Focus could improve the emotional symptoms and the problematic alcohol use.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 47-53"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}