AlcoholPub Date : 2024-12-01DOI: 10.1016/j.alcohol.2024.10.034
L. Rutt, R. McCullough
{"title":"31. Redefining canonical Wnt/β-catenin signaling in hepatic stellate cells as a critical modulator for fibrosis in models of alcohol-associated liver disease","authors":"L. Rutt, R. McCullough","doi":"10.1016/j.alcohol.2024.10.034","DOIUrl":"10.1016/j.alcohol.2024.10.034","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 216-217"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143142149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Examination of factors related to problem drinking among the working population: The Japanese civil servants study","authors":"Takashi Shigeno , Takashi Tatsuse , Michikazu Sekine , Masaaki Yamada","doi":"10.1016/j.alcohol.2024.02.001","DOIUrl":"10.1016/j.alcohol.2024.02.001","url":null,"abstract":"<div><div>Problem drinking affects not only the health of a population but also the productivity of a nation, especially if it is rampant among the working population. This study examines the association between problem drinking and work characteristics, work-family status, and social situations among the Japanese working population. Multivariable logistic regression analysis was performed on the basis of gender on 3136 participants (men: 65.1%, women: 34.9%) adopted from the Japanese Civil Servants Study in 2014 (response rate: 87.8%), to examine the factors related to problem drinking, after adjusting for frequency and quantity of drinking. Problem drinking was assessed using the Cutdown, Annoyed, Guilty, and Eye-opener (CAGE) questionnaire. The presence of problem drinking was found in 24.3% of men and 10.3% of women. The analysis showed that in men, poor work performance (OR: 1.34, 95% CI: 1.00–1.79), high family-to-work conflict (OR: 1.54, 95% CI: 1.14–2.09), and high work-to-family conflict (OR: 1.63, 95% CI: 1.14–2.34) were significantly associated with problem drinking, whereas in women, high work-to-family conflict (OR: 2.45, 95% CI: 1.21–4.95) was significantly associated with problem drinking. Although the number of close friends is negatively associated with problem drinking in women, the significance disappeared in the fully adjusted model. It can be concluded that it is important for both men and women to strike a balance between work and family life. Moreover, owing to gender differences, work performance may be important for men, and the presence of close friends may be important for women, in reducing the risk of problem drinking.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 199-207"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139713537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AlcoholPub Date : 2024-12-01DOI: 10.1016/j.alcohol.2024.10.036
P. Shukla, A. Meena, S. Bhalani, P. Raju, C. Shekhar, N. Shashikanth, C. Nguyen, B. Jones, R.K. Rao
{"title":"33. Comparing the effect of chronic alcohol feeding and corticosterone treatment on the gut-liver axis in C57BL6 and DBA mouse strains","authors":"P. Shukla, A. Meena, S. Bhalani, P. Raju, C. Shekhar, N. Shashikanth, C. Nguyen, B. Jones, R.K. Rao","doi":"10.1016/j.alcohol.2024.10.036","DOIUrl":"10.1016/j.alcohol.2024.10.036","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Page 217"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AlcoholPub Date : 2024-12-01DOI: 10.1016/j.alcohol.2024.10.022
S. Mahalingam, J. Kramer, R. Bellamkonda, O. Ethiraj, C. Casey, L. Leggio, K. Kharbanda, K. Rasineni
{"title":"19. Does ethanol exposure have any direct effects on the ghrelin system?","authors":"S. Mahalingam, J. Kramer, R. Bellamkonda, O. Ethiraj, C. Casey, L. Leggio, K. Kharbanda, K. Rasineni","doi":"10.1016/j.alcohol.2024.10.022","DOIUrl":"10.1016/j.alcohol.2024.10.022","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Page 213"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AlcoholPub Date : 2024-12-01DOI: 10.1016/j.alcohol.2024.10.026
M. New-Aaron, S.M. Yeligar
{"title":"23. Alcohol and HIV increase the risk of pneumonia due to impaired bacterial clearance by alveolar macrophages","authors":"M. New-Aaron, S.M. Yeligar","doi":"10.1016/j.alcohol.2024.10.026","DOIUrl":"10.1016/j.alcohol.2024.10.026","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Page 214"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AlcoholPub Date : 2024-12-01DOI: 10.1016/j.alcohol.2024.02.006
Dongil Keum, Alexandre E. Medina
{"title":"The effect of developmental alcohol exposure on multisensory integration is larger in deeper cortical layers","authors":"Dongil Keum, Alexandre E. Medina","doi":"10.1016/j.alcohol.2024.02.006","DOIUrl":"10.1016/j.alcohol.2024.02.006","url":null,"abstract":"<div><div>Fetal Alcohol Spectrum Disorders (FASD) are one of the most common causes of mental disability in the world. Despite efforts to increase public awareness of the risks of drinking during pregnancy, epidemiological studies indicate a prevalence of 1–6% in all births. There is growing evidence that deficits in sensory processing may contribute to social problems observed in FASD. Multisensory (MS) integration occurs when a combination of inputs from two sensory modalities leads to enhancement or suppression of neuronal firing. MS enhancement is usually linked to processes that facilitate cognition and reaction time, whereas MS suppression has been linked to filtering unwanted sensory information. The rostral portion of the posterior parietal cortex (PPr) of the ferret is an area that shows robust visual-tactile integration and displays both MS enhancement and suppression. Recently, our lab demonstrated that ferrets exposed to alcohol during the “third trimester equivalent” of human gestation show less MS enhancement and more MS suppression in PPr than controls. Here we complement these findings by comparing <em>in vivo</em> electrophysiological recordings from channels located in shallow and deep cortical layers. We observed that while the effects of alcohol (less MS enhancement and more MS suppression) were found in all layers, the magnitude of these effects was more pronounced in putative layers V-VI. These findings extend our knowledge of the sensory deficits of FASD.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 193-198"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139992080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"14. Alcohol use and the fecal microbiome among those seeking care in the emergency department for acute mild traumatic brain injury","authors":"A.J. Hoisington, C.E. Stamper, E.J. Kovacs, L.A. Brenner","doi":"10.1016/j.alcohol.2024.10.017","DOIUrl":"10.1016/j.alcohol.2024.10.017","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 211-212"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}