Alcohol最新文献_第10页

Evaluating a 30-day alcohol abstinence challenge in heavy-drinking individuals with and without chronic pain: Feasibility, safety, and perceived benefits 对患有或不患有慢性疼痛的酗酒者进行为期 30 天的戒酒挑战评估：可行性、安全性和可感知的益处。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-01 Epub Date: 2024-11-01 DOI: 10.1016/j.alcohol.2024.10.046

Dokyoung S. You , Maisa S. Ziadni , Noel Vest , Nareh Megerdichian , Tara Maronesy , Ralph J. Castro , Beth D. Darnall , Sean C. Mackey , Keith Humphreys

{"title":"Evaluating a 30-day alcohol abstinence challenge in heavy-drinking individuals with and without chronic pain: Feasibility, safety, and perceived benefits","authors":"Dokyoung S. You , Maisa S. Ziadni , Noel Vest , Nareh Megerdichian , Tara Maronesy , Ralph J. Castro , Beth D. Darnall , Sean C. Mackey , Keith Humphreys","doi":"10.1016/j.alcohol.2024.10.046","DOIUrl":"10.1016/j.alcohol.2024.10.046","url":null,"abstract":"<div><h3>Introduction</h3><div>To combat high-risk alcohol consumption, we introduced a 30-day alcohol abstinence challenge targeted at heavy drinkers with and without chronic pain. Our study aimed to assess the challenge's feasibility and safety and to explore its perceived benefits. Our exploratory aim was to identify participants' coping strategies during the challenge.</div></div><div><h3>Methods</h3><div>Our single-arm study recruited heavy drinkers from a pain clinic and a university setting (n = 34, 64.7% chronic pain). Participants underwent a modified community-based 30-day challenge, which included motivational interviewing, an individualized start date, and weekly phone check-ins.</div></div><div><h3>Results</h3><div>We found the 30-day challenge was feasible and safe; 72.3% of eligible heavy drinkers participated in the challenge with no serious adverse events. Most challengers (94.1%) reported some benefit from the challenge, which included improvements in alcohol withdrawal symptoms, sleep, and alcohol abstinence self-efficacy, but not in pain. We identified 25 perceived benefits and 21 coping strategies.</div></div><div><h3>Conclusion</h3><div>Our study confirms that a 30-day alcohol abstinence challenge is a feasible and safe intervention for heavy drinkers with and without chronic pain, yielding notable health benefits. The challenge also facilitated the development of effective coping strategies. Future studies should explore the long-term benefits of such interventions in broader outpatient settings.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"122 ","pages":"Pages 91-100"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The alcohol exposome 酒精暴露。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-01 Epub Date: 2024-12-23 DOI: 10.1016/j.alcohol.2024.12.003

Nousha H. Sabet , Todd A. Wyatt

{"title":"The alcohol exposome","authors":"Nousha H. Sabet , Todd A. Wyatt","doi":"10.1016/j.alcohol.2024.12.003","DOIUrl":"10.1016/j.alcohol.2024.12.003","url":null,"abstract":"<div><div>Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries. This manuscript presents selected key variables that represent the <em>Alcohol Exposome</em>. The primary variables that make up the <em>Alcohol Exposome</em> can include comorbidities such as cigarettes, poor diet, occupational hazards, environmental hazards, infectious agents, and aging. In addition to representing multiple factors, the <em>Alcohol Exposome</em> examines the various types of intercellular communications that are carried from one organ system to another and may greatly impact the types of injuries and metabolites caused by alcohol exposure. The intent of defining the <em>Alcohol Exposome</em> is to bring the newly expanded definition of <em>Exposomics,</em> meaning the study of the exposome, to the field of alcohol research and to emphasize the need for examining research results in a non-isolated environment representing a more relevant manner in which all human physiology exists.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"122 ","pages":"Pages 81-89"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-dependent effects of ethanol withdrawal from a single- and repeated binge episode exposures on social anxiety-like behavior and neuropeptide gene expression in adolescent rats 单次和多次暴饮暴食暴露乙醇戒断对青春期大鼠社交焦虑样行为和神经肽基因表达的性别依赖性影响

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-01 Epub Date: 2024-10-21 DOI: 10.1016/j.alcohol.2024.10.001

Peter T. Penta, Susanna Villarreal, Caitlin I. Rameas, Ella C. Collins, Trevor T. Towner, Elena I. Varlinskaya, David F. Werner

{"title":"Sex-dependent effects of ethanol withdrawal from a single- and repeated binge episode exposures on social anxiety-like behavior and neuropeptide gene expression in adolescent rats","authors":"Peter T. Penta, Susanna Villarreal, Caitlin I. Rameas, Ella C. Collins, Trevor T. Towner, Elena I. Varlinskaya, David F. Werner","doi":"10.1016/j.alcohol.2024.10.001","DOIUrl":"10.1016/j.alcohol.2024.10.001","url":null,"abstract":"<div><div>Ethanol withdrawal sensitivity is a risk factor for the development of alcohol use disorder. Heavy episodic drinking during adolescence often encompasses repeated periods of withdrawal. Adolescent intermittent ethanol exposure of laboratory rodents produces several neurobiological deficits that differ between sexes, but the sensitivity to withdrawal as a contributor to the observed sex differences is not clear. The current study assessed the impact of acute withdrawal from a single- and repeated binge ethanol episodes during adolescence as well as protracted abstinence from repeated binge episodes on social anxiety-like behavior (indexed <em>via</em> significant decreases of social investigation) as well as oxytocin (OXT) and vasopressin (AVP) system gene expression in the hypothalamus (HYP) and central amygdala (CeA) in male and female Sprague Dawley rats. Females displayed social anxiety-like behavior during withdrawal from a single binge episode, whereas both sexes showed social anxiety-like changes following acute withdrawal from repeated binge episodes. After a period of protracted abstinence, only males still displayed ethanol-associated social alterations. Analysis of gene expression in separate, non-socially tested subjects revealed that withdrawal from repeated binge episodes during adolescence increased AVP gene expression in the HYP of males and decreased it in females. Males also displayed increased AVP and OXTR gene expression during acute withdrawal from repeated binge episodes in the CeA, with these changes persisting into adulthood. Together, these findings suggest that adolescent females are sensitive to withdrawal from both acute and repeated ethanol exposures, whereas males are sensitive to withdrawal from repeated ethanol exposures, with affective and transcriptional changes persisting into adulthood.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"122 ","pages":"Pages 71-80"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of serum BDNF levels in alcohol withdrawal syndrome with and without other medical co-morbidities 调查有无其他并发症的酒精戒断综合征患者的血清 BDNF 水平。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-01 Epub Date: 2024-01-17 DOI: 10.1016/j.alcohol.2023.12.006

Magda Malewska-Kasprzak , Agnieszka Permoda-Pachuta , Maria Skibińska , Marta Malinowska-Kubiak , Filip Rybakowski , Monika Dmitrzak-Węglarz

{"title":"Investigation of serum BDNF levels in alcohol withdrawal syndrome with and without other medical co-morbidities","authors":"Magda Malewska-Kasprzak , Agnieszka Permoda-Pachuta , Maria Skibińska , Marta Malinowska-Kubiak , Filip Rybakowski , Monika Dmitrzak-Węglarz","doi":"10.1016/j.alcohol.2023.12.006","DOIUrl":"10.1016/j.alcohol.2023.12.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Consequences of alcohol use disorder (AUD) are associated with mental and somatic burdens that result in alcohol withdrawal syndrome (AWS), with 30% of AWS cases leading to life-threatening delirium tremens (DTs). So far, biomarkers for tracking abstinence syndrome that are useful in clinical practice have yet to be detected. Current research focuses on brain-derived neurotrophic factor (BDNF) effects on neurogenesis, modulation of plasticity, and its role in the pathogenesis of AWS and DTs.</div></div><div><h3>Aims</h3><div>The present study aimed to assess pro-BDNF and BDNF concentrations in a group of patients with AWS. Changes in BDNF and prof-BDNF were also evaluated with attention to subgroups of patients with coexisting mental and somatic disorders, with a particular emphasis on the presence or absence of DTs.</div></div><div><h3>Results</h3><div>The AWS group had a higher concentration of BDNF and a lower concentration of pro-BDNF compared to the control group, and BDNF increased during 7 days of hospitalisation. Patients with comorbid psychiatric disorders had higher levels of pro-BDNF than those without disease and also had higher levels of BDNF at the end of the study than at the beginning. On the other hand, patients with coexisting somatic diseases had higher levels of pro-BDNF at the beginning than at the end of the study, while patients with delirium had higher BDNF levels at the end of the study than at the beginning.</div></div><div><h3>Conclusions</h3><div>The obtained results indicate that pro-BDNF and BDNF may be useful markers for the course of withdrawal syndrome. In particular, BDNF showed an association with the development of delirium complications. The authors are aware of several limitations of the work only men in the SG, different age between SG and CG.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"122 ","pages":"Pages 1-9"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding drunkorexia behaviors among college students using the theory of planned behavior 用计划行为理论理解大学生醉酒行为。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-01 Epub Date: 2024-12-31 DOI: 10.1016/j.alcohol.2024.12.008

Amir Bhochhibhoya , Shannon N. Speed , Rose Marie Ward , Paul Branscum

引用次数: 0

Burden of alcohol use and inclusion of alcohol use disorder medications in the essential medicine lists across 132 countries: An observational study 132 个国家的酒精使用负担以及将酒精使用障碍药物纳入基本药物清单的情况：一项观察性研究。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-01 Epub Date: 2024-02-27 DOI: 10.1016/j.alcohol.2024.02.007

Arpit Parmar , Dinesh Prasad Sahu , Priyamadhaba Behera

{"title":"Burden of alcohol use and inclusion of alcohol use disorder medications in the essential medicine lists across 132 countries: An observational study","authors":"Arpit Parmar , Dinesh Prasad Sahu , Priyamadhaba Behera","doi":"10.1016/j.alcohol.2024.02.007","DOIUrl":"10.1016/j.alcohol.2024.02.007","url":null,"abstract":"<div><div>Harmful use of alcohol affects the health of the population. The treatment coverage of alcohol use disorders (AUD) varies among countries. The study aimed to determine the inclusion of AUD medicines in various national Essential Medicine Lists (EMLs) and its association with alcohol consumption. It was a secondary data analysis of alcohol consumptions and AUD-related medicines in EML. Data were extracted from the WHO Global Essential Medicines database and the WHO Global Status Report on Alcohol and Health 2018. Data were extracted for 194 countries. Only 132 of 194 countries (68.0%) had EML, and among the 132 countries only 27.3% had included AUD medicines in their EML. Only 36 countries had included any of the AUD medicines in their EML. Disulfiram was included by 23 countries, while acamprosate and naltrexone were included by only four and 19 countries, respectively. Among the countries, 36.1% were from upper-middle income countries and 16.65 were from low-income countries. The inclusion of AUD medicines in national EML was neither associated with alcohol consumption parameters nor the alcohol consumption-related policy parameters. Considering the high prevalence of AUD and its complications, there is an urgent need to focus on including AUD medicines in national EMLs for making AUD treatment available and accessible across the world.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"122 ","pages":"Pages 111-114"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detecting the comorbidity of attention deficit hyperactivity disorder (ADHD) in a population of outpatients with alcohol use disorder (AUD): The role of personality traits, age at first alcohol use and level of craving 检测酒精使用障碍（AUD）门诊患者中注意力缺陷多动障碍（ADHD）的合并症：人格特征、首次饮酒年龄和渴求程度的作用。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-01 Epub Date: 2024-11-04 DOI: 10.1016/j.alcohol.2024.11.001

Monica L. Roman , Clément Vansteene , Daphnée Poupon , Philip Gorwood

{"title":"Detecting the comorbidity of attention deficit hyperactivity disorder (ADHD) in a population of outpatients with alcohol use disorder (AUD): The role of personality traits, age at first alcohol use and level of craving","authors":"Monica L. Roman , Clément Vansteene , Daphnée Poupon , Philip Gorwood","doi":"10.1016/j.alcohol.2024.11.001","DOIUrl":"10.1016/j.alcohol.2024.11.001","url":null,"abstract":"<div><div>Attention-deficit/hyperactivity disorder (ADHD) commonly affects individuals with alcohol use disorder (AUD). However, despite the negative outcomes associated with this comorbidity, ADHD is underdiagnosed in this population. We aim to identify clinical parameters and propose cutoff scores enabling the detection of ADHD among patients with AUD. We retrospectively analyzed data from 199 patients, out of a global sample of 412 who were consecutively admitted to a day hospital for alcohol-related problems between 2009 and 2022. We found that lower level of self-directedness, higher levels of novelty seeking, self-transcendence, harm avoidance and craving, and earlier first alcohol consumption could accurately predict the presence of ADHD in AUD (AUC = 0.926). Self-directedness and novelty seeking had the best predictive abilities: a self-directedness score below 52 was associated with an accuracy of 82% and, combined with a novelty seeking score over 53, the accuracy reached 85%. Such findings could be useful to help clinicians detect ADHD in patients with AUD so that they can receive the adequate care.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"122 ","pages":"Pages 63-70"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion 小鼠自愿饮酒和禁酒诱发负性情绪模型的性别差异

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 Epub Date: 2024-07-23 DOI: 10.1016/j.alcohol.2024.07.004

Amanda L. Salazar, Samuel W. Centanni

{"title":"Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion","authors":"Amanda L. Salazar, Samuel W. Centanni","doi":"10.1016/j.alcohol.2024.07.004","DOIUrl":"10.1016/j.alcohol.2024.07.004","url":null,"abstract":"<div><p>Alcohol Use Disorder (AUD) is a growing problem worldwide, causing an incredible burden on health and the economy. Though AUD impacts people of all backgrounds and demographics, increasing evidence has suggested robust sex differences in alcohol drinking patterns and AUD-induced negative emotionality or hyperkatifeia. Rates of problematic drinking have significantly risen among women, and women face more severe negative emotional consequences in abstinence such as increased risk of comorbidity with an anxiety or mood disorder and more severe symptoms of depression. As such, a bevy of preclinical literature using contingent methods of alcohol (ethanol) consumption has amassed in recent years to better understand sex as a biological variable in alcohol drinking and abstinence-induced negative emotionality. Mice are widely used to model alcohol drinking, as they are conducive to genetic manipulation strategies, and many strains will voluntarily consume alcohol. Sex-specific results from these mouse studies, however, have been inconsistent. Therefore, this review aims to summarize the current knowledge on sex differences in AUD-related contingent ethanol drinking and abstinence-induced negative emotionality in mice. Various contingent mouse drinking models and negative emotional-based behavioral paradigms are introduced and subsequently discussed in the context of sex differences to show increasing indications of sex specificity in mouse preclinical studies of AUD. With this review, we hope to inform future research on potential sex differences in preclinical mouse models of AUD and provide mounting evidence supporting the need for more widespread inclusion of preclinical female subjects in future studies.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 45-57"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141763107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

32. Alcohol-induced tissue injury at the gut-liver-brain axis is more severe in diabetic mice 32. 酒精引起的肠-肝-脑轴组织损伤在糖尿病小鼠中更为严重

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 Epub Date: 2024-12-10 DOI: 10.1016/j.alcohol.2024.10.035

N. Shashikanth , L. Basa , R. Rajenthiran, C. Nguyen, P. Raju, S.C. Lee, C. Shekhar, F. Giorgianni, R.K. Rao

引用次数: 0

12. Role of Foxp3+ regulatory T cells in chronic ethanol consumption and sepsis pathogenesis 12. Foxp3+调节性T细胞在慢性乙醇消耗和脓毒症发病中的作用

IF 2.5 4区医学

Alcohol Pub Date : 2024-12-01 Epub Date: 2024-12-10 DOI: 10.1016/j.alcohol.2024.10.015

M.B. Gutierrez, C.M. Coopersmith, M.L. Ford

引用次数: 0