Alcohol最新文献 - Book学术

Corrigendum to “Time-course concentration of ethanol, acetaldehyde and acetate in rat brain dialysate following alcohol self-administration” [Alcohol 123 (2025) 69–76] “自我给药后大鼠脑透析液中乙醇、乙醛和醋酸盐的时间过程浓度”的勘误表[酒精123 (2025)69-76]

IF 2.5 4区医学

Alcohol Pub Date : 2025-04-23 DOI: 10.1016/j.alcohol.2025.03.004

Tse-Ang Lee , Hongjoo J. Lee , Regina A. Mangieri , Rueben Gonzales , Heba Ajmal , Tanya Hutter

引用次数: 0

New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting 饮酒对免疫、炎症和器官功能影响的新进展：2024年酒精和免疫学研究兴趣小组（AIRIG）会议总结

IF 2.5 4区医学

Alcohol Pub Date : 2025-04-21 DOI: 10.1016/j.alcohol.2025.04.002

Madison M. Tschann , Vidula Vachharajani , Eileen M. Redmond , Andrew Hoisington , Sarah E. Cohen , Moses New-Aaron , Cristina Llorente , Janos Paloczi , Claudia R. Keating , Wiramon Rungratanawanich , Ellen L. Burnham , John J. Callaci , Preeti Raju , Weizhe Zhong , Abhishek Mandal , Justine R. Zimmerly , Adriana S.P. Nuncio , Pranoti Mandrekar , Rebecca L. McCullough , Rachel H. McMahan , Mashkoor A. Choudhry

{"title":"New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting","authors":"Madison M. Tschann , Vidula Vachharajani , Eileen M. Redmond , Andrew Hoisington , Sarah E. Cohen , Moses New-Aaron , Cristina Llorente , Janos Paloczi , Claudia R. Keating , Wiramon Rungratanawanich , Ellen L. Burnham , John J. Callaci , Preeti Raju , Weizhe Zhong , Abhishek Mandal , Justine R. Zimmerly , Adriana S.P. Nuncio , Pranoti Mandrekar , Rebecca L. McCullough , Rachel H. McMahan , Mashkoor A. Choudhry","doi":"10.1016/j.alcohol.2025.04.002","DOIUrl":"10.1016/j.alcohol.2025.04.002","url":null,"abstract":"<div><div>The 29th annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held on November 22nd, 2024, at Loyola University Chicago, Health Science Campus, Maywood, Illinois. The meeting was divided into three plenary sessions and a poster session. The overall focus of this year’s meeting was on alcohol and host immunity, alcohol and organ dysfunction, and alcohol, inflammation, and tissue injury. The presentations in each session shared the latest developments on the impact of alcohol in a wide variety of fields including trauma, emergency care and hospitalization, cardiovascular health, neurodegenerative disease, gut microbiome, and hepatology.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"126 ","pages":"Pages 1-10"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the synergy between prenatal ethanol and postnatal adolescent ethanol exposure 产前乙醇和产后青少年乙醇暴露的协同作用分析

IF 2.5 4区医学

Alcohol Pub Date : 2025-04-09 DOI: 10.1016/j.alcohol.2025.04.001

Leonardo Marengo , Rodrigo García Virgolini , Victoria Mujica , María Carolina Fabio , Ricardo Marcos Pautassi

{"title":"Analysis of the synergy between prenatal ethanol and postnatal adolescent ethanol exposure","authors":"Leonardo Marengo , Rodrigo García Virgolini , Victoria Mujica , María Carolina Fabio , Ricardo Marcos Pautassi","doi":"10.1016/j.alcohol.2025.04.001","DOIUrl":"10.1016/j.alcohol.2025.04.001","url":null,"abstract":"<div><div>Prenatal ethanol exposure (PEE) is associated with long-lasting neurodevelopmental alterations that increase susceptibility to adverse behavioral outcomes, including greater likelihood of binge drinking during adolescence. However, the interactive effects of these two developmental risk factors remain underexplored. The present study investigated the synergistic impact of PEE and adolescent binge-like ethanol exposure on behavioral and ethanol consumption patterns in Wistar rats. Pregnant dams received ethanol (2.0 g/kg/day) or vehicle from gestational days 17–20. Offspring were subjected to intermittent ethanol exposure (4.0 g/kg/day, two days on–two days off) or vehicle from postnatal days 23–36. Behavioral assessments included tests for anxiety-like behaviors (light–dark box test), anhedonia (sucrose preference test), exploratory behavior (multivariate concentric square field test), and voluntary ethanol consumption in early adulthood. PEE was associated with increased overall fluid consumption (p = 0.001, η<sup>2</sup>p = 0.17) and a sex-dependent increase in ethanol intake (p = 0.001, η<sup>2</sup>p = 0.05). PEE rats displayed reduced sucrose preference (p = 0.02, η<sup>2</sup>p = 0.07), suggesting an anhedonic-like phenotype independent of adolescent ethanol exposure. The latter exposure induced an anxious phenotype, characterized by reduced time in the illuminated compartment of the light–dark box test, which was attenuated in PEE-exposed rats (p = 0.03, η<sup>2</sup>p = 0.06). These findings suggest that PEE (a) facilitates ethanol consumption in offspring, potentially through tolerance mechanisms or altered chemosensory processing; and (b) modulates anxiety-like behaviors induced by adolescent ethanol exposure. Understanding these interactions is critical for elucidating the mechanisms underlying alcohol use disorders and designing targeted interventions for at-risk populations.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"125 ","pages":"Pages 25-33"},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol diminishes barrier integrity in human stem cell-derived brain microvascular endothelial cells: Role of reactive oxygen species 酒精降低人干细胞来源的脑微血管内皮细胞屏障完整性：活性氧的作用

IF 2.5 4区医学

Alcohol Pub Date : 2025-04-03 DOI: 10.1016/j.alcohol.2025.03.005

Kameron T. Bell , Jason M. Hughes , Wesley A. Borman , Ryan D. Stoffel , Scott G. Canfield

{"title":"Alcohol diminishes barrier integrity in human stem cell-derived brain microvascular endothelial cells: Role of reactive oxygen species","authors":"Kameron T. Bell , Jason M. Hughes , Wesley A. Borman , Ryan D. Stoffel , Scott G. Canfield","doi":"10.1016/j.alcohol.2025.03.005","DOIUrl":"10.1016/j.alcohol.2025.03.005","url":null,"abstract":"<div><div>The World Health Organization has linked alcohol consumption to over 200 diseases including neurodegenerative diseases. A dysfunctional blood–brain barrier (BBB) has been found to be influential in a number of brain disorders. The BBB is critical in maintaining homeostasis between the brain vasculature and parenchyma and a loss in barrier integrity would enable otherwise impermeable immune cells, molecules, and inflammatory mediators to reach the brain parenchyma. A subset of studies demonstrated that alcohol could diminish BBB integrity, but it is unclear if this effect translates clinically. In this study, we utilize a human stem cell-derived BBB model with near <em>in vivo</em> properties to investigate the effects of alcohol on critical barrier properties. Barrier forming brain-like microvascular endothelial cells (BMECs) were derived from human induced pluripotent stem cells (iPSCs) and exposed to several alcohol concentrations. Alcohol decreased barrier integrity observed by a loss in trans-endothelial electrical resistance and an increase in sodium fluorescein permeability. Alcohol decreased expression and junctional localization of tight junction proteins, a critical component to barrier integrity. Additionally, alcohol did not affect efflux transporter activity or cell viability in BMECs. The detrimental effects of alcohol on BBB properties were due to in part elevated reactive oxygen species (ROS); as scavenging ROS improved barrier properties, including the restoration of tight junction expression and localization. These data suggest that excessive alcohol consumption could diminish the BBB and contribute to the development or exacerbation of brain disorders.</div></div><div><h3>Clinical trial number and registry URL</h3><div>Not applicable.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"125 ","pages":"Pages 55-66"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological and demographic drivers of alcohol-attributable pancreatitis from 1990 to 2021: Findings from the 2021 Global Burden of Disease study 1990年至2021年酒精所致胰腺炎的流行病学和人口统计学驱动因素：来自2021年全球疾病负担研究的结果发表于：酒精。

IF 2.5 4区医学

Alcohol Pub Date : 2025-03-21 DOI: 10.1016/j.alcohol.2025.03.001

Tang Yujin , Dai Dandan , Zhong Qian , Pan Wenhao , Di Xingwei

{"title":"Epidemiological and demographic drivers of alcohol-attributable pancreatitis from 1990 to 2021: Findings from the 2021 Global Burden of Disease study","authors":"Tang Yujin , Dai Dandan , Zhong Qian , Pan Wenhao , Di Xingwei","doi":"10.1016/j.alcohol.2025.03.001","DOIUrl":"10.1016/j.alcohol.2025.03.001","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol significantly contributes to pancreatitis, causing high global mortality and health burden. This study examines trends in alcohol-attributable pancreatitis (AAP) from 1990 to 2021 using Global Burden of Disease (GBD) 2021 data, focusing on demographic, temporal, and regional variations to inform policymaking.</div></div><div><h3>Methods</h3><div>AAP-related deaths and disability-adjusted life years (DALYs) were analyzed across 204 countries from 1990 to 2021, stratified by Sociodemographic Index (SDI), gender, and age groups. An age-period-cohort model assessed age-standardized DALY rates (ASDR), and decomposition analysis quantified impacts of population growth, aging, and epidemiological changes.</div></div><div><h3>Results</h3><div>AAP-related DALYs rose from 401,700 in 1990 to 699,300 in 2021, though ASDR and ASMR showed declines globally. Burden increased notably in low and lower-middle SDI regions, especially among those under 40, while high SDI regions achieved better control. Males faced a disproportionately high burden due to alcohol consumption patterns, although some regions saw rising female burdens. Low-SDI areas suffered from limited healthcare, increasing alcohol use, and weak policies, with younger populations contributing significantly to rising burdens. Projections estimate 1.146 million DALYs annually by 2050, with males comprising over 90%. A GBD-AAP visualization platform was developed to present burden data and trends.</div></div><div><h3>Conclusions</h3><div>AAP exhibits significant regional and gender disparities. Targeted measures, including alcohol regulation, resource allocation, and public health education, are critical in low-SDI regions and among young males to mitigate AAP burden. The GBD-AAP platform offers valuable tool for targeted interventions.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"125 ","pages":"Pages 67-78"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Individual differences in punished alcohol self-administration are unaltered by alcohol vapor exposure 受惩罚的酒精自我管理的个体差异不受酒精蒸气暴露的影响。

IF 2.5 4区医学

Alcohol Pub Date : 2025-03-17 DOI: 10.1016/j.alcohol.2025.03.003

Maya N. Bluitt , Ana C. Muñoz , Joyce Besheer

{"title":"Individual differences in punished alcohol self-administration are unaltered by alcohol vapor exposure","authors":"Maya N. Bluitt , Ana C. Muñoz , Joyce Besheer","doi":"10.1016/j.alcohol.2025.03.003","DOIUrl":"10.1016/j.alcohol.2025.03.003","url":null,"abstract":"<div><div>Continued alcohol use despite negative consequences is a defining feature of alcohol use disorder (AUD). It remains poorly understood whether individual variability in drinking despite negative consequences is due to inherent differences or emerges after prolonged alcohol use. The goal of the present study was to use a rat model of drinking despite negative consequences to assess individual differences in foot shock-punished alcohol self-administration prior to and following alcohol vapor exposure in male Wistar rats. After baseline operant self-administration was established, rats underwent additional self-administration sessions in which random, response-contingent foot shock punishment was introduced. Average percent change from baseline was calculated for each rat during punished sessions and rats were classified into shock-sensitive (SS) and shock-resistant (SR) subgroups using the top and bottom thirds. Rats then underwent 3 cycles of air or alcohol vapor exposure every other week, with unpunished self-administration sessions occurring during the intervening weeks. Following the last vapor cycle, rats were re-assessed for resistance to foot shock during punished self-administration sessions. Alcohol vapor exposure had no effect on punished self-administration overall, nor by subgroup. Examination of individual differences showed that rats classified as SR showed increased unpunished self-administration relative to baseline regardless of air vs. vapor condition. These data suggest that alcohol history has a minimal effect on individual differences in foot shock-punished self-administration.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"125 ","pages":"Pages 43-52"},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of baclofen to reduce alcohol-attributable hospitalizations and emergency department admissions 使用巴氯芬减少酒精引起的住院和急诊住院。

IF 2.5 4区医学

Alcohol Pub Date : 2025-03-15 DOI: 10.1016/j.alcohol.2025.03.002

Ming-Chyi Huang , Kevin Tsai , Yu-Hsuan Joni Shao

{"title":"The use of baclofen to reduce alcohol-attributable hospitalizations and emergency department admissions","authors":"Ming-Chyi Huang , Kevin Tsai , Yu-Hsuan Joni Shao","doi":"10.1016/j.alcohol.2025.03.002","DOIUrl":"10.1016/j.alcohol.2025.03.002","url":null,"abstract":"<div><h3>Aims</h3><div>The potential benefit of baclofen in reducing hospitalizations and emergency department (ED) admissions attributed to alcohol-related diagnoses has not been conclusively established. This study aimed to examine the relationship between baclofen use and the incidence of alcohol-attributable hospitalizations and ED admissions in the general population.</div></div><div><h3>Methods</h3><div>We conducted a self-controlled case series study (SCCS) using data from the Taiwan National Health Insurance Research Database. 2904 patients who had at least one alcohol-attributable hospitalization or emergency department admission and were prescribed 28 or more days of baclofen unrelated to alcohol were included. Conditional Poisson regression was used to estimate the incidence rate ratio (IRR) and 95% confidence interval (CI) for the risk of alcohol-attributable hospitalizations and ED admissions during exposure to baclofen, as well as the pre- and post-exposure periods, relative to the baseline period. The contribution of concomitant psychotropic medication use was also assessed.</div></div><div><h3>Results</h3><div>Baclofen was associated with a reduced incidence of alcohol-attributable hospitalizations (IRR = 0.64; 95% CI: 0.53∼0.77) and ED admissions (IRR = 0.56; 95% CI: 0.49∼0.65) in multivariate models. No statistically significant reduction was observed in any admission method in either the pre- or post-exposure period. A dose-dependent response in ED admissions was observed with baclofen, i.e. >60 mg/day associated with a greater decrease in the IRR (0.25, 95% CI: 0.10∼0.62) relative to doses of <30 (0.63, 95% CI: 0.53∼0.75) and 30–60 mg/day (IRR = 0.50, 95% CI: 0.40∼0.63).</div></div><div><h3>Conclusions</h3><div>These findings suggest a possible beneficial effect of baclofen in reducing the incidence of alcohol-attributable hospitalizations and ED admissions.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"125 ","pages":"Pages 35-41"},"PeriodicalIF":2.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain predicts past-month co-use of alcohol and cannabis among emerging adults: Results from the Population Assessment of Tobacco and Health (PATH) Study 疼痛预测过去一个月初成人酒精和大麻的共同使用：烟草和健康人口评估（PATH）研究的结果。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-25 DOI: 10.1016/j.alcohol.2025.02.003

Callon M. Williams , Nadine R. Mastroleo , Mark F. Lenzenweger , Emily L. Zale

{"title":"Pain predicts past-month co-use of alcohol and cannabis among emerging adults: Results from the Population Assessment of Tobacco and Health (PATH) Study","authors":"Callon M. Williams , Nadine R. Mastroleo , Mark F. Lenzenweger , Emily L. Zale","doi":"10.1016/j.alcohol.2025.02.003","DOIUrl":"10.1016/j.alcohol.2025.02.003","url":null,"abstract":"<div><div>Alcohol use, cannabis use, and pain are public health concerns among emerging adults (18–24 years old). Co-use of alcohol and cannabis is of particular concern since individuals who co-use alcohol and cannabis use more of each substance and experience greater substance-related harm. Pain and substance use frequently co-occur, and a growing body of literature indicates pain is unique risk factor for substance use. The goal of the current study was to examine moderate/severe pain (vs. no/low pain) as a prospective predictor of engaging in co-use of alcohol and cannabis among emerging adults, and to test sex as a moderator of this hypothesized relationship. Data were drawn from Waves 1–5 of the Population Assessment of Tobacco and Health Study (<em>n</em> = 3544). Unadjusted logistic regression revealed that those with moderate/severe pain at baseline were 1.4 times more likely to engage in past-month co-use of alcohol and cannabis over the next four years (<em>p</em> = .046). The effects of pain on co-use were no longer significant after inclusion of covariates and a pain∗sex interaction term, which was also nonsignificant (<em>ps</em> > .05). These findings provide initial support for pain as a risk factor for engaging in co-use of alcohol and cannabis during emerging adulthood. Future research should continue investigating how pain may motivate co-use of alcohol and cannabis, exploring how pain is associated with other measures of co-use, and determining how providers can incorporate pain-substance use psychoeducation for emerging adults in clinical settings.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"124 ","pages":"Pages 111-119"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of plastic sipper devices on alcohol self-administration in rodents: Limitations for long-term access paradigms 塑料吸管装置对啮齿动物酒精自我管理的影响：长期获取范式的局限性。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-11 DOI: 10.1016/j.alcohol.2025.02.002

David L. Haggerty , Sara E.M.M.F. Badaro , Eva Nadpara , Carly B. Fabian , Karina P. Abrahao , David M. Lovinger , Max E. Joffe

{"title":"Impact of plastic sipper devices on alcohol self-administration in rodents: Limitations for long-term access paradigms","authors":"David L. Haggerty , Sara E.M.M.F. Badaro , Eva Nadpara , Carly B. Fabian , Karina P. Abrahao , David M. Lovinger , Max E. Joffe","doi":"10.1016/j.alcohol.2025.02.002","DOIUrl":"10.1016/j.alcohol.2025.02.002","url":null,"abstract":"<div><div>Open source devices are becoming widely used in behavioral neuroscience. Despite their advantages in cost effectiveness, modularity, and customization, measurements obtained using newly developed devices may not always recapitulate measurements from existing and validated equipment, potentially due to the materials used in manufacture. In this study, we evaluated a commonly used open-source optical lickometer that delivers fluid via a Hydropac® plastic valve in a multi-site intermittent access two-bottle choice (IA2BC) paradigm for alcohol consumption. Mice were tested with both traditional metal sippers and plastic sippers equipped with Hydropac® valves to assess differences in alcohol intake, preference, and total fluid consumption. Our findings revealed that mice displayed reduced intake and preference for alcohol (10–20% v/v) delivered via the Hydropac® containing plastic sippers. Notably, the effect was observed at both testing sites, suggesting a generalizable phenomenon. The decreased intake was also specific to alcohol, as water, quinine, and sucrose consumption were unaffected by sipper type. To investigate the underlying cause of the reduced alcohol consumption, we pre-incubated Hydropac® valves in 20% alcohol and found that the pre-treated alcohol reduced intake even when delivered via metal sippers. This suggests that prolonged interaction between alcohol and the components of the Hydropac® valves alter the fluid, likely by generating unpalatable contaminants. These results highlight a limitation of using plastic sippers in long-term alcohol self-administration studies. While these devices may remain suitable for limited access paradigms their use in extended access protocols may compromise data integrity. Our study underscores the need for rigorous validation of open-source hardware in each research project.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"125 ","pages":"Pages 17-24"},"PeriodicalIF":2.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippocampal overexpression of tissue-type plasminogen activator “tPA” attenuates social defeat-induced depression and ethanol related behavior in mice 海马组织型纤溶酶原激活物“tPA”的过度表达减轻了小鼠社交失败诱导的抑郁和乙醇相关行为。

IF 2.5 4区医学

Alcohol Pub Date : 2025-02-10 DOI: 10.1016/j.alcohol.2025.02.001

Amine Bahi

{"title":"Hippocampal overexpression of tissue-type plasminogen activator “tPA” attenuates social defeat-induced depression and ethanol related behavior in mice","authors":"Amine Bahi","doi":"10.1016/j.alcohol.2025.02.001","DOIUrl":"10.1016/j.alcohol.2025.02.001","url":null,"abstract":"<div><div>Depression and anxiety disorders are often exacerbated by social stress, necessitating the exploration of molecular mechanisms underlying stress resilience. Tissue plasminogen activator (tPA), a serine protease with pleiotropic effects in the brain, plays a critical role in modulating neuroplasticity and stress responses. This study investigates the behavioral and molecular effects of tPA gain-of-function in a social stress paradigm in male C57BL/6 mice using lentiviral vectors. Behaviorally, hippocampal tPA gain-of-function mitigated depression-like responses in the novelty-suppressed feeding, sucrose splash, tail suspension, and forced swim tests following exposure to chronic social stress. Additionally, in a two-bottle choice drinking paradigm, tPA overexpression reduced social stress-induced ethanol intake and preference, suggesting a role in dampening maladaptive coping behaviors. However, analysis of tastants’ intake and preference revealed no significant effects of tPA overexpression, indicating that it does not influence hedonic responses under stress conditions. Molecularly, tPA overexpression preserved hippocampal tPA mRNA expression and maintained levels of mature brain-derived neurotrophic factor in the hippocampus despite chronic stress exposure. These findings highlight the potential neuroprotective effects of tPA in maintaining hippocampal plasticity and mitigating stress-induced dysregulation of critical neurotrophic pathways. Collectively, this study underscores the potential of tPA as a therapeutic target for stress-induced mood and substance use disorders by modulating behavioral and neurobiological responses to chronic social stress.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"125 ","pages":"Pages 1-15"},"PeriodicalIF":2.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0