Alcohol最新文献

{"title":"35. Hepatic stellate cell-intrinsic role for cytoplasmic stress granule proteins in IRF3-mediated fibrogenic responses to TGFβ","authors":"J. Travers, J. Wu, L.E. Nagy","doi":"10.1016/j.alcohol.2024.10.038","DOIUrl":"10.1016/j.alcohol.2024.10.038","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Page 218"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"41. Liver sinusoidal endothelial cells exhibit a tolerance-like innate immune memory in response to priming by interferons","authors":"W. Zhong, B. Swartzwelter, F. Xhafi, M. Liu","doi":"10.1016/j.alcohol.2024.10.044","DOIUrl":"10.1016/j.alcohol.2024.10.044","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 219-220"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"16. Assessing the role of ABL2 in the progression of alcohol-associated liver disease","authors":"C.R. Keating , G. Malnassy , S. Gad, X. Ding, Z. Sun, A. Koleske, W. Qiu","doi":"10.1016/j.alcohol.2024.10.019","DOIUrl":"10.1016/j.alcohol.2024.10.019","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Page 212"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18. Gut microbial dysbiosis after ethanol and burn injury correlates with lung cathelicidin-related antimicrobial peptide mRNA expression","authors":"S. Khair, R.H. McMahan, K.M. Najarro, D.N. Frank, E.J. Kovacs","doi":"10.1016/j.alcohol.2024.10.021","DOIUrl":"10.1016/j.alcohol.2024.10.021","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Page 213"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3. Rituximab provides successful recovery in a poorly managed Pemphigus Vulgaris (PV) patient that erupted after the IV dose of SARS—CoV-2 vaccination in a diabetic patient","authors":"N.A. Azim, C.P. Dolehide, A. Azim","doi":"10.1016/j.alcohol.2024.10.006","DOIUrl":"10.1016/j.alcohol.2024.10.006","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 208-209"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4. Involvement of opioid signaling pathway in the transition of alcohol’s properties from analgesia to its induced pain","authors":"M. Bishir , W. Huang , T. Rengifo , A.E. Pehlivan , S.B. Chidambaram , S.L. Chang","doi":"10.1016/j.alcohol.2024.10.007","DOIUrl":"10.1016/j.alcohol.2024.10.007","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Page 209"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"5. PBMC-derived microglia as a window into the brain: a beneficial tool for understanding the impact of AUD on CNS","authors":"M.B. Blanton , H. Hemati , H.E. True , R. Khadka , K.A. Grant , I. Messaoudi","doi":"10.1016/j.alcohol.2024.10.008","DOIUrl":"10.1016/j.alcohol.2024.10.008","url":null,"abstract":"","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Page 209"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-optimal touch modulates alcohol-cue-elicited heart rate variability in alcohol use disorder patients during early abstinence: A randomized controlled study","authors":"Juliana Harkki ,&nbsp;Pauli Tuovinen ,&nbsp;Veikko Jousmäki ,&nbsp;Goncalo Barreto ,&nbsp;Pekka Rapeli ,&nbsp;Jussi Palomäki ,&nbsp;Jonne Annevirta ,&nbsp;Anna–Helena Puisto ,&nbsp;Francis McGlone ,&nbsp;Heikki Nieminen ,&nbsp;Hannu Alho","doi":"10.1016/j.alcohol.2024.11.004","DOIUrl":"10.1016/j.alcohol.2024.11.004","url":null,"abstract":"<div><div>Alcohol Use Disorder (AUD) is a chronic brain disorder associated with a high risk of relapse and a limited treatment efficacy. Relapses may occur even after long periods of abstinence and are often triggered by stress or cue induced alcohol craving. C-tactile afferents (CT) are cutaneous nerve fibers postulated to encode pleasant affective touch and known to modulate physiological stress responses. However, their translational potential has not yet been explored extensively in controlled clinical trials. This randomized controlled study aimed to investigate the potential of CT stimulation in modulating relapse predicting biomarkers, physiological cue-reactivity, and subjective alcohol craving in AUD patients in early abstinence.</div><div>Twenty-one participants meeting DSM-5 criteria for mild to moderate AUD received CT-optimal touch or a non-CT-optimal control treatment while exposed to neutral, stress-inducing, and alcohol-related visual stimuli. The tactile treatment was provided with a robotic device, eliminating the social elements of touch. Heart rate variability (HRV), salivary cortisol, and subjective craving were assessed at the baseline, during and after the treatment and stimuli exposure.</div><div>The results showed that CT-optimal touch significantly reduced alcohol-cue-elicited standard deviation of normal-to-normal intervals (SDNN) HRV compared to the control group, shifting the HRV reactivity to the direction known to indicate lower relapse susceptibility. Cortisol levels showed no significant differences between the groups, and subjective alcohol craving increased after alcohol cue exposure in both groups.</div><div>This study found that CT-optimal touch modulates autonomic cue-reactivity in AUD patients, encouraging further research on the therapeutic potential of affective touch. Future research should explore the long-term effects and real-world clinical relevance of CT-optimal touch in alcohol relapse prevention.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"123 ","pages":"Pages 19-26"},"PeriodicalIF":2.5,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in alcohol use disorder trends from 2009–2019: An intersectional analysis","authors":"T.L. Verplaetse ,&nbsp;R.F. Carretta ,&nbsp;C.A. Struble ,&nbsp;B. Pittman ,&nbsp;W. Roberts ,&nbsp;Y. Zakiniaeiz ,&nbsp;M.R. Peltier ,&nbsp;S.A. McKee","doi":"10.1016/j.alcohol.2024.11.003","DOIUrl":"10.1016/j.alcohol.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>Trend estimates from national surveys over the last 20 years have suggested converging rates of alcohol use over time between adult men and women. However, limited research has utilized an intersectional lens to examine how sociodemographic characteristics influence gender differences in these trends.</div></div><div><h3>Methods</h3><div>The current study used data from the National Survey on Drug Use and Health (NSDUH) to examine whether gender intersected with race/ethnicity, age, education level, marital status, employment status, household income, and urbanicity on temporal trends (2009–2019) in alcohol use disorder (AUD). Logistic regression and linear trend analyses were conducted to examine interaction effects of sociodemographic variables and changes in rates of AUD over time in males and females.</div></div><div><h3>Results</h3><div>We observed decreasing rates of AUD over time in males and females, with larger declines in males (<em>p</em> = 0.01; OR = 0.96 in males vs. OR = 0.98 in females). We identified subpopulations of females that demonstrated little or no reductions during this timeframe (2009–2019), which varied by race/ethnicity, age, marital status, employment, and income but not by education or urbanicity. In adults aged 49 years and younger (overall <em>p</em> = 0.02; ages 18–25 OR = 0.92 in males vs. 0.96 in females, ages 26–29 OR = 0.97 in males vs. OR = 0.99 in females), and in those employed (overall <em>p</em> = 0.05; OR = 0.96 in males vs. OR = 0.99 in females), women demonstrated smaller declines in comparison to men. Additionally, women who reported that they were Black (<em>p</em> = 0.006; OR = 0.94 in males vs. OR = 1 in females), single (<em>p</em> = 0.009; OR = 0.94 in males vs. 0.96 in females) or earning between $20,000 and $49,000 (<em>p</em> = 0.012; OR = 0.96 in males vs. 0.98 in females), had smaller or no declines in AUD in compared to men with the same demographic characteristic.</div></div><div><h3>Conclusions</h3><div>Our findings provide support for converging rates of AUD between genders and newly identify subpopulations of females that may be at heightened risk.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"123 ","pages":"Pages 101-107"},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single essential oils and their binary mixtures protect against ethanol-induced defects in a zebrafish fetal alcohol spectrum disorder model at the same level as folic acid","authors":"Andressa Raphaely de Lima Silva ,&nbsp;Maria Letícia Santos Carnaúba da Silva ,&nbsp;Jadson Freitas da Silva ,&nbsp;Katarine Evelyn Falcão e Falcão ,&nbsp;James A. Marrs ,&nbsp;Marilia Ribeiro Sales Cadena ,&nbsp;Pabyton Gonçalves Cadena","doi":"10.1016/j.alcohol.2024.11.002","DOIUrl":"10.1016/j.alcohol.2024.11.002","url":null,"abstract":"<div><div>This study evaluated protective effects of clove (SEO), thyme white (TEO), oregano (OEO), and caraway (CEO) essential oils (EOs), and their binary mixtures, in a zebrafish fetal alcohol spectrum disorder model. Furthermore, folic acid (FA) was used for comparison as it had previously shown protection against ethanol (EtOH)-induced defects. The co-exposure of zebrafish embryos to EtOH (150 mM) and FA (75 μM) or EOs and their binary mixtures (0.5–1 mg/L) was carried out during 6 or 22 h postfertilization (hpf). Different developmental endpoints (epiboly measurement, survival rate at 24 hpf, embryonic developmental progression measurement at 24 hpf, larval development at 48–96 hpf, and hatching rate at 72–96 hpf) were evaluated at 8–96 hpf. EtOH exposure reduced epiboly. Only FA and the SEO + TEO binary mixture protected against these defects, and SEO and TEO single exposure showed partial protection. Therefore, these groups were chosen for subsequent experiments. At 24 hpf, EtOH showed developmental delay and hatching rate was delayed at 72 hpf. FA, SEO, TEO, and SEO + TEO partially protected against these defects. This study supports the conclusion that FA partially protects against EtOH-induced defects. SEO and TEO single exposure partially protect against EtOH-induced defects. However, the binary mixture of SEO + TEO was more effective, showing similar efficacy as FA.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"123 ","pages":"Pages 77-86"},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}