IF 2.5 4区医学

Alcohol Pub Date : 2024-03-04 DOI: 10.1016/j.alcohol.2024.02.008

{"title":"A role for circuitry of the cortical amygdala in excessive alcohol drinking, withdrawal, and alcohol use disorder","authors":"","doi":"10.1016/j.alcohol.2024.02.008","DOIUrl":"10.1016/j.alcohol.2024.02.008","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) poses a significant public health challenge. Individuals with AUD engage in chronic and excessive alcohol consumption, leading to cycles of intoxication, withdrawal, and craving behaviors. This review explores the involvement of the cortical amygdala (CoA), a cortical brain region that has primarily been examined in relation to olfactory behavior, in the expression of alcohol dependence and excessive alcohol drinking. While extensive research has identified the involvement of numerous brain regions in AUD, the CoA has emerged as a relatively understudied yet promising candidate for future study. The CoA plays a vital role in rewarding and aversive signaling and olfactory-related behaviors and has recently been shown to be involved in alcohol-dependent drinking in mice. The CoA projects directly to brain regions that are critically important for AUD, such as the central amygdala, bed nucleus of the stria terminalis, and basolateral amygdala. These projections may convey key modulatory signaling that drives excessive alcohol drinking in alcohol-dependent subjects. This review summarizes existing knowledge on the structure and connectivity of the CoA and its potential involvement in AUD. Understanding the contribution of this region to excessive drinking behavior could offer novel insights into the etiology of AUD and potential therapeutic targets.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 151-159"},"PeriodicalIF":2.5,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study 基于与酒精相关的面部潮红反应，饮酒对高血压风险的影响：来自健康体检者研究。

IF 2.5 4区医学

Alcohol Pub Date : 2024-03-01 DOI: 10.1016/j.alcohol.2024.02.010

{"title":"Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study","authors":"","doi":"10.1016/j.alcohol.2024.02.010","DOIUrl":"10.1016/j.alcohol.2024.02.010","url":null,"abstract":"<div><h3>Background</h3><div>Alcohol consumption is a significant public health concern in Korea, with many individuals engaging in risky drinking behaviors. This study aims to analyze the association between facial flushing responses and the progression of hypertension in Korean adults, stratified by gender, using a large-scale prospective cohort study.</div></div><div><h3>Methods</h3><div>This study included 39,868 participants (10,868 males and 29,000 females) from the health examinees cohort. Participants were divided into two groups according to their weekly drinking patterns (moderate and heavy) and facial flushing responses (non-flusher and flusher) for statistical analysis. A multivariate Cox proportional hazards regression model was used to calculate hazard ratios and 95% confidence intervals between flushing response after alcohol consumption and hypertension risk.</div></div><div><h3>Results</h3><div>In males, the flusher group with a moderate alcohol intake pattern had a decreased risk of incident hypertension compared with non-flushers. In females, the flusher group had relatively higher risk of pre-hypertension and hypertension compared to the non-flusher group.</div></div><div><h3>Conclusion</h3><div>The association between facial flushing and hypertension varies depending on the level of alcohol consumption and should be considered in relation to gender differences. Further research is needed to understand the relationship between facial flushing response and the risk of hypertension based on alcohol consumption levels.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 133-139"},"PeriodicalIF":2.5,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance on a relational integration task is impaired during hangover 宿醉时，关系整合任务的表现会受到影响。

IF 2.5 4区医学

Alcohol Pub Date : 2024-02-28 DOI: 10.1016/j.alcohol.2024.02.009

{"title":"Performance on a relational integration task is impaired during hangover","authors":"","doi":"10.1016/j.alcohol.2024.02.009","DOIUrl":"10.1016/j.alcohol.2024.02.009","url":null,"abstract":"<div><p>Recently, researchers have proposed an updated model of executive functions that includes relational integration, the mental ability to bind information into more complex structures. Hangover is known to disrupt other core components of executive functions, but little is known about how it influences relational integration. Therefore, this study aimed to investigate how hangover influences performance on a relational integration task. Twenty-seven participants completed an online relational integration task and mood- and emotion-regulation questionnaires during a hangover and no-hangover condition in this naturalistic design study. Results indicated that relational integration was impaired in hangover (<em>p</em> < 0.001, η<sub>p</sub><sup>2</sup> = 0.562) relative to the no-hangover condition. In addition, participants experienced greater difficulties in regulating emotions (<em>p</em> < 0.001, <em>d</em> = 0.85) and lower mood (<em>p</em> < 0.001, <em>d</em> = 0.88) during hangover. These results suggest that relational integration is impaired in hangover and add weight to the argument that cognitive impairments in hangover may be due to the hangover-related impact on domain-general processing resources.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 95-102"},"PeriodicalIF":2.5,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0741832924000351/pdfft?md5=39cf62349504b06e6ace51a5985eca10&pid=1-s2.0-S0741832924000351-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute and chronic alcohol modulation of extended amygdala calcium dynamics 急性和慢性酒精对扩展杏仁核钙动力学的调节作用

IF 2.3 4区医学

Alcohol Pub Date : 2024-02-27 DOI: 10.1016/j.alcohol.2024.02.004

Alison V. Roland , Tzu-Hao Harry Chao , Olivia J. Hon , Samantha N. Machinski , Tori R. Sides , Sophia I. Lee , Yen-Yu Ian Shih , Thomas L. Kash

{"title":"Acute and chronic alcohol modulation of extended amygdala calcium dynamics","authors":"Alison V. Roland , Tzu-Hao Harry Chao , Olivia J. Hon , Samantha N. Machinski , Tori R. Sides , Sophia I. Lee , Yen-Yu Ian Shih , Thomas L. Kash","doi":"10.1016/j.alcohol.2024.02.004","DOIUrl":"10.1016/j.alcohol.2024.02.004","url":null,"abstract":"<div><p>The central amygdala (CeA) and bed nucleus of the stria terminalis (BNST) are reciprocally connected nodes of the extended amygdala thought to play an important role in alcohol consumption. Studies of immediate-early genes indicate that BNST and CeA are acutely activated following alcohol drinking and may signal alcohol reward in nondependent drinkers, while stress signaling in the extended amygdala following chronic alcohol exposure drives increased drinking via negative reinforcement. However, the temporal dynamics of neuronal activation in these regions during drinking behavior are poorly understood. In this study, we used fiber photometry and the genetically encoded calcium sensor GCaMP6s to assess acute changes in neuronal activity during alcohol consumption in BNST and CeA before and after a chronic drinking paradigm. Activity was examined in the pan-neuronal population and separately in dynorphinergic neurons. BNST and CeA showed increased pan-neuronal activity during acute consumption of alcohol and other fluid tastants of positive and negative valence, as well as highly palatable chow. Responses were greatest during initial consummatory bouts and decreased in amplitude with repeated consumption of the same tastant, suggesting modulation by stimulus novelty. Dynorphin neurons showed similar consumption-associated calcium increases in both regions. Following three weeks of continuous alcohol access (CA), calcium increases in dynorphin neurons during drinking were maintained, but pan-neuronal activity and BNST-CeA coherence were altered in a sex-specific manner. These results indicate that BNST and CeA, and dynorphin neurons specifically, are engaged during drinking behavior, and activity dynamics are influenced by stimulus novelty and chronic alcohol.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"116 ","pages":"Pages 53-64"},"PeriodicalIF":2.3,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health disparities in time to diagnosis and survival post-diagnosis of cirrhosis in individuals with alcohol use disorder: A retrospective cohort study 酒精使用障碍患者肝硬化诊断时间和诊断后存活率的健康差异：一项回顾性队列研究。

IF 2.5 4区医学

Alcohol Pub Date : 2024-02-24 DOI: 10.1016/j.alcohol.2024.02.005

{"title":"Health disparities in time to diagnosis and survival post-diagnosis of cirrhosis in individuals with alcohol use disorder: A retrospective cohort study","authors":"","doi":"10.1016/j.alcohol.2024.02.005","DOIUrl":"10.1016/j.alcohol.2024.02.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the impact of race, gender, and ethnicity on the progression from diagnosis to cirrhosis and subsequent survival in patients with alcohol use disorder, with a specific focus on identifying potential disparities in health outcomes.</div></div><div><h3>Method</h3><div>Employing a STROBE-compliant, retrospective cohort design, we analyzed data from patients diagnosed with alcohol use disorder from January 2000 to December 2022, using the University of California Health Data Warehouse. We estimated survival functions using the Kaplan–Meier method and assessed demographic associations using both bivariate and multivariate Cox proportional hazards models.</div></div><div><h3>Results</h3><div>The analysis highlighted a significant association between Hispanic ethnicity and an accelerated timeline for both the diagnosis of alcohol-related cirrhosis following diagnosis of alcohol use disorder and mortality post-cirrhosis diagnosis. The former was evident only in bivariate analysis, but the latter association persisted in multivariate analysis. Gender did not demonstrate a significant correlation with the time to these outcomes, though multiracial identification emerged as a protective factor.</div></div><div><h3>Conclusions</h3><div>The study reveals critical health disparities in the progression and outcomes of cirrhosis, particularly between Hispanic and non-Hispanic patients. These findings underscore the urgent need for targeted healthcare interventions and policies that address these disparities. Future research should delve deeper into the multifaceted factors influencing these outcomes, facilitating the development of more nuanced and effective prevention and treatment strategies for alcohol use disorder and its severe complications.</div></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 141-146"},"PeriodicalIF":2.5,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rapid procedure to assess shifts in discriminative control over drinking during recovery-like behavior 在类似恢复行为中评估对饮酒的辨别控制转变的快速程序。

IF 2.5 4区医学

Alcohol Pub Date : 2024-02-21 DOI: 10.1016/j.alcohol.2024.01.007

{"title":"A rapid procedure to assess shifts in discriminative control over drinking during recovery-like behavior","authors":"","doi":"10.1016/j.alcohol.2024.01.007","DOIUrl":"10.1016/j.alcohol.2024.01.007","url":null,"abstract":"<div><h3>Background</h3><p>Previously, we reported that recovery-like behavior decreases stimulus control over drinking, and this likely plays a role in the clinical observation that longer recovery increases relapse resistance. Those studies were conducted using a procedure that required repeated assessment, preventing a longitudinal analysis of the changes in stimulus control over time in each individual. Here we recapitulate those results and extend them to female rats using a more efficient procedure that allows repeated assessment of changes in stimulus control over drinking during recovery.</p></div><div><h3>Methods</h3><p>Under a multiple concurrent schedule, rats were trained to reliably respond predominantly for ethanol (concurrent Ethanol FR5, Food FR150) in the presence of one stimulus and for food (concurrent Ethanol FR5, Food FR5) in the presence of another stimulus. Stimuli were either lights or tones, depending on the group. After that, a drinking phase in which only the stimulus occasioning ethanol responding was presented (10 or 20 sessions) followed by recovery-like sessions in which only the stimulus occasioning food responding was presented. During these sessions, rats were exposed to the ethanol stimulus under extinction during the first component on sessions 0, 1, 2, 4, 8, and 16. The number of food responses during these stimulus exposures prior to the first five ethanol responses was the primary measure.</p></div><div><h3>Results</h3><p>Consistent with the earlier procedure, the number of food responses during ethanol tests increased as a function of the number of recovery sessions completed, regardless of whether the stimuli were visual or auditory. However, there were no significant effects of extended alcohol exposure or sex.</p></div><div><h3>Conclusions</h3><p>A rapid procedure consistent with the earlier procedure and clinical evidence was developed in which stimulus control over drinking decreased following longer periods of recovery. Under conditions tested, stimulus type, length of drinking history, and sex did not affect this relationship.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"121 ","pages":"Pages 87-93"},"PeriodicalIF":2.5,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of alcohol on the composition and metabolism of the intestinal microbiota among people with HIV: A cross-sectional study 酒精对艾滋病毒感染者肠道微生物群组成和代谢的影响：一项横断面研究

IF 2.5 4区医学

Alcohol Pub Date : 2024-02-20 DOI: 10.1016/j.alcohol.2024.02.003

{"title":"Effects of alcohol on the composition and metabolism of the intestinal microbiota among people with HIV: A cross-sectional study","authors":"","doi":"10.1016/j.alcohol.2024.02.003","DOIUrl":"10.1016/j.alcohol.2024.02.003","url":null,"abstract":"<div><h3>Objectives</h3><p>Alcohol consumption is not uncommon among people with HIV (PWH) and may exacerbate HIV-induced intestinal damage, and further lead to dysbiosis and increased intestinal permeability. This study aimed to determine the changes in the fecal microbiota and its association with alcohol consumption in HIV-infected patients.</p></div><div><h3>Methods</h3><p>A cross-sectional survey was conducted between November 2021 and May 2022, and 93 participants were recruited. To investigate the alterations of alcohol misuse on fecal microbiology in HIV-infected individuals, we performed 16s rDNA gene sequencing on fecal samples from the low-to-moderate drinking (n = 21) and non-drinking (n = 72) groups.</p></div><div><h3>Results</h3><p>Comparison between groups using alpha and beta diversity showed that the diversity of stool microbiota in the low-to-moderate drinking group did not differ from that of the non-drinking group (all <em>p</em> > 0.05). The Linear discriminant Analysis effect size (LEfSe) algorithm was used to determine the bacterial taxa associated with alcohol consumption, and the results showed altered fecal bacterial composition in HIV-infected patients who consumed alcohol; <em>Coprobacillus</em>, <em>Pseudobutyrivibrio</em>, and <em>Peptostreptococcaceae</em> were enriched, and <em>Pasteurellaceae</em> and <em>Xanthomonadaceae</em> were depleted. In addition, by using the Kyoto Encyclopedia of Genes and Genomes (KEGG), functional microbiome features were also found to be altered in the low-to-moderate drinking group compared to the control group, showing a reduction in metabolic pathways (<em>p</em> = 0.036) and cardiovascular disease pathways (<em>p</em> = 0.006).</p></div><div><h3>Conclusion</h3><p>Low-to-moderate drinking will change the composition, metabolism, and cardiovascular disease pathways of the gut microbiota of HIV-infected patients.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"120 ","pages":"Pages 151-159"},"PeriodicalIF":2.5,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0741832924000193/pdfft?md5=9b427fbac5552a8f54716e90ec1f3ecb&pid=1-s2.0-S0741832924000193-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139922589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theory of Planned Behavior and alcohol use in adolescents in Ecuador. Structural linear regression analysis 计划行为理论与厄瓜多尔青少年饮酒情况。结构线性回归分析。

IF 2.5 4区医学

Alcohol Pub Date : 2024-02-13 DOI: 10.1016/j.alcohol.2024.02.002

引用次数: 0

Succession 继承

IF 2.3 4区医学

Alcohol Pub Date : 2024-02-01 DOI: 10.1016/j.alcohol.2023.11.007

David M. Lovinger

引用次数: 0

Ceftriaxone alters the gut microbiome composition and reduces alcohol intake in male and female Sprague–Dawley rats 头孢曲松能改变雄性和雌性 Sprague-Dawley 大鼠的肠道微生物群组成并减少酒精摄入量

IF 2.5 4区医学

Alcohol Pub Date : 2024-01-28 DOI: 10.1016/j.alcohol.2024.01.006

{"title":"Ceftriaxone alters the gut microbiome composition and reduces alcohol intake in male and female Sprague–Dawley rats","authors":"","doi":"10.1016/j.alcohol.2024.01.006","DOIUrl":"10.1016/j.alcohol.2024.01.006","url":null,"abstract":"<div><p>Ceftriaxone is an antibiotic that increases central nervous system (CNS) protein expression of the glutamate transporters GLT-1 and xCT and ameliorates pathological behaviors in rodent models of neurological disease and substance use disorder. However, little ceftriaxone passes through the blood–brain barrier, the CNS binding partner of ceftriaxone is unknown, and ceftriaxone does not consistently upregulate GLT-1 and xCT in cell culture. Ceftriaxone alters the gut microbiome composition in rodents and humans, and the microbiome–gut–brain axis regulates drug-seeking. Thus, here we test the hypothesis that ceftriaxone reduces alcohol intake while ameliorating alcohol-induced disruption of the gut microbiome composition. Male and female Sprague–Dawley rats received intermittent access to alcohol (IAA) while controls received access to only water. Following 17 IAA sessions, ceftriaxone/vehicle treatment was given for 5 days. Analysis of the gut microbiome composition was assessed by 16S rRNA gene amplicon sequencing conducted on fecal pellets collected prior to and after alcohol consumption and following ceftriaxone treatment. Male rats displayed escalated alcohol intake and preference over the course of the 17 sessions; however, total alcohol intake did not differ between the sexes. Ceftriaxone reduced alcohol intake and preference in male and female rats. While alcohol affected a diverse set of amplicon sequencing variants (ASV), ceftriaxone markedly reduced the diversity of microbial communities reflected by a blooming of the <em>Enterococcaceae</em> family. The remaining effects of ceftriaxone, however, encompassed families both affected and unaffected by prior alcohol drinking and highlight the <em>Ruminococcaceae</em> and <em>Muribaculaceae</em> families as bidirectionally modulated by alcohol and ceftriaxone. Altogether, our study confirms that ceftriaxone reduces alcohol intake in rats and partially reverses alcohol-induced dysbiosis.</p></div>","PeriodicalId":7712,"journal":{"name":"Alcohol","volume":"120 ","pages":"Pages 169-178"},"PeriodicalIF":2.5,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139578806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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